DK1333846T3 - Fremstilling og xenotransplantation af porcine øer - Google Patents

Fremstilling og xenotransplantation af porcine øer

Info

Publication number
DK1333846T3
DK1333846T3 DK01979134.2T DK01979134T DK1333846T3 DK 1333846 T3 DK1333846 T3 DK 1333846T3 DK 01979134 T DK01979134 T DK 01979134T DK 1333846 T3 DK1333846 T3 DK 1333846T3
Authority
DK
Denmark
Prior art keywords
pancreas
preparation
islets
culture
xenotransplantation
Prior art date
Application number
DK01979134.2T
Other languages
English (en)
Inventor
Robert Bartlet Professor Elliott
Guiseppe Basta
Giovanni Luca
Riccardo Calafiore
Original Assignee
Diatranz Otsuka Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NZ50761600A external-priority patent/NZ507616A/en
Application filed by Diatranz Otsuka Ltd filed Critical Diatranz Otsuka Ltd
Application granted granted Critical
Publication of DK1333846T3 publication Critical patent/DK1333846T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Physiology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Nutrition Science (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
DK01979134.2T 2000-10-17 2001-10-16 Fremstilling og xenotransplantation af porcine øer DK1333846T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NZ50761600A NZ507616A (en) 2000-10-17 2000-10-17 Preparation and xenotransplantation of porcine islets in the presence of sertoli cells, for treatment of diabetes
NZ50796300 2000-11-02
PCT/NZ2001/000228 WO2002032437A1 (en) 2000-10-17 2001-10-16 Preparation and xenotransplantation or porcine islets

Publications (1)

Publication Number Publication Date
DK1333846T3 true DK1333846T3 (da) 2012-08-06

Family

ID=26652219

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01979134.2T DK1333846T3 (da) 2000-10-17 2001-10-16 Fremstilling og xenotransplantation af porcine øer

Country Status (7)

Country Link
US (2) US20040014212A1 (da)
EP (1) EP1333846B1 (da)
AT (1) ATE553766T1 (da)
AU (2) AU2002211122B2 (da)
DK (1) DK1333846T3 (da)
ES (1) ES2386505T3 (da)
WO (1) WO2002032437A1 (da)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7399751B2 (en) * 1999-11-04 2008-07-15 Sertoli Technologies, Inc. Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
US20090047325A1 (en) * 1999-04-30 2009-02-19 Neurotrophincell Pty. Limited Xenotransplant for cns therapy
US20050265977A1 (en) * 1999-04-30 2005-12-01 Elliott Robert B Xenotransplant for CNS therapy
EP1176970B1 (en) * 1999-04-30 2010-05-19 NeurotrophinCell Pty Ltd Xenotransplant for cns therapy
US20030108539A1 (en) * 2000-02-14 2003-06-12 Christophe Bonny Cell-permeable peptide inhibitors of the JNK signal transduction pathway
ES2272482T3 (es) * 2000-01-20 2007-05-01 Diabcell Pty Limited Preparacion y xenotransplante de islotes porcinos.
WO2003027270A1 (en) * 2001-09-28 2003-04-03 Diabcell Pty Limited Growing xenotransplant material in culture
NZ515310A (en) * 2001-11-07 2004-08-27 Diabcell Pty Ltd Methods of treatment and delivery modes
CN1791670A (zh) * 2003-06-24 2006-06-21 戴伯塞尔有限公司 用于异种移植的用猪支持细胞培养的猪胰岛
US20050118145A1 (en) * 2003-07-03 2005-06-02 Jannette Dufour Compositions containing sertoli cells and myoid cells and use thereof in cellular transplants
NZ539491A (en) 2005-04-15 2008-04-30 Living Cell Products Pty Ltd Swine population and uses thereof
NZ536009A (en) 2005-04-18 2007-01-26 Neurotrophincell Pty Ltd Choroid plexus preparation and uses thereof
NZ540597A (en) * 2005-06-08 2007-02-23 Neurotrophincell Pty Ltd A method for preventing the onset of type I diabetes comprising administering an implantable composition comprising living choroid plexus cells
WO2007031098A1 (en) 2005-09-12 2007-03-22 Xigen S.A. Cell-permeable peptide inhibitors of the jnk signal transduction pathway
AU2007278850B2 (en) * 2006-07-28 2013-06-06 Sertocell Biotechnology (Us) Corp. Adult sertoli cells and uses thereof
WO2009143864A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases
WO2009143865A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2010072228A1 (en) 2008-12-22 2010-07-01 Xigen S.A. Novel transporter constructs and transporter cargo conjugate molecules
EA025142B1 (ru) 2009-08-28 2016-11-30 Сернова Корпорэйнш Способ и устройство для клеточной трансплантации
WO2011160653A1 (en) 2010-06-21 2011-12-29 Xigen S.A. Novel jnk inhibitor molecules
AU2010362444B2 (en) 2010-10-14 2015-08-06 Xigen Inflammation Ltd. Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases
WO2012113859A1 (en) 2011-02-23 2012-08-30 Université Catholique de Louvain Modified pig islets for diabetes treatment
US9557433B2 (en) * 2011-03-23 2017-01-31 Seismic Global Ambient, Llc Fracture imaging methods employing skeletonization of seismic emission tomography data
US9389326B2 (en) * 2011-03-23 2016-07-12 Global Ambient Seismic, Inc. Methods, systems and devices for near-well fracture monitoring using tomographic fracture imaging techniques
US9442205B2 (en) * 2011-03-23 2016-09-13 Global Ambient Seismic, Inc. Method for assessing the effectiveness of modifying transmissive networks of natural reservoirs
US9810803B2 (en) * 2011-03-23 2017-11-07 Seismic Global Ambient, Llc Method for subsurface mapping using seismic emissions
WO2013091670A1 (en) 2011-12-21 2013-06-27 Xigen S.A. Novel jnk inhibitor molecules for treatment of various diseases
WO2015197097A1 (en) 2014-06-26 2015-12-30 Xigen Inflammation Ltd. New use for jnk inhibitor molecules for treatment of various diseases
ES2870085T3 (es) 2013-06-26 2021-10-26 Xigen Inflammation Ltd Inhibidores peptídicos permeables a células de la ruta de transducción de señales de JNK para el tratamiento de la cistitis
WO2014206427A1 (en) 2013-06-26 2014-12-31 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
EP3604498A1 (en) 2014-04-11 2020-02-05 Université catholique de Louvain Transgenic pig islets and uses thereof for treating diabetes
WO2018195402A1 (en) 2017-04-20 2018-10-25 Egenesis, Inc. Methods for generating genetically modified animals
CN115003316A (zh) * 2020-01-28 2022-09-02 株式会社大塚制药工场 含胰岛胶囊的制造方法
ES3056172T3 (en) 2020-06-17 2026-02-18 Otsuka Pharma Factory Inc Encapsulated pancreatic islet

