ATE84515T1 - Antikrebsverbindungen. - Google Patents

Antikrebsverbindungen.

Info

Publication number: ATE84515T1
Authority: AT; Austria
Prior art keywords: substituted; chem; formula; cancer; links
Prior art date: 1987-03-11

Application number

AT88301440T

Other languages

English (en)

Inventor

Bernt Borretzen

Rolf Olaf Larsen

John Michael Dornish

Reidar Oftebro

Erik Olai Pettersen

Original Assignee

Norsk Hydro As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-11

Filing date

1988-02-19

Publication date

1993-01-15

1988-02-19 Application filed by Norsk Hydro As filed Critical Norsk Hydro As

1993-01-15 Application granted granted Critical

1993-01-15 Publication of ATE84515T1 publication Critical patent/ATE84515T1/de

Links

230000001093 anti-cancer Effects 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
150000003934 aromatic aldehydes Chemical class 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)

AT88301440T 1987-03-11 1988-02-19 Antikrebsverbindungen. ATE84515T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB878705780A GB8705780D0 (en)	1987-03-11	1987-03-11	Anticancer compounds
EP88301440A EP0283139B1 (de)	1987-03-11	1988-02-19	Antikrebsverbindungen

Publications (1)

Publication Number	Publication Date
ATE84515T1 true ATE84515T1 (de)	1993-01-15

Family

ID=10613770

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88301440T ATE84515T1 (de)	1987-03-11	1988-02-19	Antikrebsverbindungen.

Country Status (12)

Country	Link
US (1)	US4874780A (de)
EP (1)	EP0283139B1 (de)
JP (1)	JP2769492B2 (de)
AT (1)	ATE84515T1 (de)
AU (1)	AU612348B2 (de)
CA (1)	CA1327038C (de)
DE (1)	DE3877386T2 (de)
DK (1)	DK173244B1 (de)
ES (1)	ES2043807T3 (de)
GB (1)	GB8705780D0 (de)
HK (1)	HK68697A (de)
NO (1)	NO171631C (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5032610A (en) *	1988-11-21	1991-07-16	Norsk Hydro As	Activity against carcinoma and method for the treatment of carcinoma
GB9026080D0 (en) *	1990-11-30	1991-01-16	Norsk Hydro As	Pharmaceutical compositions
GB9026114D0 (en) *	1990-11-30	1991-01-16	Norsk Hydro As	New compounds
HU208084B (en) *	1991-10-31	1993-08-30	Hyd Kutato Fejlesztoe Kft	Process for producing compositions suitable for curing tumorous diseases
GB9201275D0 (en) *	1992-01-21	1992-03-11	Norsk Hydro As	New compounds
GB9201274D0 (en) *	1992-01-21	1992-03-11	Norsk Hydro As	New compounds
GB9400047D0 (en) *	1994-01-04	1994-03-02	Norsk Hydro As	Pharmaceutical compositions
US6334997B1 (en) *	1994-03-25	2002-01-01	Isotechnika, Inc.	Method of using deuterated calcium channel blockers
KR100477070B1 (ko) *	1994-03-25	2006-04-21	이소테크니카 인코포레이티드	중수소화작용에의한의약품의효능강화법
DE4417865A1 (de) *	1994-05-20	1995-11-23	Behringwerke Ag	Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie
DE4427690A1 (de) *	1994-08-04	1996-02-08	Bogdahn Ulrich Prof	Deuterium enthaltende pharmazeutische Zusammensetzung als Zytostatikum oder Tumor-Therapeutikum
NO309305B1 (no) *	1999-02-19	2001-01-15	Norsk Hydro As	Anvendelse av benzaldehydderivater ved fremstilling av farmasöytiske preparater for forebygging og/eller behandling av kreft, samt visse nye benzaldehydderivater
US9023336B2 (en) *	2013-03-15	2015-05-05	Deuterra Agrochemicals, LLC	Deuterium-enriched aldehydes
US9713330B1 (en)	2013-03-15	2017-07-25	Deuteria Agrochemicals, Llc	Deuterium-enriched aldehydes
CN116726183A (zh)	2015-08-03	2023-09-12	Enb治疗公司	用于治疗与etbr激活相关的癌症的组合物和方法
WO2019140324A1 (en)	2018-01-12	2019-07-18	Enb Therapeutics, Inc.	Deuterated compounds, compositions, and methods for treating cancers associated with etbr activation
CN108383697B (zh) *	2018-02-12	2021-11-19	中山大学	一种以卤甲基化合物为原料制备氘代醛的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS52108027A (en) *	1976-03-09	1977-09-10	Rikagaku Kenkyusho	Anticarcinogen
GB1582666A (en) *	1976-08-24	1981-01-14	Rikagaku Kenkyusho	Treatment of malignant conditions with mandelic acid or derivatives thereof
US4146651A (en) *	1977-05-20	1979-03-27	Canada Packers Limited	Acetals and ketals of ascorbic acid and anti-nitrosamine compositions and methods using same
US4297289A (en) *	1980-07-17	1981-10-27	Wisconsin Alumni Research Foundation	Vitamin D compounds isotopically substituted at carbon 6 and process for their preparation
US4423236A (en) *	1980-08-14	1983-12-27	National Foundation For Cancer Research, Inc.	5,6,-0-Isoalkylidene ascorbic acid derivatives
JPS60139619A (ja) *	1983-12-27	1985-07-24	Mutsuyuki Kochi	Ｏ−ベンジリデン−アスコルビン酸又はその塩よりなる抗腫瘍剤

