DK1401841T3 - Substituerede 1-oxa-2,8-diaza-spiro[4,5]dec-2-en-derivater som lægemidler mod smerte - Google Patents

Substituerede 1-oxa-2,8-diaza-spiro[4,5]dec-2-en-derivater som lægemidler mod smerte

Info

Publication number: DK1401841T3
Authority: DK; Denmark
Prior art keywords: diaza; oxa; spiro; medicines; pain
Prior art date: 2001-06-25

Application number

DK02735422T

Other languages

English (en)

Inventor

Joerg Holenz

Helmut Heinrich Buschmann

Werner Guenter Englberger

Tieno Germann

Hagen-Heinrich Hennies

Corinna Maul

Bernd Sundermann

Michael Haurand

Original Assignee

Gruenenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-25

Filing date

2002-06-21

Publication date

2005-09-19

2002-06-21 Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh

2005-09-19 Application granted granted Critical

2005-09-19 Publication of DK1401841T3 publication Critical patent/DK1401841T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
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- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
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- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/08—Antiallergic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Addiction (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Immunology (AREA)
Child & Adolescent Psychology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Otolaryngology (AREA)

DK02735422T 2001-06-25 2002-06-21 Substituerede 1-oxa-2,8-diaza-spiro[4,5]dec-2-en-derivater som lægemidler mod smerte DK1401841T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10130020A DE10130020A1 (de)	2001-06-25	2001-06-25	Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate
PCT/EP2002/006880 WO2003000699A1 (de)	2001-06-25	2002-06-21	Substituierte 1-oxa-2,8-diaza-spiro[4,5]dec-2-en-derivate als arzneimittel gegen schmerz

Publications (1)

Publication Number	Publication Date
DK1401841T3 true DK1401841T3 (da)	2005-09-19

Family

ID=7689008

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02735422T DK1401841T3 (da)	2001-06-25	2002-06-21	Substituerede 1-oxa-2,8-diaza-spiro[4,5]dec-2-en-derivater som lægemidler mod smerte

Country Status (29)

Country	Link
US (2)	US8048890B2 (da)
EP (1)	EP1401841B1 (da)
JP (1)	JP4410554B2 (da)
KR (1)	KR100917112B1 (da)
CN (1)	CN1315840C (da)
AR (1)	AR036098A1 (da)
AT (1)	ATE302782T1 (da)
AU (1)	AU2002310768B2 (da)
BR (1)	BR0211053A (da)
CA (1)	CA2451859C (da)
CO (1)	CO5540301A2 (da)
CZ (1)	CZ20033432A3 (da)
DE (2)	DE10130020A1 (da)
DK (1)	DK1401841T3 (da)
EC (1)	ECSP034924A (da)
ES (1)	ES2245402T3 (da)
HU (1)	HU228774B1 (da)
IL (2)	IL159544A0 (da)
MX (1)	MXPA03012013A (da)
NO (1)	NO332217B1 (da)
NZ (1)	NZ530689A (da)
PE (1)	PE20030146A1 (da)
PL (1)	PL214290B1 (da)
PT (1)	PT1401841E (da)
RU (1)	RU2296128C2 (da)
SI (1)	SI1401841T1 (da)
SK (1)	SK287390B6 (da)
WO (1)	WO2003000699A1 (da)
ZA (1)	ZA200400489B (da)

