ATE218859T1 - Liganden des neuropeptids y - Google Patents

Liganden des neuropeptids y

Info

Publication number: ATE218859T1
Authority: AT; Austria
Prior art keywords: neuropeptide; ligands; formula; agonists; regulators
Prior art date: 1996-08-23

Application number

AT97939524T

Other languages

English (en)

Inventor

Vlad Edward Gregor

Yufeng Hong

Anthony Lai Ling

Eileen Valenzuela Tompkins

Original Assignee

Agouron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-23

Filing date

1997-08-22

Publication date

2002-06-15

1997-08-22 Application filed by Agouron Pharma filed Critical Agouron Pharma

2002-06-15 Application granted granted Critical

2002-06-15 Publication of ATE218859T1 publication Critical patent/ATE218859T1/de

Links

101710151321 Melanostatin Proteins 0.000 title abstract 3
URPYMXQQVHTUDU-OFGSCBOVSA-N nucleopeptide y Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 URPYMXQQVHTUDU-OFGSCBOVSA-N 0.000 title abstract 3
239000003446 ligand Substances 0.000 title abstract 2
102100028427 Pro-neuropeptide Y Human genes 0.000 title 1
102400000064 Neuropeptide Y Human genes 0.000 abstract 2
239000000556 agonist Substances 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Vascular Medicine (AREA)
Child & Adolescent Psychology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)

AT97939524T 1996-08-23 1997-08-22 Liganden des neuropeptids y ATE218859T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2579196P	1996-08-23	1996-08-23
PCT/US1997/014854 WO1998007420A1 (en)	1996-08-23	1997-08-22	Neuropeptide-y ligands

Publications (1)

Publication Number	Publication Date
ATE218859T1 true ATE218859T1 (de)	2002-06-15

Family

ID=21828075

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97939524T ATE218859T1 (de)	1996-08-23	1997-08-22	Liganden des neuropeptids y

Country Status (11)

Country	Link
US (1)	US6849733B1 (de)
EP (1)	EP0984778B1 (de)
JP (1)	JP2001502296A (de)
AT (1)	ATE218859T1 (de)
AU (1)	AU4159297A (de)
CA (1)	CA2268051A1 (de)
DE (1)	DE69713402T2 (de)
DK (1)	DK0984778T3 (de)
ES (1)	ES2176776T3 (de)
PT (1)	PT984778E (de)
WO (1)	WO1998007420A1 (de)

Families Citing this family (40)

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SE9703414D0 (sv) *	1997-09-23	1997-09-23	Astra Ab	New compounds
SE9802206D0 (sv) *	1998-06-22	1998-06-22	Astra Pharma Inc	Novel compounds
SE9802207D0 (sv) *	1998-06-22	1998-06-22	Astra Pharma Inc	Novel compounds
EP1033366A3 (de) *	1999-02-18	2000-12-27	Pfizer Products Inc.	Amid-Derivate mit Neuropeptid Y (NPY) -antagonistischer Wirkung
US6774243B2 (en)	1999-08-24	2004-08-10	Agouron Pharmaceuticals, Inc.	Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates
US6355807B1 (en)	1999-08-24	2002-03-12	Agouron Pharmaceuticals, Inc.	Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates
DZ3415A1 (fr)	2000-08-31	2002-03-07	Chiron Corp	Guanidinobenzamides comme mc4-r agonistes.
MXPA03002594A (es) *	2000-10-30	2003-06-30	Warner Lambert Co	Ligandos de amidinourea del receptor de serotonina y composiciones, sus usos farmaceuticos y procedimientos para su sintesis.
EP1767525A1 (de)	2001-04-09	2007-03-28	Novartis Vaccines and Diagnostics, Inc.	Guanidinoverbindungen als Melanocortin-4-Rezeptor (MC4-R) Agonisten
DE60333937D1 (de)	2002-05-23	2010-10-07	Novartis Vaccines & Diagnostic	Substituierte quinazolinone verbindungen
JP4806628B2 (ja)	2003-05-05	2011-11-02	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤
KR20060018217A (ko)	2003-05-23	2006-02-28	카이론 코포레이션	Ｍｃ4-ｒ 작용제로서 구아니디노-치환된 퀴나졸리논 화합물
WO2005049027A2 (en)	2003-11-03	2005-06-02	Probiodrug Ag	Combinations useful for the treatment of neuronal disorders
EP1686996A4 (de)	2003-11-19	2008-11-12	Novartis Vaccines & Diagnostic	Chinazolinon-verbindungen mit verringerter bioakkumulation
KR101099206B1 (ko)	2004-02-05	2011-12-27	프로비오드룩 아게	신규한 글루타미닐 시클라제 저해제
WO2006108218A1 (en) *	2005-04-15	2006-10-19	Regenertech Pty Limited	Use of neuropeptide y (npy) and agonists and antagonists thereof for tissue regeneration
WO2007002220A2 (en) *	2005-06-21	2007-01-04	Bristol-Myers Squibb Company	Aminoacetamide acyl guanidines as beta-secretase inhibitors
EP2774925B1 (de)	2005-11-08	2016-12-28	Vertex Pharmaceuticals Incorporated	Heterocyclische Modulatoren von ATP-bindenden Kassettentransportern
US7671221B2 (en)	2005-12-28	2010-03-02	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
US7657504B2 (en) *	2006-10-10	2010-02-02	Microsoft Corporation	User interface for displaying images of sights
US7754739B2 (en)	2007-05-09	2010-07-13	Vertex Pharmaceuticals Incorporated	Modulators of CFTR
US8278345B2 (en)	2006-11-09	2012-10-02	Probiodrug Ag	Inhibitors of glutaminyl cyclase
JP5523107B2 (ja)	2006-11-30	2014-06-18	プロビオドルグエージー	グルタミニルシクラーゼの新規阻害剤
EP2481408A3 (de)	2007-03-01	2013-01-09	Probiodrug AG	Neue Verwendung von Inhibitoren der Glutaminyl Cyclase
WO2008128985A1 (en)	2007-04-18	2008-10-30	Probiodrug Ag	Thiourea derivatives as glutaminyl cyclase inhibitors
WO2008141119A2 (en)	2007-05-09	2008-11-20	Vertex Pharmaceuticals Incorporated	Modulators of cftr
PL2231606T3 (pl)	2007-12-07	2013-07-31	Vertex Pharma	Sposoby wytwarzania kwasów cykloalkilokarboksyamidopirydynobenzoesowych
HUE031913T2 (en)	2007-12-07	2017-08-28	Vertex Pharma	Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
JP5523352B2 (ja)	2008-02-28	2014-06-18	バーテックスファーマシューティカルズインコーポレイテッド	Ｃｆｔｒ修飾因子としてのへテロアリール誘導体
MX2012002993A (es)	2009-09-11	2012-04-19	Probiodrug Ag	Derivados heterociclicos como inhibidores de ciclasa glutaminilo.
JP6026284B2 (ja)	2010-03-03	2016-11-16	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤
US8269019B2 (en)	2010-03-10	2012-09-18	Probiodrug Ag	Inhibitors
RS62767B1 (sr)	2010-04-07	2022-01-31	Vertex Pharma	Farmaceutski sastavi 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il) ciklopropankarboksamido)-3-metilpiriodin-2-il)benzojeve kiseline i njihova primena
WO2011131748A2 (en)	2010-04-21	2011-10-27	Probiodrug Ag	Novel inhibitors
ES2570167T3 (es)	2011-03-16	2016-05-17	Probiodrug Ag	Derivados de benzimidazol como inhibidores de glutaminil ciclasa
MX355183B (es)	2012-01-25	2018-04-09	Vertex Pharma	Formulaciones de acido 3- (6- (1- (2.2- difluorobenzo [d] [1,3] dioxol-5-il) ciclopropancarboxamido) -3- metilpiridin-2-il) benzoico.
HRP20210516T2 (hr)	2013-11-12	2021-10-01	Vertex Pharmaceuticals Incorporated	Postupak proizvodnje farmaceutskih pripravaka za liječenje bolesti koje su posredovane putem cftr
KR102576006B1 (ko)	2014-11-18	2023-09-06	버텍스 파마슈티칼스 인코포레이티드	고처리량 시험 고성능 액체 크로마토그래피의 수행 방법
WO2018097126A1 (ja) *	2016-11-25	2018-05-31	日本曹達株式会社	グアニジン化合物および殺菌剤
PL3461819T3 (pl)	2017-09-29	2020-11-30	Probiodrug Ag	Inhibitory cyklazy glutaminylowej

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JPS58501467A (ja) *	1981-08-24	1983-09-01	ロウラ−　インタ−ナシヨナル（オ−バ−シ−ズ）　インコ−ポレ−テツド	伝染病の治療
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DE4301452A1 (de) *	1993-01-20	1994-07-21	Thomae Gmbh Dr K	Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4326465A1 (de) *	1993-01-20	1995-02-09	Thomae Gmbh Dr K	Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2701480B1 (fr)	1993-02-15	1995-05-24	Sanofi Elf	Composés à groupe sulfamoyle et amidino, leur procédé de préparation et les compositions pharmaceutiques les contenant.
US6562862B1 (en)	1994-10-20	2003-05-13	Eli Lilly And Company	Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y
EP0716854A3 (de)	1994-10-20	1996-08-28	Lilly Co Eli	Zusammensetzungen zur Inhibierung von Neuropeptid Y
PL321136A1 (en)	1994-11-07	1997-11-24	Pfizer	Some substituted derivatives of bencylamine as a new class of specific ligands of neuropeptide y1

1997
- 1997-08-22 ES ES97939524T patent/ES2176776T3/es not_active Expired - Lifetime
- 1997-08-22 PT PT97939524T patent/PT984778E/pt unknown
- 1997-08-22 DK DK97939524T patent/DK0984778T3/da active
- 1997-08-22 EP EP97939524A patent/EP0984778B1/de not_active Expired - Lifetime
- 1997-08-22 CA CA002268051A patent/CA2268051A1/en not_active Abandoned
- 1997-08-22 WO PCT/US1997/014854 patent/WO1998007420A1/en not_active Ceased
- 1997-08-22 AT AT97939524T patent/ATE218859T1/de not_active IP Right Cessation
- 1997-08-22 US US08/916,527 patent/US6849733B1/en not_active Expired - Fee Related
- 1997-08-22 AU AU41592/97A patent/AU4159297A/en not_active Abandoned
- 1997-08-22 JP JP10511019A patent/JP2001502296A/ja not_active Ceased
- 1997-08-22 DE DE69713402T patent/DE69713402T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0984778B1 (de)	2002-06-12
JP2001502296A (ja)	2001-02-20
DK0984778T3 (da)	2002-09-16
US6849733B1 (en)	2005-02-01
AU4159297A (en)	1998-03-06
ES2176776T3 (es)	2002-12-01
EP0984778A1 (de)	2000-03-15
DE69713402D1 (de)	2002-07-18
CA2268051A1 (en)	1998-02-26
WO1998007420A1 (en)	1998-02-26
DE69713402T2 (de)	2002-11-07
EP0984778A4 (de)	2000-06-07
PT984778E (pt)	2002-09-30

Legal Events

Date	Code	Title	Description
2002-11-15	UEP	Publication of translation of european patent specification
2007-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69713402D1 (de)	2002-07-18	Liganden des neuropeptids y
UY34152A (es)	2013-02-28	?oxazolidinonas substituidas y su uso?.
SK86699A3 (en)	2000-11-07	Nitrogen containing heteroaromatics as factor xa inhibitors
EP0599532A3 (de)	1995-05-31	Härtbare Einkomponenten-Organosiloxanzusammensetzungen.
DK0572166T3 (da)	1997-09-01	Hidtil ukendte 7beta-substitueret-4-aza-5beta-androstan-3-oner som 5beta-reduktaseinhibitorer
AU1980997A (en)	1997-09-16	Synthetic Multimerizing Agents
TR199901653T2 (xx)	1999-10-21	Fitalazinonlar.
BG104670A (en)	2001-05-31	4-(2-keto-1-benzimidazolinyl)piperidinne compounds as orl1-receptor agonists
BR9808491A (pt)	2000-05-23	Compostos calcilìticos
ATE228111T1 (de)	2002-12-15	M-amidinophenyl-analoga als faktor-xa-inhibitoren
BG103310A (en)	2000-05-31	Benzonaphthyridins as bronchial therapeutical means
IT1269176B (it)	1997-03-21	Eterobicicli ad attivita' fungicida
SE0004245D0 (sv)	2000-11-20	Novel compounds and their use
SG52766A1 (en)	1998-09-28	Organic compounds
TR199903014T2 (xx)	2000-05-22	5-HT1F Agonistleri olarak yararl� karboksamitler.
NO981393D0 (no)	1998-03-27	Guanidinoproteasehemmere
BG105539A (bg)	2001-12-29	Елетриптан хидробромид монохидрат
GB2324091A (en)	1998-10-14	Metalloproteinase inhibitors
DK1204659T3 (da)	2004-04-05	Serotonerge benzofuraner
RU95106653A (ru)	1996-11-20	Производные 2-имидазолин-5-онов и 2-имидазолин-5-тионов и фунгицидные композиции на их основе
DK1377574T3 (da)	2005-04-25	6-phenylbenzonaphtyridiner
EA199900534A1 (ru)	2000-02-28	Имидазопиридазины
ATE280169T1 (de)	2004-11-15	Serotonerge benzothiophene
TR200100133T2 (tr)	2001-06-21	FKBP İnhibitörleri
ES2103794T3 (es)	1997-10-01	Pirazolinas, pirazolidinas e hidrazinas artropodicidas.