DK1404809T3 - Forbedrede hudsubstitutter og anvendelser deraf - Google Patents

Forbedrede hudsubstitutter og anvendelser deraf

Info

Publication number
DK1404809T3
DK1404809T3 DK02725028.1T DK02725028T DK1404809T3 DK 1404809 T3 DK1404809 T3 DK 1404809T3 DK 02725028 T DK02725028 T DK 02725028T DK 1404809 T3 DK1404809 T3 DK 1404809T3
Authority
DK
Denmark
Prior art keywords
improved skin
skin substitutes
substitutes
improved
skin
Prior art date
Application number
DK02725028.1T
Other languages
English (en)
Inventor
Cathy Ann-Rasmussen Ivarie
Paul Barth Conrad
Allen Comer
Lynn Allen-Hoffmann
Michael Hoffmann
Original Assignee
Stratatech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stratatech Corp filed Critical Stratatech Corp
Application granted granted Critical
Publication of DK1404809T3 publication Critical patent/DK1404809T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/33—Insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/04—Screening or testing on artificial tissues
    • C12N2503/06—Screening or testing on artificial skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/148—Screening for cosmetic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK02725028.1T 2001-03-02 2002-03-01 Forbedrede hudsubstitutter og anvendelser deraf DK1404809T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27303401P 2001-03-02 2001-03-02
US28789801P 2001-05-01 2001-05-01
PCT/US2002/006088 WO2002070729A2 (en) 2001-03-02 2002-03-01 Improved skin substitutes and uses thereof

Publications (1)

Publication Number Publication Date
DK1404809T3 true DK1404809T3 (da) 2014-03-17

Family

ID=26955894

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02725028.1T DK1404809T3 (da) 2001-03-02 2002-03-01 Forbedrede hudsubstitutter og anvendelser deraf

Country Status (11)