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DE102005016170A1 (de) *	2005-04-07	2006-10-12	Grünenthal GmbH	4,5,6,7- Tetrahydro-isoxazolo(4,5c)pyridin-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
DE102005044813A1 (de)	2005-05-19	2007-10-04	Grünenthal GmbH	Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
DE102005044814A1 (de) *	2005-05-19	2006-11-23	Grünenthal GmbH	Substituierte Sprio-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
DE102005023784A1 (de) *	2005-05-19	2006-11-30	Grünenthal GmbH	Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
US8653068B2 (en)	2009-10-30	2014-02-18	Pain Therapeutics, Inc.	Filamin A binding anti-inflammatory and analgesic
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US8614324B2 (en) *	2008-10-31	2013-12-24	Pain Therapeutics, Inc.	Filamin A binding anti-inflammatory and analgesic
AU2009308769B2 (en) *	2008-10-31	2015-03-12	Pain Therapeutics, Inc.	Filamin A-binding anti-inflammatory analgesic
US8580808B2 (en) *	2009-10-30	2013-11-12	Pain Therapeutic, Inc.	Filamin A-binding anti-inflammatory analgesic
US20100279996A1 (en) *	2009-05-04	2010-11-04	Lindsay Burns Barbier	Novel analgesic that binds filamin a
CA2750777C (en) *	2009-01-26	2018-04-03	Israel Institute For Biological Research	Bicyclic heterocyclic spiro compounds
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US8741892B2 (en)	2011-12-05	2014-06-03	Boehringer Ingelheim International Gmbh	Compounds
US8642774B2 (en) *	2011-12-08	2014-02-04	Boehringer Ingelheim International Gmbh	Compounds
US8846948B2 (en)	2011-12-13	2014-09-30	Boehringer Ingelheim International Gmbh	Compounds
US8796467B2 (en)	2011-12-13	2014-08-05	Boehringer Ingelheim International Gmbh	Compounds
US8716277B2 (en)	2011-12-14	2014-05-06	Boehringer Ingelheim International Gmbh	Substituted imidazole compounds useful as positive allosteric modulators of mGlu5 receptor activity
US8883789B2 (en)	2011-12-14	2014-11-11	Boehringer Ingelheim International Gmbh	Piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors
US8937176B2 (en)	2011-12-14	2015-01-20	Boehringer Ingelheim International Gmbh	Compounds
US8889677B2 (en)	2012-01-17	2014-11-18	Boehringer Ingellheim International GmbH	Substituted triazoles useful as mGlu5 receptor modulators
JP6417324B2 (ja)	2012-07-13	2018-11-07	ペインセラピューティクスインコーポレイテッド	τリン酸化を阻害する方法
WO2014012054A1 (en)	2012-07-13	2014-01-16	Pain Therapeutics, Inc.	Alzheimer's disease assay in a living patent
US9433604B2 (en)	2013-10-08	2016-09-06	Pain Therapeutics Inc.	Method for inhibiting growth of cancer cells
EA037481B1 (ru)	2016-01-13	2021-04-01	Грюненталь Гмбх	Производные 3-((гетеро-)арил)алкил-8-амино-2-оксо-1,3-диазаспиро[4.5]декана
BR112018014302B1 (pt)	2016-01-13	2023-10-17	Grünenthal GmbH	Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano
DK3402785T3 (da)	2016-01-13	2020-04-20	Gruenenthal Gmbh	3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decan-derivater
MX379359B (es)	2016-01-13	2025-03-11	Gruenenthal Gmbh	Derivados de 8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano.
AU2017206908B2 (en)	2016-01-13	2020-07-09	Grünenthal GmbH	3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
JP6886074B2 (ja)	2017-04-12	2021-06-16	イルドンファーマシューティカルカンパニーリミテッド	核受容体の効能剤であるイソオキサゾール誘導体及びその用途
CN109793713B (zh) *	2019-03-26	2021-05-28	李世系	一种用于麻醉的短效催眠镇静的药物组合物及其注射剂制备方法及应用

