DK1242405T3 - Fremgangsmåde til fremstilling af 4-(heteroaryl-methyl)-1(2H)-phthalazinoner - Google Patents

Fremgangsmåde til fremstilling af 4-(heteroaryl-methyl)-1(2H)-phthalazinoner

Info

Publication number: DK1242405T3
Authority: DK; Denmark
Prior art keywords: phthalazinones; heteroaryl; methyl; preparation; reaction
Prior art date: 1999-12-23

Application number

DK00983354T

Other languages

Danish (da)

English (en)

Inventor

Thomas Heiner

Harribert Neh

Orlin Petrov

Martin Krueger

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-23

Filing date

2000-12-20

Publication date

2004-11-01

2000-12-20 Application filed by Schering Ag filed Critical Schering Ag

2004-11-01 Application granted granted Critical

2004-11-01 Publication of DK1242405T3 publication Critical patent/DK1242405T3/da

Links

238000000034 method Methods 0.000 title abstract 4
IJAPPYDYQCXOEF-UHFFFAOYSA-N phthalazin-1(2H)-one Chemical class C1=CC=C2C(=O)NN=CC2=C1 IJAPPYDYQCXOEF-UHFFFAOYSA-N 0.000 title 1
NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 abstract 1
NIQMWTLRDNQDIA-UHFFFAOYSA-N 4-(pyridin-4-ylmethyl)-2h-phthalazin-1-one Chemical compound C12=CC=CC=C2C(=O)NN=C1CC1=CC=NC=C1 NIQMWTLRDNQDIA-UHFFFAOYSA-N 0.000 abstract 1
238000010306 acid treatment Methods 0.000 abstract 1
239000002671 adjuvant Substances 0.000 abstract 1
230000007613 environmental effect Effects 0.000 abstract 1
IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
BGUWFUQJCDRPTL-UHFFFAOYSA-N pyridine-4-carbaldehyde Chemical compound O=CC1=CC=NC=C1 BGUWFUQJCDRPTL-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Catalysts (AREA)

DK00983354T 1999-12-23 2000-12-20 Fremgangsmåde til fremstilling af 4-(heteroaryl-methyl)-1(2H)-phthalazinoner DK1242405T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19963607A DE19963607B4 (de)	1999-12-23	1999-12-23	Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen
PCT/EP2000/013027 WO2001047912A1 (de)	1999-12-23	2000-12-20	Verfahren zur herstellung von 4-(heteroaryl-methyl)-halogen-1(2h)-phthalazinonen

Publications (1)

Publication Number	Publication Date
DK1242405T3 true DK1242405T3 (da)	2004-11-01

Family

ID=7934888

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00983354T DK1242405T3 (da)	1999-12-23	2000-12-20	Fremgangsmåde til fremstilling af 4-(heteroaryl-methyl)-1(2H)-phthalazinoner

Country Status (31)

Country	Link
US (1)	US6891041B2 (sr)
EP (1)	EP1242405B1 (sr)
JP (1)	JP2003529555A (sr)
KR (1)	KR100654265B1 (sr)
CN (1)	CN1221545C (sr)
AT (1)	ATE273972T1 (sr)
AU (1)	AU772981B2 (sr)
BG (1)	BG65387B1 (sr)
BR (1)	BR0016634A (sr)
CA (1)	CA2395407C (sr)
CZ (1)	CZ20022146A3 (sr)
DE (2)	DE19963607B4 (sr)
DK (1)	DK1242405T3 (sr)
EE (1)	EE04940B1 (sr)
ES (1)	ES2223626T3 (sr)
HR (1)	HRP20020605B1 (sr)
HU (1)	HUP0300992A3 (sr)
IL (2)	IL150017A0 (sr)
MX (1)	MXPA02006224A (sr)
NO (1)	NO321357B1 (sr)
NZ (1)	NZ519285A (sr)
PL (1)	PL200714B1 (sr)
PT (1)	PT1242405E (sr)
RO (1)	RO121211B1 (sr)
RS (1)	RS50458B (sr)
RU (1)	RU2250900C2 (sr)
SI (1)	SI1242405T1 (sr)
SK (1)	SK285522B6 (sr)
UA (1)	UA72021C2 (sr)
WO (1)	WO2001047912A1 (sr)
ZA (1)	ZA200205853B (sr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1296984B1 (it) *	1997-12-19	1999-08-03	Zambon Spa	Derivati ftalazinici inibitori della fosfodiesterasi 4
US7151102B2 (en) *	2000-10-30	2006-12-19	Kudos Pharmaceuticals Limited	Phthalazinone derivatives
GB0419072D0 (en)	2004-08-26	2004-09-29	Kudos Pharm Ltd	Phthalazinone derivatives
UY30639A1 (es) *	2006-10-17	2008-05-31	Kudos Pharm Ltd	Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
AU2008313467B2 (en) *	2007-10-17	2013-08-29	Kudos Pharmaceuticals Limited	4- [3- (4-cyclopropanecarbonyl-piperazine-1-carbonyl) -4 -fluoro-benzyl] -2H-phthalazin-1-one
BR122021018683B1 (pt) *	2008-10-07	2022-11-16	Kudos Pharmaceuticals Limited	Formulação farmacêutica de 4-[3-(4-ciclopropanocarbonil- piperazina-1-carbonil)-4-flúor- benzil]-2h-ftalazin-1-ona, uso de um polímero de matriz, forma de dosagem e método para produzir uma dispersão amorfa sólida
CN105307655B (zh)	2013-03-13	2019-05-03	弗拉特利发现实验室有限责任公司	哒嗪酮化合物及其用于制备治疗囊肿状纤维化的药物的应用
WO2016146303A1 (en) *	2015-03-19	2016-09-22	Clariant International Ltd	Biodegradable sugar-amide-surfactants for enhanced oil recovery

