ATE446366T1 - Agonistische monoklonale antikörper gegen trkc - Google Patents
Agonistische monoklonale antikörper gegen trkcInfo
- Publication number
- ATE446366T1 ATE446366T1 AT01950429T AT01950429T ATE446366T1 AT E446366 T1 ATE446366 T1 AT E446366T1 AT 01950429 T AT01950429 T AT 01950429T AT 01950429 T AT01950429 T AT 01950429T AT E446366 T1 ATE446366 T1 AT E446366T1
- Authority
- AT
- Austria
- Prior art keywords
- monoclonal antibodies
- trkc
- antibodies against
- agonistic monoclonal
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21314100P | 2000-06-22 | 2000-06-22 | |
| US23831900P | 2000-10-05 | 2000-10-05 | |
| PCT/US2001/020153 WO2001098361A2 (en) | 2000-06-22 | 2001-06-22 | Agonist anti-trk-c monoclonal antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE446366T1 true ATE446366T1 (de) | 2009-11-15 |
Family
ID=26907807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01950429T ATE446366T1 (de) | 2000-06-22 | 2001-06-22 | Agonistische monoklonale antikörper gegen trkc |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US7384632B2 (de) |
| EP (1) | EP1292680B1 (de) |
| JP (1) | JP2004500873A (de) |
| KR (1) | KR100823764B1 (de) |
| CN (1) | CN100519749C (de) |
| AT (1) | ATE446366T1 (de) |
| AU (2) | AU7142201A (de) |
| BR (1) | BR0112272A (de) |
| CA (1) | CA2412494C (de) |
| DE (1) | DE60140252D1 (de) |
| DK (1) | DK1292680T3 (de) |
| HU (1) | HU228310B1 (de) |
| IL (2) | IL153375A0 (de) |
| MX (1) | MXPA02012602A (de) |
| NZ (1) | NZ523105A (de) |
| PL (1) | PL208113B1 (de) |
| WO (1) | WO2001098361A2 (de) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5877016A (en) * | 1994-03-18 | 1999-03-02 | Genentech, Inc. | Human trk receptors and neurotrophic factor inhibitors |
| DE60140868D1 (de) | 2000-06-05 | 2010-02-04 | Brigham & Womens Hospital | Für ein homologes des humanen, für mehrfachresistenz verantwortlichen, p-glykoproteins auf chromosom 7p15-21 kodierendes gen sowie verwendungen dafür |
| ATE446366T1 (de) * | 2000-06-22 | 2009-11-15 | Genentech Inc | Agonistische monoklonale antikörper gegen trkc |
| GB0210783D0 (en) * | 2002-05-10 | 2002-06-19 | Polonelli Luciano | Anti-microbial polypeptides |
| US20070122852A1 (en) * | 2002-11-13 | 2007-05-31 | Micromet Ag | Method for identifying antigen specific b cells |
| WO2004058190A2 (en) | 2002-12-23 | 2004-07-15 | Rinat Neuroscience Corp. | Methods for treating taxol-induced sensory neuropathy |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| EP1620127A4 (de) * | 2003-03-20 | 2007-04-04 | Rinat Neuroscience Corp | Verfahren zur behandlung von taxol-induzierten darmstörungen |
| KR20070001932A (ko) * | 2003-12-23 | 2007-01-04 | 리나트 뉴로사이언스 코퍼레이션 | 작용물질 항 티알케이씨 항체 및 그의 사용 방법 |
| AR054260A1 (es) * | 2005-04-26 | 2007-06-13 | Rinat Neuroscience Corp | Metodos de tratamiento de enfermedades de la neurona motora inferior y composiciones utilizadas en los mismos |
| JP2008545781A (ja) * | 2005-06-06 | 2008-12-18 | ワイス | 抗TrkBモノクローナル抗体およびその使用 |
| NZ596992A (en) * | 2005-06-30 | 2013-07-26 | Abbott Lab | Il-12/p40 binding proteins |
| EP2289909B1 (de) | 2005-11-30 | 2014-10-29 | AbbVie Inc. | Screeningsverfahren, Verfahren zur Reinigung von nicht-diffundierenden Beta-Oligomeren, selektive Antikörper gegen genannten nichtdiffundierende Beta-Oligomere und Verfahren zur Herstellung von genannten Antikörpern |
| KR101667623B1 (ko) | 2005-11-30 | 2016-10-19 | 애브비 인코포레이티드 | 아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의 용도 |
