DK1280521T3 - Vaccinesammensætning, fremgangsmåde til fremstilling deraf og fremgangsmåde til vaccination af hvirveldyr - Google Patents
Vaccinesammensætning, fremgangsmåde til fremstilling deraf og fremgangsmåde til vaccination af hvirveldyrInfo
- Publication number
- DK1280521T3 DK1280521T3 DK01935330T DK01935330T DK1280521T3 DK 1280521 T3 DK1280521 T3 DK 1280521T3 DK 01935330 T DK01935330 T DK 01935330T DK 01935330 T DK01935330 T DK 01935330T DK 1280521 T3 DK1280521 T3 DK 1280521T3
- Authority
- DK
- Denmark
- Prior art keywords
- antigen
- vaccine composition
- alginate
- improved
- microparticles
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 4
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 241000251539 Vertebrata <Metazoa> Species 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 238000002255 vaccination Methods 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 5
- 102000036639 antigens Human genes 0.000 abstract 5
- 108091007433 antigens Proteins 0.000 abstract 5
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 abstract 3
- 229940072056 alginate Drugs 0.000 abstract 3
- 229920000615 alginic acid Polymers 0.000 abstract 3
- 235000010443 alginic acid Nutrition 0.000 abstract 3
- 239000011859 microparticle Substances 0.000 abstract 3
- 239000002736 nonionic surfactant Substances 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- 229920000463 Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) Polymers 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- 229910052788 barium Inorganic materials 0.000 abstract 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 229920003086 cellulose ether Polymers 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 abstract 1
- 238000005070 sampling Methods 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 229910052712 strontium Inorganic materials 0.000 abstract 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 229920000428 triblock copolymer Polymers 0.000 abstract 1
- 239000007762 w/o emulsion Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20386400P | 2000-05-12 | 2000-05-12 | |
| PCT/US2001/015235 WO2001087270A2 (en) | 2000-05-12 | 2001-05-11 | Vaccine composition, method of preparing the same, and method of vaccinating vertebrates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1280521T3 true DK1280521T3 (da) | 2005-08-08 |
Family
ID=22755628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01935330T DK1280521T3 (da) | 2000-05-12 | 2001-05-11 | Vaccinesammensætning, fremgangsmåde til fremstilling deraf og fremgangsmåde til vaccination af hvirveldyr |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6656470B2 (da) |
| EP (1) | EP1280521B1 (da) |
| AT (1) | ATE299696T1 (da) |
| AU (1) | AU2001261433A1 (da) |
| DE (1) | DE60112073T2 (da) |
| DK (1) | DK1280521T3 (da) |
| ES (1) | ES2243497T3 (da) |
| PT (1) | PT1280521E (da) |
| WO (1) | WO2001087270A2 (da) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030026782A1 (en) * | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| US6693086B1 (en) * | 1998-06-25 | 2004-02-17 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
| US20030022854A1 (en) | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
| PT1280521E (pt) * | 2000-05-12 | 2005-10-31 | Pharmacia & Upjohn Co Llc | Composicao de vacina, metodo para a sua preparacao, e metodo de vacinacao de vertebrados |
| CA2439802A1 (en) * | 2001-03-05 | 2002-09-12 | Forinnova As | Immune response potentiation |
| FR2823119B1 (fr) * | 2001-04-05 | 2004-02-20 | Seppic Sa | Adjuvant d'immunite contenant un cation metallique complexe et vaccin le contenant |
| US7119172B2 (en) * | 2001-05-21 | 2006-10-10 | The Brigham And Women's Hospital, Inc. | P. aeruginosa mucoid exopolysaccharide specific binding peptides |
| US6962813B2 (en) * | 2001-05-21 | 2005-11-08 | The Brigham And Women's Hospital, Inc. | P. aeruginosa mucoid exopolysaccharide specific binding peptides |
| US6678583B2 (en) * | 2001-08-06 | 2004-01-13 | Seminet, Inc. | Robotic storage buffer system for substrate carrier pods |
