DK1400245T3 - Borsyresalte anvendelige til parenterale formuleringer til selektiv thrombininhibering - Google Patents

Borsyresalte anvendelige til parenterale formuleringer til selektiv thrombininhibering

Info

Publication number: DK1400245T3
Authority: DK; Denmark
Prior art keywords: boric acid; acid salts; parenteral formulations; salts useful; thrombin inhibition
Prior art date: 2002-09-09

Application number

DK03255590T

Other languages

Danish (da)

English (en)

Inventor

David Jonathan Madge

Mark Dolman

Sophie-Marie Combe-Marzelle

Anthony James Kennedy

Sanjay Kumar Kakkar

John Joseph Deadman

Armin Walter

Alfred Olbrich

Dieter Krimmer

Andrea Maria Th Weiland-Weibel

Original Assignee

Trigen Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-09

Filing date

2003-09-09

Publication date

2006-08-28

2002-09-09 Priority claimed from GB0220764A external-priority patent/GB0220764D0/en

2002-09-09 Priority claimed from GB0220822A external-priority patent/GB0220822D0/en

2003-04-04 Priority claimed from GB0307817A external-priority patent/GB0307817D0/en

2003-05-16 Priority claimed from GB0311237A external-priority patent/GB0311237D0/en

2003-07-04 Priority claimed from GB0315691A external-priority patent/GB0315691D0/en

2003-09-09 Application filed by Trigen Ltd filed Critical Trigen Ltd

2006-08-28 Application granted granted Critical

2006-08-28 Publication of DK1400245T3 publication Critical patent/DK1400245T3/da

Links

238000009472 formulation Methods 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
108090000190 Thrombin Proteins 0.000 title 1
KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical class OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 title 1
230000005764 inhibitory process Effects 0.000 title 1
229960004072 thrombin Drugs 0.000 title 1
-1 boronate anions Chemical class 0.000 abstract 2
208000007536 Thrombosis Diseases 0.000 abstract 1
150000008064 anhydrides Chemical class 0.000 abstract 1
230000002785 anti-thrombosis Effects 0.000 abstract 1
ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 abstract 1
125000005620 boronic acid group Chemical class 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
229910021645 metal ion Inorganic materials 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Hematology (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK03255590T 2002-09-09 2003-09-09 Borsyresalte anvendelige til parenterale formuleringer til selektiv thrombininhibering DK1400245T3 (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
GB0220764A GB0220764D0 (en)	2002-09-09	2002-09-09	Boropeptides
GB0220822A GB0220822D0 (en)	2002-09-09	2002-09-09	Boropeptides
GB0307817A GB0307817D0 (en)	2003-04-04	2003-04-04	Boronic acid compounds
GB0311237A GB0311237D0 (en)	2003-05-16	2003-05-16	Boronic acid compounds
GB0315691A GB0315691D0 (en)	2003-07-04	2003-07-04	Boropeptides
US48578603P	2003-07-08	2003-07-08

Publications (1)

Publication Number	Publication Date
DK1400245T3 true DK1400245T3 (da)	2006-08-28

Family

ID=31721886

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK03255629T DK1396270T3 (da)	2002-09-09	2003-09-09	Borsyresalte
DK03255590T DK1400245T3 (da)	2002-09-09	2003-09-09	Borsyresalte anvendelige til parenterale formuleringer til selektiv thrombininhibering

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK03255629T DK1396270T3 (da)	2002-09-09	2003-09-09	Borsyresalte

Country Status (19)

Country	Link
EP (8)	EP1561466A3 (de)
JP (3)	JP2006509034A (de)
KR (2)	KR20050057295A (de)
CN (2)	CN100447151C (de)
AT (3)	ATE324899T1 (de)
AU (3)	AU2003263343A1 (de)
BR (1)	BR0314450A (de)
CA (3)	CA2535792A1 (de)
CY (1)	CY1105381T1 (de)
DE (3)	DE60304956T2 (de)
DK (2)	DK1396270T3 (de)
ES (2)	ES2264515T3 (de)
IL (1)	IL167294A (de)
MX (2)	MXPA05002661A (de)
NZ (2)	NZ539333A (de)
PL (2)	PL376439A1 (de)
PT (1)	PT1396270E (de)
SI (2)	SI1396270T1 (de)
WO (3)	WO2004022070A1 (de)

