DK1401438T3 - Anvendelse af cyclopamin i behandlingen af basalt cellecarcinom og andre tumorer - Google Patents

Anvendelse af cyclopamin i behandlingen af basalt cellecarcinom og andre tumorer

Info

Publication number: DK1401438T3
Authority: DK; Denmark
Prior art keywords: cyclopamine; treatment; tumors; cell carcinoma; basal cell
Prior art date: 2001-07-02

Application number

DK01952097T

Other languages

English (en)

Inventor

Sinan Tas

Oktay Avci

Original Assignee

Sinan Tas

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-02

Filing date

2001-07-02

Publication date

2006-02-13

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21619326&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1401438(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-07-02 Application filed by Sinan Tas filed Critical Sinan Tas

2006-02-13 Application granted granted Critical

2006-02-13 Publication of DK1401438T3 publication Critical patent/DK1401438T3/da

Links

QASFUMOKHFSJGL-LAFRSMQTSA-N Cyclopamine Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H](CC2=C3C)[C@@H]1[C@@H]2CC[C@@]13O[C@@H]2C[C@H](C)CN[C@H]2[C@H]1C QASFUMOKHFSJGL-LAFRSMQTSA-N 0.000 title abstract 3
206010028980 Neoplasm Diseases 0.000 title abstract 3
QASFUMOKHFSJGL-UHFFFAOYSA-N cyclopamine Natural products C1C=C2CC(O)CCC2(C)C(CC2=C3C)C1C2CCC13OC2CC(C)CNC2C1C QASFUMOKHFSJGL-UHFFFAOYSA-N 0.000 title abstract 3
206010004146 Basal cell carcinoma Diseases 0.000 title 1
241000027355 Ferocactus setispinus Species 0.000 abstract 2
230000006907 apoptotic process Effects 0.000 abstract 2
230000011664 signaling Effects 0.000 abstract 2
210000004881 tumor cell Anatomy 0.000 abstract 2
230000008034 disappearance Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Cosmetics (AREA)
Medicines Containing Plant Substances (AREA)

DK01952097T 2001-07-02 2001-07-02 Anvendelse af cyclopamin i behandlingen af basalt cellecarcinom og andre tumorer DK1401438T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/TR2001/000027 WO2002078703A1 (en)	2001-07-02	2001-07-02	Use of cyclopamine in the treatment of basal cell carcinoma and other tumors

Publications (1)

Publication Number	Publication Date
DK1401438T3 true DK1401438T3 (da)	2006-02-13

Family

ID=21619326

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK01952097T DK1401438T3 (da)	2001-07-02	2001-07-02	Anvendelse af cyclopamin i behandlingen af basalt cellecarcinom og andre tumorer
DK02736467T DK1411938T3 (da)	2001-07-02	2002-04-19	Anvendelse af cyclopamin til fremstilling af et medikament til behandling af psoriasis

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK02736467T DK1411938T3 (da)	2001-07-02	2002-04-19	Anvendelse af cyclopamin til fremstilling af et medikament til behandling af psoriasis

Country Status (14)