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266480A (en) * 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US4850993A (en) * 1986-12-22 1989-07-25 Miles Laboratories, Inc. Blood bag system incorporating quinolone carboxylic, acid derivatives
US5871472A (en) * 1987-11-17 1999-02-16 Brown University Research Foundation Planting devices for the focal release of neuroinhibitory compounds
US5283187A (en) * 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US5650148A (en) * 1988-12-15 1997-07-22 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system
CA2109085C (en) * 1991-04-25 2003-03-11 Keith E. Dionne Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
US6231881B1 (en) * 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
JPH08509215A (ja) * 1993-04-13 1996-10-01 アメリカ合衆国 移植治療のための神経由来胎児セルラインの使用
US6090400A (en) * 1994-02-07 2000-07-18 The Trustees Of The Childhood Diabetes Transplant Research Trust Pharmaceutical preparation and method for treatment of diabetes
US5849285A (en) * 1994-04-13 1998-12-15 Research Corporation Technologies, Inc. Autoimmune disease treatment with sertoli cells and in vitro co-culture of mammal cells with sertoli cells
US5550050A (en) * 1994-04-15 1996-08-27 Cytotherapeutics, Inc. Method for implanting encapsulated cells in a host
US6001647A (en) * 1994-04-28 1999-12-14 Ixion Biotechnology, Inc. In vitro growth of functional islets of Langerhans and in vivo uses thereof
US5587309A (en) * 1994-04-29 1996-12-24 The United States Of America As Represented By The Department Of Health And Human Services Method of stimulating proliferation and differentiation of human fetal pancreatic cells ex vivo
US5561108A (en) * 1994-07-29 1996-10-01 Bayer Corporation Preparation of α1 -antichymotrypsin
US5853385A (en) * 1994-08-26 1998-12-29 Cytotherapeutics, Inc. Encapsulated PC12 cell transplants for treatment of Parkinson's disease
US5898066A (en) * 1994-08-26 1999-04-27 Children's Medical Center Corporation Trophic factors for central nervous system regeneration
US6225310B1 (en) * 1996-01-17 2001-05-01 Novo Nordisk A/S Fused 1,2,4-thiadiazine derivatives, their preparation and use
CA2179341A1 (en) * 1996-04-12 1997-10-13 Gregory S. Korbutt Methods for isolating, enriching and increasing the maturation of cells
AU8186498A (en) * 1997-08-26 1999-03-11 Diatranz Limited Treatment for diabetes
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
US6432710B1 (en) * 1998-05-22 2002-08-13 Isolagen Technologies, Inc. Compositions for regenerating tissue that has deteriorated, and methods for using such compositions
CA2355675C (en) * 1998-12-15 2006-07-04 Universidad Nacional Autonoma De Mexico Process and device for facilitating the implantation of biological material
US6365385B1 (en) * 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US20050265977A1 (en) * 1999-04-30 2005-12-01 Elliott Robert B Xenotransplant for CNS therapy
US20040213768A1 (en) * 1999-04-30 2004-10-28 Elliott Robert Bartlett Preparation for biotransplantation and xenotransplantion and uses thereof
ES2272482T3 (es) * 2000-01-20 2007-05-01 Diabcell Pty Limited Preparacion y xenotransplante de islotes porcinos.
NZ515310A (en) * 2001-11-07 2004-08-27 Diabcell Pty Ltd Methods of treatment and delivery modes

Also Published As

Publication number Publication date
ES2386505T3 (es) 2012-08-22
ATE553766T1 (de) 2012-05-15
EP1333846B1 (en) 2012-04-18
AU2002211122B2 (en) 2005-06-23
AU1112202A (en) 2002-04-29
EP1333846A1 (en) 2003-08-13
US20040014212A1 (en) 2004-01-22
EP1333846A4 (en) 2008-02-20
US20080070301A1 (en) 2008-03-20
WO2002032437A1 (en) 2002-04-25

Similar Documents

Publication Publication Date Title
DK1333846T3 (da) Fremstilling og xenotransplantation af porcine øer
DK1248640T3 (da) Xenotransplantation af svineöer og deres fremstilling
MIRKOVITCH et al. Successful intrasplenic autotransplantation of pancreatic tissue in totally pancreatectomised dogs
Scharp et al. Transplantation of islets of Langerhans in diabetic rhesus monkeys
STEINBERGER et al. Initiation of spermatogenesis in vitro
US4935000A (en) Extracellular matrix induction method to produce pancreatic islet tissue
DK0871414T3 (da) Fremgangsmåder til fremstilling af væv til implantering
NO320713B1 (no) Farmasoytisk preparat som omfatter Sertoli-celler og celler som produserer en biologisk faktor, seksjonert sett med beholdere for cellene, produktartikkel som omfatter et embaleringsmateriale med Sertoli-celler og fremgangsmate for okning av utvinning og profilering av celler ex vivo.
Archer et al. Control of streptozotocin diabetes in Chinese hamsters by cultured mouse islet cells without immunosuppression: a preliminary report
CA2488414A1 (en) Primary cultured adipocytes for gene therapy
EP1438395B1 (en) Growing xenotransplant material in culture
Levy et al. Intrathymic islet transplantation in the canine: I. histological and functional evidence of autologous intrathymic islet engraftment and survival in pancreatectomized recipients1
US20210187164A1 (en) Methods for tissue decellularization
HK1041442A1 (zh) 改善胚胎腎移植物功能的組合物及方法
Tatarkiewicz et al. Porcine neonatal pancreatic cell clusters in tissue culture: Benefits of serum and immobilization in alginate hydrogel1
Vo et al. Lowering of blood glucose to nondiabetic levels in a hyperglycemic pig by allografting of fetal pig isletlike cell clusters1
NZ502473A (en) The preparation of encapsulated pancreatic beta islet cells treated with nicotinamide from piglets able to produce porcine insulin
WO2000067672A3 (en) Tissue engineering for making tubular implants
JP2007195573A (ja) 移植用膵島の分離方法
Peterson et al. Human fetal pancreas transplants
Pakhomov et al. Insulin treatment of mice recipients preserves β-cell function in porcine islet transplantation
KR100788800B1 (ko) 자가 탄성연골로 캡슐화된 이식물 및 이의 제조방법
Prochorov et al. Long-term normalization of diabetes mellitus after xenotransplantation of fetal pancreatic islet cells into the blood stream without immunosuppresive therapy
CA1298551C (en) Extracellular matrix induction method to produce pancreatic islet tissue
Lampe et al. Autotransplantation of porcine islets of Langerhans