DK1292680T3 - Agonist-anti-TrkC monoklonale antistoffer - Google Patents
Agonist-anti-TrkC monoklonale antistofferInfo
- Publication number
- DK1292680T3 DK1292680T3 DK01950429.9T DK01950429T DK1292680T3 DK 1292680 T3 DK1292680 T3 DK 1292680T3 DK 01950429 T DK01950429 T DK 01950429T DK 1292680 T3 DK1292680 T3 DK 1292680T3
- Authority
- DK
- Denmark
- Prior art keywords
- monoclonal antibodies
- trkc
- agonist
- trkc monoclonal
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21314100P | 2000-06-22 | 2000-06-22 | |
| US23831900P | 2000-10-05 | 2000-10-05 | |
| PCT/US2001/020153 WO2001098361A2 (en) | 2000-06-22 | 2001-06-22 | Agonist anti-trk-c monoclonal antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1292680T3 true DK1292680T3 (da) | 2010-03-08 |
Family
ID=26907807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01950429.9T DK1292680T3 (da) | 2000-06-22 | 2001-06-22 | Agonist-anti-TrkC monoklonale antistoffer |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US7384632B2 (da) |
| EP (1) | EP1292680B1 (da) |
| JP (1) | JP2004500873A (da) |
| KR (1) | KR100823764B1 (da) |
| CN (1) | CN100519749C (da) |
| AT (1) | ATE446366T1 (da) |
| AU (2) | AU2001271422B2 (da) |
| BR (1) | BR0112272A (da) |
| CA (1) | CA2412494C (da) |
| DE (1) | DE60140252D1 (da) |
| DK (1) | DK1292680T3 (da) |
| HU (1) | HU228310B1 (da) |
| IL (2) | IL153375A0 (da) |
| MX (1) | MXPA02012602A (da) |
| NZ (1) | NZ523105A (da) |
| PL (1) | PL208113B1 (da) |
| WO (1) | WO2001098361A2 (da) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5877016A (en) * | 1994-03-18 | 1999-03-02 | Genentech, Inc. | Human trk receptors and neurotrophic factor inhibitors |
| EP1290028B1 (en) | 2000-06-05 | 2009-12-23 | The Brigham And Women's Hospital, Inc. | A GENE ENCODING A MULTIDRUG RESISTANCE HUMAN P-GLYCOPROTEIN HOMOLOGUE ON CHROMOSOME 7p15-21 AND USES THEREOF |
| CA2412494C (en) * | 2000-06-22 | 2012-10-23 | Genentech, Inc. | Agonist anti-trk-c monoclonal antibodies |
| GB0210783D0 (en) * | 2002-05-10 | 2002-06-19 | Polonelli Luciano | Anti-microbial polypeptides |
| WO2004044584A1 (en) * | 2002-11-13 | 2004-05-27 | Micromet Ag | Method for identifying antigen specific b cells |
| NZ540879A (en) * | 2002-12-23 | 2008-08-29 | Rinat Neuroscience Corp | Methods for treating taxol-induced sensory neuropathy |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| JP2006520806A (ja) * | 2003-03-20 | 2006-09-14 | ライナット ニューロサイエンス コーポレイション | タキソール誘導性腸障害を処置する方法 |
| AP2006003670A0 (en) | 2003-12-23 | 2006-06-30 | Rinat Neuroscience Corp | Agonist anti-TRKC antibodies and methods using same |
| AR054260A1 (es) * | 2005-04-26 | 2007-06-13 | Rinat Neuroscience Corp | Metodos de tratamiento de enfermedades de la neurona motora inferior y composiciones utilizadas en los mismos |
| GT200600240A (es) * | 2005-06-06 | 2007-03-14 | Anticuerpos monoclonales anti-trkb y usos de los mismos | |
| CN103145842A (zh) * | 2005-06-30 | 2013-06-12 | Abbvie公司 | Il-12/p40结合蛋白 |
| US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
| HRP20140240T4 (hr) * | 2005-11-30 | 2017-02-24 | Abbvie Inc. | Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba |
| CN101400367A (zh) | 2006-02-02 | 2009-04-01 | 瑞纳神经科学公司 | 施用trkb激动剂治疗不希望的重量减轻或进食障碍的方法 |
| HUE059011T2 (hu) | 2006-05-31 | 2022-09-28 | Childrens Medical Center | Immunmodulátorként szolgáló ABC5-pozitív mezenchimális õssejtek |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| JP5576659B2 (ja) * | 2006-12-05 | 2014-08-20 | ザ ロイヤル インスティテューション フォー ジ アドバンスメント オブ ラーニング/ マギル ユニバーシティ | Trkレセプター調節因子の使用方法 |
