DK1289527T3 - (+)-alfa.(2,3-dimethoxyphenyl)-1-(2-(4-fluorphenyl)-ethyl)-4-piperodonmethanol eller dets prolægemiddel til behandling af demens eller kognitiv svækkelse - Google Patents

(+)-alfa.(2,3-dimethoxyphenyl)-1-(2-(4-fluorphenyl)-ethyl)-4-piperodonmethanol eller dets prolægemiddel til behandling af demens eller kognitiv svækkelse

Info

Publication number: DK1289527T3
Authority: DK; Denmark
Prior art keywords: piperodone; dimethoxyphenyl; dementia; prodrug; fluorophenyl
Prior art date: 2000-05-25

Application number

DK01939312T

Other languages

English (en)

Inventor

Richard Scheyer

Stephen Sorensen

Janice Hitchcock

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-25

Filing date

2001-05-23

Publication date

2008-07-14

2001-05-23 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2008-07-14 Application granted granted Critical

2008-07-14 Publication of DK1289527T3 publication Critical patent/DK1289527T3/da

Links

OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 title 3
125000001617 2,3-dimethoxy phenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] 0.000 title 1
-1 2- (4-fluorophenyl) ethyl Chemical group 0.000 title 1
208000028698 Cognitive impairment Diseases 0.000 title 1
206010012289 Dementia Diseases 0.000 title 1
208000010877 cognitive disease Diseases 0.000 title 1
229940002612 prodrug Drugs 0.000 title 1
239000000651 prodrug Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pyridine Compounds (AREA)

DK01939312T 2000-05-25 2001-05-23 (+)-alfa.(2,3-dimethoxyphenyl)-1-(2-(4-fluorphenyl)-ethyl)-4-piperodonmethanol eller dets prolægemiddel til behandling af demens eller kognitiv svækkelse DK1289527T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20694300P	2000-05-25	2000-05-25
PCT/US2001/016653 WO2001089498A2 (en)	2000-05-25	2001-05-23	USE OF (+)-α -(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL OR ITS PRODRUG IN THE TREATMENT OF SYMPTOMS OF DEMENTIA AND DOPAMINE INDUCED PSYCHOSIS

Publications (1)

Publication Number	Publication Date
DK1289527T3 true DK1289527T3 (da)	2008-07-14

Family

ID=22768607

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01939312T DK1289527T3 (da)	2000-05-25	2001-05-23	(+)-alfa.(2,3-dimethoxyphenyl)-1-(2-(4-fluorphenyl)-ethyl)-4-piperodonmethanol eller dets prolægemiddel til behandling af demens eller kognitiv svækkelse

Country Status (20)