| US20070248611A1 (en) | 2006-02-02 | 2007-10-25 | Pfizer Inc | Methods wanted for treating unwanted weight loss or eating disorders by administering a trkb agonist |
| ES2918323T3 (es) | 2006-05-31 | 2022-07-15 | Childrens Medical Center | Células madre mesenquimatosas ABC5 positivas como inmunomoduladores |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| EP2099468B1 (de) * | 2006-12-05 | 2018-07-11 | The Royal Institution for the Advancement of Learning/McGill University | Verfahren zur verwendung von trk-rezeptormodulatoren |
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| EP2486928A1 (de) | 2007-02-27 | 2012-08-15 | Abbott GmbH & Co. KG | Verfahren zur Behandlung von Amyloidosen |
| SI2155248T1 (sl) | 2007-04-12 | 2015-12-31 | The Brigham And Women's Hospital, Inc. | Ciljanje ABCB5 za zdravljenje raka |
| US8168757B2 (en) * | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
| CA2724830A1 (en) * | 2008-05-21 | 2009-11-26 | Centre Leon Berard | Inhibition of the nt-3:trkc bound and its application to the treatment of cancer such as neuroblastoma |
| CA2952692C (en) | 2008-09-22 | 2020-04-28 | Array Biopharma Inc. | Substituted imidazo[1,2b]pyridazine compounds |
| SG10201900514RA (en) | 2008-10-22 | 2019-02-27 | Array Biopharma Inc | Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors |
| US20110287034A1 (en) | 2008-11-14 | 2011-11-24 | The Brigham And Womens Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
| US11542328B2 (en) | 2008-11-14 | 2023-01-03 | The Brigham And Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
| KR101781228B1 (ko) | 2008-12-19 | 2017-09-22 | 바이오겐 인터내셔널 뉴로사이언스 게엠베하 | 인간 항-알파-시누클레인 자가항체 |
| EP2421900A1 (de) | 2009-04-24 | 2012-02-29 | Alper Biotech, Llc | Monoklonale antikörper gegen pcbp-1-antigene, und anwendungen davon |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| US8709424B2 (en) * | 2009-09-03 | 2014-04-29 | Merck Sharp & Dohme Corp. | Anti-GITR antibodies |
| EP2558494B1 (de) | 2010-04-15 | 2018-05-23 | AbbVie Inc. | Amyloid-beta-bindende proteine |
| BR112012029405B1 (pt) | 2010-05-20 | 2021-01-05 | Array Biopharma Inc. | compostos macrocíclicos como inibidores de trk quinase, composição farmacêutica, uso de um composto de fórmula i ou um sal farmaceuticamente aceitável do mesmo, processo para a preparação de um composto |
| WO2012009577A2 (en) * | 2010-07-14 | 2012-01-19 | Alper Biotech, Llc | Monoclonal antibodies against pcbp-1 antigens, and uses therefor |
| MX358739B (es) | 2010-08-14 | 2018-09-03 | Abbvie Inc Star | Proteinas de union a amiloide beta. |
| WO2012027821A1 (en) * | 2010-09-03 | 2012-03-08 | The Royal Institution For The Advancement Of Learning / Mcgill University | A trkc receptor agonist antibody to treat neurodegenerative and motor neuron diseases |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9783601B2 (en) | 2010-12-01 | 2017-10-10 | Alderbio Holdings Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| EP4086338A1 (de) | 2011-03-17 | 2022-11-09 | Minerva Biotechnologies Corporation | Verfahren zur herstellung pluripotenter stammzellen |
| MX357193B (es) | 2011-06-23 | 2018-06-29 | Univ Zuerich | Moleculas de union anti-alfa sinucleina. |
| EP2726103B1 (de) * | 2011-07-01 | 2018-09-05 | The Trustees Of The University Of Pennsylvania | Antikörper gegen properdin und verwendungen davon |