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2001
- 2001-06-25 DE DE10130020A patent/DE10130020A1/de not_active Withdrawn
2002
- 2002-06-19 AR ARP020102303A patent/AR036098A1/es unknown
- 2002-06-21 PL PL367748A patent/PL214290B1/pl not_active IP Right Cessation
- 2002-06-21 CZ CZ20033432A patent/CZ20033432A3/cs unknown
- 2002-06-21 AT AT02735422T patent/ATE302782T1/de active
- 2002-06-21 PE PE2002000537A patent/PE20030146A1/es not_active Application Discontinuation
- 2002-06-21 DK DK02735422T patent/DK1401841T3/da active
- 2002-06-21 RU RU2004100823/04A patent/RU2296128C2/ru not_active IP Right Cessation
- 2002-06-21 SI SI200230221T patent/SI1401841T1/sl unknown
- 2002-06-21 JP JP2003507102A patent/JP4410554B2/ja not_active Expired - Fee Related
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- 2002-06-21 PT PT02735422T patent/PT1401841E/pt unknown
- 2002-06-21 CA CA2451859A patent/CA2451859C/en not_active Expired - Fee Related
- 2002-06-21 EP EP02735422A patent/EP1401841B1/de not_active Expired - Lifetime
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- 2002-06-21 BR BR0211053-9A patent/BR0211053A/pt not_active IP Right Cessation
- 2002-06-21 AU AU2002310768A patent/AU2002310768B2/en not_active Ceased
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- 2002-06-21 MX MXPA03012013A patent/MXPA03012013A/es active IP Right Grant
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- 2002-06-21 CN CNB028166825A patent/CN1315840C/zh not_active Expired - Fee Related
- 2002-06-21 IL IL15954402A patent/IL159544A0/xx unknown
- 2002-06-21 WO PCT/EP2002/006880 patent/WO2003000699A1/de not_active Ceased
- 2002-06-21 KR KR1020037016835A patent/KR100917112B1/ko not_active Expired - Fee Related
- 2002-06-21 DE DE50204037T patent/DE50204037D1/de not_active Expired - Lifetime
2003
- 2003-12-19 NO NO20035730A patent/NO332217B1/no not_active IP Right Cessation
- 2003-12-22 EC EC2003004924A patent/ECSP034924A/es unknown
- 2003-12-22 CO CO03111723A patent/CO5540301A2/es active IP Right Grant
- 2003-12-24 US US10/744,082 patent/US8048890B2/en not_active Expired - Fee Related
- 2003-12-24 IL IL159544A patent/IL159544A/en not_active IP Right Cessation
2004
- 2004-01-22 ZA ZA200400489A patent/ZA200400489B/en unknown
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Also Published As

Publication number	Publication date
ECSP034924A (es)	2004-02-26
DE10130020A1 (de)	2003-12-04
US8557796B2 (en)	2013-10-15
WO2003000699A8 (de)	2003-11-20
JP4410554B2 (ja)	2010-02-03
CA2451859C (en)	2011-06-14
WO2003000699A1 (de)	2003-01-03
HU228774B1 (en)	2013-05-28
PL214290B1 (pl)	2013-07-31
US20040192916A1 (en)	2004-09-30
NZ530689A (en)	2005-07-29
PL367748A1 (en)	2005-03-07
CZ20033432A3 (cs)	2004-05-12
HUP0400810A3 (en)	2007-11-28
BR0211053A (pt)	2004-07-20
EP1401841A1 (de)	2004-03-31
NO332217B1 (no)	2012-07-30
AU2002310768B2 (en)	2007-01-11
CN1547584A (zh)	2004-11-17
NO20035730L (no)	2004-02-19
PE20030146A1 (es)	2003-03-15
ATE302782T1 (de)	2005-09-15
CN1315840C (zh)	2007-05-16
SK287390B6 (sk)	2010-08-09
MXPA03012013A (es)	2004-03-26
RU2296128C2 (ru)	2007-03-27
ES2245402T3 (es)	2006-01-01
ZA200400489B (en)	2004-10-14
HUP0400810A2 (hu)	2004-07-28
CO5540301A2 (es)	2005-07-29
HK1064669A1 (en)	2005-02-04
SI1401841T1 (sl)	2006-02-28
JP2004536095A (ja)	2004-12-02
US20110224172A1 (en)	2011-09-15
CA2451859A1 (en)	2003-01-03
AR036098A1 (es)	2004-08-11
KR100917112B1 (ko)	2009-09-11
EP1401841B1 (de)	2005-08-24
PT1401841E (pt)	2005-11-30
IL159544A (en)	2009-05-04
SK15702003A3 (sk)	2004-07-07
IL159544A0 (en)	2004-06-01
US8048890B2 (en)	2011-11-01
DE50204037D1 (de)	2005-09-29
NO20035730D0 (no)	2003-12-19
KR20040008226A (ko)	2004-01-28
RU2004100823A (ru)	2005-06-20

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