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GB0405267D0 (en) *	2004-03-09	2004-04-21	Trigen Ltd	Compounds
GB0405272D0 (en) *	2004-03-09	2004-04-21	Trigen Ltd	Compounds
GB0405280D0 (en) *	2004-03-09	2004-04-21	Trigen Ltd	Compounds
AR049384A1 (es)	2004-05-24	2006-07-26	Glaxo Group Ltd	Derivados de purina
WO2006059082A1 (en) *	2004-11-30	2006-06-08	Trigen Limited	Oxidised lipids as reversal agents for boronic acid drugs
GB0514809D0 (en)	2005-07-19	2005-08-24	Glaxo Group Ltd	Compounds
GB0515003D0 (en) *	2005-07-21	2005-08-31	Univ Aston	Medical devices and coatings therefor
US7261742B2 (en)	2005-10-13	2007-08-28	S.C. Johnson & Son, Inc.	Method of deodorizing a textile
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WO2009139864A2 (en) *	2008-05-13	2009-11-19	The Regents Of The University Of California	Fluorescence detection of poison oak oil
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WO2014172627A1 (en)	2013-04-19	2014-10-23	Thomas Jefferson University	Caveolin-1 related methods for treating glioblastoma with temozolomide
JP6662865B2 (ja) *	2014-10-01	2020-03-11	メルクパテントゲゼルシャフトミットベシュレンクテルハフツングＭｅｒｃｋＰａｔｅｎｔＧｅｓｅｌｌｓｃｈａｆｔｍｉｔｂｅｓｃｈｒａｅｎｋｔｅｒＨａｆｔｕｎｇ	ボロン酸誘導体
JP7164521B2 (ja)	2016-06-21	2022-11-01	オリオン・オフサルモロジー・エルエルシー	炭素環式プロリンアミド誘導体
HUE064412T2 (hu)	2016-06-21	2024-03-28	Orion Ophthalmology LLC	Heterociklusos prolinamid-származékok
CN109187155B (zh) *	2018-07-27	2021-08-13	临沂大学	一种水样中有效硼的提取纯化方法和一种硼同位素组成的测试方法
KR102104507B1 (ko) *	2019-08-23	2020-04-24	브릿지바이오테라퓨틱스(주)	팔미토일-l-프롤릴-l-프롤릴-글리실-l-타이로신 나트륨을 포함하는 약제학적 제제 및 이의 제조방법
CN116940580A (zh) *	2021-03-05	2023-10-24	Ａｇｃ株式会社	化合物、化合物的制造方法及表面处理剂的制造方法
CN113121666B (zh) *	2021-03-10	2023-09-12	厦门大学	抗菌肽Scybaumancin105-127及其应用
CN114106346B (zh) *	2021-10-29	2023-04-18	重庆第二师范学院	一种稀土双金属电致化学发光材料及其制备方法和应用

