DK1404656T3 - Derivater af benzimidazol til behandling af sygdomme forbundet med en aktivering af mikroglia, såsom inflammatoriske, allergiske, inficerende eller autoimmune sygdomme - Google Patents
Derivater af benzimidazol til behandling af sygdomme forbundet med en aktivering af mikroglia, såsom inflammatoriske, allergiske, inficerende eller autoimmune sygdommeInfo
- Publication number
- DK1404656T3 DK1404656T3 DK02740766T DK02740766T DK1404656T3 DK 1404656 T3 DK1404656 T3 DK 1404656T3 DK 02740766 T DK02740766 T DK 02740766T DK 02740766 T DK02740766 T DK 02740766T DK 1404656 T3 DK1404656 T3 DK 1404656T3
- Authority
- DK
- Denmark
- Prior art keywords
- microglia
- activation
- treatment
- derivatives
- infecting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10135050A DE10135050A1 (de) | 2001-07-09 | 2001-07-09 | 1-Ary1-2-N-, S- oder O-substituierte Benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate |
| PCT/EP2002/007561 WO2003006438A1 (de) | 2001-07-09 | 2002-07-05 | Benzimidazolderivate zur behandlung von mikroglia-aktivierung assoziierten erkrankungen wie inflammatorische, allergische, infektiöse oder autoimmune erkrankungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1404656T3 true DK1404656T3 (da) | 2005-09-12 |
Family
ID=7692286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02740766T DK1404656T3 (da) | 2001-07-09 | 2002-07-05 | Derivater af benzimidazol til behandling af sygdomme forbundet med en aktivering af mikroglia, såsom inflammatoriske, allergiske, inficerende eller autoimmune sygdomme |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1404656B9 (da) |
| JP (1) | JP4351042B2 (da) |
| AT (1) | ATE295838T1 (da) |
| DE (2) | DE10135050A1 (da) |
| DK (1) | DK1404656T3 (da) |
| ES (1) | ES2242866T3 (da) |
| PE (1) | PE20030236A1 (da) |
| PT (1) | PT1404656E (da) |
| UY (1) | UY27372A1 (da) |
| WO (1) | WO2003006438A1 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10207843A1 (de) * | 2002-02-15 | 2003-09-04 | Schering Ag | Mikrolia-Inhibitoren zur Unterbrechung von Interleukin 12 und IFN-gamma vermittelten Immunreaktionen |
| JP2005536533A (ja) | 2002-08-08 | 2005-12-02 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 置換ベンゾイミダゾール化合物 |
| AU2003301436A1 (en) | 2002-10-17 | 2004-05-04 | Amgen Inc. | Benzimidazole derivatives and their use as vanilloid receptor ligands |
| US20080021069A1 (en) * | 2004-10-08 | 2008-01-24 | Takeda Pharmaceutical Company Limited | Receptor Function Regulating Agent |
| EP1838306B1 (en) | 2005-01-11 | 2010-11-17 | NeuroSearch A/S | Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels |
| CN103435552A (zh) * | 2013-06-28 | 2013-12-11 | 浙江工业大学 | 一种1,2-二取代苯并咪唑类化合物的制备方法 |
| EP3860998B1 (en) | 2018-10-05 | 2023-12-27 | Annapurna Bio Inc. | Compounds and compositions for treating conditions associated with apj receptor activity |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8300736D0 (sv) * | 1983-02-11 | 1983-02-11 | Haessle Ab | Novel pharmacologically active compounds |
| US4520196A (en) * | 1983-08-18 | 1985-05-28 | American Home Products Corporation | α-Mercaptophenylacetic acid derivatives of imidazole-containing compounds and analogues thereof |
| EP0251536A1 (en) * | 1986-06-24 | 1988-01-07 | FISONS plc | Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors |
| JPH06759B2 (ja) * | 1989-09-22 | 1994-01-05 | ファイザー製薬株式会社 | 新規なベンゾイミダゾール化合物 |
| US5210091A (en) * | 1991-06-24 | 1993-05-11 | Neurosearch A/S | Imidazole compounds and their use |
| EP0520200B1 (en) * | 1991-06-24 | 1998-02-18 | Neurosearch A/S | Imidazole compounds, their preparation and use |
| DE4129603A1 (de) * | 1991-09-06 | 1993-03-11 | Thomae Gmbh Dr K | Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DK154092D0 (da) * | 1992-12-23 | 1992-12-23 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
| DE4330959A1 (de) * | 1993-09-09 | 1995-03-16 | Schering Ag | Neue Benzimidazolderivate, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
| US5552426A (en) * | 1994-04-29 | 1996-09-03 | Eli Lilly And Company | Methods for treating a physiological disorder associated with β-amyloid peptide |
| GB9518552D0 (en) * | 1995-09-11 | 1995-11-08 | Fujisawa Pharmaceutical Co | New heterocyclic compounds |
| DE19816915A1 (de) * | 1998-04-16 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue Peptide, Verfahren zu ihrer Herstellung und diese Peptide enthaltende pharmazeutische Zusammensetzungen |