1987
- 1987-03-11 GB GB878705780A patent/GB8705780D0/en active Pending
- 1987-03-11 US US07/024,783 patent/US4874780A/en not_active Expired - Lifetime
1988
- 1988-02-19 AT AT88301440T patent/ATE84515T1/de not_active IP Right Cessation
- 1988-02-19 ES ES88301440T patent/ES2043807T3/es not_active Expired - Lifetime
- 1988-02-19 DE DE8888301440T patent/DE3877386T2/de not_active Expired - Fee Related
- 1988-02-19 EP EP88301440A patent/EP0283139B1/de not_active Expired - Lifetime
- 1988-02-26 AU AU12331/88A patent/AU612348B2/en not_active Ceased
- 1988-03-04 NO NO880964A patent/NO171631C/no not_active IP Right Cessation
- 1988-03-10 CA CA000561032A patent/CA1327038C/en not_active Expired - Fee Related
- 1988-03-10 DK DK198801297A patent/DK173244B1/da not_active IP Right Cessation
- 1988-03-11 JP JP63056496A patent/JP2769492B2/ja not_active Expired - Lifetime
1997
- 1997-05-22 HK HK68697A patent/HK68697A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO880964D0 (no)	1988-03-04
EP0283139B1 (de)	1993-01-13
DK129788D0 (da)	1988-03-10
DE3877386D1 (de)	1993-02-25
EP0283139A2 (de)	1988-09-21
AU612348B2 (en)	1991-07-11
US4874780A (en)	1989-10-17
DK129788A (da)	1988-09-12
ES2043807T3 (es)	1994-01-01
DE3877386T2 (de)	1993-08-12
CA1327038C (en)	1994-02-15
JPS63250341A (ja)	1988-10-18
GB8705780D0 (en)	1987-04-15
JP2769492B2 (ja)	1998-06-25
NO880964L (no)	1988-09-12
AU1233188A (en)	1988-09-15
HK68697A (en)	1997-05-30
NO171631C (no)	1993-04-14
DK173244B1 (da)	2000-05-22
EP0283139A3 (en)	1989-01-18
NO171631B (no)	1993-01-04

Legal Events

Date	Code	Title	Description
1993-09-15	UEP	Publication of translation of european patent specification
2003-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE3877386D1 (de)	1993-02-25	Antikrebsverbindungen.
FI905215A0 (fi)	1990-10-23	Bensimidazolderivat, deras framstaellning och anvaendning.
LU91210I2 (fr)	2006-11-06	Emodepside & Praziquantel ainsi que leurs dérivés pharmaceutiqement acceptables (PROFENDER)
ATE145400T1 (de)	1996-12-15	Naphthalin-derivate
ATE117681T1 (de)	1995-02-15	Chinolinderivate, ihre herstellung und verwendung.
ATE103592T1 (de)	1994-04-15	Carbamoylpyrrolidonderivate, ihre verwendung und herstellung.
IL92992A0 (en)	1990-09-17	Acrylic acid derivatives and their use as fungicides
SE8802402D0 (sv)	1988-06-28	Novel esters
ES2065994T3 (es)	1995-03-01	Beta-dicetonas substituidas.
NO941832D0 (no)	1994-05-16	Benzopyranderivater og deres anvendelse
ATE140001T1 (de)	1996-07-15	Isochromanderivate
DK0478194T3 (da)	1995-08-28	Bis-(2-aminocarbonylcykloalk-1-enyl)-disulfider, fremstilling og anvendelse heraf
ATE69605T1 (de)	1991-12-15	Azolylpropenyl- und azolylmethyloxiran-derivate und diese enthaltende fungizide.
DE69106298D1 (de)	1995-02-09	4,5-Polymethylen-4-isothiazolin-3-on-Derivate mit biocider Wirkung.
ATE105565T1 (de)	1994-05-15	Pradimicinderivate.
DK0481742T3 (da)	1997-12-29	Piperazinderivater
IT1180645B (it)	1987-09-23	Intermedi per la sintesi di acidi carbossilici
ES2070873T3 (es)	1995-06-16	Carbinoloimidazoles antiinflamatorios.