DK1289985T3 - Beta-carbolinderivater anvendelige som phosphodiesteraseinhibitorer - Google Patents

Beta-carbolinderivater anvendelige som phosphodiesteraseinhibitorer

Info

Publication number: DK1289985T3
Authority: DK; Denmark
Prior art keywords: beta; phosphodiesterase inhibitors; derivatives useful; carboline derivatives; carboline
Prior art date: 2000-05-17

Application number

DK01935038T

Other languages

Danish (da)

English (en)

Inventor

Zhihua Sui

Mark J Macielag

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-17

Filing date

2001-05-03

Publication date

2004-04-05

2001-05-03 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2004-04-05 Application granted granted Critical

2004-04-05 Publication of DK1289985T3 publication Critical patent/DK1289985T3/da

Links

229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 title 1
239000002571 phosphodiesterase inhibitor Substances 0.000 title 1
AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical class N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Gynecology & Obstetrics (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK01935038T 2000-05-17 2001-05-03 Beta-carbolinderivater anvendelige som phosphodiesteraseinhibitorer DK1289985T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20466700P	2000-05-17	2000-05-17
PCT/US2001/014357 WO2001087038A2 (fr)	2000-05-17	2001-05-03	Derives $g(b)-carboline utiles en tant qu'inhibiteurs de la phosphodiesterase

Publications (1)

Publication Number	Publication Date
DK1289985T3 true DK1289985T3 (da)	2004-04-05

Family

ID=22758909

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01935038T DK1289985T3 (da)	2000-05-17	2001-05-03	Beta-carbolinderivater anvendelige som phosphodiesteraseinhibitorer

Country Status (31)

Country	Link
US (2)	US6492358B2 (fr)
EP (1)	EP1289985B1 (fr)
JP (1)	JP5014551B2 (fr)
KR (1)	KR20030031482A (fr)
CN (1)	CN1255403C (fr)
AR (1)	AR028576A1 (fr)
AT (1)	ATE256127T1 (fr)
AU (2)	AU2001261167B2 (fr)
BG (1)	BG66141B1 (fr)
CA (1)	CA2409715C (fr)
CZ (1)	CZ20023934A3 (fr)
DE (1)	DE60101479T2 (fr)
DK (1)	DK1289985T3 (fr)
ES (1)	ES2211806T3 (fr)
GE (1)	GEP20053511B (fr)
HR (1)	HRP20020910B1 (fr)
HU (1)	HUP0302412A3 (fr)
IL (2)	IL152873A0 (fr)
MX (1)	MXPA02011426A (fr)
MY (1)	MY128479A (fr)
NO (1)	NO324251B1 (fr)
NZ (1)	NZ522731A (fr)
PL (1)	PL205507B1 (fr)
PT (1)	PT1289985E (fr)
RU (1)	RU2271358C2 (fr)
SK (1)	SK16972002A3 (fr)
TR (1)	TR200302309T4 (fr)
TW (1)	TWI286553B (fr)
UA (1)	UA74826C2 (fr)
WO (1)	WO2001087038A2 (fr)
ZA (1)	ZA200210111B (fr)

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ES2248412T3 (es) *	2001-02-12	2006-03-16	Lilly Icos Llc	Derivados de carbolina.
ES2272695T3 (es) *	2001-02-12	2007-05-01	Lilly Icos Llc	Derivados de carbolina.
EP1383765B1 (fr) *	2001-04-25	2006-12-13	Lilly Icos LLC	Dérives de carboline en tant qu'inhibiteurs de phosphodiesterase 5 (PDE 5) pour le traitement des maladies cardiovasculaires et le dysfonctionnement érectile
EP1401835A1 (fr) *	2001-06-05	2004-03-31	Lilly Icos LLC	Derives de carboline utilises comme inhibiteurs de pde-5
DE60213798T2 (de) *	2001-06-21	2007-08-16	Lilly Icos Llc, Wilmington	Carbolinderivate als pdev inhibitoren
ES2289159T3 (es)	2001-11-14	2008-02-01	Ortho-Mcneil Pharmaceutical Corporation	Derivados tetraciclicos sustituidos de pirroloquinolona utilizados como inhibidores de fosfodiesterasa.
CA2475108A1 (fr) *	2002-02-07	2003-08-14	Mitchell S. Steiner	Traitement de l'hyperplasie prostatique benigne a l'aide de modulateurs selectifs des recepteurs androgenes (sarm)
DE60317684T4 (de) *	2002-06-19	2011-06-22	Janssen Pharmaceutica N.V., 2340	SUBSTITUIERTE 2,4-DIHYDROPYRROLOc3,4BÜCHINOLIN-9-ONDERIVATE, DIE SICH ALS PHOSPHODIESTERASEINHIBITOREN EIGNEN
US7872133B2 (en) *	2003-06-23	2011-01-18	Ono Pharmaceutical Co., Ltd.	Tricyclic heterocycle compound
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WO2013106547A1 (fr)	2012-01-10	2013-07-18	President And Fellows Of Harvard College	Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation
US10092574B2 (en)	2012-09-26	2018-10-09	Valorisation-Recherche, Limited Partnership	Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
WO2017168174A1 (fr)	2016-04-02	2017-10-05	N4 Pharma Uk Limited	Nouvelles formes pharmaceutiques du sildénafil
CN107216327A (zh) *	2017-06-27	2017-09-29	山东大学	5型磷酸二酯酶抑制剂及其制备方法和用途
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2001
- 2001-03-05 UA UA2002119179A patent/UA74826C2/uk unknown
- 2001-05-02 US US09/847,767 patent/US6492358B2/en not_active Expired - Lifetime
- 2001-05-03 KR KR1020027015581A patent/KR20030031482A/ko not_active Withdrawn
- 2001-05-03 GE GE5003A patent/GEP20053511B/en unknown
- 2001-05-03 IL IL15287301A patent/IL152873A0/xx unknown
- 2001-05-03 PT PT01935038T patent/PT1289985E/pt unknown
- 2001-05-03 AT AT01935038T patent/ATE256127T1/de active
- 2001-05-03 AU AU2001261167A patent/AU2001261167B2/en not_active Ceased
- 2001-05-03 AU AU6116701A patent/AU6116701A/xx active Pending
- 2001-05-03 WO PCT/US2001/014357 patent/WO2001087038A2/fr not_active Ceased
- 2001-05-03 JP JP2001583517A patent/JP5014551B2/ja not_active Expired - Fee Related
- 2001-05-03 HU HU0302412A patent/HUP0302412A3/hu unknown
- 2001-05-03 CA CA2409715A patent/CA2409715C/fr not_active Expired - Fee Related
- 2001-05-03 CN CNB018128432A patent/CN1255403C/zh not_active Expired - Fee Related
- 2001-05-03 CZ CZ20023934A patent/CZ20023934A3/cs unknown
- 2001-05-03 NZ NZ522731A patent/NZ522731A/en not_active IP Right Cessation
- 2001-05-03 DK DK01935038T patent/DK1289985T3/da active
- 2001-05-03 RU RU2002133867/04A patent/RU2271358C2/ru not_active IP Right Cessation
- 2001-05-03 ES ES01935038T patent/ES2211806T3/es not_active Expired - Lifetime
- 2001-05-03 PL PL365445A patent/PL205507B1/pl unknown
- 2001-05-03 TR TR2003/02309T patent/TR200302309T4/xx unknown
- 2001-05-03 DE DE60101479T patent/DE60101479T2/de not_active Expired - Lifetime
- 2001-05-03 MX MXPA02011426A patent/MXPA02011426A/es active IP Right Grant
- 2001-05-03 SK SK1697-2002A patent/SK16972002A3/sk unknown
- 2001-05-03 EP EP01935038A patent/EP1289985B1/fr not_active Expired - Lifetime
- 2001-05-03 HR HR20020910A patent/HRP20020910B1/xx not_active IP Right Cessation
- 2001-05-16 MY MYPI20012323A patent/MY128479A/en unknown
- 2001-05-16 AR ARP010102326A patent/AR028576A1/es unknown
2002
- 2002-01-21 TW TW091100842A patent/TWI286553B/zh not_active IP Right Cessation
- 2002-10-01 US US10/261,861 patent/US6864253B2/en not_active Expired - Lifetime
- 2002-11-15 IL IL152873A patent/IL152873A/en not_active IP Right Cessation
- 2002-11-18 BG BG107285A patent/BG66141B1/bg unknown
- 2002-11-18 NO NO20025527A patent/NO324251B1/no not_active IP Right Cessation
- 2002-12-12 ZA ZA200210111A patent/ZA200210111B/en unknown

Also Published As

Publication number	Publication date
MXPA02011426A (es)	2004-09-06
WO2001087038A3 (fr)	2002-05-16
ZA200210111B (en)	2004-03-12
NZ522731A (en)	2004-09-24
PL205507B1 (pl)	2010-04-30
US6492358B2 (en)	2002-12-10
IL152873A (en)	2012-01-31
UA74826C2 (en)	2006-02-15
HK1051368A1 (en)	2003-08-01
SK16972002A3 (sk)	2003-11-04
CN1255403C (zh)	2006-05-10
US6864253B2 (en)	2005-03-08
NO20025527L (no)	2003-01-16
IL152873A0 (en)	2003-06-24
ATE256127T1 (de)	2003-12-15
MY128479A (en)	2007-02-28
GEP20053511B (en)	2005-05-10
DE60101479T2 (de)	2005-04-28
AR028576A1 (es)	2003-05-14
BG66141B1 (bg)	2011-07-29
CZ20023934A3 (cs)	2003-10-15
HRP20020910A2 (en)	2004-12-31
CN1446217A (zh)	2003-10-01
CA2409715C (fr)	2010-09-14
RU2271358C2 (ru)	2006-03-10
BG107285A (bg)	2003-07-31
US20020010189A1 (en)	2002-01-24
US20030166641A1 (en)	2003-09-04
AU2001261167B2 (en)	2006-10-05
JP5014551B2 (ja)	2012-08-29
AU6116701A (en)	2001-11-26
HRP20020910B1 (hr)	2011-02-28
TWI286553B (en)	2007-09-11
NO20025527D0 (no)	2002-11-18
HUP0302412A2 (hu)	2003-11-28
EP1289985A2 (fr)	2003-03-12
CA2409715A1 (fr)	2001-11-22
PL365445A1 (en)	2005-01-10
NO324251B1 (no)	2007-09-17
KR20030031482A (ko)	2003-04-21
EP1289985B1 (fr)	2003-12-10
HUP0302412A3 (en)	2007-02-28
ES2211806T3 (es)	2004-07-16
TR200302309T4 (tr)	2004-02-23
PT1289985E (pt)	2004-03-31
DE60101479D1 (en)	2004-01-22
JP2003533453A (ja)	2003-11-11
WO2001087038A2 (fr)	2001-11-22

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DK1296981T3 (da)	2005-07-25	Substituerede pyrrolopyridinonderivater som phosphodiesteraseinhibitorer
DE50104434D1 (de)	2004-12-09	Lactam-substituierte pyrazolopyridinderivate
SI1289985T1 (en)	2004-04-30	Beta-carboline derivatives useful as inhibitors of phosphodiesterase