ATE327972T1 - Verfahren zur herstellung von optisch-reinen (r)- und (s)- didesmethylsibutramin - Google Patents
Verfahren zur herstellung von optisch-reinen (r)- und (s)- didesmethylsibutraminInfo
- Publication number
- ATE327972T1 ATE327972T1 AT01901941T AT01901941T ATE327972T1 AT E327972 T1 ATE327972 T1 AT E327972T1 AT 01901941 T AT01901941 T AT 01901941T AT 01901941 T AT01901941 T AT 01901941T AT E327972 T1 ATE327972 T1 AT E327972T1
- Authority
- AT
- Austria
- Prior art keywords
- optically pure
- didesmethilsibutramin
- producing optically
- racemic
- disclosed
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical class C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 abstract 2
- 229940094659 Dopamine reuptake inhibitor Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000221 dopamine uptake inhibitor Substances 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/18—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/44—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
- C07C47/457—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/480,889 US6399826B1 (en) | 1999-08-11 | 2000-01-11 | Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE327972T1 true ATE327972T1 (de) | 2006-06-15 |
Family
ID=23909753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01901941T ATE327972T1 (de) | 2000-01-11 | 2001-01-10 | Verfahren zur herstellung von optisch-reinen (r)- und (s)- didesmethylsibutramin |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6399826B1 (de) |
| EP (2) | EP1632471A1 (de) |
| JP (1) | JP2003519675A (de) |
| AT (1) | ATE327972T1 (de) |
| AU (1) | AU782567B2 (de) |
| CA (1) | CA2396950A1 (de) |
| CY (1) | CY1106150T1 (de) |
| DE (1) | DE60120109T2 (de) |
| DK (1) | DK1246789T3 (de) |
| ES (1) | ES2260195T3 (de) |
| PT (1) | PT1246789E (de) |
| WO (1) | WO2001051453A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6476078B2 (en) * | 1999-08-11 | 2002-11-05 | Sepracor, Inc. | Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction |
| US6974838B2 (en) * | 1998-08-24 | 2005-12-13 | Sepracor Inc. | Methods of treating or preventing pain using sibutramine metabolites |
| CA2429047A1 (en) * | 2000-11-15 | 2002-05-23 | Tap Pharmaceutical Products, Inc. | Treatment of anti-depression drug-induced sexual dysfunction with apomorphine |
| US20050192271A1 (en) * | 2003-07-15 | 2005-09-01 | Hythiam, Inc. | Use of selective chloride channel modulators to treat alcohol and/or stimulant substance abuse |
| JP2005522525A (ja) * | 2002-04-10 | 2005-07-28 | アプシンターム・リミテッド・ライアビリティ・カンパニー | アミン立体異性体の製造方法 |
| PL375032A1 (en) * | 2002-10-05 | 2005-11-14 | Hanmi Pharm.Co, Ltd. | Pharmaceutical composition comprising crystalline sibutramine methanesulfonate hemihydrate |
| KR100536750B1 (ko) * | 2002-10-05 | 2005-12-16 | 한미약품 주식회사 | 시부트라민 메탄술폰산염의 결정성 반수화물을 포함하는약학 조성물 |
| CL2004000826A1 (es) * | 2003-04-25 | 2005-03-04 | Pfizer | Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129 |
| WO2005041988A1 (en) * | 2003-10-22 | 2005-05-12 | University Of Florida | Method and composition for pain amelioration |
| US20050209220A1 (en) * | 2004-03-19 | 2005-09-22 | Jeffrey Conforti | Treatment of peripheral neuropathy |
