DK1270570T3 - Amidforbindelser og anvendelse deraf - Google Patents

Amidforbindelser og anvendelse deraf

Info

Publication number: DK1270570T3
Authority: DK; Denmark
Prior art keywords: compound; drug; shows; hydrogen; formula
Prior art date: 2000-03-16

Application number

DK01912460T

Other languages

English (en)

Inventor

Shinichi Takanashi

Yoichiro Naito

Hiroshi Tanaka

Masayoshi Uehata

Koshiro Katayama

Original Assignee

Mitsubishi Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-16

Filing date

2001-03-16

Publication date

2006-10-02

2001-03-16 Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp

2006-10-02 Application granted granted Critical

2006-10-02 Publication of DK1270570T3 publication Critical patent/DK1270570T3/da

Links

-1 Amide Compounds Chemical class 0.000 title abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
238000010521 absorption reaction Methods 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229940079593 drug Drugs 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
102000000568 rho-Associated Kinases Human genes 0.000 abstract 2
108010041788 rho-Associated Kinases Proteins 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000029142 excretion Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000004060 metabolic process Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940126585 therapeutic drug Drugs 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Gynecology & Obstetrics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Ophthalmology & Optometry (AREA)
Pregnancy & Childbirth (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Virology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Transplantation (AREA)
Hospice & Palliative Care (AREA)

DK01912460T 2000-03-16 2001-03-16 Amidforbindelser og anvendelse deraf DK1270570T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2000074764		2000-03-16

Publications (1)

Publication Number	Publication Date
DK1270570T3 true DK1270570T3 (da)	2006-10-02

Family

ID=18592757

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01912460T DK1270570T3 (da)	2000-03-16	2001-03-16	Amidforbindelser og anvendelse deraf

Country Status (16)

Country	Link
US (1)	US6933305B2 (da)
EP (1)	EP1270570B1 (da)
JP (1)	JP4776136B2 (da)
KR (2)	KR100818061B1 (da)
CN (1)	CN1198804C (da)
AT (1)	ATE327993T1 (da)
AU (1)	AU2001241183A1 (da)
CA (1)	CA2403321C (da)
CY (1)	CY1105575T1 (da)
DE (1)	DE60120138T8 (da)
DK (1)	DK1270570T3 (da)
ES (1)	ES2266171T3 (da)
HK (1)	HK1049837B (da)
PT (1)	PT1270570E (da)
SI (1)	SI1270570T1 (da)
WO (1)	WO2001068607A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2707827A1 (en) *	2001-04-11	2002-10-24	Senju Pharmaceutical Co., Ltd.	Visual function disorder improving agents containing rho kinase inhibitors
GB0206860D0 (en) *	2002-03-22	2002-05-01	Glaxo Group Ltd	Compounds
AU2003220935A1 (en) *	2002-04-03	2003-10-13	Sumitomo Pharmaceuticals Company, Limited.	Benzamide derivatives
AU2003249534A1 (en) *	2002-08-13	2004-02-25	Warner-Lambert Company Llc	6,6-fused heteroaryl derivatives as matrix metalloproteinase inhibitors
ATE525111T1 (de) *	2003-04-18	2011-10-15	Senju Pharma Co	2-chloro-6,7-dimethoxy-n-5 ä5-(1)h- indazolylüquinazolin-4-amin, n-(1-benzyl-4- piperidinyl)-1h-indazol-5-amin dihydrochlorid, 4- ä2-(2,3,4,5,6-
CN100390173C (zh) *	2003-06-06	2008-05-28	旭化成制药株式会社	3环系化合物
US7160894B2 (en) *	2003-06-06	2007-01-09	Asahi Kasei Pharma Corporation	Tricyclic compound
TWI346112B (en) *	2004-02-25	2011-08-01	Nissan Chemical Ind Ltd	Benzopyran compound
CA2590261C (en) *	2004-12-27	2011-08-16	Alcon, Inc.	Aminopyrazine analogs for treating glaucoma and other rho kinase-mediated diseases and conditions
CR9465A (es) *	2005-03-25	2008-06-19	Surface Logix Inc	Compuestos mejorados farmacocineticamente
JP4972551B2 (ja)	2005-06-21	2012-07-11	興和株式会社	緑内障の予防又は治療剤
PL1905452T3 (pl)	2005-07-12	2013-11-29	Kowa Co	Środek do zapobiegania lub leczenia jaskry
US7867999B1 (en)	2005-12-22	2011-01-11	Alcon Research, Ltd.	Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions
JP2009521494A (ja)	2005-12-22	2009-06-04	アルコンリサーチ，リミテッド	ｒｈｏキナーゼ媒介性疾患および状態を治療するための（インダゾール−５−イル）−ピラジンおよび（１，３−ジヒドロインドール−２−オン）−ピラジン
EP1891958A1 (en) *	2006-08-03	2008-02-27	Universite Pierre Et Marie Curie (Paris Vi)	Rho/Rock/PI3/Akt kinase inhibitors for the treatment of diseases associated with protozoan parasites.
US20090036465A1 (en) *	2006-10-18	2009-02-05	United Therapeutics Corporation	Combination therapy for pulmonary arterial hypertension
US20110052562A1 (en) *	2007-12-19	2011-03-03	The Scripps Research Institute	Benzimidazoles and analogs as rho kinase inhibitors
WO2009079009A1 (en) *	2007-12-19	2009-06-25	Yangbo Feng	Anilides and analogs as rho kinase inhibitors
JP2011507848A (ja) *	2007-12-21	2011-03-10	ザスクリプスリサーチインスティチュート	Ｒｈｏキナーゼインヒビターとしてのベンゾピランおよびアナログ
EP2628482A1 (en)	2012-02-17	2013-08-21	Academisch Medisch Centrum	Rho kinase inhiitors for use in the treatment of neuroblastoma
WO2018052967A1 (en) *	2016-09-13	2018-03-22	Arbutus Biopharma, Inc.	Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same
WO2019099560A1 (en)	2017-11-14	2019-05-23	The Schepens Eye Research Institute, Inc.	Runx1 inhibition for treatment of proliferative vitreoretinopathy and conditions associated with epithelial to mesenchymal transition
US12281308B2 (en)	2018-08-29	2025-04-22	University Of Massachusetts	Inhibition of protein kinases to treat Friedreich ataxia
KR20230106648A (ko) *	2020-11-10	2023-07-13	포그혼 쎄라퓨틱스 인크.	화합물 및 그의 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ334613A (en) *	1996-08-12	2002-02-01	Welfide Corp	Pharmaceutical agents comprising Rho kinase inhibitor
JPH11130751A (ja) *	1997-10-30	1999-05-18	Yoshitomi Pharmaceut Ind Ltd	アミド化合物およびそれらの酸付加塩の標識化合物
JP2000063274A (ja)	1998-08-20	2000-02-29	Yoshitomi Pharmaceut Ind Ltd	喘息抑制用吸入剤

2001
- 2001-03-16 KR KR1020077016191A patent/KR100818061B1/ko not_active Expired - Fee Related
- 2001-03-16 CA CA002403321A patent/CA2403321C/en not_active Expired - Fee Related
- 2001-03-16 SI SI200130601T patent/SI1270570T1/sl unknown
- 2001-03-16 HK HK03101951.2A patent/HK1049837B/en not_active IP Right Cessation
- 2001-03-16 CN CNB018066534A patent/CN1198804C/zh not_active Expired - Fee Related
- 2001-03-16 US US10/221,655 patent/US6933305B2/en not_active Expired - Fee Related
- 2001-03-16 DE DE60120138T patent/DE60120138T8/de active Active
- 2001-03-16 EP EP01912460A patent/EP1270570B1/en not_active Expired - Lifetime
- 2001-03-16 KR KR1020027012156A patent/KR100818060B1/ko not_active Expired - Fee Related
- 2001-03-16 AT AT01912460T patent/ATE327993T1/de active
- 2001-03-16 PT PT01912460T patent/PT1270570E/pt unknown
- 2001-03-16 WO PCT/JP2001/002132 patent/WO2001068607A1/ja not_active Ceased
- 2001-03-16 DK DK01912460T patent/DK1270570T3/da active
- 2001-03-16 JP JP2001567702A patent/JP4776136B2/ja not_active Expired - Fee Related
- 2001-03-16 ES ES01912460T patent/ES2266171T3/es not_active Expired - Lifetime
- 2001-03-16 AU AU2001241183A patent/AU2001241183A1/en not_active Abandoned
2006
- 2006-08-25 CY CY20061101198T patent/CY1105575T1/el unknown

Also Published As

Publication number	Publication date
DE60120138D1 (de)	2006-07-06
CY1105575T1 (el)	2010-07-28
DE60120138T2 (de)	2007-03-29
DE60120138T8 (de)	2007-10-11
KR100818061B1 (ko)	2008-04-01
SI1270570T1 (sl)	2006-10-31
CN1418194A (zh)	2003-05-14
CA2403321A1 (en)	2001-09-20
HK1049837B (en)	2007-01-19
KR100818060B1 (ko)	2008-03-31
EP1270570A1 (en)	2003-01-02
KR20070087087A (ko)	2007-08-27
ES2266171T3 (es)	2007-03-01
KR20020081455A (ko)	2002-10-26
PT1270570E (pt)	2006-10-31
WO2001068607A1 (en)	2001-09-20
CN1198804C (zh)	2005-04-27
AU2001241183A1 (en)	2001-09-24
HK1049837A1 (en)	2003-05-30
US20030158413A1 (en)	2003-08-21
US6933305B2 (en)	2005-08-23
ATE327993T1 (de)	2006-06-15
EP1270570B1 (en)	2006-05-31
JP4776136B2 (ja)	2011-09-21
CA2403321C (en)	2009-07-14
EP1270570A4 (en)	2004-02-18

Publication	Publication Date	Title
SI1270570T1 (sl)	2006-10-31	Amidne spojine in njihova uporaba
IS2293B (is)	2007-10-15	Arýl sambrædd asapólýsýklísk efnasambönd
ATE361287T1 (de)	2007-05-15	Neue indol-2-on derivate
SE0104332D0 (sv)	2001-12-19	Therapeutic agents
WO2002080846A3 (en)	2003-12-04	Epothilone derivatives and methods for making and using the same
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