DK497685A - Ketongruppeholdige oxindol-3-carboxamid-derivater og laegemiddel indeholdende saadanne derivater - Google Patents

Ketongruppeholdige oxindol-3-carboxamid-derivater og laegemiddel indeholdende saadanne derivater Download PDF

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Publication number
DK497685A
DK497685A DK497685A DK497685A DK497685A DK 497685 A DK497685 A DK 497685A DK 497685 A DK497685 A DK 497685A DK 497685 A DK497685 A DK 497685A DK 497685 A DK497685 A DK 497685A
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DK
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Prior art keywords
derivatives
ketoon
oxindol
contained
carboxamide
Prior art date
Application number
DK497685A
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English (en)
Other versions
DK163990B (da
DK497685D0 (da
DK163990C (da
Inventor
Jr Lawrence Sherman Melvin
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/666,953 external-priority patent/US4644005A/en
Application filed by Pfizer filed Critical Pfizer
Publication of DK497685D0 publication Critical patent/DK497685D0/da
Publication of DK497685A publication Critical patent/DK497685A/da
Publication of DK163990B publication Critical patent/DK163990B/da
Application granted granted Critical
Publication of DK163990C publication Critical patent/DK163990C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK497685A 1984-10-31 1985-10-30 Oxindol-3-carboxamid-derivater og farmaceutiske praeparater indeholdende disse DK163990C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/666,953 US4644005A (en) 1984-10-31 1984-10-31 Oxindole antiinflammatory agents
US66695384 1984-10-31
US76299885 1985-08-06
US06/762,998 US4686224A (en) 1984-10-31 1985-08-06 Oxindole antiinflammatory agents

Publications (4)

Publication Number Publication Date
DK497685D0 DK497685D0 (da) 1985-10-30
DK497685A true DK497685A (da) 1986-05-01
DK163990B DK163990B (da) 1992-04-27
DK163990C DK163990C (da) 1992-09-21

Family

ID=27099577

Family Applications (1)

Application Number Title Priority Date Filing Date
DK497685A DK163990C (da) 1984-10-31 1985-10-30 Oxindol-3-carboxamid-derivater og farmaceutiske praeparater indeholdende disse

Country Status (16)

Country Link
US (1) US4686224A (da)
EP (1) EP0181136B1 (da)
KR (1) KR870001269B1 (da)
AU (1) AU555051B2 (da)
CA (1) CA1247099A (da)
DE (1) DE3585719D1 (da)
DK (1) DK163990C (da)
ES (1) ES8707731A1 (da)
FI (1) FI81340C (da)
GR (1) GR852629B (da)
HU (1) HU194168B (da)
IE (1) IE58207B1 (da)
IL (1) IL76854A (da)
PH (3) PH20985A (da)
PL (2) PL145239B1 (da)
PT (1) PT81393B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008146A1 (en) * 1989-01-10 1990-07-26 Pfizer Inc. Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides
WO1990008145A1 (en) * 1989-01-10 1990-07-26 Pfizer Inc. Anti-inflammatory 1-heteroaryl-3-acyl-2-oxindoles
JPH0717589B2 (ja) * 1990-01-22 1995-03-01 ファイザー製薬株式会社 新規１，３―ジカルボニル化合物およびその組成物
CH687764A5 (de) * 1992-07-02 1997-02-14 Lonza Ag Gampel Wallis Geschof Verfahren zur Herstellung von 7-Acylindolen.
US5449788A (en) * 1994-01-28 1995-09-12 Catalytica, Inc. Process for preparing 2-oxindole-1-carboxamides
GB9414139D0 (en) * 1994-07-13 1994-08-31 Smithkline Beecham Plc Novel compounds
WO2002022556A1 (en) * 2000-09-14 2002-03-21 Mitsubishi Pharma Corporation Novel amide derivatives and medicinal use thereof ugs
WO2002070478A1 (en) 2001-03-06 2002-09-12 Astrazeneca Ab Indolone derivatives having vascular-damaging activity
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2005041957A1 (en) * 2003-10-29 2005-05-12 Pfizer Products Inc. Oxindole derivatives and their use as phosphodiesterase type 2 inhibitors
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
TR201908314T4 (tr) 2009-02-20 2019-06-21 2 Bbb Medicines B V Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN104130176A (zh) * 2014-06-13 2014-11-05 天津科技大学 一种1,5-二取代吲哚酮类衍生物及其应用
WO2025143096A1 (ja) * 2023-12-29 2025-07-03 キッセイ薬品工業株式会社 含窒素縮環化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE756447A (fr) * 1969-10-15 1971-03-22 Pfizer Oxindolecarboxamides
US3749731A (en) * 1971-07-08 1973-07-31 Warner Lambert Co 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
DE3114351A1 (de) * 1981-04-09 1982-11-04 Hoechst Ag, 6000 Frankfurt "oxindol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung"
AU8509882A (en) * 1981-06-30 1983-01-06 Merck & Co., Inc. Tricyclic derivatives of substituted pyrrole acids
DE3582890D1 (de) * 1984-02-07 1991-06-20 Pfizer 2-oxindolzwischenprodukte.
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
IE57741B1 (en) * 1984-03-19 1993-03-24 Pfizer Process for making 2-oxindole-1-carboxamides and intermediates therefor

Also Published As

Publication number Publication date
EP0181136A3 (en) 1987-10-28
FI81340B (fi) 1990-06-29
HUT39428A (en) 1986-09-29
PL255990A1 (en) 1987-03-23
PH23130A (en) 1989-05-05
PL145239B1 (en) 1988-08-31
PL262327A1 (en) 1987-11-02
FI854258L (fi) 1986-05-01
DK163990B (da) 1992-04-27
IE852703L (en) 1986-04-30
FI81340C (fi) 1990-10-10
IE58207B1 (en) 1993-07-28
GR852629B (da) 1986-03-04
PH20985A (en) 1987-06-18
ES8707731A1 (es) 1987-08-16
HU194168B (en) 1988-01-28
PL150842B1 (en) 1990-07-31
AU555051B2 (en) 1986-09-11
DK497685D0 (da) 1985-10-30
IL76854A (en) 1989-05-15
ES554609A0 (es) 1987-08-16
US4686224A (en) 1987-08-11
KR860003260A (ko) 1986-05-21
PT81393A (en) 1985-11-01
PT81393B (pt) 1988-02-17
IL76854A0 (en) 1986-02-28
FI854258A0 (fi) 1985-10-30
AU4918985A (en) 1986-05-08
EP0181136A2 (en) 1986-05-14
CA1247099A (en) 1988-12-20
KR870001269B1 (ko) 1987-06-30
DE3585719D1 (de) 1992-04-30
PH24091A (en) 1990-03-05
DK163990C (da) 1992-09-21
EP0181136B1 (en) 1992-03-25

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