DK1399138T3 - Fremgangsmåde til fremstilling af faste formuleringer af natrium-3-hydroxy-3-methylbutyrat - Google Patents

Fremgangsmåde til fremstilling af faste formuleringer af natrium-3-hydroxy-3-methylbutyrat

Info

Publication number: DK1399138T3
Authority: DK; Denmark
Prior art keywords: methylbutyrate; hydroxy; sodium; solid formulations; preparation
Prior art date: 2001-05-18

Application number

DK02743039T

Other languages

Danish (da)

English (en)

Inventor

Brigitta Heyl-Frank

Heike Irle

Daniel Pianzola

Barry Jackson

Uwe Zacher

Original Assignee

Lonza Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-18

Filing date

2002-05-17

Publication date

2006-04-24

2002-05-17 Application filed by Lonza Ag filed Critical Lonza Ag

2006-04-24 Application granted granted Critical

2006-04-24 Publication of DK1399138T3 publication Critical patent/DK1399138T3/da

Links

238000000034 method Methods 0.000 title abstract 3
CPRWZXWNQXUOOJ-UHFFFAOYSA-M sodium;3-hydroxy-3-methylbutanoate Chemical compound [Na+].CC(C)(O)CC([O-])=O CPRWZXWNQXUOOJ-UHFFFAOYSA-M 0.000 title abstract 3
238000009472 formulation Methods 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
239000007787 solid Substances 0.000 title abstract 2
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
WHBGXDGQNOAWLX-UHFFFAOYSA-N 4,4-dimethyloxetan-2-one Chemical compound CC1(C)CC(=O)O1 WHBGXDGQNOAWLX-UHFFFAOYSA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000377 silicon dioxide Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Hematology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Fodder In General (AREA)
Fats And Perfumes (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

DK02743039T 2001-05-18 2002-05-17 Fremgangsmåde til fremstilling af faste formuleringer af natrium-3-hydroxy-3-methylbutyrat DK1399138T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP01112236		2001-05-18

Publications (1)

Publication Number	Publication Date
DK1399138T3 true DK1399138T3 (da)	2006-04-24

Family

ID=8177477

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02743039T DK1399138T3 (da)	2001-05-18	2002-05-17	Fremgangsmåde til fremstilling af faste formuleringer af natrium-3-hydroxy-3-methylbutyrat

Country Status (16)

Country	Link
US (1)	US7026507B2 (cs)
EP (1)	EP1399138B1 (cs)
JP (1)	JP4166580B2 (cs)
CN (1)	CN100542525C (cs)
AT (1)	ATE317259T1 (cs)
AU (1)	AU2002338953B2 (cs)
BR (1)	BR0209820A (cs)
CA (1)	CA2447417C (cs)
CZ (1)	CZ302823B6 (cs)
DE (1)	DE50205794D1 (cs)
DK (1)	DK1399138T3 (cs)
ES (1)	ES2257559T3 (cs)
HU (1)	HUP0400080A3 (cs)
MX (1)	MXPA03010610A (cs)
PL (1)	PL367221A1 (cs)
WO (1)	WO2002094255A1 (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0402118D0 (en)	2004-01-30	2004-03-03	Merck Sharp & Dohme	Polymorphic forms of a GABAA agonist
EP1848420A4 (en)	2005-01-28	2008-01-23	Merck & Co Inc	POLYMORPH SHAPES OF A GABAA AGONIST
CN103479584A (zh) *	2008-05-02	2014-01-01	吉里德科学公司	固体载体颗粒在改善药物制剂加工性中的应用
EP2295593A1 (en) *	2009-09-15	2011-03-16	Philippe Marliere	Method for the enymatic production of 3-hydroxy-3-methylbutyric acid from acetone and acetyl-CoA
WO2012140276A2 (en) *	2011-11-17	2012-10-18	Lonza Ltd	Process for the preparation of 3-hydroxy-3-methylbutyric acid or its calcium salts
KR20180088809A (ko)	2015-11-19	2018-08-07	가부시키가이샤 오츠카 세이야쿠 코죠	3-히드록시이소발레르산의 1가 양이온염의 결정 및 그 결정의 제조 방법
EP3476825A4 (en)	2016-06-24	2020-02-26	Kyowa Hakko Bio Co., Ltd.	CRYSTAL OF BETA-HYDROXY-BETA-METHYLBUTTERIC ACID-AMINO ACID SALT AND PRODUCTION METHOD THEREFOR
WO2019016883A1 (ja) *	2017-07-19	2019-01-24	小林香料株式会社	３－ヒドロキシ－３－メチルブタン酸又はその塩の製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2142314C (en) *	1992-09-16	1999-06-01	Steven L. Nissen	Method of reducing blood levels of total cholesterol and low-density lipoprotein cholesterol
US5348979A (en)	1992-12-23	1994-09-20	Iowa State University Research Foundation Inc.	Method of promoting nitrogen retention in humans
US6090978A (en) *	1996-07-19	2000-07-18	Met-Rx Usa, Inc.	Process for manufacturing 3-hydroxy-3-methylbutanoic acid
AU6495298A (en)	1997-02-10	1998-08-26	Lonza A.G.	Process for preparing 3-hydroxy-3-methylbutyric acid or its salts
EP1109798B1 (en) *	1998-09-03	2005-10-12	Firmenich Sa	Geranic acid derivatives