| RU2635289C2 (ru) * | 2012-05-09 | 2017-11-09 | Конинклейке Филипс Н.В. | Медицинский интерфейс слежения, обеспечивающий интервенционную информацию |
| CN104870474B (zh) | 2012-10-04 | 2019-03-12 | 诺沃姆德治疗公司 | 用于治疗溶血性疾病的旁路途径特异性抗体 |
| IL290905B2 (en) | 2014-11-16 | 2023-09-01 | Array Biopharma Inc | Crystal form of (s)–n-(5–)–2–(r))5,2-difluorophenyl)-pyrrolidine-1-yl)-pyrazolo[5,1-a]pyrimidine-3-yl)-3 -Hydroxypyrrolidine-1-carboxamide hydrogen sulfate |
| MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| HK1253093A1 (zh) | 2015-06-01 | 2019-06-06 | Loxo Oncology Inc. | 诊断和治疗癌症的方法 |
| BR112017021484A2 (pt) | 2015-06-05 | 2018-07-03 | Novartis Ag | anticorpos de direcionamento à proteína morfogenética óssea 9 (bmp9) e métodos para os mesmos |
| EP3322706B1 (de) | 2015-07-16 | 2020-11-11 | Array Biopharma, Inc. | Substituierte pyrazol[1,5-a]pyridin-verbindungen als ret-kinasehemmer |
| CA2993645A1 (en) | 2015-07-28 | 2017-02-02 | Otonomy, Inc. | Trkb or trkc agonist compositions and methods for the treatment of otic conditions |
| WO2017075107A1 (en) | 2015-10-26 | 2017-05-04 | Nanda Nisha | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| HUE057837T2 (hu) * | 2015-11-03 | 2022-06-28 | Janssen Biotech Inc | PD-1-et specifikusan kötõ ellenanyagok és alkalmazásaik |
| TW201736399A (zh) | 2015-12-31 | 2017-10-16 | 財團法人生物技術開發中心 | 抗vegfr抗體及其應用 |
| TN2019000332A1 (en) | 2016-04-04 | 2021-05-07 | Loxo Oncology Inc | Methods of treating pediatric cancers |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| EP3439662B1 (de) | 2016-04-04 | 2024-07-24 | Loxo Oncology, Inc. | Flüssige formulierungen von (s)-n-(5-((r)-2-(2,5-difluorphenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidin-1-carboxamid |
| LT3800189T (lt) | 2016-05-18 | 2023-10-10 | Loxo Oncology, Inc. | (s)-n-(5-((r)-2-(2,5-difluorfenil)pirolidin-1-il)pirazolo[1,5-a]pirimidin-3- il)-3-hidroksipirolidin-1-karboksamido gavimas |
| CN109689027A (zh) | 2016-06-29 | 2019-04-26 | 奥德纳米有限公司 | 甘油三酯耳用制剂及其用途 |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| CN110337448B (zh) * | 2016-12-23 | 2023-08-08 | 瑞美德生物医药科技有限公司 | 使用与程序性死亡配体1(pd-l1)结合的抗体的免疫疗法 |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| CN110267960B (zh) | 2017-01-18 | 2022-04-26 | 阿雷生物药品公司 | 作为RET激酶抑制剂的取代的吡唑并[1,5-a]吡嗪化合物 |
| EP3596126A4 (de) * | 2017-03-15 | 2021-03-03 | Tsinghua University | Neuartige anti-trkb-antikörper |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| CN111108120A (zh) * | 2017-07-03 | 2020-05-05 | 财团法人生物技术开发中心 | 抗人类血管内皮生长因子受体的抗体及其应用 |
| CN118370815A (zh) | 2017-08-22 | 2024-07-23 | 渤健马萨诸塞州股份有限公司 | 含有抗β淀粉样蛋白抗体的药物组合物 |
| EP3687546A4 (de) | 2017-09-26 | 2022-01-26 | The Trustees Of The University Of Pennsylvania | Zusammensetzungen und verfahren zur behandlung von herzkrankheiten über neuausgerichtete t-zell-immuntherapien |
| TWI876442B (zh) | 2017-10-10 | 2025-03-11 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| AU2018346978B2 (en) * | 2017-10-13 | 2024-02-15 | Mapp Biopharmaceutical, Inc. | Anti-respiratory syncytial virus antibodies, methods of their generation and use |
| MA50456A (fr) | 2017-10-26 | 2020-09-02 | Array Biopharma Inc | Formulations d'un inhibiteur de kinase trk macrocyclique |
| CA3087578C (en) | 2018-01-18 | 2023-08-08 | Array Biopharma Inc. | Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors |
| CA3087354C (en) | 2018-01-18 | 2023-01-03 | Array Biopharma Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| CA3087972C (en) | 2018-01-18 | 2023-01-10 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| CA3095366A1 (en) | 2018-03-29 | 2019-10-03 | Loxo Oncology, Inc. | Treatment of trk-associated cancers |
| KR102653681B1 (ko) | 2018-07-31 | 2024-04-03 | 록쏘 온콜로지, 인코포레이티드 | (s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의분무-건조된 분산물 및 제제 |
| ES2922314T3 (es) | 2018-09-10 | 2022-09-13 | Array Biopharma Inc | Compuestos heterocíclicos condensados como inhibidores de cinasa RET |
| EP3898615A1 (de) | 2018-12-19 | 2021-10-27 | Array Biopharma, Inc. | 7-((3,5-dimethoxyphenyl)amino)chinoxalin-derivate als fgfr-inhibitoren zur behandlung von krebs |
| JP2022515198A (ja) | 2018-12-19 | 2022-02-17 | アレイ バイオファーマ インコーポレイテッド | FGFRチロシンキナーゼの阻害剤としての置換ピラゾロ[1,5-a]ピリジン化合物 |
| EP4034554A4 (de) * | 2019-09-23 | 2023-10-25 | The Trustees of the University of Pennsylvania | Zerstörung von tumorgewebe durch targeting von fibroblasten-aktivierungsprotein (fap) |
| EP4041290A4 (de) | 2019-09-23 | 2024-02-07 | The Trustees of the University of Pennsylvania | Monoklonaler antikörper gegen fibroblasten-aktivierungsprotein des hundes, das mit fibroblasten-aktivierungsprotein (fap) der maus und des menschen kreuzreagiert |
| CN117447602B (zh) * | 2023-12-22 | 2024-03-19 | 北京索莱宝科技有限公司 | 猪IgM的抗体及其应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| IL95511A (en) * | 1989-08-30 | 2000-10-31 | Max Planck Gesellschaft | Neurotrophin-3 a novel neurotrophic factor related to nerve growth and brain derived neurotrophic factor |
| CA2040099A1 (en) | 1990-05-01 | 1991-11-02 | Mariano Barbacid | Tyrosine kinase negative trkb |
| US5364769A (en) | 1990-09-25 | 1994-11-15 | Genentech, Inc. | Nucleic acid encoding neurotrophic factor four (NT-4), vectors, host cells and methods of production |
| US5348856A (en) | 1991-07-08 | 1994-09-20 | E. R. Squibb & Sons, Inc. | DNA encoding TRKC protein |
| ATE206056T1 (de) | 1992-06-08 | 2001-10-15 | Takeda Chemical Industries Ltd | Therapeutisches agens für neutropenie |
| US5855885A (en) * | 1993-01-22 | 1999-01-05 | Smith; Rodger | Isolation and production of catalytic antibodies using phage technology |
| US5659791A (en) * | 1993-04-26 | 1997-08-19 | Microsoft Corporation | Encapsulation of extracted portions of documents into objects |
| WO1995014930A1 (en) | 1993-11-23 | 1995-06-01 | Genentech, Inc. | Kinase receptor activation assay |
| CA2175893C (en) | 1993-11-23 | 2010-06-22 | Paul J. Godowski | Protein tyrosine kinases named rse |
| US5753225A (en) | 1993-12-03 | 1998-05-19 | The Regents Of The University Of California | Antibodies that mimic actions of neurotrophins |
| US5877016A (en) * | 1994-03-18 | 1999-03-02 | Genentech, Inc. | Human trk receptors and neurotrophic factor inhibitors |
| JPH07285912A (ja) * | 1994-04-19 | 1995-10-31 | Asahi Chem Ind Co Ltd | 新規化合物am5221 |
| WO1996036361A1 (en) * | 1995-05-18 | 1996-11-21 | The Regents Of The University Of Michigan | Dna binding antibodies |
| US6018032A (en) * | 1995-09-11 | 2000-01-25 | Kyowa Hakko Kogyo Co., Ltd. | Antibody against human interleukin-5-receptor α chain |
| GB9525180D0 (en) * | 1995-12-08 | 1996-02-07 | Univ Mcgill | Design of hormone-like antibodies with agonistic and antagonistic fuctions |
| EP0977860A1 (de) * | 1997-04-25 | 2000-02-09 | Genentech, Inc. | Ngf variante |
| EP1126869B1 (de) | 1998-10-28 | 2008-09-03 | Cornell Research Foundation, Inc. | Methoden zur regulierung der angiogenese und vaskuläre integrität mittels trk rezeptor liganden bdnf, nt-3 und nt-4 |
