DK1299103T3 - 4,5-dihydro-thiazol-2-ylamin og deres anvendelse som inhibitorer for NO-synthase - Google Patents

4,5-dihydro-thiazol-2-ylamin og deres anvendelse som inhibitorer for NO-synthase

Info

Publication number: DK1299103T3
Authority: DK; Denmark
Prior art keywords: ylamine; thiazol; dihydro; synthase inhibitors; synthase
Prior art date: 2000-06-09

Application number

DK01943579T

Other languages

English (en)

Inventor

Eric Bacque

Serge Mignani

Antony Bigot

Jean-Christophe Carry

Dominique Damour

Claude Guyon

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-09

Filing date

2001-06-07

Publication date

2006-01-23

2001-06-07 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2006-01-23 Application granted granted Critical

2006-01-23 Publication of DK1299103T3 publication Critical patent/DK1299103T3/da

Links

REGFWZVTTFGQOJ-UHFFFAOYSA-N 4,5-dihydro-1,3-thiazol-2-amine Chemical compound NC1=NCCS1 REGFWZVTTFGQOJ-UHFFFAOYSA-N 0.000 title 1
102000008299 Nitric Oxide Synthase Human genes 0.000 title 1
108010021487 Nitric Oxide Synthase Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/18—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Hematology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Toxicology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)

DK01943579T 2000-06-09 2001-06-07 4,5-dihydro-thiazol-2-ylamin og deres anvendelse som inhibitorer for NO-synthase DK1299103T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0007396A FR2810036B1 (fr)	2000-06-09	2000-06-09	Derives de 4,5-dihydro-1,3-thiazol-2-ylamine, leur preparation et les compositions phamarceutiques les contenant

Publications (1)

Publication Number	Publication Date
DK1299103T3 true DK1299103T3 (da)	2006-01-23

Family

ID=8851133

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01943579T DK1299103T3 (da)	2000-06-09	2001-06-07	4,5-dihydro-thiazol-2-ylamin og deres anvendelse som inhibitorer for NO-synthase

Country Status (27)

Country	Link
EP (1)	EP1299103B1 (da)
JP (1)	JP4171297B2 (da)
KR (1)	KR20030017990A (da)
CN (1)	CN1441673A (da)
AP (1)	AP2002002707A0 (da)
AT (1)	ATE305298T1 (da)
AU (2)	AU6612301A (da)
BR (1)	BR0111543A (da)
CA (1)	CA2411572C (da)
DE (1)	DE60113686T2 (da)
DK (1)	DK1299103T3 (da)
DZ (1)	DZ3366A1 (da)
EA (1)	EA200300009A1 (da)
EC (1)	ECSP024374A (da)
ES (1)	ES2246327T3 (da)
FR (1)	FR2810036B1 (da)
HR (1)	HRP20020971A2 (da)
HU (1)	HUP0300996A3 (da)
IL (1)	IL153327A0 (da)
MA (1)	MA25815A1 (da)
MX (1)	MXPA02012072A (da)
NO (1)	NO20025885L (da)
NZ (1)	NZ522967A (da)
OA (1)	OA12285A (da)
PL (1)	PL360282A1 (da)
WO (1)	WO2001093867A1 (da)
ZA (1)	ZA200209770B (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005063732A1 (en) *	2003-12-23	2005-07-14	Microbia, Inc.	Compounds and methods for the treatment of asthma

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL107771A0 (en) *	1992-11-27	1994-02-27	Wellcome Found	Pharmaceutical compositions containing isothiourea derivatives certain such novel compounds and their preparation
AU688811B2 (en) *	1993-10-21	1998-03-19	G.D. Searle & Co.	Amidino derivatives useful as nitric oxide synthase inhibitors
WO1996014842A1 (en) *	1994-11-15	1996-05-23	Merck & Co., Inc.	Substituted heterocycles as inhibitors of nitric oxide synthase

2000
- 2000-06-09 FR FR0007396A patent/FR2810036B1/fr not_active Expired - Fee Related
2001
- 2001-06-07 KR KR1020027016786A patent/KR20030017990A/ko not_active Withdrawn
- 2001-06-07 HR HR20020971A patent/HRP20020971A2/xx not_active Application Discontinuation
- 2001-06-07 DZ DZ013366A patent/DZ3366A1/xx active
- 2001-06-07 JP JP2002501440A patent/JP4171297B2/ja not_active Expired - Fee Related
- 2001-06-07 CA CA002411572A patent/CA2411572C/fr not_active Expired - Fee Related
- 2001-06-07 EP EP01943579A patent/EP1299103B1/fr not_active Expired - Lifetime
- 2001-06-07 ES ES01943579T patent/ES2246327T3/es not_active Expired - Lifetime
- 2001-06-07 AU AU6612301A patent/AU6612301A/xx active Pending
- 2001-06-07 IL IL15332701A patent/IL153327A0/xx unknown
- 2001-06-07 HU HU0300996A patent/HUP0300996A3/hu unknown
- 2001-06-07 MX MXPA02012072A patent/MXPA02012072A/es active IP Right Grant
- 2001-06-07 AU AU2001266123A patent/AU2001266123B2/en not_active Ceased
- 2001-06-07 AP APAP/P/2002/002707A patent/AP2002002707A0/en unknown
- 2001-06-07 PL PL36028201A patent/PL360282A1/xx unknown
- 2001-06-07 OA OA1200200371A patent/OA12285A/fr unknown
- 2001-06-07 DK DK01943579T patent/DK1299103T3/da active
- 2001-06-07 AT AT01943579T patent/ATE305298T1/de not_active IP Right Cessation
- 2001-06-07 DE DE60113686T patent/DE60113686T2/de not_active Expired - Lifetime
- 2001-06-07 WO PCT/FR2001/001759 patent/WO2001093867A1/fr not_active Ceased
- 2001-06-07 NZ NZ522967A patent/NZ522967A/en unknown
- 2001-06-07 EA EA200300009A patent/EA200300009A1/ru unknown
- 2001-06-07 BR BR0111543-0A patent/BR0111543A/pt not_active Application Discontinuation
- 2001-06-07 CN CN01812587A patent/CN1441673A/zh active Pending
2002
- 2002-12-02 ZA ZA200209770A patent/ZA200209770B/en unknown
- 2002-12-06 NO NO20025885A patent/NO20025885L/no not_active Application Discontinuation
- 2002-12-09 EC EC2002004374A patent/ECSP024374A/es unknown
- 2002-12-09 MA MA26940A patent/MA25815A1/fr unknown

