DK140408B - Analogifremgangsmaade til fremstilling af n-(heteroarylmethyl)-7alfa-acyl-6,14-endoetheno-eller-endoethano-tetrahydronororipaviner eller thebainer eller syreadditionssalte deraf - Google Patents

Analogifremgangsmaade til fremstilling af n-(heteroarylmethyl)-7alfa-acyl-6,14-endoetheno-eller-endoethano-tetrahydronororipaviner eller thebainer eller syreadditionssalte deraf

Info

Publication number: DK140408B
Authority: DK; Denmark
Prior art keywords: thebainer; tetrahydronororipavins; endoetheno; 7alfa; endoethano
Prior art date: 1972-06-19

Application number

DK336273AA

Other languages

English (en)

Other versions

DK140408C (da

Inventor

A Langbein

H Merz

G Walther

K Stockhaus

Original Assignee

Boehringer Sohn Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-06-19

Filing date

1973-06-18

Publication date

1979-08-20

1973-06-18 Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim

1979-08-20 Publication of DK140408B publication Critical patent/DK140408B/da

1980-01-21 Application granted granted Critical

1980-01-21 Publication of DK140408C publication Critical patent/DK140408C/da

Links

239000002253 acid Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK336273A 1972-06-19 1973-06-18 Analogifremgangsmaade til fremstilling af n-(heteroarylmethyl)-7alfa-acyl-6,14-endoetheno- eller -endoethano-tetrahydronororipaviner eller-thebainer eller syreadditionssalte deraf DK140408C (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2229770A DE2229770A1 (de)	1972-06-19	1972-06-19	N-(heteroarylmethyl)-7alpha-acyl6,14-endoaethenotetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung

Publications (2)

Publication Number	Publication Date
DK140408B true DK140408B (da)	1979-08-20
DK140408C DK140408C (da)	1980-01-21

Family

ID=5848095

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK336273A DK140408C (da)	1972-06-19	1973-06-18	Analogifremgangsmaade til fremstilling af n-(heteroarylmethyl)-7alfa-acyl-6,14-endoetheno- eller -endoethano-tetrahydronororipaviner eller-thebainer eller syreadditionssalte deraf

Country Status (14)

Country	Link
US (1)	US3931187A (da)
JP (1)	JPS5732073B2 (da)
AT (6)	AT328625B (da)
BE (1)	BE801083A (da)
CH (6)	CH597233A5 (da)
DE (1)	DE2229770A1 (da)
DK (1)	DK140408C (da)
ES (5)	ES416038A1 (da)
FI (1)	FI56180C (da)
FR (1)	FR2189054B1 (da)
GB (1)	GB1430958A (da)
NL (1)	NL7308482A (da)
NO (1)	NO137998C (da)
SE (1)	SE409035B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62298530A (ja) *	1986-06-16	1987-12-25	Otsuka Pharmaceut Co Ltd	坐薬用医薬組成物
KR20000016052A (ko)	1997-03-27	2000-03-25	히라이 가쯔히꼬	몰피난 유도체 및 의약용도_
JP2013529595A (ja)	2010-06-11	2013-07-22	ローズテクノロジーズ	第３級アミンのｎ−脱アルキル化方法
ES2645725T3 (es)	2010-06-11	2017-12-07	Rhodes Technologies	Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
US9315514B2 (en)	2012-08-27	2016-04-19	Rhodes Technologies	1,3-dioxanomorphides and 1,3-dioxanocodides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3474101A (en) *	1960-09-05	1969-10-21	Reckitt & Sons Ltd	Thebaine and oripavine derivatives
GB1223445A (en) *	1968-07-18	1971-02-24	Reckitt & Colmann Prod Ltd	Improvements in or relating to derivatives of morphine, their salts, and processes for their preparation
US3560505A (en) *	1969-05-15	1971-02-02	American Cyanamid Co	Substituted 7-(1-alkoxy - 1 - alken-1-yl)-7,8-dihydro-6-methoxy-6,14-endo- (etheno or ethano) codides and morphides
US3562279A (en) *	1969-05-15	1971-02-09	American Cyanamid Co	Substituted 7,8-dihydro - 6 - methoxy-6,14-endo(etheno or ethano)morphide - 7-ketones and n-cycloalkylmethyl - 7,8-dihydro - 6 - methoxy-6,14-endo(etheno or ethano) norcodide-7-ketones
DE2107989A1 (de) *	1971-02-19	1972-09-07	Boehringer Sohn Ingelheim	N-(Furyl-methy])-morphinane, deren Säureadditionssalze sowie Verfahren zu deren Herstellung