| US7039499B1 (en) * | 2002-08-02 | 2006-05-02 | Seminet Inc. | Robotic storage buffer system for substrate carrier pods |
| KR100548925B1 (ko) * | 2002-10-23 | 2006-02-02 | 한미약품 주식회사 | 약물의 경구투여용 서방성 조성물 |
| CA2520660C (en) * | 2003-03-28 | 2013-08-20 | Sigmoid Biotechnologies Limited | Solid oral dosage form containing seamless microcapsules |
| AU2004226605A1 (en) * | 2003-04-02 | 2004-10-14 | Coley Pharmaceutical Group, Ltd. | Immunostimulatory nucleic acid oil-in-water formulations for topical application |
| US20050013812A1 (en) * | 2003-07-14 | 2005-01-20 | Dow Steven W. | Vaccines using pattern recognition receptor-ligand:lipid complexes |
| US7081227B2 (en) * | 2004-06-07 | 2006-07-25 | The Reagents Of The University Of California | Amphiphilic mediated sample preparation for micro-flow cytometry |
| US20060062779A1 (en) * | 2004-09-21 | 2006-03-23 | The Brigham And Women's Hospital, Inc. | Methods and compositions relating to mannuronic acid specific binding peptides |
| EP2444071A1 (en) * | 2004-09-27 | 2012-04-25 | Sigmoid Pharma Limited | Minicapsule formulations |
| WO2006059846A1 (en) * | 2004-12-01 | 2006-06-08 | Lg Life Sciences, Ltd. | Formulation of sec1 mutated protein and method for formulation of the same |
| US20060177468A1 (en) * | 2005-01-05 | 2006-08-10 | Philadelphia Health and Education Corporation (d/b/a Drexel University College of Medicine | Delivery vehicles, bioactive substances and viral vaccines |
| WO2007084500A2 (en) * | 2006-01-13 | 2007-07-26 | Advanced Bionutrition Corporation | Continuous spray-capture production system |
| EP2079456B1 (en) | 2007-04-04 | 2012-12-05 | Sigmoid Pharma Limited | Pharmaceutical cyclosporin compositions |
| EP2586428B1 (en) * | 2007-04-26 | 2023-11-08 | Sublimity Therapeutics Limited | Manufacture of multiple minicapsules |
| CA2685591A1 (en) * | 2007-05-01 | 2008-11-06 | Sigmoid Pharma Limited | Pharmaceutical nimodipine compositions |
| WO2009005709A1 (en) * | 2007-06-28 | 2009-01-08 | Surmodics, Inc. | Polypeptide microparticles |
| ES2649112T3 (es) | 2009-05-18 | 2018-01-10 | Sigmoid Pharma Limited | Composición que comprende gotas de aceite |
| CN107582526A (zh) * | 2009-08-12 | 2018-01-16 | 希格默伊德药业有限公司 | 包含聚合物基质和油相的免疫调节组合物 |
| GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| US20140356396A1 (en) * | 2011-08-25 | 2014-12-04 | Brian L. Pulliam | Rotavirus preparations with excess calcium ions and high viscosities that ensure viability at elevated temperatures |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| CN113750075A (zh) | 2013-12-06 | 2021-12-07 | 英特维特国际股份有限公司 | 用于经口递送生物活性剂的组合物 |
| EP3881829A1 (en) | 2014-11-07 | 2021-09-22 | Sublimity Therapeutics Limited | Compositions comprising cyclosporin |
| WO2017097844A1 (en) * | 2015-12-07 | 2017-06-15 | Schlumberger Norge As | Microsphere compositions and methods for production in oil-based drilling fluids |
| WO2020014644A1 (en) * | 2018-07-12 | 2020-01-16 | The Regents Of The University Of Michigan | Compositions and methods for metal containing formulations capable of modulating immune response |
| GB202205231D0 (en) * | 2022-04-09 | 2022-05-25 | Nasaleze Patents Ltd | Vaccine compositions |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1050353B (it) | 1966-01-06 | 1981-03-10 | Ceskoslovenska Akademie Ved | Supporti per sostanze biologigamente attive |
| EG10802A (en) | 1971-02-19 | 1976-10-31 | Bayer Ag | A process for embeding veterinary substances and their protection against the influence of the gastric juice of the rumen |
| US4178361A (en) | 1973-09-10 | 1979-12-11 | Union Corporation | Sustained release pharmaceutical composition |
| US4220152A (en) | 1978-05-08 | 1980-09-02 | Pfizer Inc. | Delivery system |
| US4391909A (en) | 1979-03-28 | 1983-07-05 | Damon Corporation | Microcapsules containing viable tissue cells |
| US4352883A (en) | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