Also Published As

Publication number	Publication date
NO20025885L (no)	2003-01-29
KR20030017990A (ko)	2003-03-04
HUP0300996A3 (en)	2006-02-28
FR2810036A1 (fr)	2001-12-14
ATE305298T1 (de)	2005-10-15
MA25815A1 (fr)	2003-07-01
AU6612301A (en)	2001-12-17
HUP0300996A2 (hu)	2003-08-28
OA12285A (en)	2006-05-12
CN1441673A (zh)	2003-09-10
NZ522967A (en)	2005-07-29
ECSP024374A (es)	2003-02-06
IL153327A0 (en)	2003-07-06
EA200300009A1 (ru)	2003-04-24
AU2001266123B2 (en)	2007-01-25
EP1299103A1 (fr)	2003-04-09
AP2002002707A0 (en)	2002-12-31
NO20025885D0 (no)	2002-12-06
ES2246327T3 (es)	2006-02-16
DE60113686T2 (de)	2006-07-13
HRP20020971A2 (en)	2005-02-28
DZ3366A1 (fr)	2001-12-13
PL360282A1 (en)	2004-09-06
BR0111543A (pt)	2003-07-01
FR2810036B1 (fr)	2004-04-23
ZA200209770B (en)	2004-03-02
CA2411572A1 (fr)	2001-12-13
WO2001093867A1 (fr)	2001-12-13
JP4171297B2 (ja)	2008-10-22
DE60113686D1 (de)	2006-02-09
JP2003535135A (ja)	2003-11-25
CA2411572C (fr)	2009-11-10
EP1299103B1 (fr)	2005-09-28
MXPA02012072A (es)	2004-08-19

Publication	Publication Date	Title
NO20026010D0 (no)	2002-12-13	Substituerte quinazolinderivater og deres anvendelse som inhibitorer
DK1268431T3 (da)	2007-12-10	3-Cyanoquinoliner, 3-cyano-1,6-naphthyridiner og 3-cyano-1,7-naphthyridiner som proteinkinaseinhibitorer
NO20021239L (no)	2002-03-13	Pteridinoner som kinase-inhibitorer
DK1140840T3 (da)	2006-07-31	omega-carboxyaryl-substituerede diphenylurinstoffer som raf-kinase-inhibitorer
DK1498413T3 (da)	2011-12-05	4-aminopicolinater og deres anvendelse som herbicider
DK1220831T3 (da)	2005-08-29	Biaryletherderivater, der er nyttige som monoamingenoptagelsesinhibitorer
DK1373224T3 (da)	2007-10-15	Nye spirotricykliske derivater og deres anvendelse som phosphodiesterase 7 inhibitorer
DK1480962T3 (da)	2011-12-05	5-Phenylthiazol-derivater og deres anvendelse som P1-3-kinaseinhibitorer
ATE524441T1 (de)	2011-09-15	Vla-4-inhibitoren
DK1347955T3 (da)	2010-06-07	Nye mandelsyrederivater og deres anvendelse som throbin-hæmmere
NO20015065D0 (no)	2001-10-18	Pyrazolobenzodiazepiner som CDK2-inhibitorer
NO20053356D0 (no)	2005-07-11	Aminindazolderivater og anvendelse derav som kinaseinhibitorer.
NO20024997D0 (no)	2002-10-17	2-guanidino-4-arylkinazoliner som NHE-3-inhibitorer
DK1330455T3 (da)	2005-12-05	Hidtil ukendte 7-azaindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling
EP1328647A4 (en)	2006-03-22	ISOMALTULOSE SYNTHASE
NO20026164L (no)	2002-12-20	Benzoksazepinoner og deres anvendelse som squalen syntase inhibitorer
NO20030813D0 (no)	2003-02-21	Bifenylderivater og deres anvendelse som integrininhibitorer
DK1214302T3 (da)	2004-02-16	Substituerede 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-oner og deres anvendelse som lipasehæmmere
NO20030243D0 (no)	2003-01-17	Nye forbindelser og deres anvendelse som glysintransportinhibitorer
NO20023893D0 (no)	2002-08-16	Aminosyreforbindelser og deres anvendelse som NEP-, ACE- og ECE-inhibitorer
NO20025884D0 (no)	2002-12-06	2-aminotiazolinderivater og deres anvendelse som NO- syntaseinhibitorer
DK1487802T3 (da)	2011-04-04	2,3-diaryl-pyrazolidin-derivater som neurotensin-nedbrydende enzyminhibitorer
NO20025885D0 (no)	2002-12-06	4,5-dihydro-tiazol-2-ylaminderivater og deres anvendelse som NO-syntaseinhibitorer
DK1115708T3 (da)	2004-08-02	Aminoalkyl-3,4-dihydriquinolinderivater som NO-synthaseinhibitorer
DK1324980T3 (da)	2008-05-13	Citrullimyciner, og fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler