DK1222193T3 - Imidazolderivater som phosphodiesterase VII-inhibitorer - Google Patents

Imidazolderivater som phosphodiesterase VII-inhibitorer

Info

Publication number: DK1222193T3
Authority: DK; Denmark
Prior art keywords: imidazole derivatives; phosphodiesterase vii; vii inhibitors; inhibitors; phosphodiesterase
Prior art date: 1999-10-21

Application number

DK00972714T

Other languages

English (en)

Inventor

Michael Eggenweiler

Jonas Rochus

Michael Wolf

Michael Gassen

Oliver Poeschke

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-21

Filing date

2000-10-10

Publication date

2003-12-01

2000-10-10 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2003-12-01 Application granted granted Critical

2003-12-01 Publication of DK1222193T3 publication Critical patent/DK1222193T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Oncology (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Transplantation (AREA)
Epidemiology (AREA)

DK00972714T 1999-10-21 2000-10-10 Imidazolderivater som phosphodiesterase VII-inhibitorer DK1222193T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19950647A DE19950647A1 (de)	1999-10-21	1999-10-21	Imidazolderivate als Phosphodiesterase VII-Hemmer
PCT/EP2000/009926 WO2001029049A2 (de)	1999-10-21	2000-10-10	Imidazolderivate als phosphodiesterase vii-hemmer

Publications (1)

Publication Number	Publication Date
DK1222193T3 true DK1222193T3 (da)	2003-12-01

Family

ID=7926352

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00972714T DK1222193T3 (da)	1999-10-21	2000-10-10	Imidazolderivater som phosphodiesterase VII-inhibitorer

Country Status (22)

Country	Link
EP (1)	EP1222193B1 (da)
JP (1)	JP2003512381A (da)
KR (1)	KR20020060201A (da)
CN (1)	CN1382146A (da)
AR (1)	AR026198A1 (da)
AT (1)	ATE247121T1 (da)
AU (1)	AU780788B2 (da)
BR (1)	BR0014922A (da)
CA (1)	CA2388314C (da)
CZ (1)	CZ293751B6 (da)
DE (2)	DE19950647A1 (da)
DK (1)	DK1222193T3 (da)
ES (1)	ES2200957T3 (da)
HU (1)	HUP0203139A3 (da)
MX (1)	MXPA02003952A (da)
NO (1)	NO20021846L (da)
PL (1)	PL355020A1 (da)
PT (1)	PT1222193E (da)
RU (1)	RU2259199C2 (da)
SK (1)	SK4922002A3 (da)
WO (1)	WO2001029049A2 (da)
ZA (1)	ZA200203995B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003053975A1 (en)	2001-12-13	2003-07-03	Daiichi Suntory Pharma Co., Ltd.	Pyrazolopyrimidinone derivatives having pde7-inhibitory activity
DE10163991A1 (de) *	2001-12-24	2003-07-03	Merck Patent Gmbh	Pyrrolo-pyrimidine
JP2006219374A (ja)	2003-06-13	2006-08-24	Daiichi Asubio Pharma Co Ltd	Ｐｄｅ７阻害作用を有するイミダゾトリアジノン誘導体
JP2006219373A (ja)	2003-06-13	2006-08-24	Daiichi Asubio Pharma Co Ltd	Ｐｄｅ７阻害作用を有するピリジニルピラゾロピリミジノン誘導体
EP2433943B1 (en)	2004-07-01	2013-09-11	Daiichi Sankyo Company, Limited	Intermediates for thienopyrazole derivatives having PDE7 inhibitory activity
WO2008119057A2 (en)	2007-03-27	2008-10-02	Omeros Corporation	The use of pde7 inhibitors for the treatment of movement disorders
US8637528B2 (en)	2007-03-27	2014-01-28	Omeros Corporation	Use of PDE7 inhibitors for the treatment of movement disorders
US9220715B2 (en)	2010-11-08	2015-12-29	Omeros Corporation	Treatment of addiction and impulse-control disorders using PDE7 inhibitors
KR20130124333A (ko)	2010-11-08	2013-11-13	오메로스 코포레이션	Pde7 억제제를 사용한 중독 및 충동-조절 장애의 치료
AU2023326563A1 (en)	2022-08-18	2025-02-27	Mitodicure Gmbh	Use of a therapeutic agent with phosphodiesterase-7 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4305954A (en) *	1981-02-11	1981-12-15	E. I. Du Pont De Nemours And Company	Antiinflammatory 3,4-dihydro(or 1,4-dihydro)-2-[(substituted)thio]-[1]benzopyrano[3,4-d]imidazoles and their corresponding sulfoxides and sulfones
HU228673B1 (en) *	1993-08-19	2013-05-28	Janssen Pharmaceutica Nv	Vasoconstrictive substituted dihydropyranopyridines, process for producing them and pharmaceutical compositions containing them
DE19632423A1 (de) *	1996-08-12	1998-02-19	Merck Patent Gmbh	Thienopyrimidine
TW591030B (en) *	1997-03-10	2004-06-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
WO2000023091A2 (en) *	1998-10-15	2000-04-27	Bioimage A/S	Specific therapeutic interventions obtained by interference with redistribution and/or targeting of cyclic nucleotide phosphodiesterases of i-kappa-b kinases
AU4589800A (en) *	1999-05-05	2000-11-21	Darwin Discovery Limited	9-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,9-dihydropurin-6-one derivatives as pde7inhibitors

