DK1323729T3 - Fremgangsmåde til syntese af (2S, 3aS, 7aS)-perhydroindol-2-carboxylsyre og estere heraf, samt anvendelse heraf ved syntese af perindopril - Google Patents

Fremgangsmåde til syntese af (2S, 3aS, 7aS)-perhydroindol-2-carboxylsyre og estere heraf, samt anvendelse heraf ved syntese af perindopril

Info

Publication number: DK1323729T3
Authority: DK; Denmark
Prior art keywords: synthesis; perhydroindole; perindopril; esters; carboxylic acid
Prior art date: 2003-03-12

Application number

DK03290607T

Other languages

English (en)

Inventor

Thierry Dubuffet

Jean-Pierre Lecouve

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-12

Filing date

2003-03-12

Publication date

2005-02-14

2003-03-12 Application filed by Servier Lab filed Critical Servier Lab

2005-02-14 Application granted granted Critical

2005-02-14 Publication of DK1323729T3 publication Critical patent/DK1323729T3/da

Links

230000015572 biosynthetic process Effects 0.000 title 2
238000003786 synthesis reaction Methods 0.000 title 2
CQYBNXGHMBNGCG-FXQIFTODSA-N (2s,3as,7as)-2,3,3a,4,5,6,7,7a-octahydro-1h-indol-1-ium-2-carboxylate Chemical compound C1CCC[C@@H]2[NH2+][C@H](C(=O)[O-])C[C@@H]21 CQYBNXGHMBNGCG-FXQIFTODSA-N 0.000 title 1
150000002148 esters Chemical class 0.000 title 1
238000000034 method Methods 0.000 title 1
IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title 1
229960002582 perindopril Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Indole Compounds (AREA)
Peptides Or Proteins (AREA)

DK03290607T 2003-03-12 2003-03-12 Fremgangsmåde til syntese af (2S, 3aS, 7aS)-perhydroindol-2-carboxylsyre og estere heraf, samt anvendelse heraf ved syntese af perindopril DK1323729T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03290607A EP1323729B1 (fr)	2003-03-12	2003-03-12	Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril

Publications (1)

Publication Number	Publication Date
DK1323729T3 true DK1323729T3 (da)	2005-02-14

Family

ID=8185879

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03290607T DK1323729T3 (da)	2003-03-12	2003-03-12	Fremgangsmåde til syntese af (2S, 3aS, 7aS)-perhydroindol-2-carboxylsyre og estere heraf, samt anvendelse heraf ved syntese af perindopril

Country Status (9)

Country	Link
EP (1)	EP1323729B1 (da)
AR (1)	AR043569A1 (da)
AT (1)	ATE281465T1 (da)
DE (1)	DE60300116T2 (da)
DK (1)	DK1323729T3 (da)
ES (1)	ES2231760T3 (da)
MY (1)	MY135652A (da)
PT (1)	PT1323729E (da)
WO (1)	WO2004083237A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004099138A2 (en) *	2003-05-12	2004-11-18	Cipla Limited	Process for the preparation of perindopril
EP1536017B1 (en)	2003-10-30	2007-04-18	Sumitomo Chemical Company, Limited	Process for producing optically active octahydro-1H-indole-2-carboxylic acid
SI21800A (sl)	2004-05-14	2005-12-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nov postopek sinteze perindoprila
AU2005327440A1 (en) *	2005-02-14	2006-08-17	Lupin Limited	Improved process for preparation of highly pure trandolapril
CN100391945C (zh) *	2005-05-31	2008-06-04	浙江大学	一种s-(-)-吲哚啉-2-羧酸的合成方法
US8558023B2 (en)	2010-04-20	2013-10-15	Chiral Quest, Inc.	Enantioselective process for cycloalkenyl β-substituted alanines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1341296C (en) *	1981-12-29	2001-09-25	Hansjorg Urbach	2-azabicycloalkane-3-carboxylic acid derivatives, processes for their preparation, agents containing these compounds and their use
FR2807431B1 (fr) *	2000-04-06	2002-07-19	Adir	Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2827860B1 (fr) *	2001-07-24	2004-12-10	Servier Lab	Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril

2003
- 2003-03-12 ES ES03290607T patent/ES2231760T3/es not_active Expired - Lifetime
- 2003-03-12 EP EP03290607A patent/EP1323729B1/fr not_active Expired - Lifetime
- 2003-03-12 DK DK03290607T patent/DK1323729T3/da active
- 2003-03-12 DE DE60300116T patent/DE60300116T2/de not_active Expired - Lifetime
- 2003-03-12 AT AT03290607T patent/ATE281465T1/de active
- 2003-03-12 PT PT03290607T patent/PT1323729E/pt unknown
2004
- 2004-03-12 WO PCT/FR2004/000592 patent/WO2004083237A1/fr not_active Ceased
- 2004-03-12 MY MYPI20040882A patent/MY135652A/en unknown
- 2004-03-12 AR ARP040100806A patent/AR043569A1/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP1323729A1 (fr)	2003-07-02
ES2231760T3 (es)	2005-05-16
DE60300116T2 (de)	2005-12-22
DE60300116D1 (de)	2004-12-09
MY135652A (en)	2008-06-30
AR043569A1 (es)	2005-08-03
PT1323729E (pt)	2005-02-28
EP1323729B1 (fr)	2004-11-03
ATE281465T1 (de)	2004-11-15
WO2004083237A1 (fr)	2004-09-30

Similar Documents

Publication	Publication Date	Title
IS7755A (is)	2005-03-17	Aðferð við framleiðslu á (S,S)-cis-2-benshýdríl-3-bensýlamínókínuklídín
FR2892117B1 (fr)	2008-05-02	Composition pyrotechnique generatrice de gaz rapide et procede d'obtention
ATE318838T1 (de)	2006-03-15	Verfahren zur synthese von (2s,3as,7as)-1-(s)- alanyl-octahydro-1h-2-carbonsäurederivaten und verwendung in der synthese von perindopril
DK1348684T3 (da)	2006-07-03	Fremgangsmåde til syntese af (2S)-indolin-2-carboxylsyre og anvendelse heraf til syntese af perindopril
EE200400107A (et)	2004-10-15	Protsess kõrgpuhta perindopriili ning sünteesis kasulike vaheühendite valmistamiseks
DK1338591T3 (da)	2006-01-23	Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og estere heraf samt anvendelse heraf ved syntese af perindopril
DK1323729T3 (da)	2005-02-14	Fremgangsmåde til syntese af (2S, 3aS, 7aS)-perhydroindol-2-carboxylsyre og estere heraf, samt anvendelse heraf ved syntese af perindopril
DK1354876T3 (da)	2005-08-15	Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og dennes estere og anvendelse heraf i syntesen af perindopril
DK1420028T3 (da)	2007-06-18	Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1272454T3 (da)	2007-09-17	Fremgangsmåde til syntese af N-[(S)-1-carboxybutyl]-(S)-alanin-estere og deres anvendelse ved syntese af perindopril
DK1319668T3 (da)	2005-02-14	Fremgangsmåde til syntese af (2S, 3aS, 7aS)-1-((S)-alanyl)-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse heraf ved syntese af perindopril
DK1403277T3 (da)	2005-11-21	Fremgangsmåde til syntest af (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse heraf ved syntese i perindopril
DK1354874T3 (da)	2005-03-14	Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og estere heraf og anvendelse heraf ved syntese af perindopril
DK1371659T3 (da)	2005-11-21	Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1354875T3 (da)	2005-03-14	Ny syntesefremgangsmåde for (2S, 3aS, 7aS)-perhydroindol-2-carboxylsyre og estere heraf samt anvendelse ved syntese af perindopril
DK1511724T3 (da)	2014-06-16	Fremgangsmåde til fremstilling af thioalkylaminderivater
DK1380591T3 (da)	2006-01-23	Fremgangsmåde til syntese af perindopril og farmaceutiske acceptable salte heraf
DK1420029T3 (da)	2008-06-16	Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1367063T3 (da)	2006-12-27	Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1362845T3 (da)	2010-01-18	Ny fremgangsmåde til fremstilling af estere af N-((S)-1-carboxybutyl)-(S)-alanin og deres anvendelse ved fremstilling af perindopril
MY136937A (en)	2008-11-28	NEW PROCESS FOR THE SYNTHESIS OF (2S, 3aS, 7aS)-1-[(S)-ALANYL]-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID COMPOUNDS AND APPLICATION IN THE SYNTHESIS OF PERINDOPRIL
DK1400531T3 (da)	2006-05-15	Fremgangsmåde til fremstilling af N-[(S)-1-ethoxycarbonyl-butyl]-(S)-alanin og anvendelse heraf ved syntese af perindopril
NO20023601D0 (no)	2002-07-29	Fremgangsmåte for hydrolysering av proteiner
DK1615945T3 (da)	2011-12-12	Glycopegyleringsfremgangsmåder og proteiner/peptider fremstillet ved fremgangsmåderne
NO20024563D0 (no)	2002-09-23	Fremgangsmåte for renfremstilling av mineraler ved bruk av CO2