DK1246789T3 - Fremgangsmåde til fremstilling af optisk ren (R)- og (S)-didesmethylsibutramin - Google Patents
Fremgangsmåde til fremstilling af optisk ren (R)- og (S)-didesmethylsibutraminInfo
- Publication number
- DK1246789T3 DK1246789T3 DK01901941T DK01901941T DK1246789T3 DK 1246789 T3 DK1246789 T3 DK 1246789T3 DK 01901941 T DK01901941 T DK 01901941T DK 01901941 T DK01901941 T DK 01901941T DK 1246789 T3 DK1246789 T3 DK 1246789T3
- Authority
- DK
- Denmark
- Prior art keywords
- optically pure
- didesmethylsibutramine
- preparation
- racemic
- disclosed
- Prior art date
Links
- WQSACWZKKZPCHN-CQSZACIVSA-N (1r)-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutan-1-amine Chemical compound C=1C=C(Cl)C=CC=1C1([C@H](N)CC(C)C)CCC1 WQSACWZKKZPCHN-CQSZACIVSA-N 0.000 title 1
- WQSACWZKKZPCHN-AWEZNQCLSA-N (1s)-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutan-1-amine Chemical compound C=1C=C(Cl)C=CC=1C1([C@@H](N)CC(C)C)CCC1 WQSACWZKKZPCHN-AWEZNQCLSA-N 0.000 title 1
- UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical class C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 abstract 2
- 229940094659 Dopamine reuptake inhibitor Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000221 dopamine uptake inhibitor Substances 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/18—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/44—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
- C07C47/457—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Addiction (AREA)
- Gynecology & Obstetrics (AREA)
- Child & Adolescent Psychology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/480,889 US6399826B1 (en) | 1999-08-11 | 2000-01-11 | Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1246789T3 true DK1246789T3 (da) | 2006-09-18 |
Family
ID=23909753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01901941T DK1246789T3 (da) | 2000-01-11 | 2001-01-10 | Fremgangsmåde til fremstilling af optisk ren (R)- og (S)-didesmethylsibutramin |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6399826B1 (da) |
| EP (2) | EP1632471A1 (da) |
| JP (1) | JP2003519675A (da) |
| AT (1) | ATE327972T1 (da) |
| AU (1) | AU782567B2 (da) |
| CA (1) | CA2396950A1 (da) |
| CY (1) | CY1106150T1 (da) |
| DE (1) | DE60120109T2 (da) |
| DK (1) | DK1246789T3 (da) |
| ES (1) | ES2260195T3 (da) |
| PT (1) | PT1246789E (da) |
| WO (1) | WO2001051453A1 (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6974838B2 (en) * | 1998-08-24 | 2005-12-13 | Sepracor Inc. | Methods of treating or preventing pain using sibutramine metabolites |
| US6476078B2 (en) * | 1999-08-11 | 2002-11-05 | Sepracor, Inc. | Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction |
| JP2004513899A (ja) * | 2000-11-15 | 2004-05-13 | タツプ・フアーマシユーテイカル・プロダクツ・インコーポレイテツド | 抗鬱薬誘発性的機能不全のアポモルヒネによる治療 |
| US20050192271A1 (en) * | 2003-07-15 | 2005-09-01 | Hythiam, Inc. | Use of selective chloride channel modulators to treat alcohol and/or stimulant substance abuse |
| US7129378B2 (en) * | 2002-04-10 | 2006-10-31 | Apsinterm, Llc | Method of preparing amine stereoisomers |
| KR100536750B1 (ko) * | 2002-10-05 | 2005-12-16 | 한미약품 주식회사 | 시부트라민 메탄술폰산염의 결정성 반수화물을 포함하는약학 조성물 |
| HRP20050307A2 (en) * | 2002-10-05 | 2006-12-31 | Hanmi Pharm. Co. Ltd. | Pharmaceutical composition comprising crystalline sibutramine methanesulfonate hemihydrate |
| CL2004000826A1 (es) * | 2003-04-25 | 2005-03-04 | Pfizer | Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129 |
| WO2005041988A1 (en) * | 2003-10-22 | 2005-05-12 | University Of Florida | Method and composition for pain amelioration |
| US20050209220A1 (en) * | 2004-03-19 | 2005-09-22 | Jeffrey Conforti | Treatment of peripheral neuropathy |
| US20060160905A1 (en) * | 2005-01-18 | 2006-07-20 | Bergeron Raymond J Jr | Compositions and methods for inhibiting pain |
| WO2006078239A1 (en) | 2005-01-18 | 2006-07-27 | University Of Florida | Compositions and methods for inhibiting pain |