1999
- 1999-10-21 DE DE19950647A patent/DE19950647A1/de not_active Withdrawn
2000
- 2000-10-10 EP EP00972714A patent/EP1222193B1/de not_active Expired - Lifetime
- 2000-10-10 JP JP2001531847A patent/JP2003512381A/ja active Pending
- 2000-10-10 AU AU11356/01A patent/AU780788B2/en not_active Ceased
- 2000-10-10 WO PCT/EP2000/009926 patent/WO2001029049A2/de not_active Ceased
- 2000-10-10 PL PL00355020A patent/PL355020A1/xx unknown
- 2000-10-10 BR BR0014922-5A patent/BR0014922A/pt not_active IP Right Cessation
- 2000-10-10 CA CA002388314A patent/CA2388314C/en not_active Expired - Fee Related
- 2000-10-10 RU RU2002111413/15A patent/RU2259199C2/ru not_active IP Right Cessation
- 2000-10-10 PT PT00972714T patent/PT1222193E/pt unknown
- 2000-10-10 ES ES00972714T patent/ES2200957T3/es not_active Expired - Lifetime
- 2000-10-10 DE DE50003309T patent/DE50003309D1/de not_active Expired - Lifetime
- 2000-10-10 AT AT00972714T patent/ATE247121T1/de not_active IP Right Cessation
- 2000-10-10 SK SK492-2002A patent/SK4922002A3/sk unknown
- 2000-10-10 HU HU0203139A patent/HUP0203139A3/hu unknown
- 2000-10-10 MX MXPA02003952A patent/MXPA02003952A/es unknown
- 2000-10-10 KR KR1020027004903A patent/KR20020060201A/ko not_active Withdrawn
- 2000-10-10 DK DK00972714T patent/DK1222193T3/da active
- 2000-10-10 CZ CZ20021251A patent/CZ293751B6/cs not_active IP Right Cessation
- 2000-10-10 CN CN00814402A patent/CN1382146A/zh active Pending
- 2000-10-20 AR ARP000105542A patent/AR026198A1/es unknown
2002
- 2002-04-19 NO NO20021846A patent/NO20021846L/no not_active Application Discontinuation
- 2002-05-20 ZA ZA200203995A patent/ZA200203995B/en unknown

Also Published As

Publication number	Publication date
ATE247121T1 (de)	2003-08-15
PT1222193E (pt)	2003-12-31
CA2388314A1 (en)	2001-04-26
AU780788B2 (en)	2005-04-14
JP2003512381A (ja)	2003-04-02
HUP0203139A2 (hu)	2003-01-28
SK4922002A3 (en)	2002-09-10
CZ20021251A3 (cs)	2002-07-17
DE50003309D1 (de)	2003-09-18
PL355020A1 (en)	2004-03-22
MXPA02003952A (es)	2004-09-06
AU1135601A (en)	2001-04-30
BR0014922A (pt)	2002-06-11
WO2001029049A3 (de)	2001-11-01
EP1222193A2 (de)	2002-07-17
EP1222193B1 (de)	2003-08-13
NO20021846D0 (no)	2002-04-19
DE19950647A1 (de)	2001-04-26
ES2200957T3 (es)	2004-03-16
NO20021846L (no)	2002-04-19
HUP0203139A3 (en)	2004-12-28
CZ293751B6 (cs)	2004-07-14
WO2001029049A2 (de)	2001-04-26
AR026198A1 (es)	2003-01-29
ZA200203995B (en)	2003-10-29
CN1382146A (zh)	2002-11-27
KR20020060201A (ko)	2002-07-16
RU2259199C2 (ru)	2005-08-27
CA2388314C (en)	2009-06-16

Publication	Publication Date	Title
NO20021239L (no)	2002-03-13	Pteridinoner som kinase-inhibitorer
NO20023828L (no)	2002-09-30	Pyrimidin-4-on derivater som LDL-PLA2 inhibitorer
ATE256127T1 (de)	2003-12-15	Betacarbolinderivate als phosphodiesterase- inhibitoren
PL365134A1 (pl)	2004-12-27	Pochodne imidazolu
DK1244647T3 (da)	2006-09-25	Quinzolinderivater som VIGF-inhibitorer
ATE360620T1 (de)	2007-05-15	Imidazolderivate
ATE278690T1 (de)	2004-10-15	Substituierte pyprolopyridinonderivate als phosphodiesterase-inhibitoren
ATE425147T1 (de)	2009-03-15	Imidazolderivate
NL300242I1 (nl)	2006-12-01	Mega-carboxyaryl gesubstitueerde difenylureums alsraf kinaseremmers.
NO20015065D0 (no)	2001-10-18	Pyrazolobenzodiazepiner som CDK2-inhibitorer
NO20022125D0 (no)	2002-05-03	Pyrrolderivater som inhibitorer for fosfodiesterase VII
DK1226143T3 (da)	2003-06-30	Imidazopyridinderivater som phosphodiesterase VII-inhibitorer
DK1228073T3 (da)	2003-11-03	Imidazolforbindelser som phosphodiesterase VII-inhibitorer
NO20016201D0 (no)	2001-12-18	Tienopyrimidiner som fosfodiesteraseinhibitorer
NO20021959D0 (no)	2002-04-25	Tetrahydrotiopyranftalazinon-derivater som PDE4-inhibitorer
NO20022123D0 (no)	2002-05-03	Osoksazolderivater for anvendelse som inhibitorer for fosfodiesterase VII
NO20021846D0 (no)	2002-04-19	Imidazolderivater som fosfodiesterase VII-inhibitorer
ATE262528T1 (de)	2004-04-15	Substituierte purine-derivate als zell- adhäsionhemmer
NO20014234D0 (no)	2001-08-31	Pyrazol-3-on-derivater som faktor-Xa-inhibitorer
ATE262517T1 (de)	2004-04-15	Thiopyranderivate as mmp-inhibitoren
EE200200389A (et)	2003-10-15	Imidasooli uued derivaadid
ATE264308T1 (de)	2004-04-15	Aminoalkyl-3,4-dihydrochinolin-derivate als no synthase inhibitoren
NO20020592D0 (no)	2002-02-06	Fluorenderivater som integrininhibitorer
DK1296981T3 (da)	2005-07-25	Substituerede pyrrolopyridinonderivater som phosphodiesteraseinhibitorer