DK1272501T3 - Fremgangsmåde til fremstilling af phosphorthioattriestere - Google Patents

Fremgangsmåde til fremstilling af phosphorthioattriestere

Info

Publication number: DK1272501T3
Authority: DK; Denmark
Prior art keywords: phosphorothioate; tristers; preparation; phosphonate; alcohol
Prior art date: 2000-03-01

Application number

DK01907898T

Other languages

English (en)

Inventor

Colin Bernard Reese

Original Assignee

Avecia Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-01

Filing date

2001-02-23

Publication date

2004-08-16

2001-02-23 Application filed by Avecia Ltd filed Critical Avecia Ltd

2004-08-16 Application granted granted Critical

2004-08-16 Publication of DK1272501T3 publication Critical patent/DK1272501T3/da

Links

238000000034 method Methods 0.000 title abstract 3
RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 title 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
108091034117 Oligonucleotide Proteins 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000008878 coupling Effects 0.000 abstract 1
239000007822 coupling agent Substances 0.000 abstract 1
238000010168 coupling process Methods 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
239000002777 nucleoside Substances 0.000 abstract 1
125000003835 nucleoside group Chemical group 0.000 abstract 1
-1 phosphorothioate triester Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Luminescent Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK01907898T 2000-03-01 2001-02-23 Fremgangsmåde til fremstilling af phosphorthioattriestere DK1272501T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0004889.2A GB0004889D0 (en)	2000-03-01	2000-03-01	Synthesis of oligonucleotides
PCT/GB2001/000764 WO2001064702A1 (en)	2000-03-01	2001-02-23	Process for the preparation of phosphorothioate triesters

Publications (1)

Publication Number	Publication Date
DK1272501T3 true DK1272501T3 (da)	2004-08-16

Family

ID=9886705

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01907898T DK1272501T3 (da)	2000-03-01	2001-02-23	Fremgangsmåde til fremstilling af phosphorthioattriestere

Country Status (21)

Country	Link
US (1)	US7022833B2 (da)
EP (1)	EP1272501B1 (da)
JP (1)	JP2003525305A (da)
KR (1)	KR20030032924A (da)
CN (1)	CN1262557C (da)
AT (1)	ATE266037T1 (da)
AU (2)	AU2001235766B2 (da)
BR (1)	BR0108771A (da)
CA (1)	CA2401083A1 (da)
CZ (1)	CZ20022930A3 (da)
DE (1)	DE60103145T2 (da)
DK (1)	DK1272501T3 (da)
ES (1)	ES2220721T3 (da)
GB (1)	GB0004889D0 (da)
HU (1)	HUP0204249A3 (da)
IL (1)	IL151238A0 (da)
MX (1)	MXPA02008530A (da)
NO (1)	NO20024155L (da)
NZ (1)	NZ520778A (da)
PL (1)	PL362067A1 (da)
WO (1)	WO2001064702A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9717158D0 (en) *	1997-08-13	1997-10-22	King S College London	Solution synthesis of oligonucleotides and their phosphorothioate analogues
AU2002339175A1 (en) *	2001-11-21	2003-06-10	Avecia Biotechnology Inc.	Coupling reagent for h-phosphonate chemistry
EP1386925A1 (en)	2002-07-31	2004-02-04	Girindus AG	Method for preparing oligonucleotides
GB0229423D0 (en) *	2002-12-18	2003-01-22	Avecia Ltd	Process
SG171914A1 (en)	2008-12-02	2011-07-28	Chiralgen Ltd	Method for the synthesis of phosphorus atom modified nucleic acids
EP2451461A4 (en)	2009-07-06	2013-05-29	Ontorii Inc	NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF
DK2620428T3 (da)	2010-09-24	2019-07-01	Wave Life Sciences Ltd	Asymmetrisk hjælpegruppe
US9605019B2 (en)	2011-07-19	2017-03-28	Wave Life Sciences Ltd.	Methods for the synthesis of functionalized nucleic acids
DK2872485T3 (da)	2012-07-13	2021-03-08	Wave Life Sciences Ltd	Asymmetrisk hjælpegruppe
JP6246121B2 (ja)	2012-07-13	2017-12-13	株式会社新日本科学	キラル核酸アジュバント
CN112007045B (zh)	2012-07-13	2026-01-06	波涛生命科学有限公司	手性控制
WO2015108048A1 (ja)	2014-01-15	2015-07-23	株式会社新日本科学	抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
US10322173B2 (en)	2014-01-15	2019-06-18	Shin Nippon Biomedical Laboratories, Ltd.	Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
EP3095461A4 (en)	2014-01-15	2017-08-23	Shin Nippon Biomedical Laboratories, Ltd.	Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
KR102423317B1 (ko)	2014-01-16	2022-07-22	웨이브 라이프 사이언시스 리미티드	키랄 디자인
WO2021243443A1 (en) *	2020-06-02	2021-12-09	The Royal Institution For The Advancement Of Learning/Mcgill University	Method for the preparation of oligonucleotides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9501465D0 (en) *	1995-01-25	1995-03-15	King S College London	Nucleoside phosphorothioate derivatives,synthesis and use thereof
US6096881A (en)	1997-05-30	2000-08-01	Hybridon, Inc.	Sulfur transfer reagents for oligonucleotide synthesis
GB9717158D0 (en) *	1997-08-13	1997-10-22	King S College London	Solution synthesis of oligonucleotides and their phosphorothioate analogues
GB9924285D0 (en) *	1999-10-14	1999-12-15	Avecia Ltd	Process