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
| DK2155248T3 (da) | 2007-04-12 | 2015-09-14 | Brigham & Womens Hospital | Målretning mod abcb5 til cancerterapi |
| EP2262837A4 (en) * | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
| JP5758289B2 (ja) * | 2008-05-21 | 2015-08-05 | サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、(セーエヌエルエス) | NT−3:TrkC結合の阻害および神経芽腫などの癌の処置へのその適用 |
| WO2010033941A1 (en) | 2008-09-22 | 2010-03-25 | Array Biopharma Inc. | Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors |
| MY169791A (en) | 2008-10-22 | 2019-05-15 | Array Biopharma Inc | Substituted pyrazolo [1,5-a] pyrimidine compounds as trk kinase inhibitors |
| PT3130923T (pt) | 2008-11-14 | 2020-06-17 | Brigham & Womens Hospital Inc | Métodos terapêuticos relacionados com células estaminais |
| US11542328B2 (en) | 2008-11-14 | 2023-01-03 | The Brigham And Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
| CN102317316B (zh) | 2008-12-19 | 2014-08-13 | 帕尼玛制药股份公司 | 人抗α突触核蛋白自身抗体 |
| EP2421900A1 (en) | 2009-04-24 | 2012-02-29 | Alper Biotech, Llc | Monoclonal antibodies against pcbp-1 antigens, and uses therefor |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| KR101790802B1 (ko) * | 2009-09-03 | 2017-10-27 | 머크 샤프 앤드 돔 코포레이션 | 항-gitr 항체 |
| US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| ME03376B (me) | 2010-05-20 | 2020-01-20 | Array Biopharma Inc | Makrociklička jedinjenja kао inhibiтori trk kinaze |
| WO2012009577A2 (en) * | 2010-07-14 | 2012-01-19 | Alper Biotech, Llc | Monoclonal antibodies against pcbp-1 antigens, and uses therefor |
| EP3533803B1 (en) | 2010-08-14 | 2021-10-27 | AbbVie Inc. | Anti-amyloid-beta antibodies |
| US9200080B2 (en) | 2010-09-03 | 2015-12-01 | Horacio Uri Saragovi | Agonistic antibodies to TrkC receptors and uses thereof |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| EP2646468B1 (en) | 2010-12-01 | 2018-07-25 | AlderBio Holdings LLC | Anti-ngf compositions and use thereof |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| EP2686418A4 (en) | 2011-03-17 | 2015-04-22 | Minerva Biotechnologies Corp | METHOD FOR THE PRODUCTION OF PLURIPOTENTAL STEM CELLS |
| SI2723379T1 (sl) | 2011-06-23 | 2019-03-29 | Biogen International Neuroscience Gmbh | Molekule, ki se vežejo ma anti alfa-sinuklein |
| KR20140064768A (ko) * | 2011-07-01 | 2014-05-28 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 항-프로퍼딘 항체 및 그의 용도 |
| US9430614B2 (en) * | 2012-05-09 | 2016-08-30 | Koninklijke Philips N.V. | Interventional information brokering medical tracking interface |
| CA2887050A1 (en) | 2012-10-04 | 2014-04-10 | Novelmed Therapeutics, Inc. | Alternative pathway specific antibodies for treating hemolytic diseases |
| CN113354649B (zh) | 2014-11-16 | 2024-12-10 | 阵列生物制药公司 | 一种新的晶型 |
| MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| HK1253093A1 (zh) | 2015-06-01 | 2019-06-06 | Loxo Oncology Inc. | 诊断和治疗癌症的方法 |
| EP3303387A2 (en) | 2015-06-05 | 2018-04-11 | Novartis AG | Antibodies targeting bone morphogenetic protein 9 (bmp9) and methods therefor |
| BR112018000808A2 (pt) | 2015-07-16 | 2018-09-04 | Array Biopharma Inc | compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase |
| KR20180037994A (ko) | 2015-07-28 | 2018-04-13 | 오토노미, 인코포레이티드 | TrkB 또는 TrkC 아고니스트 조성물 및 귀 병태의 치료 방법 |
| EP3368039A1 (en) | 2015-10-26 | 2018-09-05 | The Regents of The University of Colorado, A Body Corporate | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| PE20181326A1 (es) | 2015-11-03 | 2018-08-20 | Janssen Biotech Inc | Anticuerpos que se unen especificamente a pd-1 y sus usos |
