ATE318838T1 - Verfahren zur synthese von (2s,3as,7as)-1-(s)- alanyl-octahydro-1h-2-carbonsäurederivaten und verwendung in der synthese von perindopril - Google Patents

Verfahren zur synthese von (2s,3as,7as)-1-(s)- alanyl-octahydro-1h-2-carbonsäurederivaten und verwendung in der synthese von perindopril

Info

Publication number
ATE318838T1
ATE318838T1 AT02291853T AT02291853T ATE318838T1 AT E318838 T1 ATE318838 T1 AT E318838T1 AT 02291853 T AT02291853 T AT 02291853T AT 02291853 T AT02291853 T AT 02291853T AT E318838 T1 ATE318838 T1 AT E318838T1
Authority
AT
Austria
Prior art keywords
synthesis
perindopril
alanyl
octahydro
acid derivatives
Prior art date
Application number
AT02291853T
Other languages
English (en)
Inventor
Tibor Mezei
Marta Porcs-Makkay
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8865826&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE318838(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of ATE318838T1 publication Critical patent/ATE318838T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
AT02291853T 2001-07-24 2002-07-23 Verfahren zur synthese von (2s,3as,7as)-1-(s)- alanyl-octahydro-1h-2-carbonsäurederivaten und verwendung in der synthese von perindopril ATE318838T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0109839A FR2827860B1 (fr) 2001-07-24 2001-07-24 Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril

Publications (1)

Publication Number Publication Date
ATE318838T1 true ATE318838T1 (de) 2006-03-15

Family

ID=8865826

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02291853T ATE318838T1 (de) 2001-07-24 2002-07-23 Verfahren zur synthese von (2s,3as,7as)-1-(s)- alanyl-octahydro-1h-2-carbonsäurederivaten und verwendung in der synthese von perindopril

Country Status (25)

Country Link
US (1) US7060842B2 (de)
EP (1) EP1256590B1 (de)
JP (1) JP3868957B2 (de)
KR (1) KR100607556B1 (de)
CN (1) CN1533398A (de)
AR (1) AR035081A1 (de)
AT (1) ATE318838T1 (de)
AU (1) AU2002334027B8 (de)
BR (1) BR0211334A (de)
CA (1) CA2455706C (de)
DE (1) DE60209458T2 (de)
DK (1) DK1256590T3 (de)
EA (1) EA005490B1 (de)
ES (1) ES2259071T3 (de)
FR (1) FR2827860B1 (de)
HU (1) HU229396B1 (de)
MA (1) MA27130A1 (de)
MX (1) MXPA04000443A (de)
NO (1) NO328234B1 (de)
NZ (1) NZ530427A (de)
PL (1) PL212408B1 (de)
PT (1) PT1256590E (de)
SI (1) SI1256590T1 (de)
WO (1) WO2003016336A1 (de)
ZA (1) ZA200400246B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE365714T1 (de) 2002-01-30 2007-07-15 Servier Lab Verfahren zur herstellung von hochreinem perindopril und zwischenverbindungen nützlich in der synthese
DE60301930T2 (de) 2003-02-28 2006-07-27 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salze
ATE395913T1 (de) 2003-02-28 2008-06-15 Servier S A Lab Verfahren zur herstellung von perindopril
DK1403277T3 (da) * 2003-02-28 2005-11-21 Servier Lab Fremgangsmåde til syntest af (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse heraf ved syntese i perindopril
ATE307801T1 (de) * 2003-02-28 2005-11-15 Servier Lab Verfahren zur synthese des (2s,3as,7as)- perhydroindol-2-carbonsäures und seiner estern, verwendung in der synthese von perindopril
DE60300106T2 (de) * 2003-03-12 2005-10-13 Les Laboratoires Servier Verfahren zur Synthese von (2S,3aS,7aS)-1-((S)-Alanyl)-octahydro-1H-indol-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril
ATE281465T1 (de) * 2003-03-12 2004-11-15 Servier Lab Verfahren zur synthese von (2s,3as,7as)- perhydroindol-2-carbonsäure und seiner estern, und verwendung in der synthese von perindopril
PT1321471E (pt) * 2003-03-12 2005-07-29 Servier Lab Novo processo de sintese do perindopril e dos seus sais aceitaveis sob o ponto de vista farmaceutico
CN100395235C (zh) 2003-06-24 2008-06-18 瑟维尔实验室 培哚普利特丁胺的新晶形
ES2271498T3 (es) 2003-07-31 2007-04-16 Les Laboratoires Servier Nuevo procedimiento de sintesis de perindopril y de sus sales farmaceuticamente aceptables.
JP4720132B2 (ja) * 2003-10-30 2011-07-13 住友化学株式会社 光学活性なｎ−保護−オクタヒドロ−１ｈ−インドール−２−カルボン酸の製造方法
EP1420030A3 (de) * 2003-12-10 2004-05-26 Les Laboratoires Servier Verfahren zur Synthese von (2S,3aS,7aS)-1-(S)-Alanyl-octahydro-1H-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
ITFI20040174A1 (it) * 2004-08-03 2004-11-03 Protera S R L Derivati arilsolfonammidici dell'acido idrossammico ad azione inibitoria di metalloproteinasi
KR101329457B1 (ko) 2006-12-19 2013-11-15 에스케이바이오팜 주식회사 옥타하이드로인돌-2-카르복시산의 제조방법
RU2433998C1 (ru) * 2010-03-16 2011-11-20 Закрытое акционерное общество "Активный Компонент" Способ получения периндоприла и его фармацевтически приемлемых солей
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2807037B1 (fr) * 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Also Published As

Publication number Publication date
SI1256590T1 (sl) 2006-06-30
US20040198988A1 (en) 2004-10-07
FR2827860A1 (fr) 2003-01-31
JP2005500386A (ja) 2005-01-06
EA005490B1 (ru) 2005-02-24
AU2002334027B8 (en) 2007-01-25
FR2827860B1 (fr) 2004-12-10
PL355159A1 (en) 2003-01-13
HUP0202437A2 (hu) 2003-02-28
DE60209458D1 (de) 2006-04-27
NO20040151L (no) 2004-01-13
EA200400110A1 (ru) 2004-06-24
NZ530427A (en) 2005-08-26
ZA200400246B (en) 2006-07-26
KR100607556B1 (ko) 2006-08-02
EP1256590B1 (de) 2006-03-01
EP1256590A1 (de) 2002-11-13
MA27130A1 (fr) 2005-01-03
MXPA04000443A (es) 2004-03-18
BR0211334A (pt) 2004-09-28
AU2002334027A1 (en) 2003-03-03
AU2002334027B2 (en) 2006-12-14
NO328234B1 (no) 2010-01-11
WO2003016336A1 (fr) 2003-02-27
ES2259071T3 (es) 2006-09-16
DE60209458T2 (de) 2006-10-12
CA2455706C (fr) 2012-01-24
DK1256590T3 (da) 2006-06-06
HUP0202437A3 (en) 2003-05-28
HU229396B1 (hu) 2013-11-28
HU0202437D0 (de) 2002-10-28
KR20040023673A (ko) 2004-03-18
AR035081A1 (es) 2004-04-14
PL212408B1 (pl) 2012-09-28
JP3868957B2 (ja) 2007-01-17
US7060842B2 (en) 2006-06-13
CN1533398A (zh) 2004-09-29
PT1256590E (pt) 2006-06-30
CA2455706A1 (fr) 2003-02-27

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