ATE324899T1 - In parenteralen formulierungen für die selektive thrombininhibierung verwendbare borsäuresalze - Google Patents

In parenteralen formulierungen für die selektive thrombininhibierung verwendbare borsäuresalze

Info

Publication number: ATE324899T1
Authority: AT; Austria
Prior art keywords: boric acid; acid salts; parenteral formulations; thrombin inhibition; salts usable
Prior art date: 2002-09-09

Application number

AT03255590T

Other languages

English (en)

Inventor

David Jonathan Madge

Mark Dolman

Sophie-Marie Combe-Marzelle

Anthony James Kennedy

Sanjay Kumar Kakkar

John Joseph Deadman

Armin Walter

Alfred Olbrich

Dieter Krimmer

Andrea Maria Th Weiland-Weibel

Original Assignee

Trigen Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-09

Filing date

2003-09-09

Publication date

2006-06-15

2002-09-09 Priority claimed from GB0220764A external-priority patent/GB0220764D0/en

2002-09-09 Priority claimed from GB0220822A external-priority patent/GB0220822D0/en

2003-04-04 Priority claimed from GB0307817A external-priority patent/GB0307817D0/en

2003-05-16 Priority claimed from GB0311237A external-priority patent/GB0311237D0/en

2003-07-04 Priority claimed from GB0315691A external-priority patent/GB0315691D0/en

2003-09-09 Application filed by Trigen Ltd filed Critical Trigen Ltd

2006-06-15 Application granted granted Critical

2006-06-15 Publication of ATE324899T1 publication Critical patent/ATE324899T1/de

Links

239000000203 mixture Substances 0.000 title abstract 2
108090000190 Thrombin Proteins 0.000 title 1
KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical class OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 title 1
230000005764 inhibitory process Effects 0.000 title 1
229960004072 thrombin Drugs 0.000 title 1
-1 boronate anions Chemical class 0.000 abstract 2
208000007536 Thrombosis Diseases 0.000 abstract 1
150000008064 anhydrides Chemical class 0.000 abstract 1
230000002785 anti-thrombosis Effects 0.000 abstract 1
ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 abstract 1
125000005620 boronic acid group Chemical class 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
229910021645 metal ion Inorganic materials 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Hematology (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT03255590T 2002-09-09 2003-09-09 In parenteralen formulierungen für die selektive thrombininhibierung verwendbare borsäuresalze ATE324899T1 (de)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
GB0220764A GB0220764D0 (en)	2002-09-09	2002-09-09	Boropeptides
GB0220822A GB0220822D0 (en)	2002-09-09	2002-09-09	Boropeptides
GB0307817A GB0307817D0 (en)	2003-04-04	2003-04-04	Boronic acid compounds
GB0311237A GB0311237D0 (en)	2003-05-16	2003-05-16	Boronic acid compounds
GB0315691A GB0315691D0 (en)	2003-07-04	2003-07-04	Boropeptides
US48578603P	2003-07-08	2003-07-08

Publications (1)

Publication Number	Publication Date
ATE324899T1 true ATE324899T1 (de)	2006-06-15

Family

ID=31721886

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT03255629T ATE325611T1 (de)	2002-09-09	2003-09-09	Borsäuresalze und deren verwendung in der bereitstellung von medikamente für die thrombosebehandlung
AT04076510T ATE376551T1 (de)	2002-09-09	2003-09-09	Peptidborsäuren und deren verwendung in der herstellung von salzen derselben
AT03255590T ATE324899T1 (de)	2002-09-09	2003-09-09	In parenteralen formulierungen für die selektive thrombininhibierung verwendbare borsäuresalze

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
AT03255629T ATE325611T1 (de)	2002-09-09	2003-09-09	Borsäuresalze und deren verwendung in der bereitstellung von medikamente für die thrombosebehandlung
AT04076510T ATE376551T1 (de)	2002-09-09	2003-09-09	Peptidborsäuren und deren verwendung in der herstellung von salzen derselben

Country Status (19)

Country	Link
EP (8)	EP1695711A3 (de)
JP (3)	JP2006509034A (de)
KR (2)	KR20050057294A (de)
CN (2)	CN100447151C (de)
AT (3)	ATE325611T1 (de)
AU (3)	AU2003263328A1 (de)
BR (1)	BR0314450A (de)
CA (3)	CA2536010A1 (de)
CY (1)	CY1105381T1 (de)
DE (3)	DE60305113T2 (de)
DK (2)	DK1396270T3 (de)
ES (2)	ES2263924T3 (de)
IL (1)	IL167294A (de)
MX (2)	MXPA05002661A (de)
NZ (2)	NZ539334A (de)
PL (2)	PL376439A1 (de)
PT (1)	PT1396270E (de)
SI (2)	SI1400245T1 (de)
WO (3)	WO2004022072A1 (de)