| US4798786A (en) | 1982-05-06 | 1989-01-17 | Stolle Research And Development Corporation | Living cells encapsulated in crosslinked protein |
| CA1196862A (en) | 1983-06-01 | 1985-11-19 | Connaught Laboratories Limited | Microencapsulation of living tissue and cells |
| US4806355A (en) | 1983-06-06 | 1989-02-21 | Connaught Laboratories Limited | Microencapsulation of living tissue and cells |
| US4689293A (en) | 1983-06-06 | 1987-08-25 | Connaught Laboratories Limited | Microencapsulation of living tissue and cells |
| GB8326633D0 (en) | 1983-08-04 | 1983-11-09 | Unilever Plc | Compositions |
| US4803168A (en) | 1983-09-01 | 1989-02-07 | Damon Biotech, Inc. | Microencapsulation with polymers |
| GB8500121D0 (en) | 1985-01-03 | 1985-02-13 | Connaught Lab | Microencapsulation of living cells |
| US4873090A (en) | 1985-03-27 | 1989-10-10 | Broncostat Pty. Limited | Non-adjuvenated vaccine |
| US4780315A (en) | 1985-11-25 | 1988-10-25 | Eastman Kodak Company | Rumen-stable pellets |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| NL8701548A (nl) * | 1987-07-01 | 1989-02-01 | Tno | Polymeer netwerk, werkwijze voor het bereiden daarvan alsmede, de toepassing daarvan voor het bekleden en/of impregneren of voor het vervaardigen van ooglenzen, alsmede gevormd voortbrengsel, geheel of ten dele bestaande uit een dergelijk polymeer netwerk. |
| US4792452A (en) * | 1987-07-28 | 1988-12-20 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| US4808404A (en) | 1988-01-11 | 1989-02-28 | A. H. Robins Company, Inc. | Live vaccine for coccidiosis utilizing coccidial sporozoites |
| JPH01313437A (ja) | 1988-06-14 | 1989-12-18 | Nippon Seibutsu Kagaku Kenkyusho | 飼料内投与用の粒子状生ワクチン及びその製法並びに鶏コクシジウム症生ワクチン |
| FR2683147B1 (fr) | 1991-10-30 | 1995-06-23 | Maingault Philippe | Systeme vehicule de principe actif permettant l'administration voie orale chez les poissons et crustaces. |
| US5352448A (en) | 1992-07-20 | 1994-10-04 | Purdue Research Foundatioin | Oral administration of antigens |
| CN1128953A (zh) | 1993-07-12 | 1996-08-14 | 病毒研究院 | 水凝胶微囊包封的疫苗 |
| US5674495A (en) | 1995-02-27 | 1997-10-07 | Purdue Research Foundation | Alginate-based vaccine compositions |
| US6214331B1 (en) * | 1995-06-06 | 2001-04-10 | C. R. Bard, Inc. | Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained |
| US6656508B2 (en) * | 1997-04-17 | 2003-12-02 | Amgen Inc. | Sustained-release alginate gels |
| KR20010003853A (ko) * | 1999-06-25 | 2001-01-15 | 박호군 | 경구용 백신으로 사용할 수 있는 알긴산염 마이크로스피어 및그 제조방법 |
| PT1280521E (pt) * | 2000-05-12 | 2005-10-31 | Pharmacia & Upjohn Co Llc | Composicao de vacina, metodo para a sua preparacao, e metodo de vacinacao de vertebrados |
-
2001
- 2001-05-11 PT PT01935330T patent/PT1280521E/pt unknown
- 2001-05-11 WO PCT/US2001/015235 patent/WO2001087270A2/en not_active Ceased
- 2001-05-11 EP EP01935330A patent/EP1280521B1/en not_active Expired - Lifetime
- 2001-05-11 DE DE60112073T patent/DE60112073T2/de not_active Expired - Fee Related
- 2001-05-11 ES ES01935330T patent/ES2243497T3/es not_active Expired - Lifetime
- 2001-05-11 AT AT01935330T patent/ATE299696T1/de not_active IP Right Cessation
- 2001-05-11 US US09/853,919 patent/US6656470B2/en not_active Expired - Fee Related
- 2001-05-11 AU AU2001261433A patent/AU2001261433A1/en not_active Abandoned
- 2001-05-11 DK DK01935330T patent/DK1280521T3/da active
-
2003
- 2003-11-10 US US10/705,660 patent/US7160544B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2243497T3 (es) | 2005-12-01 |
| US20020009457A1 (en) | 2002-01-24 |
| AU2001261433A1 (en) | 2001-11-26 |
| WO2001087270A2 (en) | 2001-11-22 |
| US20040071727A1 (en) | 2004-04-15 |
| DE60112073T2 (de) | 2006-04-20 |
| US7160544B2 (en) | 2007-01-09 |
| WO2001087270B1 (en) | 2002-08-15 |
| DE60112073D1 (de) | 2005-08-25 |
| WO2001087270A3 (en) | 2002-05-16 |
| HK1049800A1 (en) | 2003-05-30 |
| ATE299696T1 (de) | 2005-08-15 |
| EP1280521B1 (en) | 2005-07-20 |
| PT1280521E (pt) | 2005-10-31 |
| EP1280521A2 (en) | 2003-02-05 |
| US6656470B2 (en) | 2003-12-02 |
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