DK1375503T3 - Dioxinoderivater og deres anvendelse som dopaminagonister - Google Patents

Dioxinoderivater og deres anvendelse som dopaminagonister

Info

Publication number
DK1375503T3
DK1375503T3 DK03021780T DK03021780T DK1375503T3 DK 1375503 T3 DK1375503 T3 DK 1375503T3 DK 03021780 T DK03021780 T DK 03021780T DK 03021780 T DK03021780 T DK 03021780T DK 1375503 T3 DK1375503 T3 DK 1375503T3
Authority
DK
Denmark
Prior art keywords
dopamine agonists
dioxin derivatives
dioxin
derivatives
dopamine
Prior art date
Application number
DK03021780T
Other languages
English (en)
Inventor
Gary Paul Stack
Young Hee Kang
Richard Eric Mewshaw
Byron Abel Bravo
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of DK1375503T3 publication Critical patent/DK1375503T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK03021780T 1995-11-06 1996-10-22 Dioxinoderivater og deres anvendelse som dopaminagonister DK1375503T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US728395P 1995-11-06 1995-11-06
US08/730,267 US5756532A (en) 1995-11-06 1996-10-15 Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives

Publications (1)

Publication Number Publication Date
DK1375503T3 true DK1375503T3 (da) 2007-01-22

Family

ID=26676776

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03021780T DK1375503T3 (da) 1995-11-06 1996-10-22 Dioxinoderivater og deres anvendelse som dopaminagonister

Country Status (21)

