ATE376551T1 - Peptidborsäuren und deren verwendung in der herstellung von salzen derselben - Google Patents

Peptidborsäuren und deren verwendung in der herstellung von salzen derselben

Info

Publication number
ATE376551T1
ATE376551T1 AT04076510T AT04076510T ATE376551T1 AT E376551 T1 ATE376551 T1 AT E376551T1 AT 04076510 T AT04076510 T AT 04076510T AT 04076510 T AT04076510 T AT 04076510T AT E376551 T1 ATE376551 T1 AT E376551T1
Authority
AT
Austria
Prior art keywords
acids
formula
peptideboric
salts
production
Prior art date
Application number
AT04076510T
Other languages
English (en)
Inventor
David Jonathan Madge
Mark Dolman
Sophie Combe-Marzelle
John Deadman
Anthony Kennedy
Sanjay Kumar Kakkar
Armin Walter
Alfred Olbrich
Dieter Krimmer
Andrea Weiland-Weibel
Original Assignee
Trigen Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0220822A external-priority patent/GB0220822D0/en
Priority claimed from GB0220764A external-priority patent/GB0220764D0/en
Priority claimed from GB0307817A external-priority patent/GB0307817D0/en
Priority claimed from GB0311237A external-priority patent/GB0311237D0/en
Priority claimed from GB0315691A external-priority patent/GB0315691D0/en
Application filed by Trigen Ltd filed Critical Trigen Ltd
Application granted granted Critical
Publication of ATE376551T1 publication Critical patent/ATE376551T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT04076510T 2002-09-09 2003-09-09 Peptidborsäuren und deren verwendung in der herstellung von salzen derselben ATE376551T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0220822A GB0220822D0 (en) 2002-09-09 2002-09-09 Boropeptides
GB0220764A GB0220764D0 (en) 2002-09-09 2002-09-09 Boropeptides
GB0307817A GB0307817D0 (en) 2003-04-04 2003-04-04 Boronic acid compounds
GB0311237A GB0311237D0 (en) 2003-05-16 2003-05-16 Boronic acid compounds
GB0315691A GB0315691D0 (en) 2003-07-04 2003-07-04 Boropeptides
US48578603P 2003-07-08 2003-07-08

Publications (1)

Publication Number Publication Date
ATE376551T1 true ATE376551T1 (de) 2007-11-15

Family

ID=31721886

Family Applications (3)

Application Number Title Priority Date Filing Date
AT03255629T ATE325611T1 (de) 2002-09-09 2003-09-09 Borsäuresalze und deren verwendung in der bereitstellung von medikamente für die thrombosebehandlung
AT03255590T ATE324899T1 (de) 2002-09-09 2003-09-09 In parenteralen formulierungen für die selektive thrombininhibierung verwendbare borsäuresalze
AT04076510T ATE376551T1 (de) 2002-09-09 2003-09-09 Peptidborsäuren und deren verwendung in der herstellung von salzen derselben

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT03255629T ATE325611T1 (de) 2002-09-09 2003-09-09 Borsäuresalze und deren verwendung in der bereitstellung von medikamente für die thrombosebehandlung
AT03255590T ATE324899T1 (de) 2002-09-09 2003-09-09 In parenteralen formulierungen für die selektive thrombininhibierung verwendbare borsäuresalze

Country Status (19)

Country Link
EP (8) EP1396270B1 (de)
JP (3) JP2006509034A (de)
KR (2) KR20050057295A (de)
CN (2) CN100447151C (de)
AT (3) ATE325611T1 (de)
AU (3) AU2003263343A1 (de)
BR (1) BR0314450A (de)
CA (3) CA2535788A1 (de)
CY (1) CY1105381T1 (de)
DE (3) DE60317039T2 (de)
DK (2) DK1396270T3 (de)
ES (2) ES2263924T3 (de)
IL (1) IL167294A (de)
MX (2) MXPA05002662A (de)
NZ (2) NZ539334A (de)
PL (2) PL376439A1 (de)
PT (1) PT1396270E (de)
SI (2) SI1396270T1 (de)
WO (3) WO2004022070A1 (de)