Country	Link
EP (4)	EP2862570A1 (da)
JP (3)	JP2004536045A (da)
KR (1)	KR20090125833A (da)
CN (2)	CN1525859B (da)
AT (2)	ATE305300T1 (da)
AU (1)	AU2001272892B8 (da)
BR (1)	BR0117063A (da)
CA (1)	CA2452151C (da)
DE (2)	DE60113733T2 (da)
DK (2)	DK1401438T3 (da)
ES (3)	ES2534400T3 (da)
PT (1)	PT1411938E (da)
RU (1)	RU2312661C2 (da)
WO (2)	WO2002078703A1 (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6984522B2 (en)	2000-08-03	2006-01-10	Regents Of The University Of Michigan	Isolation and use of solid tumor stem cells
US8044259B2 (en)	2000-08-03	2011-10-25	The Regents Of The University Of Michigan	Determining the capability of a test compound to affect solid tumor stem cells
EP2862570A1 (en) *	2001-07-02	2015-04-22	Sinan Tas	Use of cyclopamine in the treatment of basal cell carcinoma and other tumors
EP1411938B1 (en) *	2001-07-02	2005-07-06	Tas, Sinan	Use of cyclopamine for the manufacture of a medicament for the treatemnt of psoriasis
US20170326118A1 (en)	2001-07-02	2017-11-16	Sinan Tas	Drug treatment of tumors wherein hedgehog/smoothened signaling is utilized for inhibition of apoptosis of tumor cells
US8653083B2 (en)	2005-08-22	2014-02-18	The Johns Hopkins University	Hedgehog pathway antagonists to treat disease
EP2511298B1 (en)	2005-10-31	2019-01-16	Oncomed Pharmaceuticals, Inc.	Compositions and Methods for Treating Cancer based on human FZD receptors
US7723477B2 (en)	2005-10-31	2010-05-25	Oncomed Pharmaceuticals, Inc.	Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
WO2008070357A2 (en) *	2006-10-31	2008-06-12	Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Smoothened polypeptides and methods of use
TWI433674B (zh)	2006-12-28	2014-04-11	Infinity Discovery Inc	環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
WO2008092002A2 (en)	2007-01-24	2008-07-31	The Regents Of The University Of Michigan	Compositions and methods for treating and diagnosing pancreatic cancer
WO2008109184A1 (en) *	2007-03-07	2008-09-12	Infinity Pharmaceuticals, Inc.	Heterocyclic cyclopamine analogs and methods of use thereof
JP2010520310A (ja) *	2007-03-07	2010-06-10	インフィニティ・ディスカバリー・インコーポレイテッド	シクロパミンラクタム類似体及びその使用方法
CN104059124A (zh)	2007-12-27	2014-09-24	无限药品股份有限公司	立体选择性还原的方法
CN101990542A (zh) *	2008-02-08	2011-03-23	德克萨斯大学董事会	环巴胺酒石酸盐及其用途
TWI506037B (zh)	2008-09-26	2015-11-01	Oncomed Pharm Inc	捲曲結合劑類及彼等之用途
US20110275576A1 (en) *	2009-01-06	2011-11-10	Utah State University	Carbohydrate-Cyclopamine Conjugates as Anticancer Agents
JP2009143963A (ja) *	2009-03-25	2009-07-02	Sinan Tas	腫瘍細胞のアポトーシスを阻害するためにヘッジホッグ／スムーズンド信号を使用する腫瘍を治療するための製薬組成物
JP6141015B2 (ja)	2009-08-05	2017-06-07	インフィニティファーマスーティカルズ、インク．	シクロパミン類似体の酵素によるアミノ基転移
TWI535445B (zh)	2010-01-12	2016-06-01	安可美德藥物股份有限公司	Ｗｎｔ拮抗劑及治療和篩選方法
WO2011123785A2 (en)	2010-04-01	2011-10-06	Oncomed Pharmaceuticals, Inc.	Frizzled-binding agents and uses thereof
US9376447B2 (en)	2010-09-14	2016-06-28	Infinity Pharmaceuticals, Inc.	Transfer hydrogenation of cyclopamine analogs
EP2911691B1 (en)	2012-10-23	2018-10-10	OncoMed Pharmaceuticals, Inc.	Methods of treating neuroendocrine tumors using wnt pathway-binding agents
JP2016510411A (ja)	2013-02-04	2016-04-07	オンコメッドファーマシューティカルズインコーポレイテッド	Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング
US9168300B2 (en)	2013-03-14	2015-10-27	Oncomed Pharmaceuticals, Inc.	MET-binding agents and uses thereof
WO2015096654A1 (zh) *	2013-12-26	2015-07-02	中国科学院上海生命科学研究院	Shh信号通路特异性抑制剂的应用
HRP20251395T1 (hr)	2015-06-04	2026-02-13	Sol-Gel Technologies Ltd.	Topikalne formulacije za isporuku spojeva inhibitora hedgehog signalnog puta i njihova uporaba
US20170231968A1 (en) *	2016-02-11	2017-08-17	PellePharm, Inc.	Method for relief of and treatment of pruritus
CN117940170A (zh)	2021-09-13	2024-04-26	辛南·塔斯	有效干预人类衰老和衰老疾病及其效果
CN114292279B (zh) *	2022-01-07	2023-05-09	吉林省农业科学院	一种藜芦抗癌有效成分环杷明提取与分离方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5851993A (en) *	1994-06-13	1998-12-22	Biotie Therapies Ltd.	Suppression of tumor cell growth by syndecan-1 ectodomain
CA2326654C (en) *	1998-04-09	2010-11-09	Johns Hopkins University School Of Medicine	Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways
RU2232758C2 (ru) *	1998-09-23	2004-07-20	Рисерч Дивелопмент Фаундейшн	Токоферолы, токотриенолы и другие производные хромана и боковых цепей и способы лечения с их использованием
US6291516B1 (en) *	1999-01-13	2001-09-18	Curis, Inc.	Regulators of the hedgehog pathway, compositions and uses related thereto
ES2233383T3 (es) *	1999-06-08	2005-06-16	Lorantis Limited	Utilizacion terapeutica de un ihibidor de la via de señalizacion hedgehog.
CA2386190C (en) *	1999-10-13	2009-04-14	Johns Hopkins University School Of Medicine	Regulators of the hedgehog pathway, compositions and uses related thereto
AU1935801A (en) *	1999-11-30	2001-06-12	Curis, Inc.	Methods and compositions for regulating lymphocyte activity
CU23175A1 (es) *	2000-07-17	2006-09-22	Ct De Investigacion Y Desarrol	Formulacion liposomica de propionato de clobetasol
EP1411938B1 (en) *	2001-07-02	2005-07-06	Tas, Sinan	Use of cyclopamine for the manufacture of a medicament for the treatemnt of psoriasis
EP2862570A1 (en) *	2001-07-02	2015-04-22	Sinan Tas	Use of cyclopamine in the treatment of basal cell carcinoma and other tumors