Country	Link
US (3)	US20020099076A1 (da)
EP (1)	EP1289527B1 (da)
JP (1)	JP2003535058A (da)
KR (1)	KR100784655B1 (da)
CN (1)	CN1436078A (da)
AR (1)	AR029666A1 (da)
AT (1)	ATE390134T1 (da)
AU (2)	AU2001264842B2 (da)
BR (1)	BR0111102A (da)
CA (1)	CA2410554C (da)
DE (1)	DE60133385T2 (da)
DK (1)	DK1289527T3 (da)
ES (1)	ES2300333T3 (da)
IL (1)	IL152908A0 (da)
MX (1)	MXPA02011511A (da)
NO (1)	NO20025630L (da)
NZ (1)	NZ522659A (da)
PT (1)	PT1289527E (da)
TW (1)	TWI299001B (da)
WO (1)	WO2001089498A2 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1534391E (pt)	2002-07-19	2007-05-31	Biovitrum Ab	Novos derivados e piperazinilo-pirazinona para o tratamento de desordens relacionadas com o receptor 5-ht
US7713954B2 (en)	2004-09-30	2010-05-11	Roche Palo Alto Llc	Compositions and methods for treating cognitive disorders
CN102114244A (zh) *	2004-09-30	2011-07-06	弗·哈夫曼-拉罗切有限公司	治疗认知障碍的组合物和方法
DE102006040278A1 (de) *	2006-08-21	2008-03-20	Technische Universität Dresden	Arzneimittel zur Behandlung des Charles-Bonnet-Syndroms
ES2890492T3 (es)	2015-07-20	2022-01-20	Acadia Pharm Inc	Métodos para preparar N-(4-fluorobencil)-N-(1-metilpiperidin-4-il)-N'-(4-(2-metilpropiloxi)fenilmetil)carbamida y su sal de tartrato y forma polimórfica C
WO2017165635A1 (en)	2016-03-25	2017-09-28	Acadia Pharmaceuticals Inc.	Combination of pimavanserin and cytochrome p450 modulators
US10953000B2 (en)	2016-03-25	2021-03-23	Acadia Pharmaceuticals Inc.	Combination of pimavanserin and cytochrome P450 modulators
EP3436010B1 (en) *	2016-03-29	2021-03-10	Acadia Pharmaceuticals Inc.	5-ht2a serotonin receptor inverse agonists or antagonists for use in reducing amyloid-beta peptides and accumulation of amyloid plaques
EP3558311A1 (en)	2016-12-20	2019-10-30	Acadia Pharmaceuticals Inc.	Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis
EP3615028A1 (en)	2017-04-28	2020-03-04	Acadia Pharmaceuticals Inc.	Pimavanserin for treating impulse control disorder
EP3675827A1 (en)	2017-08-30	2020-07-08	Acadia Pharmaceuticals Inc.	Formulations of pimavanserin

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4912117A (en) *	1985-07-02	1990-03-27	Merrell Dow Pharmaceuticals Inc.	Novel chemical compounds
US5169096A (en) *	1985-07-02	1992-12-08	Merrell Dow Pharmaceuticals Inc.	N-aralkyl-piperidine-methanol derivatives
US4783471A (en) *	1985-07-02	1988-11-08	Merrell Dow Pharmaceuticals Inc.	N-aralkyl piperidine methanol derivatives and the uses thereof
US5021428A (en) *	1985-07-02	1991-06-04	Merrell Dow Pharmaceuticals Inc.	Novel chemical compounds for the prophylactic treatment of migraine
US4877798A (en) *	1987-11-23	1989-10-31	Merrell Dow Pharmaceuticals Inc.	Treatment of fibromyalgia
EP0325063B1 (en) *	1988-01-21	1994-03-09	Merrell Dow Pharmaceuticals Inc.	Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia
US5106855A (en) *	1989-12-20	1992-04-21	Merrell Dow Pharmaceuticals Inc.	Method for the treatment of glaucoma
US6004980A (en) *	1990-06-01	1999-12-21	Merrell Pharmaceuticals, Inc.	(+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
KR100211713B1 (ko) *	1990-06-01	1999-08-02	슈테펜 엘. 네스비트	(+)-알파-(2,3-디메톡시페닐)-1-[2-(4-플루오로페닐)에틸]-4-피페리딘메탄올
US5618824A (en) *	1994-03-09	1997-04-08	Merrell Pharmaceuticals Inc.	Treatment of obsessive-compulsive disorders with 5-HT2 antagonists
FR2738819B1 (fr) *	1995-09-14	1997-12-05	Sanofi Sa	Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant
EP0796619A1 (en) *	1996-03-21	1997-09-24	Merrell Pharmaceuticals Inc.	Use of (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethanol in treating depressive disorders and bipolar disorders
US6028083A (en) *	1997-07-25	2000-02-22	Hoechst Marion Roussel, Inc.	Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol
WO1999020315A1 (en) *	1997-10-23	1999-04-29	The Research Foundation Of State University Of New York	Methods of screening potential atypical antipsychotic drugs
HRP20080389A2 (hr) *	1998-08-28	2008-11-30	Aventis Pharmaceuticals Inc.	UPOTREBA R-(+)-α-(2,3-DIMETOKSIFENIL)-1-[2-(4-FLUORFENIL)ETIL]-4-PIPERIDINMETANOLA ZA LIJEČENJE POREMEĆAJA SPAVANJA
IL142479A0 (en) *	1998-10-14	2002-03-10	Aventis Pharma Inc	Esters of (+)-alpha-(2,3-dimethoxyphenyl) -1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol and their use as prodrugs of the 5ht2a receptor antagonist mdl 110,907
US6455526B1 (en) *	1998-12-16	2002-09-24	Aventis Pharmaceuticals, Inc.	Biodegradable polymer encapsulated pharmaceutical compositions and method for preparing the same