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2003
- 2003-09-09 CA CA002535792A patent/CA2535792A1/en not_active Abandoned
- 2003-09-09 DE DE60304956T patent/DE60304956T2/de not_active Expired - Lifetime
- 2003-09-09 CN CNB038213907A patent/CN100447151C/zh not_active Expired - Fee Related
- 2003-09-09 EP EP04076548A patent/EP1561466A3/de not_active Withdrawn
- 2003-09-09 PT PT03255629T patent/PT1396270E/pt unknown
- 2003-09-09 JP JP2004569793A patent/JP2006509034A/ja active Pending
- 2003-09-09 EP EP03255629A patent/EP1396270B1/de not_active Expired - Lifetime
- 2003-09-09 PL PL03376439A patent/PL376439A1/xx unknown
- 2003-09-09 EP EP06113409A patent/EP1695711A3/de not_active Withdrawn
- 2003-09-09 JP JP2004569795A patent/JP2006511593A/ja active Pending
- 2003-09-09 EP EP04076521A patent/EP1466917A1/de not_active Withdrawn
- 2003-09-09 SI SI200330344T patent/SI1396270T1/sl unknown
- 2003-09-09 AT AT03255590T patent/ATE324899T1/de not_active IP Right Cessation
- 2003-09-09 NZ NZ539333A patent/NZ539333A/en unknown
- 2003-09-09 WO PCT/GB2003/003883 patent/WO2004022070A1/en not_active Ceased
- 2003-09-09 WO PCT/GB2003/003897 patent/WO2004022072A1/en not_active Ceased
- 2003-09-09 DE DE60317039T patent/DE60317039T2/de not_active Expired - Lifetime
- 2003-09-09 EP EP04076510A patent/EP1466916B1/de not_active Expired - Lifetime
- 2003-09-09 ES ES03255590T patent/ES2264515T3/es not_active Expired - Lifetime
- 2003-09-09 MX MXPA05002661A patent/MXPA05002661A/es active IP Right Grant
- 2003-09-09 AT AT04076510T patent/ATE376551T1/de not_active IP Right Cessation
- 2003-09-09 DE DE60305113T patent/DE60305113T2/de not_active Expired - Lifetime
- 2003-09-09 CA CA002536010A patent/CA2536010A1/en not_active Abandoned
- 2003-09-09 SI SI200330345T patent/SI1400245T1/sl unknown
- 2003-09-09 KR KR1020057004077A patent/KR20050057295A/ko not_active Ceased
- 2003-09-09 BR BR0314450-0A patent/BR0314450A/pt not_active IP Right Cessation
- 2003-09-09 NZ NZ539334A patent/NZ539334A/en not_active IP Right Cessation
- 2003-09-09 WO PCT/GB2003/003887 patent/WO2004022071A1/en not_active Ceased
- 2003-09-09 KR KR1020057004076A patent/KR20050057294A/ko not_active Ceased
- 2003-09-09 CA CA002535788A patent/CA2535788A1/en not_active Abandoned
- 2003-09-09 CN CNB038214032A patent/CN100553639C/zh not_active Expired - Fee Related
- 2003-09-09 AU AU2003263343A patent/AU2003263343A1/en not_active Abandoned
- 2003-09-09 EP EP06113648A patent/EP1695712A3/de not_active Withdrawn
- 2003-09-09 EP EP03255590A patent/EP1400245B1/de not_active Expired - Lifetime
- 2003-09-09 AT AT03255629T patent/ATE325611T1/de not_active IP Right Cessation
- 2003-09-09 ES ES03255629T patent/ES2263924T3/es not_active Expired - Lifetime
- 2003-09-09 JP JP2004569794A patent/JP2006503903A/ja active Pending
- 2003-09-09 DK DK03255629T patent/DK1396270T3/da active
- 2003-09-09 AU AU2003263333A patent/AU2003263333A1/en not_active Abandoned
- 2003-09-09 DK DK03255590T patent/DK1400245T3/da active
- 2003-09-09 MX MXPA05002662A patent/MXPA05002662A/es not_active Application Discontinuation
- 2003-09-09 AU AU2003263328A patent/AU2003263328A1/en not_active Abandoned
- 2003-09-09 PL PL376535A patent/PL376535A1/pl unknown
- 2003-09-09 EP EP03255604A patent/EP1396269A1/de not_active Withdrawn
2005
- 2005-03-07 IL IL167294A patent/IL167294A/en not_active IP Right Cessation
2006
- 2006-07-03 CY CY20061100903T patent/CY1105381T1/el unknown

