ATE301128T1 - Verfahren zur arylierung von funktionalisierten o-allyl erythromycin derivaten - Google Patents
Verfahren zur arylierung von funktionalisierten o-allyl erythromycin derivatenInfo
- Publication number
- ATE301128T1 ATE301128T1 AT02741957T AT02741957T ATE301128T1 AT E301128 T1 ATE301128 T1 AT E301128T1 AT 02741957 T AT02741957 T AT 02741957T AT 02741957 T AT02741957 T AT 02741957T AT E301128 T1 ATE301128 T1 AT E301128T1
- Authority
- AT
- Austria
- Prior art keywords
- arylation
- erythromycin
- heck reaction
- derivative
- alkenylaryl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 238000006254 arylation reaction Methods 0.000 title abstract 3
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title abstract 2
- 238000007341 Heck reaction Methods 0.000 abstract 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- 230000035484 reaction time Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29432601P | 2001-05-30 | 2001-05-30 | |
| PCT/US2002/018348 WO2002096922A1 (en) | 2001-05-30 | 2002-05-21 | An arylation method for the functionalization of o-allyl erythromycin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE301128T1 true ATE301128T1 (de) | 2005-08-15 |
Family
ID=23132927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02741957T ATE301128T1 (de) | 2001-05-30 | 2002-05-21 | Verfahren zur arylierung von funktionalisierten o-allyl erythromycin derivaten |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7071314B2 (de) |
| EP (1) | EP1399458B1 (de) |
| JP (1) | JP2004536075A (de) |
| KR (1) | KR20040014537A (de) |
| CN (1) | CN100422201C (de) |
| AT (1) | ATE301128T1 (de) |
| BR (1) | BR0206106A (de) |
| CA (1) | CA2449173A1 (de) |
| DE (1) | DE60205377T2 (de) |
| DK (1) | DK1399458T3 (de) |
| ES (1) | ES2246403T3 (de) |
| IL (1) | IL159004A0 (de) |
| MX (1) | MXPA03010939A (de) |
| TW (1) | TWI246515B (de) |
| WO (1) | WO2002096922A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101309903B (zh) * | 2005-11-16 | 2012-10-03 | 弗·哈夫曼-拉罗切有限公司 | 制备thoc的新方法 |
| US7595300B2 (en) * | 2005-12-13 | 2009-09-29 | Kosan Biosciences Incorporated | 7-quinolyl ketolide antibacterial agents |
| WO2009019868A1 (ja) | 2007-08-06 | 2009-02-12 | Taisho Pharmaceutical Co., Ltd. | １０ａ、１２位架橋型１０ａ－アザライド化合物 |
| EP2287173A4 (de) | 2008-05-15 | 2013-06-19 | Taisho Pharmaceutical Co Ltd | 10a-azalidverbindung mit 4-gliedriger ringstruktur |
| KR200457752Y1 (ko) * | 2008-12-02 | 2012-01-02 | 다폰 일렉트로닉스 코퍼레이션 | 변압기 및 백라이트 장치 |
| CN102766181A (zh) * | 2011-05-06 | 2012-11-07 | 上海医药工业研究院 | 6-o-取代的红霉素衍生物的制备方法 |
| CN116715628B (zh) * | 2023-06-15 | 2025-09-02 | 中国科学技术大学 | 一种喹啉取代的高烯丙胺类化合物的合成方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331803A (en) | 1980-06-04 | 1982-05-25 | Taisho Pharmaceutical Co., Ltd. | Novel erythromycin compounds |
| JPS5896097A (ja) | 1981-12-01 | 1983-06-07 | Taisho Pharmaceut Co Ltd | エリスロマイシンｂ誘導体 |
| US5872229A (en) | 1995-11-21 | 1999-02-16 | Abbott Laboratories | Process for 6-O-alkylation of erythromycin derivatives |