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GB0405272D0 (en) *	2004-03-09	2004-04-21	Trigen Ltd	Compounds
GB0405267D0 (en) *	2004-03-09	2004-04-21	Trigen Ltd	Compounds
GB0405280D0 (en) *	2004-03-09	2004-04-21	Trigen Ltd	Compounds
PE20060272A1 (es)	2004-05-24	2006-05-22	Glaxo Group Ltd	(2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
WO2006059082A1 (en) *	2004-11-30	2006-06-08	Trigen Limited	Oxidised lipids as reversal agents for boronic acid drugs
GB0514809D0 (en)	2005-07-19	2005-08-24	Glaxo Group Ltd	Compounds
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AU2009318101A1 (en) *	2008-11-21	2010-05-27	Iroko Cardio Llc	Method for reducing thrombocytopenia and thrombocytopenia-associated mortality
EP2399129B1 (de)	2009-02-20	2015-11-25	Michael P. Lisanti	Verfahren zur diagnose bzw. prognose eines neoplasmas einschliesslich der bestimmung des expressionsgrads eines proteins in stromazellen neben dem neoplasma
CN101928329B (zh) *	2009-06-19	2013-07-17	北京大学	三肽硼酸(酯)类化合物、其制备方法和应用
GB2523211B (en)	2012-01-27	2020-03-18	Univ Jefferson	MCT protein inhibitor-related prognostic and therapeutic methods
EP2986290A4 (de)	2013-04-19	2017-01-04	Thomas Jefferson University	Caveolin-1-verwandte verfahren zur behandlung von glioblastom mit temozolomid
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JP7179721B2 (ja)	2016-06-21	2022-11-29	オリオン・オフサルモロジー・エルエルシー	複素環式プロリンアミド誘導体
JP7164521B2 (ja)	2016-06-21	2022-11-01	オリオン・オフサルモロジー・エルエルシー	炭素環式プロリンアミド誘導体
CN109187155B (zh) *	2018-07-27	2021-08-13	临沂大学	一种水样中有效硼的提取纯化方法和一种硼同位素组成的测试方法
KR102104507B1 (ko) *	2019-08-23	2020-04-24	브릿지바이오테라퓨틱스(주)	팔미토일-l-프롤릴-l-프롤릴-글리실-l-타이로신 나트륨을 포함하는 약제학적 제제 및 이의 제조방법
CN116940580A (zh) *	2021-03-05	2023-10-24	Ａｇｃ株式会社	化合物、化合物的制造方法及表面处理剂的制造方法
CN113121666B (zh) *	2021-03-10	2023-09-12	厦门大学	抗菌肽Scybaumancin105-127及其应用
CN114106346B (zh) *	2021-10-29	2023-04-18	重庆第二师范学院	一种稀土双金属电致化学发光材料及其制备方法和应用

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2003
- 2003-09-09 DE DE60305113T patent/DE60305113T2/de not_active Expired - Lifetime
- 2003-09-09 AT AT03255629T patent/ATE325611T1/de not_active IP Right Cessation
- 2003-09-09 BR BR0314450-0A patent/BR0314450A/pt not_active IP Right Cessation
- 2003-09-09 AU AU2003263328A patent/AU2003263328A1/en not_active Abandoned
- 2003-09-09 ES ES03255629T patent/ES2263924T3/es not_active Expired - Lifetime
- 2003-09-09 EP EP06113409A patent/EP1695711A3/de not_active Withdrawn
- 2003-09-09 AT AT04076510T patent/ATE376551T1/de not_active IP Right Cessation
- 2003-09-09 DE DE60317039T patent/DE60317039T2/de not_active Expired - Lifetime
- 2003-09-09 MX MXPA05002661A patent/MXPA05002661A/es active IP Right Grant
- 2003-09-09 KR KR1020057004076A patent/KR20050057294A/ko not_active Ceased
- 2003-09-09 PT PT03255629T patent/PT1396270E/pt unknown
- 2003-09-09 EP EP03255604A patent/EP1396269A1/de not_active Withdrawn
- 2003-09-09 PL PL03376439A patent/PL376439A1/xx unknown
- 2003-09-09 EP EP03255629A patent/EP1396270B1/de not_active Expired - Lifetime
- 2003-09-09 DK DK03255629T patent/DK1396270T3/da active
- 2003-09-09 PL PL376535A patent/PL376535A1/pl unknown
- 2003-09-09 MX MXPA05002662A patent/MXPA05002662A/es not_active Application Discontinuation
- 2003-09-09 WO PCT/GB2003/003897 patent/WO2004022072A1/en not_active Ceased
- 2003-09-09 CA CA002536010A patent/CA2536010A1/en not_active Abandoned
- 2003-09-09 NZ NZ539334A patent/NZ539334A/en not_active IP Right Cessation
- 2003-09-09 CN CNB038213907A patent/CN100447151C/zh not_active Expired - Fee Related
- 2003-09-09 EP EP04076510A patent/EP1466916B1/de not_active Expired - Lifetime
- 2003-09-09 EP EP06113648A patent/EP1695712A3/de not_active Withdrawn
- 2003-09-09 DE DE60304956T patent/DE60304956T2/de not_active Expired - Lifetime
- 2003-09-09 CN CNB038214032A patent/CN100553639C/zh not_active Expired - Fee Related
- 2003-09-09 JP JP2004569793A patent/JP2006509034A/ja active Pending
- 2003-09-09 WO PCT/GB2003/003887 patent/WO2004022071A1/en not_active Ceased
- 2003-09-09 EP EP04076521A patent/EP1466917A1/de not_active Withdrawn
- 2003-09-09 AT AT03255590T patent/ATE324899T1/de not_active IP Right Cessation
- 2003-09-09 DK DK03255590T patent/DK1400245T3/da active
- 2003-09-09 AU AU2003263343A patent/AU2003263343A1/en not_active Abandoned
- 2003-09-09 SI SI200330345T patent/SI1400245T1/sl unknown
- 2003-09-09 WO PCT/GB2003/003883 patent/WO2004022070A1/en not_active Ceased
- 2003-09-09 JP JP2004569795A patent/JP2006511593A/ja active Pending
- 2003-09-09 CA CA002535788A patent/CA2535788A1/en not_active Abandoned
- 2003-09-09 KR KR1020057004077A patent/KR20050057295A/ko not_active Ceased
- 2003-09-09 EP EP03255590A patent/EP1400245B1/de not_active Expired - Lifetime
- 2003-09-09 EP EP04076548A patent/EP1561466A3/de not_active Withdrawn
- 2003-09-09 JP JP2004569794A patent/JP2006503903A/ja active Pending
- 2003-09-09 SI SI200330344T patent/SI1396270T1/sl unknown
- 2003-09-09 NZ NZ539333A patent/NZ539333A/en unknown
- 2003-09-09 CA CA002535792A patent/CA2535792A1/en not_active Abandoned
- 2003-09-09 AU AU2003263333A patent/AU2003263333A1/en not_active Abandoned
- 2003-09-09 ES ES03255590T patent/ES2264515T3/es not_active Expired - Lifetime
2005
- 2005-03-07 IL IL167294A patent/IL167294A/en not_active IP Right Cessation
2006
- 2006-07-03 CY CY20061100903T patent/CY1105381T1/el unknown