| US6656474B1 (en) * | 1999-01-15 | 2003-12-02 | Regeneron Pharmaceuticals, Inc. | Methods of using a neurotrophin and its analogues for the treatment of gastrointestinal hypomotility disorders |
| ATE446366T1 (de) * | 2000-06-22 | 2009-11-15 | Genentech Inc | Agonistische monoklonale antikörper gegen trkc |
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2001
- 2001-06-22 AT AT01950429T patent/ATE446366T1/de not_active IP Right Cessation
- 2001-06-22 BR BR0112272-0A patent/BR0112272A/pt not_active IP Right Cessation
- 2001-06-22 HU HU0300841A patent/HU228310B1/hu unknown
- 2001-06-22 NZ NZ523105A patent/NZ523105A/en not_active IP Right Cessation
- 2001-06-22 JP JP2002504316A patent/JP2004500873A/ja active Pending
- 2001-06-22 IL IL15337501A patent/IL153375A0/xx unknown
- 2001-06-22 EP EP01950429A patent/EP1292680B1/de not_active Expired - Lifetime
- 2001-06-22 DE DE60140252T patent/DE60140252D1/de not_active Expired - Lifetime
- 2001-06-22 WO PCT/US2001/020153 patent/WO2001098361A2/en not_active Ceased
- 2001-06-22 DK DK01950429.9T patent/DK1292680T3/da active
- 2001-06-22 CN CNB018144217A patent/CN100519749C/zh not_active Expired - Lifetime
- 2001-06-22 CA CA2412494A patent/CA2412494C/en not_active Expired - Lifetime
- 2001-06-22 AU AU7142201A patent/AU7142201A/xx active Pending
- 2001-06-22 MX MXPA02012602A patent/MXPA02012602A/es active IP Right Grant
- 2001-06-22 PL PL359926A patent/PL208113B1/pl unknown
- 2001-06-22 KR KR1020027017506A patent/KR100823764B1/ko not_active Expired - Lifetime
- 2001-06-22 AU AU2001271422A patent/AU2001271422B2/en not_active Ceased
- 2001-06-22 US US10/312,316 patent/US7384632B2/en not_active Expired - Lifetime
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2002
- 2002-12-11 IL IL153375A patent/IL153375A/en active IP Right Grant
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- 2006-10-16 US US11/581,865 patent/US7615383B2/en not_active Expired - Lifetime
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2009
- 2009-06-04 US US12/478,501 patent/US20100003261A1/en not_active Abandoned
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- 2011-08-05 US US13/198,979 patent/US20120045443A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PL208113B1 (pl) | 2011-03-31 |
| DK1292680T3 (da) | 2010-03-08 |
| PL359926A1 (en) | 2004-09-06 |
| US7384632B2 (en) | 2008-06-10 |
| US7615383B2 (en) | 2009-11-10 |
| HUP0300841A2 (hu) | 2004-06-28 |
| CA2412494A1 (en) | 2001-12-27 |
| IL153375A (en) | 2009-06-15 |
| EP1292680B1 (de) | 2009-10-21 |
| MXPA02012602A (es) | 2003-05-14 |
| CA2412494C (en) | 2012-10-23 |
| CN100519749C (zh) | 2009-07-29 |
| WO2001098361A9 (en) | 2003-03-06 |
| WO2001098361A3 (en) | 2002-05-02 |
| US20040137513A1 (en) | 2004-07-15 |
| US20070036794A1 (en) | 2007-02-15 |
| KR20030036240A (ko) | 2003-05-09 |
| EP1292680A2 (de) | 2003-03-19 |
| BR0112272A (pt) | 2003-05-06 |
| HU228310B1 (en) | 2013-03-28 |
| US20100003261A1 (en) | 2010-01-07 |
| AU2001271422B2 (en) | 2005-12-22 |
| HUP0300841A3 (en) | 2005-11-28 |
| DE60140252D1 (de) | 2009-12-03 |
| KR100823764B1 (ko) | 2008-04-21 |
| CN1447857A (zh) | 2003-10-08 |
| JP2004500873A (ja) | 2004-01-15 |
| WO2001098361A2 (en) | 2001-12-27 |
| IL153375A0 (en) | 2003-07-06 |
| NZ523105A (en) | 2004-07-30 |
| AU7142201A (en) | 2002-01-02 |
| US20120045443A1 (en) | 2012-02-23 |
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