DK1244433T3 - Anvendelse af ikke-humant SHIP2-knockout-pattedyr - Google Patents

Anvendelse af ikke-humant SHIP2-knockout-pattedyr

Info

Publication number: DK1244433T3
Authority: DK; Denmark
Prior art keywords: ship2; inhibitor; human; present; knockout mammals
Prior art date: 1999-11-03

Application number

DK00974190T

Other languages

Danish (da)

English (en)

Inventor

Christophe Erneux

Stephane Schurmans

Original Assignee

Euroscreen Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-03

Filing date

2000-10-31

Publication date

2006-07-10

2000-10-31 Application filed by Euroscreen Sa filed Critical Euroscreen Sa

2006-07-10 Application granted granted Critical

2006-07-10 Publication of DK1244433T3 publication Critical patent/DK1244433T3/da

Links

101000688606 Homo sapiens Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Proteins 0.000 title abstract 2
241000124008 Mammalia Species 0.000 title abstract 2
102000044926 human INPPL1 Human genes 0.000 title 1
239000003112 inhibitor Substances 0.000 abstract 2
SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 abstract 1
102100024242 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Human genes 0.000 abstract 1
230000037430 deletion Effects 0.000 abstract 1
238000012217 deletion Methods 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 abstract 1
229960000367 inositol Drugs 0.000 abstract 1
102000030582 inositol polyphosphate 5-phosphatase Human genes 0.000 abstract 1
108060004006 inositol polyphosphate 5-phosphatase Proteins 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Obesity (AREA)
Endocrinology (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Investigating Or Analysing Biological Materials (AREA)
Liquid Crystal (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK00974190T 1999-11-03 2000-10-31 Anvendelse af ikke-humant SHIP2-knockout-pattedyr DK1244433T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP99870229A EP1097713A1 (fr)	1999-11-03	1999-11-03	Inhibiteur de la inositol-phosphatase ship-2

Publications (1)

Publication Number	Publication Date
DK1244433T3 true DK1244433T3 (da)	2006-07-10

Family

ID=8243920

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00974190T DK1244433T3 (da)	1999-11-03	2000-10-31	Anvendelse af ikke-humant SHIP2-knockout-pattedyr

Country Status (9)

Country	Link
US (4)	US6703215B2 (fr)
EP (2)	EP1097713A1 (fr)
JP (1)	JP2003515532A (fr)
AT (1)	ATE318511T1 (fr)
CA (1)	CA2388180C (fr)
DE (1)	DE60026347T2 (fr)
DK (1)	DK1244433T3 (fr)
ES (1)	ES2259293T3 (fr)
WO (1)	WO2001032186A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1097713A1 (fr) *	1999-11-03	2001-05-09	Euroscreen S.A.	Inhibiteur de la inositol-phosphatase ship-2
US20020165192A1 (en) *	2000-09-19	2002-11-07	Kerr William G.	Control of NK cell function and survival by modulation of ship activity
US7691821B2 (en) *	2001-09-19	2010-04-06	University Of South Florida	Inhibition of SHIP to enhance stem cell harvest and transplantation
AU2001292753A1 (en) *	2000-09-19	2002-04-02	University Of South Florida	Control of nk cell function and survival by modulation of ship activity
US20070224124A1 (en) *	2002-09-30	2007-09-27	University Of South Florida	Novel SH2containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein
US7763592B1 (en)	2003-11-20	2010-07-27	University Of South Florida	SHIP-deficiency to increase megakaryocyte progenitor production
US7807646B1 (en) *	2003-11-20	2010-10-05	University Of South Florida	SHIP-deficiency to increase megakaryocyte progenitor production
EP1987837A1 (fr) *	2007-05-02	2008-11-05	Technische Universität Dresden Medizinische Fakultät Carl Gustav Carus	Composition pharmaceutique pour augmenter la sécrétion d'insuline de cellules pancréatiques ß
WO2012169571A1 (fr) *	2011-06-09	2012-12-13	国立大学法人富山大学	Nouveau dérivé de n-(pyridin-2-yl)alcanamide et inhibiteur de ship2 contenant celui-ci en tant que substance active
US20170336425A1 (en) *	2016-05-18	2017-11-23	The Cleveland Clinic Foundation	Pip2 as a marker for hdl function and cardiovascular disease risk

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5023248A (en) *	1984-10-23	1991-06-11	Perstorp Ab	Method of treating diabetes with inositol triphosphate
JP2750239B2 (ja) *	1991-08-14	1998-05-13	三共株式会社	アデノホスチンａまたはｂならびにその製法
US6218162B1 (en) *	1995-09-27	2001-04-17	Gerald Krystal	SH2-containing inositol-phosphatase
GB9525702D0 (en) *	1995-12-15	1996-02-14	Ciba Geigy Ag	Process for activating a kinase
US5885980A (en) *	1996-06-25	1999-03-23	Enrique G. Gutierrez	Composition and method for treating diabetes
CN1145489C (zh) *	1996-09-20	2004-04-14	加利福尼亚大学董事会	肌醇多磷酸酯衍生物及其使用方法
US6025198A (en) *	1999-06-25	2000-02-15	Isis Pharmaceuticals Inc.	Antisense modulation of Ship-2 expression
EP1097713A1 (fr) *	1999-11-03	2001-05-09	Euroscreen S.A.	Inhibiteur de la inositol-phosphatase ship-2