| US20060160905A1 (en) * | 2005-01-18 | 2006-07-20 | Bergeron Raymond J Jr | Compositions and methods for inhibiting pain |
| WO2006078239A1 (en) | 2005-01-18 | 2006-07-27 | University Of Florida | Compositions and methods for inhibiting pain |
| MX2009002781A (es) | 2006-09-15 | 2009-03-30 | Reviva Pharmaceuticals Inc | Sintesis, metodos de uso y composiciones de cicloalquilmetilaminas . |
| US8604244B2 (en) | 2010-07-02 | 2013-12-10 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives |
| CN101555214B (zh) | 2008-04-08 | 2012-07-11 | 北京嘉事联博医药科技有限公司 | 苯基环丁基酰胺衍生物及其光学异构体、制备方法和用途 |
| US20100311710A1 (en) * | 2008-12-06 | 2010-12-09 | Auspex Pharmaceuticals, Inc. | Cyclobutanemethanamine inhibitors of monoamine reuptake |
| ES2537387T3 (es) | 2009-12-04 | 2015-06-08 | Perkinelmer, Inc. | Método de uso de inhibidores de la recaptación de la dopamina y sus análogos para el tratamiento de los síntomas de la diabetes y el retraso o la prevención de las afecciones patológicas asociadas con la diabetes |
| KR20140110014A (ko) | 2011-12-30 | 2014-09-16 | 레비바 파마슈티칼스, 아이엔씨. | 페닐시클로알킬메틸아민 유도체의 조성물, 합성, 및 사용 방법 |
| GB202114564D0 (en) * | 2021-10-12 | 2021-11-24 | Actimed Therapeutics Ltd | Oral formulation |
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| WO2000056149A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Method of treating anxiety disorders |
| BR0009026A (pt) | 1999-03-19 | 2003-03-05 | Knoll Gmbh | Método de tratamento de distúrbio alimentìcio |
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-
2000
- 2000-01-11 US US09/480,889 patent/US6399826B1/en not_active Expired - Fee Related
-
2001
- 2001-01-10 EP EP05108783A patent/EP1632471A1/de not_active Withdrawn
- 2001-01-10 JP JP2001551835A patent/JP2003519675A/ja active Pending
- 2001-01-10 AU AU27793/01A patent/AU782567B2/en not_active Ceased
- 2001-01-10 WO PCT/US2001/000762 patent/WO2001051453A1/en not_active Ceased
- 2001-01-10 DK DK01901941T patent/DK1246789T3/da active
- 2001-01-10 EP EP01901941A patent/EP1246789B1/de not_active Expired - Lifetime
- 2001-01-10 CA CA002396950A patent/CA2396950A1/en not_active Abandoned
- 2001-01-10 ES ES01901941T patent/ES2260195T3/es not_active Expired - Lifetime
- 2001-01-10 DE DE60120109T patent/DE60120109T2/de not_active Expired - Fee Related
- 2001-01-10 PT PT01901941T patent/PT1246789E/pt unknown
- 2001-01-10 AT AT01901941T patent/ATE327972T1/de not_active IP Right Cessation
-
2002
- 2002-06-04 US US10/160,033 patent/US6710087B2/en not_active Expired - Fee Related
-
2006
- 2006-08-30 CY CY20061101224T patent/CY1106150T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2260195T3 (es) | 2006-11-01 |
| EP1632471A1 (de) | 2006-03-08 |
| JP2003519675A (ja) | 2003-06-24 |
| AU2779301A (en) | 2001-07-24 |
| CY1106150T1 (el) | 2011-06-08 |
| DE60120109D1 (de) | 2006-07-06 |
| AU782567B2 (en) | 2005-08-11 |
| US6710087B2 (en) | 2004-03-23 |
| CA2396950A1 (en) | 2001-07-19 |
| PT1246789E (pt) | 2006-10-31 |
| US6399826B1 (en) | 2002-06-04 |
| DK1246789T3 (da) | 2006-09-18 |
| EP1246789A1 (de) | 2002-10-09 |
| DE60120109T2 (de) | 2006-10-19 |
| EP1246789B1 (de) | 2006-05-31 |
| WO2001051453A1 (en) | 2001-07-19 |
| US20020183281A1 (en) | 2002-12-05 |
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