Country Link
US (2) US5756532A (da)
EP (3) EP1375503B1 (da)
JP (1) JP4311770B2 (da)
KR (1) KR100566678B1 (da)
CN (1) CN1084748C (da)
AR (2) AR004284A1 (da)
AT (1) ATE349450T1 (da)
AU (1) AU701624B2 (da)
CA (1) CA2189524C (da)
CZ (1) CZ291731B6 (da)
DE (1) DE69636801T2 (da)
DK (1) DK1375503T3 (da)
ES (1) ES2277014T3 (da)
HU (1) HU224841B1 (da)
IL (1) IL119565A (da)
MX (1) MX9605367A (da)
NO (1) NO317054B1 (da)
NZ (1) NZ299693A (da)
PT (1) PT1375503E (da)
RU (1) RU2178416C2 (da)
SK (1) SK282168B6 (da)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9627005D0 (en) * 1996-12-27 1997-02-12 Knoll Ag Therapeutic agents
GB9704948D0 (en) * 1997-03-11 1997-04-30 Knoll Ag Therapeutic agents
US6362009B1 (en) 1997-11-21 2002-03-26 Merck & Co., Inc. Solid phase synthesis of heterocycles
CZ20021880A3 (cs) * 1999-12-10 2002-08-14 Wyeth Farmaceutický prostředek
US6350773B1 (en) * 1999-12-10 2002-02-26 American Home Products Corporation Therapeutic combinations of (S)-2-(benzylamino-methyl)-2,3,8,9,-tetrahydro 7H-1,4-dioxino{2,3-e}indol-8-one and neuroleptics for the treatment or prevention of psychotic disorders
US20060287335A1 (en) * 2000-11-28 2006-12-21 Wyeth Serotonergic agents for treating sexual dysfunction
US20060223824A1 (en) * 2000-11-28 2006-10-05 Wyeth Serotonergic agents
US6458802B1 (en) 2001-03-14 2002-10-01 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline
US6803368B2 (en) 2001-04-25 2004-10-12 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diaza-cyclopenta[a]naphthalene
US6821981B2 (en) 2001-04-26 2004-11-23 Wyeth Azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]-quinoline as 5-HT1A antagonists
EP1381612A1 (en) * 2001-04-26 2004-01-21 Wyeth Antidepressant aza-heterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline
ES2247327T3 (es) * 2001-04-26 2006-03-01 Wyeth Derivados azaheterociclimetilicos antidepresivos (isrs) de 7,8-dihidro-3h-6,9-dioxa-1,3-diazaciclopenta(a) naftaleno.
US6861434B2 (en) * 2001-04-26 2005-03-01 Wyeth Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one
US6927226B2 (en) 2001-04-26 2005-08-09 Wyeth Antidepressant azaheterocyclymethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalene
US6800641B2 (en) 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene
US6800648B2 (en) 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one
ES2269678T3 (es) * 2001-04-26 2007-04-01 Wyeth Derivados azaheterociclilmetilicos antidepresivos de 2,3-dihidro-1,4-dioxino (2,3f) quinolaxina.
US7008944B2 (en) * 2001-04-26 2006-03-07 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-Dioxino[2,3-f]quinoxaline
US6861427B2 (en) * 2001-04-26 2005-03-01 Wyeth Azabicyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinoline as 5-HT1A antagonists
US6800642B2 (en) 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-2,6,9-trioxa-3-aza-cyclopenta[a]naphthalene
US6555560B2 (en) 2001-04-30 2003-04-29 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
US6906206B2 (en) 2001-04-30 2005-06-14 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
CN1247590C (zh) * 2001-05-17 2006-03-29 惠氏公司 2,3－二氢－1,4－二氧芑并[2,3－f]喹啉衍生物的合成方法
US6541502B1 (en) 2001-07-20 2003-04-01 Wyeth 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity
US6541501B2 (en) 2001-07-20 2003-04-01 Wyeth 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity
WO2003010169A1 (en) * 2001-07-25 2003-02-06 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 7, 8-dihydro-6h-5-oxa-1-aza-phenanthrene
US7135479B2 (en) 2002-09-12 2006-11-14 Wyeth Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
US6800637B2 (en) * 2002-09-12 2004-10-05 Wyeth Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
US6939877B2 (en) * 2002-09-12 2005-09-06 Wyeth Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
US7153849B2 (en) * 2002-09-12 2006-12-26 Wyeth Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans
CN100352820C (zh) * 2002-09-12 2007-12-05 惠氏公司 抗抑郁的杂环稠合的苯并二噁烷的氮杂环甲基衍生物
TW200517106A (en) * 2003-10-29 2005-06-01 Wyeth Corp Sustained release pharmaceutical compositions
KR100823805B1 (ko) * 2004-05-05 2008-04-21 에프. 호프만-라 로슈 아게 5-ｈｔ6 수용체, 5-ｈｔ2ａ 수용체 또는 둘다를 조절하기에유용한 아릴설포닐 벤조다이옥산
EP1856126A2 (en) 2005-02-17 2007-11-21 Wyeth a Corporation of the State of Delaware Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
CN101137648A (zh) * 2005-03-01 2008-03-05 惠氏公司 结晶和非晶4－氰基－n－{(2r)－2－[4－(2,3－二氢－苯并[1,4]二氧杂环己烯－5－基)－哌嗪－1－基]－丙基}－n－吡啶－2－基－苯甲酰胺盐酸盐
MX2007012882A (es) * 2005-04-22 2007-12-10 Wyeth Corp Nuevas combinaciones terapeuticas para el tratamiento o prevencion de la depresion.
TW200811182A (en) * 2006-05-25 2008-03-01 Wyeth Corp Oxindoledioxans, synthesis thereof, and intermediates thereto
WO2008118935A1 (en) * 2007-03-26 2008-10-02 Neurogen Corporation Compounds and processes for preparing substituted aminomethyl-2,3,8,9-tetrahydro-7h-1,4-dioxino[2,3-e]indol-8-ones
JP5755217B2 (ja) * 2009-03-30 2015-07-29 トランステック・ファーマ，エルエルシー 置換アゾアントラセン誘導体、その医薬組成物とその使用の方法
RU2554883C1 (ru) * 2014-05-27 2015-06-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) Применение производных ацеталей пиридоксина в качестве антагонистов пуринорецепторов
RU2554885C1 (ru) * 2014-05-27 2015-06-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) Антагонисты пуринорецепторов на основе новых производных пиридоксина

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991013872A1 (en) * 1990-03-15 1991-09-19 The Upjohn Company Therapeutically useful heterocyclic indole compounds
US5189171A (en) * 1991-06-21 1993-02-23 American Home Products Corporation Antipsychotic benzodioxan derivatives
US5126366A (en) * 1991-06-21 1992-06-30 American Home Products Corporation Aminophenoxyalkyl derivatives of benzodioxan
US5166367A (en) * 1991-06-21 1992-11-24 American Home Products Corporation Antipsychotic benzodioxan derivatives
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
US5235055A (en) * 1992-09-02 1993-08-10 American Home Products Corporation Antipsychotic quinoline derivatives of benzodioxanmethylamine
US5245051A (en) * 1992-09-03 1993-09-14 American Home Products Corporation Antipsychotic chroman derivatives of benzodioxanmethylamine