| JP2000509712A (ja) | 1996-05-07 | 2000-08-02 | アボツト・ラボラトリーズ | ６―ｏ―置換エリスロマイシン及びその製造方法 |
| UA51730C2 (uk) | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
| ZA987689B (en) * | 1997-09-02 | 1999-02-24 | Abbott Lab | 3-descladinose 6-O substituted erythromycin derivatives |
| US6124269A (en) | 1997-10-29 | 2000-09-26 | Abbott Laboratories | 2-Halo-6-O-substituted ketolide derivatives |
| IL135792A0 (en) | 1997-12-01 | 2001-05-20 | Abbott Lab | 6-o-alkyl derivatives of erythronolide b |
| US5932710A (en) | 1997-12-01 | 1999-08-03 | Abbott Laboratories | Process for preparing 6-O-alkyl-9-oxime erythromycin B |
| US6040440A (en) | 1998-03-06 | 2000-03-21 | Abbott Laboratories | Hypophosphite deoxygenation reactions in the synthesis of erythromycin derivatives |
| KR20020008127A (ko) * | 1999-03-15 | 2002-01-29 | 스티븐 에프. 웨인스톡 | 항균 활성을 갖는 6-ｏ-치환된 매크롤라이드 |
| US6437106B1 (en) * | 1999-06-24 | 2002-08-20 | Abbott Laboratories | Process for preparing 6-o-substituted erythromycin derivatives |
-
2002
- 2002-05-20 TW TW091110509A patent/TWI246515B/zh not_active IP Right Cessation
- 2002-05-21 DK DK02741957T patent/DK1399458T3/da active
- 2002-05-21 MX MXPA03010939A patent/MXPA03010939A/es active IP Right Grant
- 2002-05-21 ES ES02741957T patent/ES2246403T3/es not_active Expired - Lifetime
- 2002-05-21 IL IL15900402A patent/IL159004A0/xx unknown
- 2002-05-21 JP JP2003500101A patent/JP2004536075A/ja active Pending
- 2002-05-21 DE DE60205377T patent/DE60205377T2/de not_active Expired - Fee Related
- 2002-05-21 EP EP02741957A patent/EP1399458B1/de not_active Expired - Lifetime
- 2002-05-21 AT AT02741957T patent/ATE301128T1/de not_active IP Right Cessation
- 2002-05-21 CA CA002449173A patent/CA2449173A1/en not_active Abandoned
- 2002-05-21 WO PCT/US2002/018348 patent/WO2002096922A1/en not_active Ceased
- 2002-05-21 CN CNB028149688A patent/CN100422201C/zh not_active Expired - Fee Related
- 2002-05-21 BR BR0206106-6A patent/BR0206106A/pt not_active IP Right Cessation
- 2002-05-21 KR KR10-2003-7015640A patent/KR20040014537A/ko not_active Ceased
- 2002-05-28 US US10/156,404 patent/US7071314B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040014537A (ko) | 2004-02-14 |
| HK1064390A1 (en) | 2005-01-28 |
| BR0206106A (pt) | 2003-10-14 |
| EP1399458B1 (de) | 2005-08-03 |
| IL159004A0 (en) | 2004-05-12 |
| TWI246515B (en) | 2006-01-01 |
| MXPA03010939A (es) | 2004-02-27 |
| CN1633443A (zh) | 2005-06-29 |
| CA2449173A1 (en) | 2002-12-05 |
| US20030125531A1 (en) | 2003-07-03 |
| WO2002096922A1 (en) | 2002-12-05 |
| US7071314B2 (en) | 2006-07-04 |
| CN100422201C (zh) | 2008-10-01 |
| DE60205377T2 (de) | 2006-05-24 |
| DE60205377D1 (de) | 2005-09-08 |
| DK1399458T3 (da) | 2005-12-12 |
| ES2246403T3 (es) | 2006-02-16 |
| JP2004536075A (ja) | 2004-12-02 |
| EP1399458A1 (de) | 2004-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1399458 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |