DK1238283T3 - Analyser for modulatorer af proteaseaktiverede receptorer (PAR) - Google Patents

Analyser for modulatorer af proteaseaktiverede receptorer (PAR)

Info

Publication number
DK1238283T3
DK1238283T3 DK00991185T DK00991185T DK1238283T3 DK 1238283 T3 DK1238283 T3 DK 1238283T3 DK 00991185 T DK00991185 T DK 00991185T DK 00991185 T DK00991185 T DK 00991185T DK 1238283 T3 DK1238283 T3 DK 1238283T3
Authority
DK
Denmark
Prior art keywords
par
modulators
protease
assays
activated receptors
Prior art date
Application number
DK00991185T
Other languages
English (en)
Inventor
Ludger Altrogge
Denis Monard
Original Assignee
Novartis Forschungsstiftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Forschungsstiftung filed Critical Novartis Forschungsstiftung
Application granted granted Critical
Publication of DK1238283T3 publication Critical patent/DK1238283T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/975Kit

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Optical Communication System (AREA)
  • Holo Graphy (AREA)
  • Gyroscopes (AREA)
DK00991185T 1999-12-15 2000-12-13 Analyser for modulatorer af proteaseaktiverede receptorer (PAR) DK1238283T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9929674.1A GB9929674D0 (en) 1999-12-15 1999-12-15 Protease-activated receptor (PAR) modulator assays
PCT/EP2000/012673 WO2001044496A2 (en) 1999-12-15 2000-12-13 Protease-activated receptor (par) modulator assays

Publications (1)

Publication Number Publication Date
DK1238283T3 true DK1238283T3 (da) 2007-04-02

Family

ID=10866389

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00991185T DK1238283T3 (da) 1999-12-15 2000-12-13 Analyser for modulatorer af proteaseaktiverede receptorer (PAR)

Country Status (11)

Country Link
US (1) US7148018B2 (da)
EP (1) EP1238283B1 (da)
AT (1) ATE349699T1 (da)
AU (1) AU3158501A (da)
CY (1) CY1106384T1 (da)
DE (1) DE60032632T2 (da)
DK (1) DK1238283T3 (da)
ES (1) ES2277866T3 (da)
GB (1) GB9929674D0 (da)
PT (1) PT1238283E (da)
WO (1) WO2001044496A2 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
JP2008510726A (ja) * 2004-08-20 2008-04-10 エントレメッド インコーポレイテッド プロテイナーゼ活性化受容体アンタゴニストを含む組成物および方法
CA2733041A1 (en) * 2008-08-05 2010-02-11 Boehringer Ingelheim International Gmbh Effectors of par-2 activation and their use in the modulation of inflammation
EP2776458B1 (en) * 2011-11-07 2018-07-25 The Scripps Research Institute Protease activated receptor-1 (par1) derived cytoprotective polypeptides and related methods
ES2909709T3 (es) * 2016-05-12 2022-05-10 Heptares Therapeutics Ltd Inhibidores del receptor 2 activado por proteasa

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR930701619A (ko) 1990-06-01 1993-06-12 레나토 스가르비 인체 면역 결핍 바이러스의 gag 단백질 전구체 p55에 대한 단일클론 항체
US5235039A (en) * 1991-06-10 1993-08-10 Eli Lilly And Company Substrates for hiv protease
US5605809A (en) 1994-10-28 1997-02-25 Oncoimmunin, Inc. Compositions for the detection of proteases in biological samples and methods of use thereof
AU4904397A (en) 1996-10-17 1998-05-11 Chiron Corporation Protease regulator screening assay
US5892014A (en) 1996-10-30 1999-04-06 The Regents Of The University Of California DNA encoding a protease-activated receptor 3
US6243980B1 (en) 1997-03-07 2001-06-12 Tropix, Inc. Protease inhibitor assay
US6111075A (en) 1998-04-01 2000-08-29 Zymogenetics, Inc. Protese-activated receptor PAR4 (ZCHEMR2)

Also Published As

Publication number Publication date
WO2001044496A2 (en) 2001-06-21
PT1238283E (pt) 2007-03-30
DE60032632D1 (de) 2007-02-08
CY1106384T1 (el) 2011-10-12
GB9929674D0 (en) 2000-02-09
US20030148921A1 (en) 2003-08-07
AU3158501A (en) 2001-06-25
WO2001044496A3 (en) 2002-05-10
US7148018B2 (en) 2006-12-12
ATE349699T1 (de) 2007-01-15
EP1238283A2 (en) 2002-09-11
EP1238283B1 (en) 2006-12-27
DE60032632T2 (de) 2007-11-15
ES2277866T3 (es) 2007-08-01

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