1999
- 1999-11-03 EP EP99870229A patent/EP1097713A1/fr not_active Withdrawn
2000
- 2000-10-31 CA CA2388180A patent/CA2388180C/fr not_active Expired - Fee Related
- 2000-10-31 DK DK00974190T patent/DK1244433T3/da active
- 2000-10-31 ES ES00974190T patent/ES2259293T3/es not_active Expired - Lifetime
- 2000-10-31 DE DE60026347T patent/DE60026347T2/de not_active Expired - Lifetime
- 2000-10-31 AT AT00974190T patent/ATE318511T1/de not_active IP Right Cessation
- 2000-10-31 EP EP00974190A patent/EP1244433B1/fr not_active Expired - Lifetime
- 2000-10-31 WO PCT/BE2000/000132 patent/WO2001032186A2/fr not_active Ceased
- 2000-10-31 JP JP2001534391A patent/JP2003515532A/ja active Pending
2001
- 2001-08-03 US US09/922,543 patent/US6703215B2/en not_active Expired - Lifetime
2003
- 2003-12-19 US US10/742,431 patent/US7094546B2/en not_active Expired - Lifetime
- 2003-12-19 US US10/742,071 patent/US20050183146A1/en not_active Abandoned
- 2003-12-19 US US10/742,430 patent/US6936452B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO2001032186A2 (fr)	2001-05-10
US7094546B2 (en)	2006-08-22
US20020106713A1 (en)	2002-08-08
CA2388180C (fr)	2012-01-03
EP1244433B1 (fr)	2006-03-01
EP1244433A2 (fr)	2002-10-02
WO2001032186A3 (fr)	2002-07-25
US20040203087A1 (en)	2004-10-14
US20040209342A1 (en)	2004-10-21
US6936452B2 (en)	2005-08-30
CA2388180A1 (fr)	2001-05-10
EP1097713A1 (fr)	2001-05-09
JP2003515532A (ja)	2003-05-07
ES2259293T3 (es)	2006-10-01
DE60026347T2 (de)	2006-12-14
US6703215B2 (en)	2004-03-09
US20050183146A1 (en)	2005-08-18
ATE318511T1 (de)	2006-03-15
DE60026347D1 (de)	2006-04-27

Publication	Publication Date	Title
DE69620241D1 (de)	2002-05-02	Gonadotropin releasing hormon- antagonisten
BR9909492A (pt)	2000-12-12	Liberação pulmonar e nasal de raloxifeno
TR199900408T2 (xx)	1999-05-21	�kameli 6,6-Heterobisiklik t�revler.
ES2121836T3 (es)	1998-12-16	Aminoguanidinas.
BG106585A (en)	2003-03-31	Kinase inhibitors as therapeutic agents
ATE218859T1 (de)	2002-06-15	Liganden des neuropeptids y
NO20003018L (no)	2000-08-04	Triazinangiogenese-inhibitorer
MX9804850A (es)	1998-09-30	Antagonistas de hormona liberadora de gonadotropina.
HRP20000292B1 (hr)	2008-09-30	2-fenil supstituirani imidazotriazinoni kao inhibitori fosfodiesteraze
DK1244433T3 (da)	2006-07-10	Anvendelse af ikke-humant SHIP2-knockout-pattedyr
DE69717268D1 (de)	2003-01-02	M-amidinophenyl-analoga als faktor-xa-inhibitoren
TR199901191T2 (xx)	1999-12-21	Benzamidoaldehitlerin sistein proteaz� inhibit�r� olarak kullan�m�.
ATE199090T1 (de)	2001-02-15	Gegenüber eigenen inhibitoren resistente t-pa mutanten
ATE252572T1 (de)	2003-11-15	5-ht1f agonisten
SV2002000244A (es)	2002-07-16	Metodos y compuestos para inhibir mrp1 ref.x-13353
DE69405785D1 (de)	1997-10-30	Fluorosiloxantrennmittelzusammensetzungen
SE9300012D0 (sv)	1993-01-05	New peptides
DE69911023D1 (de)	2003-10-09	Antagonisten des gonadotropin freisetzenden hormons
BR0015301A (pt)	2002-07-09	Recipiente para limpadores úmidos
DK0941975T3 (da)	2002-04-22	Injiceringscement indeholdende korrosionshæmmere
AR020106A1 (es)	2002-04-10	Variantes estabilizadas del inhibidor de la subtilisina de streptomyces, gen mutante que la codifica y composicion que comprende dicha variante
BG105539A (bg)	2001-12-29	Елетриптан хидробромид монохидрат
AR026901A1 (es)	2003-03-05	Peptidos con n-alquilacion que tienen actividad antiangiogenica
NO308829B1 (no)	2000-11-06	Anvendelse av forbindelsen finasterid for fremstilling av et preparat for behandling av kronisk prostatitt hos menn
BR0112338A (pt)	2003-07-22	Composto, composição farmacêutica, e, uso de um composto