| JP2000026430A (ja) * | 1998-07-02 | 2000-01-25 | Taisho Pharmaceut Co Ltd | ２、５、６−置換ベンズイミダゾール化合物誘導体 |
| DE19900355A1 (de) * | 1999-01-07 | 2000-07-13 | Merck Patent Gmbh | Benzimidazolderivate |
| CA2369544A1 (en) * | 1999-04-02 | 2000-10-12 | Robert W. Desimone | Aryl and heteroaryl fused aminoalkyl-imidazole derivatives:selective modulators of bradykinin b2 receptors |
| AU5636900A (en) * | 1999-06-30 | 2001-01-31 | Merck & Co., Inc. | Src kinase inhibitor compounds |
| HUP0202263A3 (en) * | 1999-12-27 | 2003-02-28 | Japan Tobacco Inc | Benzimidazole, indole and imidazo-pyridine derivatives and pharmaceutical compositions containing them |
| AU782993B2 (en) * | 2000-01-14 | 2005-09-15 | Bayer Intellectual Property Gmbh | 1,2-diaryl benzimidazoles for treating illnesses associated with a microglia activation |
-
2001
- 2001-07-09 DE DE10135050A patent/DE10135050A1/de not_active Ceased
-
2002
- 2002-07-05 EP EP02740766A patent/EP1404656B9/de not_active Expired - Lifetime
- 2002-07-05 AT AT02740766T patent/ATE295838T1/de not_active IP Right Cessation
- 2002-07-05 DE DE50203154T patent/DE50203154D1/de not_active Expired - Lifetime
- 2002-07-05 UY UY27372A patent/UY27372A1/es not_active Application Discontinuation
- 2002-07-05 ES ES02740766T patent/ES2242866T3/es not_active Expired - Lifetime
- 2002-07-05 PT PT02740766T patent/PT1404656E/pt unknown
- 2002-07-05 DK DK02740766T patent/DK1404656T3/da active
- 2002-07-05 JP JP2003512210A patent/JP4351042B2/ja not_active Expired - Fee Related
- 2002-07-05 WO PCT/EP2002/007561 patent/WO2003006438A1/de not_active Ceased
- 2002-07-09 PE PE2002000612A patent/PE20030236A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP4351042B2 (ja) | 2009-10-28 |
| ATE295838T1 (de) | 2005-06-15 |
| PT1404656E (pt) | 2005-09-30 |
| EP1404656A1 (de) | 2004-04-07 |
| JP2004536123A (ja) | 2004-12-02 |
| UY27372A1 (es) | 2003-01-31 |
| WO2003006438A1 (de) | 2003-01-23 |
| EP1404656B9 (de) | 2005-10-19 |
| PE20030236A1 (es) | 2003-04-10 |
| ES2242866T3 (es) | 2005-11-16 |
| EP1404656B1 (de) | 2005-05-18 |
| DE10135050A1 (de) | 2003-02-06 |
| DE50203154D1 (de) | 2005-06-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60323133D1 (de) | Cyclohexylverbindungen als ccr5-antagonisten | |
| ATE384724T1 (de) | Cyclopropylverbindungen als ccr5 antagonisten | |
| EA200401167A1 (ru) | Производные тропана в качестве модуляторов ccr5 | |
| CY1111693T1 (el) | Αντιιικοι παραγοντες | |
| NO20052739L (no) | CCR5-antagonister som medikamenter | |
| DE60322423D1 (de) | Pyrrolidin- und azetidinverbindungen alsccr5-antagonisten | |
| YU37904A (sh) | Benzimidazoli kao korisni inhibitori proteinske kinaze | |
| NO20025601L (no) | Arylmetylaminderivater for anvendelse som tryptaseinhibitorer | |
| EA200600225A1 (ru) | Производные пиперазина для лечения вич инфекций | |
| BR0113838A (pt) | Derivados de n-fenil-2-pirimidina-amina | |
| ATE512976T1 (de) | Hemmer des hepatitis-c-virus | |
| ATE264846T1 (de) | Substituierte benzimidazol-derivaten und ihre verwendung zur behandlung retroviraler infektionen | |
| NO20055649L (no) | Substituert dihydrokinazolin med antiviale egenskaper | |
| DE60211539D1 (de) | Imidazopyridinderivate zur verwendung bei der behandlung von herpes-vireninfektion | |
| BR0306922A (pt) | N-pirazinil-fenilsulfonamidas e seu uso no tratamento de doenças mediadas por quimocina | |
| ATE410426T1 (de) | Heterocyclische verbindungen alsccr5-antagonisten | |
| MXPA04001256A (es) | Productos de combinacion de derivados de propanolamina aril substituidos con otros ingredientes activos y su uso. | |
| NO20054848L (no) | Substituerte p-diaminobenzenderivater | |
| ATE349448T1 (de) | Pyrazol-3,4-d-pyrimidinderivate und ihre verwendung bei der behandlung von h.pylori- infektionen | |
| MX2007011695A (es) | Derivados de oxindol sustituido, medicamentos que contienen dichos derivados y uso de los mismos. | |
| DK1246808T3 (da) | 1,2-diarylbenzimidazoler til behandling af sygdomme, som er associeret med en mikroglia-aktivering | |
| MX9202612A (es) | Antagonista de leucotrieno b4. | |
| ECSP055844A (es) | Nuevos compuestos triciclicos | |
| ATE369348T1 (de) | Zyklisierte benzamid-neurokinin-antagonisten zur verwendung in therapie | |
| DK1404656T3 (da) | Derivater af benzimidazol til behandling af sygdomme forbundet med en aktivering af mikroglia, såsom inflammatoriske, allergiske, inficerende eller autoimmune sygdomme |