Country Link
US (3) US6846675B2 (da)
EP (1) EP1404809B1 (da)
JP (2) JP4317366B2 (da)
AU (3) AU2002255618B2 (da)
CA (1) CA2439899C (da)
DK (1) DK1404809T3 (da)
ES (1) ES2457092T3 (da)
IL (3) IL157667A0 (da)
NZ (4) NZ549526A (da)
PT (1) PT1404809E (da)
WO (1) WO2002070729A2 (da)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6974697B2 (en) 2001-03-02 2005-12-13 Stratech Corporation Skin substitutes with improved barrier function
DE60332256D1 (de) 2002-04-30 2010-06-02 Stratatech Corp Exogene angiogene wachstumsfaktoren exprimierende keratinozyten
FR2847268B1 (fr) * 2002-11-19 2006-09-29 Coletica Procede d'identification d'une modification eventuelle d'au moins un parametre biologique mettant en oeuvre des cellules vivantes soumises a un stress et des cellules vivantes non soumises a ce meme stress
US7169382B2 (en) * 2003-01-30 2007-01-30 L'oreal Reconstructed epidermis/skin equivalent comprising a ceramide 7 and /or 5.5 and lipid lamellar vesicular compositions comprising ceramide 7 and/or 5.5 compounds
JP2007500196A (ja) * 2003-05-24 2007-01-11 バイヤースドルフ・アクチエンゲゼルシヤフト 化粧品の成分として使用される組織培養培地
EP3100611B1 (en) * 2003-08-01 2018-09-12 Stratatech Corporation Human skin equivalents expressing exogenous polypeptides
CA2553334C (en) * 2004-01-16 2014-02-25 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg Preparation of fibroblast-populated connective tissue substitute
US20060193777A1 (en) * 2005-02-25 2006-08-31 Southall Michael D Method of screening compounds for potential efficacy for the treatment of signs of aging
CA2600177C (en) * 2005-03-01 2011-06-14 Stratatech Corporation Human skin equivalents expressing exogenous polypeptides
WO2006101834A1 (en) * 2005-03-17 2006-09-28 Stratatech Corporation Skin substitutes with improved purity
JP2007127444A (ja) * 2005-11-01 2007-05-24 Toyobo Co Ltd 保湿性評価方法
US20090145087A1 (en) * 2007-11-14 2009-06-11 Stratatech Corporation Cold storage of organotypically cultured skin equivalents for clinical applications
WO2009155334A1 (en) 2008-06-20 2009-12-23 Escape Therapeutics, Inc. Differentiation of mesenchymal stem cells into fibroblasts, compositions comprising mesenchymal stem cell-derived fibroblasts, and methods of using the same
JP5632383B2 (ja) * 2008-11-04 2014-11-26 ストラタテック コーポレーション 即時使用のための乾燥され、放射線照射された皮膚同等物
EP2243825A1 (en) * 2009-04-01 2010-10-27 Universität zu Köln Method for the generation of a skin model and skin model
US20100330046A1 (en) * 2009-05-21 2010-12-30 Stratatech Corporation Human skin substitutes expressing il-12
DE202009008315U1 (de) * 2009-06-17 2009-09-24 M & Fc Holding Llc Gehäuse aus faserverstärktem Kunststoff
JP6010460B2 (ja) * 2009-08-25 2016-10-19 セルビシオ アンダルス デ サルＳｅｒｖｉｃｉｏ Ａｎｄａｌｕｚ Ｄｅ Ｓａｌｕｄ フィブリンおよびアガロース生体材料を用いる組織工学による、人工組織の製造
JP5653449B2 (ja) 2009-12-01 2015-01-14 株式会社ブリヂストン 変性ゴム組成物およびその調製方法
FR2957090A1 (fr) * 2010-03-05 2011-09-09 Immunosearch Methode d'evaluation du potentiel irritant d'un compose test
FR2957088A1 (fr) * 2010-03-05 2011-09-09 Immunosearch Methode d'evaluation du potentiel sensibilisant et/ou irritant d'un compose test
FR2957089A1 (fr) * 2010-03-05 2011-09-09 Immunosearch Methode d'evaluation du potentiel sensibilisant d'un compose test
US8597948B2 (en) 2011-03-10 2013-12-03 First Principles, Inc. Cloned biological material medical device and method thereof
FR2993282B1 (fr) 2012-07-13 2017-11-10 Expanscience Lab Procede d'identification de marqueurs moleculaires de la peau d'enfant
EP3470018B1 (en) 2013-03-13 2021-07-28 Stratatech Corporation Cryopreservation of viable human skin substitutes
FR3011008B1 (fr) 2013-09-24 2017-12-29 Expanscience Lab Procedes d'evaluation des effets deleteres des uv sur la peau d'enfant
US9545302B2 (en) 2013-11-20 2017-01-17 Dermagenesis Llc Skin printing and auto-grafting
FR3016373B1 (fr) 2014-01-10 2018-01-19 Laboratoires Expanscience Modele de peau de mammelon reconstitue
