DK129788A - Deutererede aromatiske aldehyder og derivater og salte deraf til avendelse som midler mod cancer - Google Patents

Deutererede aromatiske aldehyder og derivater og salte deraf til avendelse som midler mod cancer

Info

Publication number: DK129788A
Authority: DK; Denmark
Prior art keywords: derivatives; salts; aromatic aldehydes; against cancer; deuterated aromatic
Prior art date: 1987-03-11

Application number

DK129788A

Other languages

English (en)

Other versions

DK129788D0 (da

DK173244B1 (da

Inventor

Bernt Boerretzen

Rolf Olaf Larsen

John Michael Dornish

Reidar Oftebro

Erik Olai Pettersen

Original Assignee

Norsk Hydro As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-11

Filing date

1988-03-10

Publication date

1988-09-12

1988-03-10 Application filed by Norsk Hydro As filed Critical Norsk Hydro As

1988-03-10 Publication of DK129788D0 publication Critical patent/DK129788D0/da

1988-09-12 Publication of DK129788A publication Critical patent/DK129788A/da

2000-05-22 Application granted granted Critical

2000-05-22 Publication of DK173244B1 publication Critical patent/DK173244B1/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines Containing Plant Substances (AREA)

DK198801297A 1987-03-11 1988-03-10 Deutererede aromatiske aldehyder og derivater og salte deraf til anvendelse mod cancer samt fremgangsmåde til fremstilling DK173244B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8705780		1987-03-11
GB878705780A GB8705780D0 (en)	1987-03-11	1987-03-11	Anticancer compounds

Publications (3)

Publication Number	Publication Date
DK129788D0 DK129788D0 (da)	1988-03-10
DK129788A true DK129788A (da)	1988-09-12
DK173244B1 DK173244B1 (da)	2000-05-22

Family

ID=10613770

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198801297A DK173244B1 (da)	1987-03-11	1988-03-10	Deutererede aromatiske aldehyder og derivater og salte deraf til anvendelse mod cancer samt fremgangsmåde til fremstilling

Country Status (12)

Country	Link
US (1)	US4874780A (da)
EP (1)	EP0283139B1 (da)
JP (1)	JP2769492B2 (da)
AT (1)	ATE84515T1 (da)
AU (1)	AU612348B2 (da)
CA (1)	CA1327038C (da)
DE (1)	DE3877386T2 (da)
DK (1)	DK173244B1 (da)
ES (1)	ES2043807T3 (da)
GB (1)	GB8705780D0 (da)
HK (1)	HK68697A (da)
NO (1)	NO171631C (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5032610A (en) *	1988-11-21	1991-07-16	Norsk Hydro As	Activity against carcinoma and method for the treatment of carcinoma
GB9026080D0 (en) *	1990-11-30	1991-01-16	Norsk Hydro As	Pharmaceutical compositions
GB9026114D0 (en) *	1990-11-30	1991-01-16	Norsk Hydro As	New compounds
HU208084B (en) *	1991-10-31	1993-08-30	Hyd Kutato Fejlesztoe Kft	Process for producing compositions suitable for curing tumorous diseases
GB9201275D0 (en) *	1992-01-21	1992-03-11	Norsk Hydro As	New compounds
GB9201274D0 (en) *	1992-01-21	1992-03-11	Norsk Hydro As	New compounds
GB9400047D0 (en) *	1994-01-04	1994-03-02	Norsk Hydro As	Pharmaceutical compositions
US6334997B1 (en)	1994-03-25	2002-01-01	Isotechnika, Inc.	Method of using deuterated calcium channel blockers
CN1087725C (zh) *	1994-03-25	2002-07-17	同位素技术有限公司	用氘代方法增强药物效果
DE4417865A1 (de) *	1994-05-20	1995-11-23	Behringwerke Ag	Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie
DE4427690A1 (de) *	1994-08-04	1996-02-08	Bogdahn Ulrich Prof	Deuterium enthaltende pharmazeutische Zusammensetzung als Zytostatikum oder Tumor-Therapeutikum
NO309305B1 (no) *	1999-02-19	2001-01-15	Norsk Hydro As	Anvendelse av benzaldehydderivater ved fremstilling av farmasöytiske preparater for forebygging og/eller behandling av kreft, samt visse nye benzaldehydderivater
US9713330B1 (en)	2013-03-15	2017-07-25	Deuteria Agrochemicals, Llc	Deuterium-enriched aldehydes
AU2014233179B2 (en) *	2013-03-15	2018-04-26	Deuteria Agrochemicals, Llc	Deuterium-enriched aldehydes
MX2018001507A (es)	2015-08-03	2018-09-18	Enb Therapeutics Llc	Composiciones y metodos para tratar cánceres asociados con la activacion del etbr.
CN111886010A (zh)	2018-01-12	2020-11-03	Enb治疗公司	用于治疗与etbr激活相关的癌症的氘化化合物、组合物和方法
CN108383697B (zh) *	2018-02-12	2021-11-19	中山大学	一种以卤甲基化合物为原料制备氘代醛的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS52108027A (en) *	1976-03-09	1977-09-10	Rikagaku Kenkyusho	Anticarcinogen
GB1582666A (en) *	1976-08-24	1981-01-14	Rikagaku Kenkyusho	Treatment of malignant conditions with mandelic acid or derivatives thereof
US4146651A (en) *	1977-05-20	1979-03-27	Canada Packers Limited	Acetals and ketals of ascorbic acid and anti-nitrosamine compositions and methods using same
US4297289A (en) *	1980-07-17	1981-10-27	Wisconsin Alumni Research Foundation	Vitamin D compounds isotopically substituted at carbon 6 and process for their preparation
US4423236A (en) *	1980-08-14	1983-12-27	National Foundation For Cancer Research, Inc.	5,6,-0-Isoalkylidene ascorbic acid derivatives
JPS60139619A (ja) *	1983-12-27	1985-07-24	Mutsuyuki Kochi	Ｏ−ベンジリデン−アスコルビン酸又はその塩よりなる抗腫瘍剤