Also Published As

Publication number	Publication date
EP1400245A1 (de)	2004-03-24
HK1063154A1 (en)	2004-12-17
AU2003263333A1 (en)	2004-03-29
JP2006509034A (ja)	2006-03-16
EP1396270B1 (de)	2006-05-10
JP2006503903A (ja)	2006-02-02
ES2263924T3 (es)	2006-12-16
BR0314450A (pt)	2005-07-26
EP1695711A2 (de)	2006-08-30
WO2004022070A1 (en)	2004-03-18
WO2004022071A1 (en)	2004-03-18
EP1396269A1 (de)	2004-03-10
CN100447151C (zh)	2008-12-31
NZ539333A (en)	2007-02-23
MXPA05002662A (es)	2005-09-20
CN1681517A (zh)	2005-10-12
EP1695712A3 (de)	2008-01-09
EP1466916A1 (de)	2004-10-13
DK1396270T3 (da)	2006-08-28
CN100553639C (zh)	2009-10-28
EP1561466A2 (de)	2005-08-10
CA2535788A1 (en)	2004-03-18
EP1400245B1 (de)	2006-05-03
ATE376551T1 (de)	2007-11-15
EP1561466A3 (de)	2006-08-23
EP1466917A1 (de)	2004-10-13
CN1684693A (zh)	2005-10-19
MXPA05002661A (es)	2005-08-19
PL376535A1 (pl)	2006-01-09
KR20050057295A (ko)	2005-06-16
JP2006511593A (ja)	2006-04-06
EP1466916B1 (de)	2007-10-24
DE60317039D1 (de)	2007-12-06
IL167294A (en)	2008-11-03
CA2536010A1 (en)	2004-03-18
CA2535792A1 (en)	2004-03-18
DE60304956T2 (de)	2007-01-25
EP1695712A2 (de)	2006-08-30
EP1695711A3 (de)	2008-01-02
DE60304956D1 (de)	2006-06-08
CY1105381T1 (el)	2010-07-28
AU2003263343A1 (en)	2004-03-29
SI1400245T1 (sl)	2006-10-31
DE60305113T2 (de)	2006-12-07
ATE325611T1 (de)	2006-06-15
PT1396270E (pt)	2006-08-31
SI1396270T1 (sl)	2006-10-31
KR20050057294A (ko)	2005-06-16
DE60305113D1 (de)	2006-06-14
ATE324899T1 (de)	2006-06-15
AU2003263328A1 (en)	2004-03-29
DE60317039T2 (de)	2008-07-31
WO2004022072A1 (en)	2004-03-18
PL376439A1 (en)	2005-12-27
NZ539334A (en)	2007-11-30
ES2264515T3 (es)	2007-01-01
EP1396270A1 (de)	2004-03-10

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DK1400245T3 (da)	2006-08-28	Borsyresalte anvendelige til parenterale formuleringer til selektiv thrombininhibering
WO2004032909A3 (en)	2004-07-01	Stabilized pharmaceutical composition containing basic excipients
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NZ337211A (en)	2000-12-22	Method of treating inflammatory, HIV diseases by using peptidyl boronic acid ester and acid compounds as proteasome inhibitors
BR0212042A (pt)	2004-08-17	Composto, composição farmacêutica, método de tratamento ou prevenção de doenças, e, uso de um composto
NO20042161L (no)	2004-08-17	Inhibitorer av 11-beta-hydroksysteroid dehydrogenase type 1
NO20051695L (no)	2005-04-05	Nye spirokondenserte kinazolinoner og deres anvendelse som fosfodiestereaseinbibitorer
BR0309342A (pt)	2005-02-15	Composto, composição farmacêutica, uso de um composto, e, método de tratamento ou profilaxia de doenças ou condições humanas
IS7839A (is)	2004-05-23	4-oxó-1-(3-setið fenýl-1,4-díhýdró-1,8-naftýridín-3-karboxamíð fosfódíesterasa-4 hindrar
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SE9803773D0 (sv)	1998-11-05	Compounds
AU2001246999A1 (en)	2001-10-23	New neurokinin antagonists for use as medicaments
SE0102057D0 (sv)	2001-06-08	New Salts I
EP1219296A4 (de)	2004-12-01	Mittel zur hemmung der sebumproduktion
DK0937043T3 (da)	2002-06-10	Substituerede tetrahydropyridin-derivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse derivater
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ATE286395T1 (de)	2005-01-15	Antithrombotische mittel
NO20022000L (no)	2002-06-27	6-metoksy-2-naftyleddiksyre-prodrogesammensetninger til behandling av inflammasjon
AU2001244999A1 (en)	2001-10-23	Naphthamide neurokinin antagonists for use as medicaments
SE0004827D0 (sv)	2000-12-22	Therapeutic compounds
WO2002018363A3 (en)	2002-06-27	3-phenyl-propanoic acid derivatives as protein tyrosine phosphatase inhibitors
CO5271692A1 (es)	2003-04-30	Agentes terapeuticos
DE60014915D1 (de)	2004-11-18	Hypoxanthin- und thiohypxanthin-verbindungen