1972
- 1972-06-19 DE DE2229770A patent/DE2229770A1/de not_active Withdrawn
1973
- 1973-06-06 AT AT265774*7A patent/AT328625B/de not_active IP Right Cessation
- 1973-06-06 AT AT266074*7A patent/AT328626B/de not_active IP Right Cessation
- 1973-06-06 AT AT265974*7A patent/AT328097B/de not_active IP Right Cessation
- 1973-06-06 AT AT265674*7A patent/AT328095B/de not_active IP Right Cessation
- 1973-06-06 AT AT265874*7A patent/AT328096B/de not_active IP Right Cessation
- 1973-06-06 AT AT494273A patent/AT325217B/de not_active IP Right Cessation
- 1973-06-13 US US05/369,499 patent/US3931187A/en not_active Expired - Lifetime
- 1973-06-14 CH CH958477A patent/CH597233A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH864473A patent/CH598260A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH958577A patent/CH596212A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH958677A patent/CH597234A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH958777A patent/CH599215A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH958377A patent/CH599214A5/xx not_active IP Right Cessation
- 1973-06-18 DK DK336273A patent/DK140408C/da active
- 1973-06-18 GB GB2887073A patent/GB1430958A/en not_active Expired
- 1973-06-18 JP JP6863373A patent/JPS5732073B2/ja not_active Expired
- 1973-06-18 BE BE132410A patent/BE801083A/xx unknown
- 1973-06-18 NO NO2519/73A patent/NO137998C/no unknown
- 1973-06-18 ES ES416038A patent/ES416038A1/es not_active Expired
- 1973-06-18 FI FI1962/73A patent/FI56180C/fi active
- 1973-06-18 SE SE7308565A patent/SE409035B/xx unknown
- 1973-06-19 NL NL7308482A patent/NL7308482A/xx not_active Application Discontinuation
- 1973-06-19 FR FR7322247A patent/FR2189054B1/fr not_active Expired
1974
- 1974-03-15 ES ES424310A patent/ES424310A1/es not_active Expired
- 1974-03-15 ES ES424307A patent/ES424307A1/es not_active Expired
- 1974-03-15 ES ES424308A patent/ES424308A1/es not_active Expired
- 1974-03-15 ES ES424309A patent/ES424309A1/es not_active Expired

Also Published As

Publication number	Publication date
AT328625B (de)	1976-03-25
ES424307A1 (es)	1976-07-01
AU5704773A (en)	1974-12-19
CH599215A5 (da)	1978-05-12
ATA265674A (de)	1975-05-15
AT328097B (de)	1976-03-10
FI56180C (fi)	1979-12-10
NO137998C (no)	1978-06-07
AT325217B (de)	1975-10-10
US3931187A (en)	1976-01-06
AT328096B (de)	1976-03-10
ES416038A1 (es)	1976-06-16
CH596212A5 (da)	1978-03-15
ES424308A1 (es)	1976-06-16
FR2189054B1 (da)	1976-12-31
SE409035B (sv)	1979-07-23
CH597234A5 (da)	1978-03-31
DK140408C (da)	1980-01-21
ATA265974A (de)	1975-05-15
GB1430958A (en)	1976-04-07
FR2189054A1 (da)	1974-01-25
AT328095B (de)	1976-03-10
BE801083A (fr)	1973-12-18
NO137998B (no)	1978-02-27
ATA265774A (de)	1975-06-15
ES424309A1 (es)	1976-06-16
ES424310A1 (es)	1976-06-16
DE2229770A1 (de)	1974-01-10
CH599214A5 (da)	1978-05-12
NL7308482A (da)	1973-12-21
CH597233A5 (da)	1978-03-31
FI56180B (fi)	1979-08-31
AT328626B (de)	1976-03-25
JPS5732073B2 (da)	1982-07-08
JPS4961188A (da)	1974-06-13
ATA265874A (de)	1975-05-15
CH598260A5 (da)	1978-04-28

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