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE567431A (sr) *	1957-05-07
GB1293565A (en) *	1969-05-03	1972-10-18	Aspro Nicholas Ltd	Aminophthalazines and pharmaceutical compositions thereof
IE47592B1 (en) *	1977-12-29	1984-05-02	Ici Ltd	Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
EP0634404A1 (en) *	1993-07-13	1995-01-18	Rhone Poulenc Agriculture Ltd.	Phtalazin derivatives and their use as pesticides
JP3919835B2 (ja) *	1994-08-09	2007-05-30	エーザイ・アール・アンド・ディー・マネジメント株式会社	縮合ピリダジン系化合物
RU2128175C1 (ru) *	1994-08-09	1999-03-27	Эйсай Ко., Лтд.	Конденсированный пиридазин или его фармакологически приемлемая соль, средство, проявляющее ингибирующую активность в отношении циклической гмф- фосфодиэстеразы
CA2173493C (en) *	1994-08-09	2008-03-25	Nobuhisa Watanabe	Fused pyridazine compounds
CA2275686C (en) *	1996-12-18	2006-10-17	Neurogen Corporation	Isoquinolinamine and phthalazinamine derivatives which interact with crf receptors
CO4950519A1 (es) *	1997-02-13	2000-09-01	Novartis Ag	Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
IT1296984B1 (it) *	1997-12-19	1999-08-03	Zambon Spa	Derivati ftalazinici inibitori della fosfodiesterasi 4
ITMI981670A1 (it) *	1998-07-21	2000-01-21	Zambon Spa	Derivati ftalazinici inibitori della fosfodiesterasi 4
ITMI981671A1 (it) *	1998-07-21	2000-01-21	Zambon Spa	Derivati ftalazinici inibitori della fosfodisterasi 4
ITMI20000261A1 (it) *	2000-02-16	2001-08-16	Zambon Group	Processo per la preparazione di piridiniliden-ftalidi