| TW201736399A (zh) | 2015-12-31 | 2017-10-16 | 財團法人生物技術開發中心 | 抗vegfr抗體及其應用 |
| AU2017246547B2 (en) | 2016-04-04 | 2023-02-23 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| FI3439662T3 (fi) | 2016-04-04 | 2024-09-04 | Loxo Oncology Inc | (s)-n-(5-((r)-2-(2,5-difluorifenyyli)pyrrolidin-1-yyli)pyratsolo[1,5-a]pyrimidin-3-yyli)-3-hydroksipyrrolidiini-1-karboksamidin nesteformulaatioita |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| EP3458456B1 (en) | 2016-05-18 | 2020-11-25 | Loxo Oncology Inc. | Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
| AU2017290256A1 (en) | 2016-06-29 | 2019-01-17 | Otonomy, Inc. | Triglyceride otic formulations and uses thereof |
| TWI752098B (zh) | 2016-10-10 | 2022-01-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| CN110337448B (zh) * | 2016-12-23 | 2023-08-08 | 瑞美德生物医药科技有限公司 | 使用与程序性死亡配体1(pd-l1)结合的抗体的免疫疗法 |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| WO2018136661A1 (en) | 2017-01-18 | 2018-07-26 | Andrews Steven W | SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS |
| CN110753702B (zh) * | 2017-03-15 | 2022-09-20 | 清华大学 | 抗trkb抗体 |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| WO2019009879A1 (en) * | 2017-07-03 | 2019-01-10 | Development Center For Biotechnology | ANTI-VEGFR ANTIBODIES AND USES THEREOF |
| CN118370815A (zh) | 2017-08-22 | 2024-07-23 | 渤健马萨诸塞州股份有限公司 | 含有抗β淀粉样蛋白抗体的药物组合物 |
| WO2019067425A1 (en) | 2017-09-26 | 2019-04-04 | The Trustees Of The University Of Pennsylvania | COMPOSITIONS AND METHODS FOR TREATING CARDIAC DISEASE BY REDIRECTED T-CELL IMMUNOTHERAPIES |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| TWI876442B (zh) | 2017-10-10 | 2025-03-11 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| AU2018346978B2 (en) * | 2017-10-13 | 2024-02-15 | Mapp Biopharmaceutical, Inc. | Anti-respiratory syncytial virus antibodies, methods of their generation and use |
| WO2019084285A1 (en) | 2017-10-26 | 2019-05-02 | Qian Zhao | FORMULATIONS OF A MACROCYCLIC TRK KINASE INHIBITOR |
| JP7060694B2 (ja) | 2018-01-18 | 2022-04-26 | アレイ バイオファーマ インコーポレイテッド | Retキナーゼ阻害剤としての置換ピロロ[2,3-d]ピリミジン化合物 |
| EP3740490A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors |
| US11472802B2 (en) | 2018-01-18 | 2022-10-18 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| WO2019191659A1 (en) | 2018-03-29 | 2019-10-03 | Loxo Oncology, Inc. | Treatment of trk-associated cancers |
| CN117285467A (zh) | 2018-07-31 | 2023-12-26 | 罗索肿瘤学公司 | 喷雾干燥的分散体和制剂 |
| CN112996794A (zh) | 2018-09-10 | 2021-06-18 | 阿雷生物药品公司 | 作为ret激酶抑制剂的稠合杂环化合物 |
| EP3898626A1 (en) | 2018-12-19 | 2021-10-27 | Array Biopharma, Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases |
| US12351571B2 (en) | 2018-12-19 | 2025-07-08 | Array Biopharma Inc. | Substituted quinoxaline compounds as inhibitors of FGFR tyrosine kinases |
| MX2022003465A (es) | 2019-09-23 | 2022-06-16 | Univ Pennsylvania | Anticuerpo monoclonal contra proteína de activación de fibroblasto canino de reacción cruzada con proteína de activación de fibroblasto (fap) de ratón y humana. |
| US12116418B2 (en) | 2019-09-23 | 2024-10-15 | The Trustees Of The University Of Pennsylvania | Disrupting tumor tissues by targeting fibroblast activation protein (FAP) |
| CN117447602B (zh) * | 2023-12-22 | 2024-03-19 | 北京索莱宝科技有限公司 | 猪IgM的抗体及其应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GR1000980B (el) * | 1989-08-30 | 1993-03-31 | Max Planck Gesellschaft | Νευροτροφινη-3,ενας νεος neυροτροφικος παραγοντας που σχετιζεται με τον παραγοντα αναπτυξης νευρων και τον νευροτροφικο παραγοντα που προερχεται απο τον εγκεφαλο. |