2001
- 2001-07-02 EP EP20140196071 patent/EP2862570A1/en not_active Withdrawn
- 2001-07-02 DK DK01952097T patent/DK1401438T3/da active
- 2001-07-02 EP EP05008758A patent/EP1561464A3/en not_active Withdrawn
- 2001-07-02 ES ES10163813.8T patent/ES2534400T3/es not_active Expired - Lifetime
- 2001-07-02 AU AU2001272892A patent/AU2001272892B8/en not_active Ceased
- 2001-07-02 EP EP01952097A patent/EP1401438B1/en not_active Revoked
- 2001-07-02 CN CN018234429A patent/CN1525859B/zh not_active Expired - Fee Related
- 2001-07-02 ES ES01952097T patent/ES2250434T3/es not_active Expired - Lifetime
- 2001-07-02 AT AT01952097T patent/ATE305300T1/de not_active IP Right Cessation
- 2001-07-02 WO PCT/TR2001/000027 patent/WO2002078703A1/en not_active Ceased
- 2001-07-02 EP EP10163813.8A patent/EP2216022B1/en not_active Expired - Lifetime
- 2001-07-02 JP JP2002576969A patent/JP2004536045A/ja active Pending
- 2001-07-02 BR BR0117063-5A patent/BR0117063A/pt active Search and Examination
- 2001-07-02 CA CA2452151A patent/CA2452151C/en not_active Expired - Fee Related
- 2001-07-02 DE DE60113733T patent/DE60113733T2/de not_active Expired - Lifetime
2002
- 2002-04-19 PT PT02736467T patent/PT1411938E/pt unknown
- 2002-04-19 ES ES02736467T patent/ES2246011T3/es not_active Expired - Lifetime
- 2002-04-19 AT AT02736467T patent/ATE299022T1/de not_active IP Right Cessation
- 2002-04-19 WO PCT/TR2002/000017 patent/WO2002078704A1/en not_active Ceased
- 2002-04-19 RU RU2004103074/15A patent/RU2312661C2/ru not_active IP Right Cessation
- 2002-04-19 DK DK02736467T patent/DK1411938T3/da active
- 2002-04-19 DE DE60204966T patent/DE60204966T2/de not_active Expired - Lifetime
- 2002-04-19 CN CNB02813429XA patent/CN1230169C/zh not_active Expired - Fee Related
2003
- 2003-03-17 KR KR1020097022024A patent/KR20090125833A/ko not_active Ceased
2010
- 2010-02-10 JP JP2010028010A patent/JP5424923B2/ja not_active Expired - Fee Related
2013
- 2013-09-18 JP JP2013193304A patent/JP2014028834A/ja not_active Ceased

Also Published As

Publication number	Publication date
CA2452151C (en)	2012-01-03
EP1401438B1 (en)	2005-09-28
EP1401438A1 (en)	2004-03-31
PT1411938E (pt)	2005-11-30
DE60204966T2 (de)	2006-05-18
WO2002078703A1 (en)	2002-10-10
CN1525859B (zh)	2010-05-05
JP2014028834A (ja)	2014-02-13
DK1411938T3 (da)	2005-11-07
DE60113733T2 (de)	2006-06-29
WO2002078703A8 (en)	2003-06-12
EP2216022A1 (en)	2010-08-11
ES2250434T3 (es)	2006-04-16
EP2862570A1 (en)	2015-04-22
AU2001272892B8 (en)	2006-05-04
ATE299022T1 (de)	2005-07-15
WO2002078704A1 (en)	2002-10-10
DE60204966D1 (de)	2005-08-11
EP1561464A2 (en)	2005-08-10
RU2312661C2 (ru)	2007-12-20
CN1230169C (zh)	2005-12-07
EP2216022B1 (en)	2015-01-07
CN1522146A (zh)	2004-08-18
EP1561464A3 (en)	2007-04-25
DE60113733D1 (de)	2006-02-09
BR0117063A (pt)	2004-07-27
ES2534400T3 (es)	2015-04-22
ATE305300T1 (de)	2005-10-15
CA2452151A1 (en)	2002-10-10
RU2004103074A (ru)	2005-05-10
KR20090125833A (ko)	2009-12-07
ES2246011T3 (es)	2006-02-01
JP2010132691A (ja)	2010-06-17
JP5424923B2 (ja)	2014-02-26
AU2001272892B2 (en)	2006-03-16
JP2004536045A (ja)	2004-12-02
CN1525859A (zh)	2004-09-01

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BR0117063A (pt)	2004-07-27	Uso de ciclopamina no tratamento de carcinoma de células basais e outros tumores
DK1196172T3 (da)	2006-06-19	(S,S)-reboxetin til behandling af kronisk smerte
MA26973A1 (fr)	2004-12-20	Activateurs glucokinase isoindolin-1-one
NZ544472A (en)	2009-04-30	Compounds and therapeutical use thereof
EP1535610A4 (en)	2008-12-31	THERAPEUTIC CANCER
ATE408601T1 (de)	2008-10-15	Fredericamycin-derivate
IL142674A0 (en)	2002-03-10	Use of paclitaxel stabilized with albumin for preparing a drug for the treatment of solid tumors and the drug obtained thereby
PT1242060E (pt)	2006-08-31	Tratamento da doenca metastatica
NO20032027L (no)	2003-07-04	Effektive antitumorbehandlinger
AU5338301A (en)	2001-10-30	Methods and compositions for modulating alpha adrenergic receptor activity
GB0121490D0 (en)	2001-10-24	Ciompounds
HRPK20041072B3 (hr)	2007-07-31	Primjena docetaxela/doxorubicina/ciklofosfamida uadjuvantnoj terapiji karcinoma dojke i jajnika
AR028476A1 (es)	2003-05-14	Tratamiento del cancer
NO20040516L (no)	2004-04-13	Kombinasjonsterapi for behandling av kreft.
EP1359909A4 (en)	2005-03-09	CANCER THERAPY USING TRIPTOLID PRODRUGS
DE60141194D1 (de)	2010-03-18	Behandlung des metastasierenden Karzinoms der Niere
AU7862401A (en)	2002-03-04	Pharmaceutical compostion comprising trkaig2 for use in the prevention and/or treatment of cancer
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GB0121494D0 (en)	2001-10-24	Compounds
IT1320192B1 (it)	2003-11-26	Composizione terapeutica per la cura della psoriasi.
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