2000
- 2000-03-01 GB GBGB0004889.2A patent/GB0004889D0/en not_active Ceased
2001
- 2001-02-23 JP JP2001564195A patent/JP2003525305A/ja active Pending
- 2001-02-23 AU AU2001235766A patent/AU2001235766B2/en not_active Ceased
- 2001-02-23 IL IL15123801A patent/IL151238A0/xx unknown
- 2001-02-23 KR KR1020027011442A patent/KR20030032924A/ko not_active Withdrawn
- 2001-02-23 EP EP01907898A patent/EP1272501B1/en not_active Expired - Lifetime
- 2001-02-23 HU HU0204249A patent/HUP0204249A3/hu unknown
- 2001-02-23 AT AT01907898T patent/ATE266037T1/de not_active IP Right Cessation
- 2001-02-23 DK DK01907898T patent/DK1272501T3/da active
- 2001-02-23 ES ES01907898T patent/ES2220721T3/es not_active Expired - Lifetime
- 2001-02-23 CA CA002401083A patent/CA2401083A1/en not_active Abandoned
- 2001-02-23 CZ CZ20022930A patent/CZ20022930A3/cs unknown
- 2001-02-23 PL PL36206701A patent/PL362067A1/xx unknown
- 2001-02-23 NZ NZ520778A patent/NZ520778A/en unknown
- 2001-02-23 BR BR0108771-1A patent/BR0108771A/pt not_active IP Right Cessation
- 2001-02-23 US US10/220,353 patent/US7022833B2/en not_active Expired - Lifetime
- 2001-02-23 AU AU3576601A patent/AU3576601A/xx active Pending
- 2001-02-23 CN CNB018058906A patent/CN1262557C/zh not_active Expired - Fee Related
- 2001-02-23 MX MXPA02008530A patent/MXPA02008530A/es not_active Application Discontinuation
- 2001-02-23 WO PCT/GB2001/000764 patent/WO2001064702A1/en not_active Ceased
- 2001-02-23 DE DE60103145T patent/DE60103145T2/de not_active Expired - Fee Related
2002
- 2002-08-30 NO NO20024155A patent/NO20024155L/no unknown

Also Published As

Publication number	Publication date
NZ520778A (en)	2004-05-28
NO20024155D0 (no)	2002-08-30
GB0004889D0 (en)	2000-04-19
US7022833B2 (en)	2006-04-04
DE60103145T2 (de)	2005-05-04
KR20030032924A (ko)	2003-04-26
IL151238A0 (en)	2003-04-10
NO20024155L (no)	2002-10-24
CN1406242A (zh)	2003-03-26
EP1272501B1 (en)	2004-05-06
CZ20022930A3 (cs)	2002-11-13
WO2001064702A1 (en)	2001-09-07
US20030099981A1 (en)	2003-05-29
ES2220721T3 (es)	2004-12-16
CA2401083A1 (en)	2001-09-07
MXPA02008530A (es)	2003-02-12
AU3576601A (en)	2001-09-12
HUP0204249A3 (en)	2004-08-30
BR0108771A (pt)	2002-11-26
CN1262557C (zh)	2006-07-05
EP1272501A1 (en)	2003-01-08
HUP0204249A2 (hu)	2003-04-28
JP2003525305A (ja)	2003-08-26
DE60103145D1 (de)	2004-06-09
PL362067A1 (en)	2004-10-18
ATE266037T1 (de)	2004-05-15
AU2001235766B2 (en)	2005-01-27

Publication	Publication Date	Title
NO20024155L (no)	2002-10-24	Fremgangsmåte for fremstilling av fosforotioattriestere
NZ502684A (en)	2002-12-20	Solution phase synthesis of phosphorothioate triesters
DE60144479D1 (da)	2011-06-01
MXPA03000803A (es)	2003-06-04	Suministro vaginal de bisfosfonatos.
DE60003281D1 (de)	2003-07-17	Thermisches Übertragungsverfahren.
EP1354955A4 (en)	2005-01-05	PROCESS FOR PREPARING PRENYL ALCOHOL
DE60105725D1 (de)	2004-10-28	Wellenleiterkopplung
NO20023868D0 (no)	2002-08-15	Forgrenete polymere overflateaktiv-middel reaksjonsprodukter, samt fremgangsmåter for fremstilling og anvendelse derav
FI20002039L (fi)	2002-03-16	Ligandimodifioidut selluloosatuotteet
DE60109229D1 (de)	2005-04-14	Tupfer
NO20013658D0 (no)	2001-07-25	Differensielt hydrostatisk overföringssystem
IT1307383B1 (it)	2001-11-06	Giunto elastico per alberi coassiali
AU2001262141A1 (en)	2001-12-20	Use of CDP-choline for the treatment of alcohol withdrawal syndrome
MY120345A (en)	2005-10-31	Dissolution inhibitor of chemically amplified photoresist and chemically amplified photoresist composition containing the same
DK1325138T3 (da)	2013-10-21	Optimeret messenger rna
IT250228Y1 (it)	2003-07-28	Esemplare di indumento intimo monouso
DE60106687D1 (de)	2004-12-02	Tupfer
AU2001287897A1 (en)	2002-04-02	Manipulation of spermatozoa
AU2001296267A1 (en)	2002-04-02	Transfer of organs from donor to recipient using an on-line communication system
FI20001167A7 (fi)	2001-11-17	Järjestelmä (ixfile) tiedonsiirron turvallisuuden takaamiseksi
IT1317829B1 (it)	2003-07-15	Processo per la preparazione di cefonicid per via enzimatica.
UA4160S (uk)	2000-12-15	Контрацептив вагінальний
SE0003236D0 (sv)	2000-09-13	Procedure for treatment of autism by inhibition of post-proline-cleaving enzymes
IT1320769B1 (it)	2003-12-10	Gel vaginale.
GB0026494D0 (en)	2000-12-13	Isolation of nucleic acid