| CA2040099A1 (en) | 1990-05-01 | 1991-11-02 | Mariano Barbacid | Tyrosine kinase negative trkb |
| US5364769A (en) | 1990-09-25 | 1994-11-15 | Genentech, Inc. | Nucleic acid encoding neurotrophic factor four (NT-4), vectors, host cells and methods of production |
| US5348856A (en) * | 1991-07-08 | 1994-09-20 | E. R. Squibb & Sons, Inc. | DNA encoding TRKC protein |
| EP0573904B1 (en) | 1992-06-08 | 2001-09-26 | Takeda Chemical Industries, Ltd. | Therapeutic agent for neutropenia |
| US5855885A (en) * | 1993-01-22 | 1999-01-05 | Smith; Rodger | Isolation and production of catalytic antibodies using phage technology |
| US5659791A (en) * | 1993-04-26 | 1997-08-19 | Microsoft Corporation | Encapsulation of extracted portions of documents into objects |
| US6025145A (en) | 1993-11-23 | 2000-02-15 | Genentech, Inc. | Kinase receptor activation assay |
| CA2175893C (en) | 1993-11-23 | 2010-06-22 | Paul J. Godowski | Protein tyrosine kinases named rse |
| US5753225A (en) | 1993-12-03 | 1998-05-19 | The Regents Of The University Of California | Antibodies that mimic actions of neurotrophins |
| US5877016A (en) * | 1994-03-18 | 1999-03-02 | Genentech, Inc. | Human trk receptors and neurotrophic factor inhibitors |
| JPH07285912A (ja) * | 1994-04-19 | 1995-10-31 | Asahi Chem Ind Co Ltd | 新規化合物am5221 |
| AU5752696A (en) * | 1995-05-18 | 1996-11-29 | Regents Of The University Of Michigan, The | Dna binding antibodies |
| ES2233974T3 (es) * | 1995-09-11 | 2005-06-16 | Kyowa Hakko Kogyo Co., Ltd. | Anticuerpo contra la cadena alfa del receptor de la interleucina 5 humana. |
| GB9525180D0 (en) | 1995-12-08 | 1996-02-07 | Univ Mcgill | Design of hormone-like antibodies with agonistic and antagonistic fuctions |
| AU7154698A (en) | 1997-04-25 | 1998-11-24 | Genentech Inc. | Ngf variants |
| WO2000024415A2 (en) | 1998-10-28 | 2000-05-04 | Cornell Research Foundation, Inc. | Methods for regulating angiogenesis and vascular integrity using trk receptor ligands |
| US6656474B1 (en) * | 1999-01-15 | 2003-12-02 | Regeneron Pharmaceuticals, Inc. | Methods of using a neurotrophin and its analogues for the treatment of gastrointestinal hypomotility disorders |
| CA2412494C (en) * | 2000-06-22 | 2012-10-23 | Genentech, Inc. | Agonist anti-trk-c monoclonal antibodies |
-
2001
- 2001-06-22 CA CA2412494A patent/CA2412494C/en not_active Expired - Lifetime
- 2001-06-22 NZ NZ523105A patent/NZ523105A/en not_active IP Right Cessation
- 2001-06-22 KR KR1020027017506A patent/KR100823764B1/ko not_active Expired - Lifetime
- 2001-06-22 PL PL359926A patent/PL208113B1/pl unknown
- 2001-06-22 BR BR0112272-0A patent/BR0112272A/pt not_active IP Right Cessation
- 2001-06-22 AT AT01950429T patent/ATE446366T1/de not_active IP Right Cessation
- 2001-06-22 AU AU2001271422A patent/AU2001271422B2/en not_active Ceased
- 2001-06-22 JP JP2002504316A patent/JP2004500873A/ja active Pending
- 2001-06-22 WO PCT/US2001/020153 patent/WO2001098361A2/en not_active Ceased
- 2001-06-22 CN CNB018144217A patent/CN100519749C/zh not_active Expired - Lifetime
- 2001-06-22 EP EP01950429A patent/EP1292680B1/en not_active Expired - Lifetime
- 2001-06-22 DE DE60140252T patent/DE60140252D1/de not_active Expired - Lifetime
- 2001-06-22 DK DK01950429.9T patent/DK1292680T3/da active
- 2001-06-22 MX MXPA02012602A patent/MXPA02012602A/es active IP Right Grant
- 2001-06-22 HU HU0300841A patent/HU228310B1/hu unknown