FR3019186B1 (fr) 2014-03-31 2019-06-07 Laboratoires Expanscience Procedes d'evaluation des effets deleteres de l'urine sur la peau d'enfant
KR101723633B1 (ko) * 2014-11-17 2017-04-06 주식회사 바이오코즈글로벌코리아 세포 배양 배지, 표피성장인자 및 소혈청알부민을 포함하는 피부 상태 개선용 화장료 조성물
US10894151B2 (en) * 2015-04-23 2021-01-19 Carnegie Mellon University Biosensor tattoos and uses therefor for biomarker monitoring
FR3045669B1 (fr) 2015-12-16 2019-04-05 Laboratoires Expanscience Procedes d'evaluation des effets de la deshydratation sur la peau d'enfant
CN109195579B (zh) 2016-04-01 2022-09-16 韩国比奥科斯全球公司 包含在细胞培养基中的白蛋白、透明质酸或胶原蛋白作为活性成分的化妆品组合物
JP6817610B2 (ja) * 2016-04-05 2021-01-20 日本メナード化粧品株式会社 三次元培養表皮モデル及びその製造方法、ならびに三次元培養表皮モデルの使用方法
FR3053053B1 (fr) 2016-06-23 2018-07-13 Laboratoires Expanscience Modeles de la dermatite atopique juvenile
EP3476933A4 (en) * 2016-06-24 2020-03-04 Shiseido Company, Ltd. THREE-DIMENSIONAL CULTURE SKIN SHEET, CELL CULTURE TANK USED FOR THE PRODUCTION THEREOF, AND METHOD FOR PRODUCING THREE-DIMENSIONAL CULTURE SKIN SHEET
FR3068045B1 (fr) 2017-06-22 2021-06-04 Expanscience Lab Modeles de peau sensible reconstituee
WO2021149761A1 (ja) * 2020-01-22 2021-07-29 国立研究開発法人産業技術総合研究所 表層に角質層が形成された不死化皮膚細胞の３次元培養物、前記３次元培養物の製造方法、および前記３次元培養物を用いた被検物質の評価方法
IL297372A (en) * 2020-05-13 2022-12-01 Stratatech Corp Sustainable bioengineered skin constructs
JP7041977B2 (ja) * 2020-11-17 2022-03-25 日本メナード化粧品株式会社 三次元培養表皮モデル及びその製造方法、ならびに三次元培養表皮モデルの使用方法
KR102583179B1 (ko) * 2020-11-27 2023-09-26 (주)엑셀세라퓨틱스 칼슘, 상피세포성장인자 및 알부민을 포함하는 각질형성세포 수립 또는 배양용 배지 조성물
FR3133198B1 (fr) 2022-03-04 2025-11-21 Pierre Fabre Dermo Cosmetique Modele de peau reconstituee
LU502391B1 (en) 2022-06-28 2024-01-09 Univerza V Mariboru A complex in vitro model of human skin, a process for preparation and use thereof
FR3138149A1 (fr) 2022-07-25 2024-01-26 Pierre Fabre Dermo-Cosmetique Méthode d’évaluation in vitro de l’activité photoprotectrice d’un actif
CN116515760A (zh) * 2023-03-24 2023-08-01 重庆医科大学 一种细胞模型、其构建方法、细胞、其制备方法及应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US569332A (en) * 1896-10-13 Gerald w
US4485096A (en) 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
US5583024A (en) 1985-12-02 1996-12-10 The Regents Of The University Of California Recombinant expression of Coleoptera luciferase
CA2018228C (en) * 1989-06-05 1996-02-27 Nancy L. Parenteau Cell culture systems and media
IL95429A (en) * 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
CA2080693C (en) * 1990-04-24 2001-11-27 Mark Eisenberg Composite living skin equivalents
IT1248934B (it) 1990-06-01 1995-02-11 Fidia Spa Membrane forate biocompatibili,processi per la loro preparazione,loro impiego come supporto per la crescita in vitro di cellule epiteliali, pelli artificiali cosi' ottenute e loro impiego nei trapianti di pelle
AT401526B (de) 1993-02-10 1996-09-25 Scheirer Winfried Reagenzlösung zur stabilisierung der lumineszenz bei der luciferasemessung
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US5693332C1 (en) * 1995-08-11 2001-01-09 Univ California Human keratinocytes supported on a hydrophilic membrane and methods of using same to effect wound closure
US5976796A (en) 1996-10-04 1999-11-02 Loma Linda University Construction and expression of renilla luciferase and green fluorescent protein fusion genes
US5968546A (en) 1997-05-16 1999-10-19 Baur; Marcus Keratinocyte culture from precursor cells
US6074859A (en) * 1997-07-08 2000-06-13 Kikkoman Corporation Mutant-type bioluminescent protein, and process for producing the mutant-type bioluminescent protein
US5994115A (en) 1997-07-22 1999-11-30 The Penn State Research Foundation Artificial system for the production of infectious human papillomavirus
US5989837A (en) * 1998-07-13 1999-11-23 Wisconsin Alumni Research Foundation Immortalized human keratinocyte cell line
US6479072B1 (en) * 1999-02-11 2002-11-12 The General Hospital Corporation Microfabricated membranes and matrices