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GB0405272D0 (en) * 2004-03-09 2004-04-21 Trigen Ltd Compounds
GB0405267D0 (en) * 2004-03-09 2004-04-21 Trigen Ltd Compounds
GB0405280D0 (en) * 2004-03-09 2004-04-21 Trigen Ltd Compounds
PE20060272A1 (es) 2004-05-24 2006-05-22 Glaxo Group Ltd (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
WO2006059082A1 (en) * 2004-11-30 2006-06-08 Trigen Limited Oxidised lipids as reversal agents for boronic acid drugs
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
GB0515003D0 (en) * 2005-07-21 2005-08-31 Univ Aston Medical devices and coatings therefor
US7261742B2 (en) 2005-10-13 2007-08-28 S.C. Johnson & Son, Inc. Method of deodorizing a textile
JP2010536875A (ja) * 2007-08-21 2010-12-02 アルザ・コーポレーシヨン ボロン酸化合物のリポソーム製剤
AU2008288917A1 (en) * 2007-08-21 2009-02-26 Alza Corporation Liposome compositions for in vivo administration of boronic acid compounds
US8389232B2 (en) * 2008-05-13 2013-03-05 The Regents Of The University Of California Fluorescence detection of poison oak oil
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WO2010059244A2 (en) * 2008-11-21 2010-05-27 Iroko Pharmaceuticals, Llc Method for reducing thrombocytopenia and thrombocytopenia-associated mortality
WO2010096574A1 (en) 2009-02-20 2010-08-26 Lisanti Michael P A method of diagnosis or prognosis of a neoplasm comprising determining the level of expression of a protein in stromal cells adjacent to the neoplasm
CN101928329B (zh) * 2009-06-19 2013-07-17 北京大学 三肽硼酸(酯)类化合物、其制备方法和应用
US10085987B2 (en) 2012-01-27 2018-10-02 Thomas Jefferson University MCT protein inhibitor-related prognostic and therapeutic methods
EP2986290A4 (de) 2013-04-19 2017-01-04 Thomas Jefferson University Caveolin-1-verwandte verfahren zur behandlung von glioblastom mit temozolomid
ES2761774T3 (es) * 2014-10-01 2020-05-21 Merck Patent Gmbh Derivados del ácido borónico
WO2017222914A1 (en) 2016-06-21 2017-12-28 Inception 4, Inc. Carbocyclic prolinamide derivatives
EP4257191A3 (de) 2016-06-21 2023-11-22 Orion Ophthalmology LLC Heterocyclische prolinamidderivate
CN109187155B (zh) * 2018-07-27 2021-08-13 临沂大学 一种水样中有效硼的提取纯化方法和一种硼同位素组成的测试方法
KR102104507B1 (ko) * 2019-08-23 2020-04-24 브릿지바이오테라퓨틱스(주) 팔미토일-l-프롤릴-l-프롤릴-글리실-l-타이로신 나트륨을 포함하는 약제학적 제제 및 이의 제조방법
JP7758028B2 (ja) * 2021-03-05 2025-10-22 Ａｇｃ株式会社 化合物、化合物の製造方法及び表面処理剤の製造方法
CN113121666B (zh) * 2021-03-10 2023-09-12 厦门大学 抗菌肽Scybaumancin105-127及其应用
CN114106346B (zh) * 2021-10-29 2023-04-18 重庆第二师范学院 一种稀土双金属电致化学发光材料及其制备方法和应用

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Also Published As

Publication number Publication date
EP1466916B1 (de) 2007-10-24
AU2003263343A1 (en) 2004-03-29
EP1396269A1 (de) 2004-03-10
DE60304956T2 (de) 2007-01-25
ATE325611T1 (de) 2006-06-15
CA2535792A1 (en) 2004-03-18
EP1400245B1 (de) 2006-05-03
CN1684693A (zh) 2005-10-19
EP1561466A2 (de) 2005-08-10
CN100447151C (zh) 2008-12-31
JP2006509034A (ja) 2006-03-16
WO2004022072A1 (en) 2004-03-18
EP1695711A3 (de) 2008-01-02
NZ539334A (en) 2007-11-30
DE60305113D1 (de) 2006-06-14
IL167294A (en) 2008-11-03
CY1105381T1 (el) 2010-07-28
EP1695711A2 (de) 2006-08-30
ES2263924T3 (es) 2006-12-16
PL376439A1 (en) 2005-12-27
SI1400245T1 (sl) 2006-10-31
DK1400245T3 (da) 2006-08-28
DK1396270T3 (da) 2006-08-28
ATE324899T1 (de) 2006-06-15
AU2003263328A1 (en) 2004-03-29
AU2003263333A1 (en) 2004-03-29
MXPA05002662A (es) 2005-09-20
PT1396270E (pt) 2006-08-31
ES2264515T3 (es) 2007-01-01
CA2536010A1 (en) 2004-03-18
EP1400245A1 (de) 2004-03-24
SI1396270T1 (sl) 2006-10-31
EP1396270B1 (de) 2006-05-10
DE60305113T2 (de) 2006-12-07
JP2006503903A (ja) 2006-02-02
CA2535788A1 (en) 2004-03-18
DE60317039T2 (de) 2008-07-31
DE60317039D1 (de) 2007-12-06
PL376535A1 (pl) 2006-01-09
HK1063154A1 (en) 2004-12-17
WO2004022070A1 (en) 2004-03-18
NZ539333A (en) 2007-02-23
CN100553639C (zh) 2009-10-28
MXPA05002661A (es) 2005-08-19
EP1695712A2 (de) 2006-08-30
WO2004022071A1 (en) 2004-03-18
JP2006511593A (ja) 2006-04-06
EP1396270A1 (de) 2004-03-10
EP1466917A1 (de) 2004-10-13
EP1466916A1 (de) 2004-10-13
EP1695712A3 (de) 2008-01-09
EP1561466A3 (de) 2006-08-23
CN1681517A (zh) 2005-10-12
DE60304956D1 (de) 2006-06-08
KR20050057295A (ko) 2005-06-16
KR20050057294A (ko) 2005-06-16
BR0314450A (pt) 2005-07-26

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