2002
- 2002-05-17 WO PCT/EP2002/005435 patent/WO2002094255A1/de not_active Ceased
- 2002-05-17 MX MXPA03010610A patent/MXPA03010610A/es active IP Right Grant
- 2002-05-17 DE DE50205794T patent/DE50205794D1/de not_active Expired - Lifetime
- 2002-05-17 HU HU0400080A patent/HUP0400080A3/hu unknown
- 2002-05-17 ES ES02743039T patent/ES2257559T3/es not_active Expired - Lifetime
- 2002-05-17 DK DK02743039T patent/DK1399138T3/da active
- 2002-05-17 EP EP02743039A patent/EP1399138B1/de not_active Expired - Lifetime
- 2002-05-17 BR BR0209820-2A patent/BR0209820A/pt not_active IP Right Cessation
- 2002-05-17 CN CNB028135997A patent/CN100542525C/zh not_active Expired - Fee Related
- 2002-05-17 JP JP2002590973A patent/JP4166580B2/ja not_active Expired - Fee Related
- 2002-05-17 US US10/478,054 patent/US7026507B2/en not_active Expired - Fee Related
- 2002-05-17 AU AU2002338953A patent/AU2002338953B2/en not_active Ceased
- 2002-05-17 PL PL02367221A patent/PL367221A1/xx not_active Application Discontinuation
- 2002-05-17 CA CA2447417A patent/CA2447417C/en not_active Expired - Fee Related
- 2002-05-17 CZ CZ20032965A patent/CZ302823B6/cs not_active IP Right Cessation
- 2002-05-17 AT AT02743039T patent/ATE317259T1/de active

Also Published As

Publication number	Publication date
CA2447417A1 (en)	2002-11-28
JP2004536065A (ja)	2004-12-02
HK1068813A1 (en)	2005-05-06
EP1399138A1 (de)	2004-03-24
CN100542525C (zh)	2009-09-23
HUP0400080A3 (en)	2004-10-28
CN1523983A (zh)	2004-08-25
AU2002338953C1 (en)	2002-12-03
WO2002094255A1 (de)	2002-11-28
EP1399138B1 (de)	2006-02-08
CZ302823B6 (cs)	2011-11-30
US20040143136A1 (en)	2004-07-22
ES2257559T3 (es)	2006-08-01
PL367221A1 (en)	2005-02-21
US7026507B2 (en)	2006-04-11
CA2447417C (en)	2011-10-04
CZ20032965A3 (cs)	2004-02-18
HUP0400080A2 (hu)	2004-05-28
ATE317259T1 (de)	2006-02-15
MXPA03010610A (es)	2004-04-02
DE50205794D1 (de)	2006-04-20
JP4166580B2 (ja)	2008-10-15
BR0209820A (pt)	2004-06-01
AU2002338953B2 (en)	2006-06-29

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