Also Published As

Publication number Publication date
NO964686L (no) 1997-05-07
KR100566678B1 (ko) 2006-11-30
DE69636801T2 (de) 2007-04-26
CZ291731B6 (cs) 2003-05-14
HUP9603057A3 (en) 1998-12-28
DE69636801D1 (de) 2007-02-08
US5756532A (en) 1998-05-26
IL119565A0 (en) 1997-03-18
CN1155546A (zh) 1997-07-30
EP1375503A1 (en) 2004-01-02
JP4311770B2 (ja) 2009-08-12
EP0771800A2 (en) 1997-05-07
HUP9603057A2 (en) 1997-05-28
US5962465A (en) 1999-10-05
PT1375503E (pt) 2007-03-30
CZ324196A3 (en) 1997-12-17
IL119565A (en) 2002-11-10
AU7055396A (en) 1997-05-15
JPH09249671A (ja) 1997-09-22
CN1084748C (zh) 2002-05-15
ES2277014T3 (es) 2007-07-01
SK282168B6 (sk) 2001-11-06
EP0771800A3 (en) 1998-01-28
NO964686D0 (no) 1996-11-05
MX9605367A (es) 1997-10-31
CA2189524C (en) 2007-05-01
AR025698A1 (es) 2002-12-11
AU701624B2 (en) 1999-02-04
AR004284A1 (es) 1998-11-04
ATE349450T1 (de) 2007-01-15
EP1726592A1 (en) 2006-11-29
NO317054B1 (no) 2004-08-02
CA2189524A1 (en) 1997-05-07
SK141496A3 (en) 1997-08-06
HU224841B1 (en) 2006-03-28
KR970027068A (ko) 1997-06-24
RU2178416C2 (ru) 2002-01-20
HU9603057D0 (en) 1996-12-30
EP1375503B1 (en) 2006-12-27
NZ299693A (en) 1997-09-22

Similar Documents

Publication Publication Date Title
DK1375503T3 (da) Dioxinoderivater og deres anvendelse som dopaminagonister
DK0847388T3 (da) Heterocyklisk substituerede biphenylamidderivater, fremstilling heraf og anvendelse heraf som fungicider
NO992725D0 (no) 6-Fenylpyridyl-2-amin-derivater anvendelige som NOS-inhibitorer
DK0906292T3 (da) Triazolylmercaptider og deres anvendelse som mikrobicider
NO961432D0 (no) Benzofiofener og beslektede forbindelser som östrogen-agonister
NO975740L (no) Arylsulfonylaminobenzenderivater og deres anvendelse som faktor Xa-inhibitorer
IS6385A (is) Ný notkun og nýjar N-asabísýkló-amíð afleiður
NO982802L (no) Nye 5-amino-3-cyano-4-etylsulfinyl-1-fenyl-pyrazol-forbindelser og deres anvendelse som pesticider
DK0832061T3 (da) Benzamidderivater og anvendelse deraf som vasopressin-antagonister
DK0516349T3 (da) 2-hydroxy-2-phenylethylamin-derivater som beta-3-adrenoceptoragonister
DK1119557T3 (da) Indeno-, naphto- og benzocyclohepta-dihydrothiazolderivater, fremstilling deraf og anvendelse deraf som anorektiske medikamenter
DK1006110T3 (da) Derivater af acylpiperazinylpyrimidiner, fremstilling deraf og anvendelse som lægemidler
NO984761D0 (no) Aminoisokinoliner og aminotienopyridinderivater og deres anvendelse som antiinflammatoriske midler
DK0736525T3 (da) Benzonitriler som 5-HT-agonister og -antagonister
NO971811D0 (no) Bicykliske tetrahydropyrazolopyridiner og deres anvendelse som legemidler
NO20011157D0 (no) Benzenderivater og farmasøytisk anvendelse derav
NO996115D0 (no) Azetidinylpropylpiperidin-derivater, intermediater og anvendelse som tachykinin-antagonister
FI962969A7 (fi) Indolijohdannaisia 5-HT1:n agonisteina
NO995513D0 (no) N-triazolyl-2-indolkarboksamider og deres anvendelse som CCK-A agonister
NO994510L (no) Substituerte isokinolin-derivater og deres anvendelse som antikonvulsanter
NO985891D0 (no) Substituerte benzamid-derivater og deres anvendelse som antikonvulsjonsmidler
DK0755386T3 (da) Benzamid-derivater, sammensætninger indeholdende nævnte derivat og anvendelse deraf
DK0747346T3 (da) N-acyl-2-arylcyclopropylmethylaminderivater som melatonerge midler
DK0833820T3 (da) Benzisoxazol- og indazolderivater som antipsykotiske midler
DK1214302T3 (da) Substituerede 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-oner og deres anvendelse som lipasehæmmere