DK1359934T3 - Tripeptider og tripeptidderivater til behandling af neurodegenerative sygdomme - Google Patents

Tripeptider og tripeptidderivater til behandling af neurodegenerative sygdomme

Info

Publication number
DK1359934T3
DK1359934T3 DK02711833T DK02711833T DK1359934T3 DK 1359934 T3 DK1359934 T3 DK 1359934T3 DK 02711833 T DK02711833 T DK 02711833T DK 02711833 T DK02711833 T DK 02711833T DK 1359934 T3 DK1359934 T3 DK 1359934T3
Authority
DK
Denmark
Prior art keywords
sub
alkyl
alkoxy
tripeptides
treatment
Prior art date
Application number
DK02711833T
Other languages
English (en)
Inventor
Jean Rapin
Hans Klaus Witzmann
Jean-Marie Grumel
Jacques Gonella
Original Assignee
Neurotell Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurotell Ag filed Critical Neurotell Ag
Application granted granted Critical
Publication of DK1359934T3 publication Critical patent/DK1359934T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK02711833T 2001-02-05 2002-02-05 Tripeptider og tripeptidderivater til behandling af neurodegenerative sygdomme DK1359934T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10105041A DE10105041A1 (de) 2001-02-05 2001-02-05 Tripeptide und Tripeptid-Derivate für die Behandlung neurodegenerativer Krankheiten
PCT/EP2002/001180 WO2002062828A2 (en) 2001-02-05 2002-02-05 Tripeptides and tripeptide derivatives for the treatment of neurodegenerative diseases

Publications (1)

Publication Number Publication Date
DK1359934T3 true DK1359934T3 (da) 2007-03-12

Family

ID=7672834

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02711833T DK1359934T3 (da) 2001-02-05 2002-02-05 Tripeptider og tripeptidderivater til behandling af neurodegenerative sygdomme

Country Status (11)