1987
- 1987-03-11 US US07/024,783 patent/US4874780A/en not_active Expired - Lifetime
- 1987-03-11 GB GB878705780A patent/GB8705780D0/en active Pending
1988
- 1988-02-19 AT AT88301440T patent/ATE84515T1/de not_active IP Right Cessation
- 1988-02-19 DE DE8888301440T patent/DE3877386T2/de not_active Expired - Fee Related
- 1988-02-19 ES ES88301440T patent/ES2043807T3/es not_active Expired - Lifetime
- 1988-02-19 EP EP88301440A patent/EP0283139B1/en not_active Expired - Lifetime
- 1988-02-26 AU AU12331/88A patent/AU612348B2/en not_active Ceased
- 1988-03-04 NO NO880964A patent/NO171631C/no not_active IP Right Cessation
- 1988-03-10 CA CA000561032A patent/CA1327038C/en not_active Expired - Fee Related
- 1988-03-10 DK DK198801297A patent/DK173244B1/da not_active IP Right Cessation
- 1988-03-11 JP JP63056496A patent/JP2769492B2/ja not_active Expired - Lifetime
1997
- 1997-05-22 HK HK68697A patent/HK68697A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0283139B1 (en)	1993-01-13
ATE84515T1 (de)	1993-01-15
NO171631C (no)	1993-04-14
JP2769492B2 (ja)	1998-06-25
DE3877386D1 (de)	1993-02-25
AU612348B2 (en)	1991-07-11
DK129788D0 (da)	1988-03-10
EP0283139A3 (en)	1989-01-18
NO880964L (no)	1988-09-12
NO880964D0 (no)	1988-03-04
AU1233188A (en)	1988-09-15
US4874780A (en)	1989-10-17
DE3877386T2 (de)	1993-08-12
JPS63250341A (ja)	1988-10-18
DK173244B1 (da)	2000-05-22
HK68697A (en)	1997-05-30
NO171631B (no)	1993-01-04
GB8705780D0 (en)	1987-04-15
CA1327038C (en)	1994-02-15
ES2043807T3 (es)	1994-01-01
EP0283139A2 (en)	1988-09-21

Legal Events

Date	Code	Title	Description
1991-03-18	PUP	Patent expired
2000-05-22	B1	Patent granted (law 1993)
2003-10-27	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
DK129788D0 (da)	1988-03-10	Deutererede aromatiske aldehyder og derivater og salte deraf til avendelse som midler mod cancer
LU91210I2 (fr)	2006-11-06	Emodepside & Praziquantel ainsi que leurs dérivés pharmaceutiqement acceptables (PROFENDER)
SE8200815L (sv)	1982-02-23	Kemisk forening till anvendning som mellanprodukt vid framstellning av vissa triazolforeningar
DK0398692T3 (da)	1996-09-16	Alkoxyiminoacetamidderivater og anvendelsen deraf som fungicider
ES410732A1 (es)	1976-04-01	Procedimiento para la preparacion de derivados olefinicos de piperidino-4-sustituidos.
ATE103592T1 (de)	1994-04-15	Carbamoylpyrrolidonderivate, ihre verwendung und herstellung.
ATE271045T1 (de)	2004-07-15	Sauerstoffhaltige heterocyclische verbindungen
IL93443A0 (en)	1990-11-29	Trifluoromethylphenylazolyl-methyloxirane derivatives and fungicides containing these compounds
ATE74608T1 (de)	1992-04-15	Chinolincarbonsaeure-derivate.
FI923033A0 (fi)	1992-06-30	N-fenyltioureaderivat och farmaceutisk anvaendning av dem.
ES411341A1 (es)	1976-03-16	Procedimiento para la preparacion de compuestos heteroci- clicos sustituidos por un radical guanidinilideno.
ATE69605T1 (de)	1991-12-15	Azolylpropenyl- und azolylmethyloxiran-derivate und diese enthaltende fungizide.
ES414343A1 (es)	1976-06-16	Procedimiento para la obtencion de derivados del acido prostanoico.
ATE28639T1 (de)	1987-08-15	Derivate von 4-(3-alkynyloxy-2-hydroxy-propyl)piperazin-1-yl-n-phenylacetamid, ihre herstellung und ihre therapeutische verwendung.
DK0478173T3 (da)	1995-06-12	4,5-polymethylen-4-isothiazolin-3-onderivater og anvendelse heraf som biocider
ES418811A1 (es)	1976-03-16	Procedimiento para la preparacion de compuestos tricicli- cos.
ATE83233T1 (de)	1992-12-15	Ethanon-oxime.
FR2694557B1 (fr)	1994-09-23	Dérivés de tétrahydronaphtalène, leur préparation, et leur application en thérapeutique.
ATE98639T1 (de)	1994-01-15	1-halogenvinyl-azole und diese enthaltende fungizide und wachstumsregulatoren.
DK1097145T3 (da)	2003-09-15	Polyhydroxyalkylpyrazinderivater, deres fremstilling og lægemidler indeholdende disse derivater
ES445339A1 (es)	1977-06-01	Un procedimiento para la preparacion de derivados pirrolidi-nicos.
ES437424A1 (es)	1977-05-01	Procedimiento para la preparacion de nuevos derivados de bi-fenililo.
GB1546702A (en)	1979-05-31	Benzofuranone derivative
ES402749A1 (es)	1976-01-01	Un procedimiento para la preparacion de derivados de tieno-diacepina.