2001
- 2001-05-18 US US09/861,980 patent/US20020099076A1/en not_active Abandoned
- 2001-05-23 AT AT01939312T patent/ATE390134T1/de not_active IP Right Cessation
- 2001-05-23 KR KR1020027015968A patent/KR100784655B1/ko not_active Expired - Fee Related
- 2001-05-23 DE DE60133385T patent/DE60133385T2/de not_active Expired - Fee Related
- 2001-05-23 ES ES01939312T patent/ES2300333T3/es not_active Expired - Lifetime
- 2001-05-23 BR BR0111102-7A patent/BR0111102A/pt not_active Application Discontinuation
- 2001-05-23 JP JP2001585743A patent/JP2003535058A/ja active Pending
- 2001-05-23 DK DK01939312T patent/DK1289527T3/da active
- 2001-05-23 WO PCT/US2001/016653 patent/WO2001089498A2/en not_active Ceased
- 2001-05-23 NZ NZ522659A patent/NZ522659A/en unknown
- 2001-05-23 EP EP01939312A patent/EP1289527B1/en not_active Expired - Lifetime
- 2001-05-23 MX MXPA02011511A patent/MXPA02011511A/es active IP Right Grant
- 2001-05-23 TW TW090112318A patent/TWI299001B/zh not_active IP Right Cessation
- 2001-05-23 CA CA002410554A patent/CA2410554C/en not_active Expired - Fee Related
- 2001-05-23 PT PT01939312T patent/PT1289527E/pt unknown
- 2001-05-23 IL IL15290801A patent/IL152908A0/xx unknown
- 2001-05-23 AR ARP010102464A patent/AR029666A1/es unknown
- 2001-05-23 AU AU2001264842A patent/AU2001264842B2/en not_active Ceased
- 2001-05-23 AU AU6484201A patent/AU6484201A/xx active Pending
- 2001-05-23 CN CN01810983A patent/CN1436078A/zh active Pending
2002
- 2002-08-13 US US10/217,843 patent/US20030036553A1/en not_active Abandoned
- 2002-11-22 NO NO20025630A patent/NO20025630L/no not_active Application Discontinuation
2004
- 2004-05-03 US US10/838,035 patent/US7132433B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20020099076A1 (en)	2002-07-25
IL152908A0 (en)	2003-06-24
JP2003535058A (ja)	2003-11-25
CA2410554C (en)	2009-02-03
KR100784655B1 (ko)	2007-12-12
BR0111102A (pt)	2003-03-11
AU6484201A (en)	2001-12-03
PL359176A1 (en)	2004-08-23
TWI299001B (en)	2008-07-21
US20030036553A1 (en)	2003-02-20
NO20025630D0 (no)	2002-11-22
ES2300333T3 (es)	2008-06-16
EP1289527B1 (en)	2008-03-26
MXPA02011511A (es)	2003-04-25
US7132433B2 (en)	2006-11-07
DE60133385T2 (de)	2009-04-23
WO2001089498A3 (en)	2002-05-10
EP1289527A2 (en)	2003-03-12
NO20025630L (no)	2003-01-24
PT1289527E (pt)	2008-05-13
KR20030034078A (ko)	2003-05-01
ATE390134T1 (de)	2008-04-15
CA2410554A1 (en)	2001-11-29
AU2001264842B2 (en)	2005-01-27
CN1436078A (zh)	2003-08-13
WO2001089498A2 (en)	2001-11-29
AR029666A1 (es)	2003-07-10
DE60133385D1 (de)	2008-05-08
US20040204457A1 (en)	2004-10-14
NZ522659A (en)	2004-06-25

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