Also Published As

Publication number	Publication date
EP1695711A2 (de)	2006-08-30
PL376535A1 (pl)	2006-01-09
WO2004022072A1 (en)	2004-03-18
IL167294A (en)	2008-11-03
DE60317039D1 (de)	2007-12-06
MXPA05002662A (es)	2005-09-20
EP1396270B1 (de)	2006-05-10
ES2264515T3 (es)	2007-01-01
CA2535792A1 (en)	2004-03-18
ATE325611T1 (de)	2006-06-15
NZ539333A (en)	2007-02-23
DE60317039T2 (de)	2008-07-31
MXPA05002661A (es)	2005-08-19
WO2004022070A1 (en)	2004-03-18
CN100553639C (zh)	2009-10-28
EP1400245A1 (de)	2004-03-24
JP2006503903A (ja)	2006-02-02
EP1396270A1 (de)	2004-03-10
EP1466916B1 (de)	2007-10-24
AU2003263328A1 (en)	2004-03-29
HK1063154A1 (en)	2004-12-17
DE60304956T2 (de)	2007-01-25
PL376439A1 (en)	2005-12-27
ES2263924T3 (es)	2006-12-16
CN1684693A (zh)	2005-10-19
KR20050057295A (ko)	2005-06-16
DK1396270T3 (da)	2006-08-28
CN100447151C (zh)	2008-12-31
EP1695712A2 (de)	2006-08-30
EP1466916A1 (de)	2004-10-13
EP1561466A3 (de)	2006-08-23
AU2003263333A1 (en)	2004-03-29
EP1466917A1 (de)	2004-10-13
EP1561466A2 (de)	2005-08-10
ATE376551T1 (de)	2007-11-15
CA2536010A1 (en)	2004-03-18
CN1681517A (zh)	2005-10-12
CY1105381T1 (el)	2010-07-28
NZ539334A (en)	2007-11-30
EP1400245B1 (de)	2006-05-03
SI1400245T1 (sl)	2006-10-31
JP2006509034A (ja)	2006-03-16
JP2006511593A (ja)	2006-04-06
PT1396270E (pt)	2006-08-31
KR20050057294A (ko)	2005-06-16
CA2535788A1 (en)	2004-03-18
DE60305113T2 (de)	2006-12-07
AU2003263343A1 (en)	2004-03-29
WO2004022071A1 (en)	2004-03-18
DK1400245T3 (da)	2006-08-28
DE60305113D1 (de)	2006-06-14
SI1396270T1 (sl)	2006-10-31
EP1695711A3 (de)	2008-01-02
EP1396269A1 (de)	2004-03-10
DE60304956D1 (de)	2006-06-08
BR0314450A (pt)	2005-07-26
EP1695712A3 (de)	2008-01-09

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