DK1399458T3 - Fremgangsmåde til arylering af funktionaliserede O-allyl-erythromycin-derivater - Google Patents

Fremgangsmåde til arylering af funktionaliserede O-allyl-erythromycin-derivater

Info

Publication number: DK1399458T3
Authority: DK; Denmark
Prior art keywords: erythromycin; heck reaction; derivative; alkenylaryl; arylating
Prior art date: 2001-05-30

Application number

DK02741957T

Other languages

English (en)

Inventor

Weijiang Zhang

Margaret Chi-Ping Hsu

Anthony R Haight

Matthew John Peterson

Bikshandarkoil A Narayanan

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-30

Filing date

2002-05-21

Publication date

2005-12-12

2002-05-21 Application filed by Abbott Lab filed Critical Abbott Lab

2005-12-12 Application granted granted Critical

2005-12-12 Publication of DK1399458T3 publication Critical patent/DK1399458T3/da

Links

238000000034 method Methods 0.000 title abstract 5
238000007341 Heck reaction Methods 0.000 abstract 4
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
238000006254 arylation reaction Methods 0.000 abstract 2
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
229910052763 palladium Inorganic materials 0.000 abstract 1
229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
230000035484 reaction time Effects 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK02741957T 2001-05-30 2002-05-21 Fremgangsmåde til arylering af funktionaliserede O-allyl-erythromycin-derivater DK1399458T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US29432601P	2001-05-30	2001-05-30

Publications (1)

Publication Number	Publication Date
DK1399458T3 true DK1399458T3 (da)	2005-12-12

Family

ID=23132927

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02741957T DK1399458T3 (da)	2001-05-30	2002-05-21	Fremgangsmåde til arylering af funktionaliserede O-allyl-erythromycin-derivater

Country Status (15)

Country	Link
US (1)	US7071314B2 (da)
EP (1)	EP1399458B1 (da)
JP (1)	JP2004536075A (da)
KR (1)	KR20040014537A (da)
CN (1)	CN100422201C (da)
AT (1)	ATE301128T1 (da)
BR (1)	BR0206106A (da)
CA (1)	CA2449173A1 (da)
DE (1)	DE60205377T2 (da)
DK (1)	DK1399458T3 (da)
ES (1)	ES2246403T3 (da)
IL (1)	IL159004A0 (da)
MX (1)	MXPA03010939A (da)
TW (1)	TWI246515B (da)
WO (1)	WO2002096922A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2629077C (en) *	2005-11-16	2014-03-18	F. Hoffmann-La Roche Ag	Novel process for the preparation of thoc
US7595300B2 (en) *	2005-12-13	2009-09-29	Kosan Biosciences Incorporated	7-quinolyl ketolide antibacterial agents
WO2009019868A1 (ja)	2007-08-06	2009-02-12	Taisho Pharmaceutical Co., Ltd.	１０ａ、１２位架橋型１０ａ－アザライド化合物
WO2009139181A1 (ja)	2008-05-15	2009-11-19	大正製薬株式会社	４員環構造を有する１０ａ－アザライド化合物
KR200457752Y1 (ko) *	2008-12-02	2012-01-02	다폰 일렉트로닉스 코퍼레이션	변압기 및 백라이트 장치
CN102766181A (zh) *	2011-05-06	2012-11-07	上海医药工业研究院	6-o-取代的红霉素衍生物的制备方法
CN116715628B (zh) *	2023-06-15	2025-09-02	中国科学技术大学	一种喹啉取代的高烯丙胺类化合物的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4331803A (en)	1980-06-04	1982-05-25	Taisho Pharmaceutical Co., Ltd.	Novel erythromycin compounds
JPS5896097A (ja)	1981-12-01	1983-06-07	Taisho Pharmaceut Co Ltd	エリスロマイシンｂ誘導体
US5872229A (en)	1995-11-21	1999-02-16	Abbott Laboratories	Process for 6-O-alkylation of erythromycin derivatives
WO1997042204A1 (en)	1996-05-07	1997-11-13	Abbott Laboratories	6-o-substituted erythromycins and method for making them
UA51730C2 (uk)	1996-09-04	2002-12-16	Ебботт Лабораторіз	6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
ZA987689B (en) *	1997-09-02	1999-02-24	Abbott Lab	3-descladinose 6-O substituted erythromycin derivatives
US6124269A (en)	1997-10-29	2000-09-26	Abbott Laboratories	2-Halo-6-O-substituted ketolide derivatives
US5932710A (en)	1997-12-01	1999-08-03	Abbott Laboratories	Process for preparing 6-O-alkyl-9-oxime erythromycin B
IL135792A0 (en)	1997-12-01	2001-05-20	Abbott Lab	6-o-alkyl derivatives of erythronolide b
US6040440A (en)	1998-03-06	2000-03-21	Abbott Laboratories	Hypophosphite deoxygenation reactions in the synthesis of erythromycin derivatives
ES2222189T3 (es) *	1999-03-15	2005-02-01	Abbott Laboratories	Macrolidos sustituidos en 6-o con una actividad antibacteriana.
US6437106B1 (en) *	1999-06-24	2002-08-20	Abbott Laboratories	Process for preparing 6-o-substituted erythromycin derivatives

2002
- 2002-05-20 TW TW091110509A patent/TWI246515B/zh not_active IP Right Cessation
- 2002-05-21 KR KR10-2003-7015640A patent/KR20040014537A/ko not_active Ceased
- 2002-05-21 IL IL15900402A patent/IL159004A0/xx unknown
- 2002-05-21 ES ES02741957T patent/ES2246403T3/es not_active Expired - Lifetime
- 2002-05-21 DK DK02741957T patent/DK1399458T3/da active
- 2002-05-21 CA CA002449173A patent/CA2449173A1/en not_active Abandoned
- 2002-05-21 EP EP02741957A patent/EP1399458B1/en not_active Expired - Lifetime
- 2002-05-21 AT AT02741957T patent/ATE301128T1/de not_active IP Right Cessation
- 2002-05-21 MX MXPA03010939A patent/MXPA03010939A/es active IP Right Grant
- 2002-05-21 JP JP2003500101A patent/JP2004536075A/ja active Pending
- 2002-05-21 BR BR0206106-6A patent/BR0206106A/pt not_active IP Right Cessation
- 2002-05-21 DE DE60205377T patent/DE60205377T2/de not_active Expired - Fee Related
- 2002-05-21 WO PCT/US2002/018348 patent/WO2002096922A1/en not_active Ceased
- 2002-05-21 CN CNB028149688A patent/CN100422201C/zh not_active Expired - Fee Related
- 2002-05-28 US US10/156,404 patent/US7071314B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATE301128T1 (de)	2005-08-15
EP1399458A1 (en)	2004-03-24
TWI246515B (en)	2006-01-01
ES2246403T3 (es)	2006-02-16
DE60205377D1 (de)	2005-09-08
BR0206106A (pt)	2003-10-14
MXPA03010939A (es)	2004-02-27
US7071314B2 (en)	2006-07-04
CN100422201C (zh)	2008-10-01
EP1399458B1 (en)	2005-08-03
JP2004536075A (ja)	2004-12-02
KR20040014537A (ko)	2004-02-14
IL159004A0 (en)	2004-05-12
CA2449173A1 (en)	2002-12-05
DE60205377T2 (de)	2006-05-24
CN1633443A (zh)	2005-06-29
HK1064390A1 (en)	2005-01-28
WO2002096922A1 (en)	2002-12-05
US20030125531A1 (en)	2003-07-03

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