- 2001-06-22 US US10/312,316 patent/US7384632B2/en not_active Expired - Lifetime
- 2001-06-22 AU AU7142201A patent/AU7142201A/xx active Pending
- 2001-06-22 IL IL15337501A patent/IL153375A0/xx unknown
-
2002
- 2002-12-11 IL IL153375A patent/IL153375A/en active IP Right Grant
-
2006
- 2006-10-16 US US11/581,865 patent/US7615383B2/en not_active Expired - Lifetime
-
2009
- 2009-06-04 US US12/478,501 patent/US20100003261A1/en not_active Abandoned
-
2011
- 2011-08-05 US US13/198,979 patent/US20120045443A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001098361A3 (en) | 2002-05-02 |
| DE60140252D1 (de) | 2009-12-03 |
| EP1292680B1 (en) | 2009-10-21 |
| HU228310B1 (en) | 2013-03-28 |
| CA2412494A1 (en) | 2001-12-27 |
| WO2001098361A2 (en) | 2001-12-27 |
| US20100003261A1 (en) | 2010-01-07 |
| EP1292680A2 (en) | 2003-03-19 |
| CN1447857A (zh) | 2003-10-08 |
| US7384632B2 (en) | 2008-06-10 |
| US20040137513A1 (en) | 2004-07-15 |
| AU2001271422B2 (en) | 2005-12-22 |
| AU7142201A (en) | 2002-01-02 |
| NZ523105A (en) | 2004-07-30 |
| IL153375A0 (en) | 2003-07-06 |
| US7615383B2 (en) | 2009-11-10 |
| ATE446366T1 (de) | 2009-11-15 |
| CA2412494C (en) | 2012-10-23 |
| MXPA02012602A (es) | 2003-05-14 |
| WO2001098361A9 (en) | 2003-03-06 |
| JP2004500873A (ja) | 2004-01-15 |
| BR0112272A (pt) | 2003-05-06 |
| IL153375A (en) | 2009-06-15 |
| US20120045443A1 (en) | 2012-02-23 |
| HUP0300841A2 (hu) | 2004-06-28 |
| HUP0300841A3 (en) | 2005-11-28 |
| KR20030036240A (ko) | 2003-05-09 |
| KR100823764B1 (ko) | 2008-04-21 |
| US20070036794A1 (en) | 2007-02-15 |
| PL359926A1 (en) | 2004-09-06 |
| PL208113B1 (pl) | 2011-03-31 |
| CN100519749C (zh) | 2009-07-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1292680T3 (da) | Agonist-anti-TrkC monoklonale antistoffer | |
| BR0011838B1 (pt) | elemento de sela e estrutura de misturador estático. | |
| NI200800032A (es) | Reducción de célula b utilizando moléculas de unión específicas cd37 y cd20 | |
| TNSN08255A1 (en) | Anti-mn antibodies and methods of using same | |
| ATE476495T1 (de) | Bazillus thuringiensis und dessen insektizide proteine | |
| EP1844077A4 (en) | DR5 ANTIBODIES AND THEIR USE | |
| TW200635608A (en) | Aβ antibodies for use in improving cognition | |
| TW200635607A (en) | Humanized Aβ antibodies for use in improving cognition | |
| TR200103756T2 (tr) | Hümanize anti-ErbB2 antikorları ve anti-ErbB2 antikorlarıyla tedavi. | |
| ATE515288T1 (de) | Carboxy-amido-triazole zur lokalisierten behandlung von augenerkrankungen | |
| YU9404A (sh) | Multimerna, usmerena kontrastna sredstva na bazi peptida | |
| EP1700120A4 (en) | MARKER FOR OPTICAL NEUROMYELITIS | |
| BRPI0515615A (pt) | métodos para tratar células cancerosas e doença imune relacionada | |
| GEP20043349B (en) | Methods of Controlling Cutworm Pests | |
| SG166768A1 (en) | Agonist anti-trkc antibodies and methods using same | |
| WO2004083241A3 (en) | Btc-interacting proteins and use thereof | |
| BRPI0508084A (pt) | método para o tratamento de um distúrbio neurológico, e, uso de meridamicina ou um sal do mesmo | |
| EP0929217A4 (en) | SORDARINE DERIVATIVES | |
| DE602006018461D1 (de) | Galk1s als modifikatoren des pten/akt-wegs | |
| ES2163988B1 (es) | Proteina con actividad antifungica. | |
| ATE238050T1 (de) | 4-cyano-4-deformylsordarizin-derivate | |
| EP1191096A4 (en) | NEW PROTEIN AND ITS DNA | |
| EP1007031A4 (en) | 4-CYANO-4-DEFORMYLSORDARINE DERIVATIVES | |
| Bowal | Freedom of Conscience and Religion | |
| WO2005046617A3 (en) | Compositions and methods for reducing microbial induced apoptosis |