Country Link
US (1) US7129213B2 (da)
EP (1) EP1359934B1 (da)
JP (1) JP4169597B2 (da)
AT (1) ATE344673T1 (da)
AU (1) AU2002231771A1 (da)
CY (1) CY1107990T1 (da)
DE (2) DE10105041A1 (da)
DK (1) DK1359934T3 (da)
ES (1) ES2275849T3 (da)
PT (1) PT1359934E (da)
WO (1) WO2002062828A2 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10105040A1 (de) * 2001-02-05 2002-08-14 Tell Pharm Ag Hergiswil Tripeptid-Derivate für die Behandlung von postläsionalen Krankheiten des Nervensystems
DE10105038B4 (de) 2001-02-05 2005-07-07 Neurotell Ag Tripeptid-Derivate für die Behandlung von postläsionalen Krankheiten des Nervensystems
DE10105041A1 (de) 2001-02-05 2002-08-14 Tell Pharm Ag Hergiswil Tripeptide und Tripeptid-Derivate für die Behandlung neurodegenerativer Krankheiten
EP1519918A1 (en) * 2002-07-02 2005-04-06 Novartis AG Peptide inhibitors of smac protein binding to inhibitor of apoptosis proteins (iap)
WO2007079977A2 (en) * 2006-01-16 2007-07-19 Dsm Ip Assets B.V. Nutraceutical compositions comprising tripeptides
US7838971B2 (en) * 2006-07-11 2010-11-23 Atmel Corporation Method to provide substrate-ground coupling for semiconductor integrated circuit dice constructed from SOI and related materials in stacked-die packages
EP2459581A4 (en) 2009-07-29 2012-12-26 Univ Chicago LIVER X-RECEPTOR AGONISTS
JP6344796B2 (ja) * 2014-09-30 2018-06-20 森永乳業株式会社 高齢者用アルツハイマー型認知症改善剤
JP6589011B2 (ja) * 2018-05-17 2019-10-09 森永乳業株式会社 脳機能障害改善用経口組成物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1323301C (en) 1987-06-05 1993-10-19 Alan I. Faden Thyrotropin-releasing hormone analogs in cns injury
FR2622581B1 (fr) * 1987-11-03 1990-02-16 Inorgan Sa Rech Develop Pharm Nouveaux derives de l-proline, leur preparation et leurs applications biologiques
EP0445606B1 (en) * 1990-02-27 1997-01-22 The Agency of Industrial Science and Technology Novel oligopeptides, pharmaceutical composition and food containing the same, and use of oligopeptides
DE4007869A1 (de) 1990-03-13 1991-09-19 Merck Patent Gmbh Aminosaeurederivate
JPH045240A (ja) * 1990-04-20 1992-01-09 Taisho Pharmaceut Co Ltd 抗痴呆剤
US5091391A (en) * 1990-08-16 1992-02-25 University Of Pittsburgh Of The Commonwealth System Of Higher Education Method of resisting neurodegenerative disorders
WO1992011850A2 (en) * 1990-12-28 1992-07-23 Cortex Pharmaceuticals, Inc. Use of calpain inhibitors in the inhibition and treatment of neurodegeneration
WO1992013549A1 (en) * 1991-02-07 1992-08-20 Research Corporation Technologies, Inc. Inhibition of cell proliferation by hydrophobic peptides
US6235929B1 (en) * 1991-12-27 2001-05-22 Georgia Tech Research Corporation Tripeptide α-ketoamides
WO1997000890A1 (fr) * 1995-06-23 1997-01-09 Hankyu-Kyoei Bussan Co., Ltd. Peptide qui inhibe l'elevation du niveau de triglyceride dans le sang, et inhibiteur d'elevation de ce niveau contenant ledit peptide comme principe actif
WO1995013069A1 (en) * 1993-11-09 1995-05-18 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
JP2800877B2 (ja) * 1993-12-28 1998-09-21 伊藤ハム株式会社 血中トリグリセリド濃度上昇抑制ペプチド及び当該ペプチドを有効成分として含む血中トリグリセリド濃度上昇抑制剤
EP0739486A4 (en) * 1994-01-13 1998-09-09 Univ Columbia SYNTHETIC RECEPTORS, LIBRARIES AND THEIR USE
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5834029A (en) * 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
JPH0940577A (ja) * 1995-05-24 1997-02-10 Mitsui Toatsu Chem Inc トリペプチド、ジペプチドを含有する医薬組成物
WO1996041638A1 (en) 1995-06-13 1996-12-27 Sanofi Winthrop, Inc. Calpain inhibitors for the treatment of neurodegenerative diseases
JPH09169797A (ja) * 1995-12-22 1997-06-30 Mitsui Toatsu Chem Inc プロテアーゼアクティベーター活性を有するペプチド
US5840838A (en) * 1996-02-29 1998-11-24 University Of Kentucky Research Foundation Process for enhancing the activity of amyloid β peptides
JP2805194B2 (ja) * 1996-03-22 1998-09-30 阪急共栄物産株式会社 血中トリグリセリド濃度上昇抑制ペプチド及び当該ペプチドを有効成分として含む血中トリグリセリド濃度上昇抑制剤
JP2001501930A (ja) * 1996-10-04 2001-02-13 オークランド ユニサーヴィスィズ リミテッド 神経酵素の調節
JP4727770B2 (ja) * 1997-09-26 2011-07-20 カルピス株式会社 尿中カテコールアミン低下、尿中ノルアドレナリン低下、尿中ドーパミン低下及びＦｉｓｃｈｅｒ比低下の少なくとも１つの軽減剤
JPH11124398A (ja) * 1997-10-22 1999-05-11 Japan Energy Corp Ｃ型肝炎ウイルス由来の抗原ペプチドとそれを用いる抗体検査薬
JP3108675B2 (ja) * 1998-03-17 2000-11-13 阪急共栄物産株式会社 脂質代謝改善剤
US6080848A (en) * 1998-05-01 2000-06-27 Incyte Pharmaceuticals, Inc. Human brain associated protein
AU1574701A (en) 1999-10-22 2001-04-30 Wrair Walter Reed Army Institute Of Research A pharmaceutical composition containing pglu-glu-pro-nh2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
JP4633876B2 (ja) * 1999-11-11 2011-02-16 カルピス株式会社 トリペプチドの製造方法
WO2001068114A1 (en) * 2000-03-10 2001-09-20 Monsanto Company Novel peptides with anti-hypertensive activity
DE10105038B4 (de) 2001-02-05 2005-07-07 Neurotell Ag Tripeptid-Derivate für die Behandlung von postläsionalen Krankheiten des Nervensystems
DE10105041A1 (de) 2001-02-05 2002-08-14 Tell Pharm Ag Hergiswil Tripeptide und Tripeptid-Derivate für die Behandlung neurodegenerativer Krankheiten
US6846641B2 (en) * 2002-04-23 2005-01-25 Agy Therapeutics, Inc. In vitro ischemia model

Also Published As

Publication number Publication date
JP4169597B2 (ja) 2008-10-22
DE60215917T2 (de) 2007-09-13
PT1359934E (pt) 2007-01-31
ATE344673T1 (de) 2006-11-15
US7129213B2 (en) 2006-10-31
JP2004526704A (ja) 2004-09-02
DE10105041A1 (de) 2002-08-14
DE60215917D1 (de) 2006-12-21
US20050101538A1 (en) 2005-05-12
EP1359934B1 (en) 2006-11-08
AU2002231771A1 (en) 2002-08-19
WO2002062828A3 (en) 2002-10-10
ES2275849T3 (es) 2007-06-16
EP1359934A2 (en) 2003-11-12
WO2002062828A2 (en) 2002-08-15
CY1107990T1 (el) 2013-09-04

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