DK127887A - Interleukin-1beta-derivater og medikamenter indeholdende saadanne derivater - Google Patents

Interleukin-1beta-derivater og medikamenter indeholdende saadanne derivater

Info

Publication number: DK127887A
Authority: DK; Denmark
Prior art keywords: derivatives; 1beta; interleukin; medicines containing; medicines
Prior art date: 1986-03-14

Application number

DK127887A

Other languages

English (en)

Other versions

DK127887D0 (da

DK171648B1 (da

Inventor

Satoru Nakai

Mayumi Kaneta

Yoshikazu Kikumoto

Yeong-Man Hong

Kazuyoshi Kawai

Setsuko Takegata

Kiyoshi Ishii

Yasuo Yanagihara

Yoshikatsu Hirai

Original Assignee

Otsuka Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-03-14

Filing date

1987-03-12

Publication date

1987-09-15

1987-03-12 Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd

1987-03-12 Publication of DK127887D0 publication Critical patent/DK127887D0/da

1987-09-15 Publication of DK127887A publication Critical patent/DK127887A/da

1997-03-03 Application granted granted Critical

1997-03-03 Publication of DK171648B1 publication Critical patent/DK171648B1/da

Links

LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical class C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Genetics & Genomics (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Pain & Pain Management (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK127887A 1986-03-14 1987-03-12 Polypeptid, der er et interleukin-1beta-derivat, gen, der koder for polypeptidet, vektor indeholdende genet, mikroorganisme indeholdende vektoren, og lægemidel indeholdende polypeptidet DK171648B1 (da)

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
JP5788586		1986-03-14
JP5788586		1986-03-14
JP14583086		1986-06-20
JP14583086		1986-06-20
JP16118486		1986-07-09
JP16118486		1986-07-09
JP20032486		1986-08-27
JP20032486		1986-08-27

Publications (3)

Publication Number	Publication Date
DK127887D0 DK127887D0 (da)	1987-03-12
DK127887A true DK127887A (da)	1987-09-15
DK171648B1 DK171648B1 (da)	1997-03-03

Family

ID=27463573

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK127887A DK171648B1 (da)	1986-03-14	1987-03-12	Polypeptid, der er et interleukin-1beta-derivat, gen, der koder for polypeptidet, vektor indeholdende genet, mikroorganisme indeholdende vektoren, og lægemidel indeholdende polypeptidet

Country Status (5)

Country	Link
EP (2)	EP0569042A1 (da)
JP (1)	JP2591615B2 (da)
DE (1)	DE3751593T2 (da)
DK (1)	DK171648B1 (da)
ES (1)	ES2009215A6 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5047505A (en) *	1987-01-27	1991-09-10	Du Pont Merck Pharmaceutical Company	High level expression in E. coli of soluble mature HIL-1beta and derivatives with altered biological activity
US4904584A (en) *	1987-12-23	1990-02-27	Genetics Institute, Inc.	Site-specific homogeneous modification of polypeptides
JP2698976B2 (ja) *	1988-02-03	1998-01-19	大日本製薬株式会社	新規ポリペプチド及びそれをコードするｄｎａ
KR960008010B1 (ko) *	1988-07-29	1996-06-19	오오쓰까세이야꾸 가부시끼가이샤	IL-1α 유도체 및 혈소판 감소증 치료 약제
JP2554528B2 (ja) *	1988-09-19	1996-11-13	大塚製薬株式会社	副腎皮質刺激ホルモン分泌能検査薬
EP0401379B1 (en) *	1988-12-06	1994-06-15	Otsuka Pharmaceutical Co., Ltd.	STABILIZED COMPOSITION OF INTERLEUKIN-1$g(b)
US5039790A (en) *	1989-01-11	1991-08-13	Monsanto Company	Bioactive fragment of interleukin-1-B that has antagonistic activity
ATE165114T1 (de) *	1989-02-27	1998-05-15	New England Medical Center Inc	Il-1, dessen biologische aktivität inhibiert ist
US5723117A (en) *	1990-08-10	1998-03-03	Otsuka Pharmaceutical Co., Ltd.	Use of interleukin-1 (IL-1) to inhibit development of hepatitis
EP0495131B1 (en) *	1990-08-10	1997-05-14	Otsuka Pharmaceutical Co., Ltd.	Agent for preventing and treating hepatitis
JP2678689B2 (ja) *	1990-08-10	1997-11-17	大塚製薬株式会社	肝炎予防・治療剤
FR2667601A1 (fr) *	1990-10-05	1992-04-10	Rhone Poulenc Sante	Polypeptides derives de l'interleukine-1 beta, procede de preparation et utilisation, notamment dans le cadre des pathologies osteoarticulaires.
AU1270592A (en) *	1991-02-05	1992-09-07	University Of Maryland	Modified interleukin-1beta
SE9201966D0 (sv) *	1992-06-25	1992-06-25	Trion Forskning & Utveckling	Interleukin-1beta deletion mutant
GB9916630D0 (en) *	1999-07-16	1999-09-15	Univ Manchester	Molecules derived from interleukins
JP2003515569A (ja) *	1999-12-03	2003-05-07	セルテックアールアンドディリミテッド	ワクチンアジュバントとして有用なインターロイキン−１ムテイン
WO2002017958A1 (de) *	2000-08-29	2002-03-07	Max-Delbrück-Centrum für Molekulare Medizin	Mittel zur beeinflussung der angiogenese
WO2005084198A2 (en) *	2004-02-27	2005-09-15	Vaxconsulting	Peptides of il1 beta and tnf alpha and method of treatment using same
WO2010105634A1 (en) *	2009-03-17	2010-09-23	United Technologies Ut Ag	Use of interleukin-1 beta in cosmetic compositions and methods thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4816436A (en) *	1986-10-29	1989-03-28	Immunex Corporation	Anti-arthritic use of interleukin-1 proteins

1987
- 1987-03-06 JP JP62052781A patent/JP2591615B2/ja not_active Expired - Lifetime
- 1987-03-12 DE DE3751593T patent/DE3751593T2/de not_active Expired - Fee Related
- 1987-03-12 DK DK127887A patent/DK171648B1/da not_active IP Right Cessation
- 1987-03-12 EP EP93107660A patent/EP0569042A1/en not_active Withdrawn
- 1987-03-12 EP EP87103609A patent/EP0237967B1/en not_active Expired - Lifetime
- 1987-03-13 ES ES8701021A patent/ES2009215A6/es not_active Expired

Also Published As

Publication number	Publication date
EP0237967B1 (en)	1995-11-15
ES2009215A6 (es)	1989-09-16
DK127887D0 (da)	1987-03-12
EP0569042A1 (en)	1993-11-10
EP0237967A3 (en)	1990-03-28
DK171648B1 (da)	1997-03-03
JPS63152398A (ja)	1988-06-24
JP2591615B2 (ja)	1997-03-19
DE3751593T2 (de)	1996-03-28
EP0237967A2 (en)	1987-09-23
DE3751593D1 (de)	1995-12-21

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Legal Events

Date	Code	Title	Description
1997-03-03	B1	Patent granted (law 1993)
2000-10-23	PBP	Patent lapsed