1999
- 1999-12-23 DE DE19963607A patent/DE19963607B4/de not_active Expired - Fee Related
2000
- 2000-12-20 ES ES00983354T patent/ES2223626T3/es not_active Expired - Lifetime
- 2000-12-20 PL PL355525A patent/PL200714B1/pl not_active IP Right Cessation
- 2000-12-20 EE EEP200200307A patent/EE04940B1/xx not_active IP Right Cessation
- 2000-12-20 KR KR1020027007997A patent/KR100654265B1/ko not_active Expired - Fee Related
- 2000-12-20 JP JP2001549382A patent/JP2003529555A/ja active Pending
- 2000-12-20 SI SI200030486T patent/SI1242405T1/xx unknown
- 2000-12-20 DK DK00983354T patent/DK1242405T3/da active
- 2000-12-20 AT AT00983354T patent/ATE273972T1/de not_active IP Right Cessation
- 2000-12-20 IL IL15001700A patent/IL150017A0/xx active IP Right Grant
- 2000-12-20 AU AU20122/01A patent/AU772981B2/en not_active Ceased
- 2000-12-20 BR BR0016634-0A patent/BR0016634A/pt not_active Application Discontinuation
- 2000-12-20 HU HU0300992A patent/HUP0300992A3/hu unknown
- 2000-12-20 RS YUP-473/02A patent/RS50458B/sr unknown
- 2000-12-20 PT PT00983354T patent/PT1242405E/pt unknown
- 2000-12-20 CZ CZ20022146A patent/CZ20022146A3/cs unknown
- 2000-12-20 NZ NZ519285A patent/NZ519285A/xx unknown
- 2000-12-20 US US10/168,794 patent/US6891041B2/en not_active Expired - Fee Related
- 2000-12-20 DE DE50007520T patent/DE50007520D1/de not_active Expired - Fee Related
- 2000-12-20 CN CNB008175608A patent/CN1221545C/zh not_active Expired - Fee Related
- 2000-12-20 RO ROA200200653A patent/RO121211B1/ro unknown
- 2000-12-20 MX MXPA02006224A patent/MXPA02006224A/es active IP Right Grant
- 2000-12-20 HR HR20020605A patent/HRP20020605B1/xx not_active IP Right Cessation
- 2000-12-20 WO PCT/EP2000/013027 patent/WO2001047912A1/de not_active Ceased
- 2000-12-20 UA UA2002076049A patent/UA72021C2/uk unknown
- 2000-12-20 SK SK892-2002A patent/SK285522B6/sk not_active IP Right Cessation
- 2000-12-20 CA CA002395407A patent/CA2395407C/en not_active Expired - Fee Related
- 2000-12-20 RU RU2002119559/04A patent/RU2250900C2/ru not_active IP Right Cessation
- 2000-12-20 EP EP00983354A patent/EP1242405B1/de not_active Expired - Lifetime
2002
- 2002-06-04 IL IL150017A patent/IL150017A/en not_active IP Right Cessation
- 2002-06-19 BG BG106843A patent/BG65387B1/bg unknown
- 2002-06-21 NO NO20023014A patent/NO321357B1/no not_active IP Right Cessation
- 2002-07-22 ZA ZA200205853A patent/ZA200205853B/en unknown

Also Published As

Publication number	Publication date
PL200714B1 (pl)	2009-01-30
DE50007520D1 (de)	2004-09-23
DE19963607B4 (de)	2005-12-15
HRP20020605B1 (en)	2007-06-30
CA2395407C (en)	2009-04-28
US6891041B2 (en)	2005-05-10
EP1242405B1 (de)	2004-08-18
US20040192695A1 (en)	2004-09-30
BG65387B1 (bg)	2008-05-30
NO20023014D0 (no)	2002-06-21
RO121211B1 (ro)	2007-01-30
AU772981B2 (en)	2004-05-13
KR20020062363A (ko)	2002-07-25
SI1242405T1 (en)	2005-02-28
NZ519285A (en)	2004-12-24
SK285522B6 (sk)	2007-03-01
EE200200307A (et)	2003-06-16
CN1413203A (zh)	2003-04-23
IL150017A0 (en)	2002-12-01
HUP0300992A2 (hu)	2003-08-28
ATE273972T1 (de)	2004-09-15
SK8922002A3 (en)	2002-11-06
UA72021C2 (en)	2005-01-17
CA2395407A1 (en)	2001-07-05
PT1242405E (pt)	2004-11-30
YU47302A (sh)	2005-06-10
BR0016634A (pt)	2002-10-15
RU2002119559A (ru)	2004-01-10
EP1242405A1 (de)	2002-09-25
HUP0300992A3 (en)	2005-11-28
JP2003529555A (ja)	2003-10-07
NO20023014L (no)	2002-06-21
ZA200205853B (en)	2004-02-18
BG106843A (en)	2003-02-28
MXPA02006224A (es)	2002-12-05
IL150017A (en)	2006-12-31
AU2012201A (en)	2001-07-09
WO2001047912A1 (de)	2001-07-05
RS50458B (sr)	2010-03-02
RU2250900C2 (ru)	2005-04-27
DE19963607A1 (de)	2001-07-12
CN1221545C (zh)	2005-10-05
ES2223626T3 (es)	2005-03-01
CZ20022146A3 (cs)	2002-09-11
EE04940B1 (et)	2007-12-17
PL355525A1 (en)	2004-05-04
KR100654265B1 (ko)	2006-12-07
HK1055296A1 (en)	2004-01-02
NO321357B1 (no)	2006-05-02
HRP20020605A2 (en)	2004-12-31

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