| EP2066329B1 (en) | 2006-09-15 | 2017-09-06 | Reviva Pharmaceuticals, Inc. | Synthesis, methods of using, and compositions of cyclobutylmethylamines |
| CN101555214B (zh) | 2008-04-08 | 2012-07-11 | 北京嘉事联博医药科技有限公司 | 苯基环丁基酰胺衍生物及其光学异构体、制备方法和用途 |
| WO2010065889A2 (en) * | 2008-12-06 | 2010-06-10 | Auspex Pharmaceutical | Cyclobutanemethanamine inhibitors of monomine reuptake |
| CN102791134B (zh) * | 2009-12-04 | 2015-04-22 | 魄金莱默有限公司 | 用多巴胺再摄取抑制剂及类似物治疗糖尿病症状和延迟或预防糖尿病相关病理学病况的方法 |
| WO2012003501A2 (en) | 2010-07-02 | 2012-01-05 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives |
| EP2797870B1 (en) | 2011-12-30 | 2019-02-20 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using 1-[1-phenyl-cyclobutyl]isobutylamine derivatives |
| GB202114564D0 (en) * | 2021-10-12 | 2021-11-24 | Actimed Therapeutics Ltd | Oral formulation |
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| CA2367022A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Method of treating sleep apnoea |
| WO2000056315A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Treatment of pain |
| WO2000056150A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Treatment of premenstrual syndrome |
| WO2000056148A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Treatment of pharmacology of drug misuse and other addictive disorders |
| US6355685B1 (en) | 1999-03-19 | 2002-03-12 | Knoll Pharmaceutical Company | Method of treating anxiety disorders |
| WO2000056321A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Treatment of hyperactivity disorders |
| US6372797B1 (en) | 1999-03-19 | 2002-04-16 | Knoll Pharmaceutical Company | Treatment of menstrual function |
| WO2000056318A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Treatment of neuropathic pain or fibromyalgia |
| WO2000054765A1 (en) | 1999-03-19 | 2000-09-21 | Knoll Gmbh | Method of treating eating disorders |
| AU3898600A (en) | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Method of treating obsessive-compulsive disorder |
| WO2000056309A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Method of treating sexual dysfunction |
| GB9914742D0 (en) * | 1999-06-24 | 1999-08-25 | Knoll Ag | Therapeutic agents |
-
2000
- 2000-01-11 US US09/480,889 patent/US6399826B1/en not_active Expired - Fee Related
-
2001
- 2001-01-10 AU AU27793/01A patent/AU782567B2/en not_active Ceased
- 2001-01-10 ES ES01901941T patent/ES2260195T3/es not_active Expired - Lifetime
- 2001-01-10 PT PT01901941T patent/PT1246789E/pt unknown
- 2001-01-10 DK DK01901941T patent/DK1246789T3/da active
- 2001-01-10 AT AT01901941T patent/ATE327972T1/de not_active IP Right Cessation
- 2001-01-10 EP EP05108783A patent/EP1632471A1/en not_active Withdrawn
- 2001-01-10 CA CA002396950A patent/CA2396950A1/en not_active Abandoned
- 2001-01-10 JP JP2001551835A patent/JP2003519675A/ja active Pending
- 2001-01-10 EP EP01901941A patent/EP1246789B1/en not_active Expired - Lifetime
- 2001-01-10 DE DE60120109T patent/DE60120109T2/de not_active Expired - Fee Related
- 2001-01-10 WO PCT/US2001/000762 patent/WO2001051453A1/en not_active Ceased
-
2002
- 2002-06-04 US US10/160,033 patent/US6710087B2/en not_active Expired - Fee Related
-
2006
- 2006-08-30 CY CY20061101224T patent/CY1106150T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20020183281A1 (en) | 2002-12-05 |
| WO2001051453A1 (en) | 2001-07-19 |
| PT1246789E (pt) | 2006-10-31 |
| EP1246789B1 (en) | 2006-05-31 |
| ATE327972T1 (de) | 2006-06-15 |
| EP1632471A1 (en) | 2006-03-08 |
| DE60120109D1 (de) | 2006-07-06 |
| CA2396950A1 (en) | 2001-07-19 |
| AU782567B2 (en) | 2005-08-11 |
| AU2779301A (en) | 2001-07-24 |
| DE60120109T2 (de) | 2006-10-19 |
| CY1106150T1 (el) | 2011-06-08 |
| US6710087B2 (en) | 2004-03-23 |
| JP2003519675A (ja) | 2003-06-24 |
| EP1246789A1 (en) | 2002-10-09 |
| ES2260195T3 (es) | 2006-11-01 |
| US6399826B1 (en) | 2002-06-04 |
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