Also Published As

Publication number Publication date
CA2439899C (en) 2015-09-29
CA2439899A1 (en) 2002-09-12
NZ549528A (en) 2008-04-30
NZ549526A (en) 2009-06-26
JP4317366B2 (ja) 2009-08-19
IL195076A (en) 2012-02-29
EP1404809A2 (en) 2004-04-07
EP1404809B1 (en) 2013-12-11
IL195076A0 (en) 2011-08-01
AU2010214639A1 (en) 2010-09-16
AU2006249240B2 (en) 2010-05-27
NZ528166A (en) 2007-05-31
EP1404809A4 (en) 2005-08-10
NZ549527A (en) 2008-04-30
ES2457092T3 (es) 2014-04-24
US20050226853A1 (en) 2005-10-13
PT1404809E (pt) 2014-03-20
US6846675B2 (en) 2005-01-25
WO2002070729A3 (en) 2004-01-22
JP2005505312A (ja) 2005-02-24
US7501238B2 (en) 2009-03-10
AU2002255618B2 (en) 2006-09-07
AU2010214639B2 (en) 2012-04-19
US20020187498A1 (en) 2002-12-12
JP4989674B2 (ja) 2012-08-01
IL157667A (en) 2009-09-22
JP2009195232A (ja) 2009-09-03
AU2006249240A1 (en) 2007-01-04
WO2002070729A2 (en) 2002-09-12
IL157667A0 (en) 2004-03-28
US7541188B2 (en) 2009-06-02
US20020164793A1 (en) 2002-11-07

Similar Documents

Publication Publication Date Title
IL195076A0 (en) Improved skin substitutes and uses thereof
DK1417175T3 (da) Substituerede dihydro-3-halo-1h-pyrazol-5-carboxylater og fremstillingog anvendelse heraf
DK1370128T3 (da) Kombineret ballepresse og ballevikler
EP1412378A4 (en) APTAMERS AND ANTIAPTAMERS
NO20024355L (no) Nukleosidforbindelser og anvendelser derav
ATE450663T1 (de) Verschleissteil und -anordnung
EP1298180A4 (en) HYDROPHOBIC AND LIPOPHOBE COMPOSITION
DE60017241D1 (de) Unterwasserbehandlungsanordnung und -verfahren
DK1390389T3 (da) Cripto-blokerende antistoffer og anvendelser deraf
DK1746375T3 (da) Oxygendrevet forbrændingssystem og anvendelser deraf
DK1455785T3 (da) Substituerede 2-thio-3,5-dicyano-4-phenyl-6-aminopyridiner og deres anvendelse
DE50112013D1 (de) Deodorantien und antiperspirantien
NO20041975D0 (no) Bicyklisk oksopyridin og oksopyrimidinderivater
NO20055568D0 (no) Substituerte 1,4-diazepiner og anvendelser derav
DK1339292T3 (da) Sammensætning og fremgangsmåde
DK1375647T3 (da) Kunstig dermis og fremstillingsfremgangsmåde dertil
IS6385A (is) Ný notkun og nýjar N-asabísýkló-amíð afleiður
NO20034159L (no) Östrogen-gestagen-kombinasjonspreparat og anvendelse derav
DK1554250T3 (da) Hidtil ukendt lactamer og anvendelser deraf
DK1322597T3 (da) Fremgangsmåde og intermediære
NO20033854D0 (no) N-but-3-enyl-norbuprenorfin og fremgangsmåter for anvendelse
DE60223576D1 (de) Hautbehandlungszusammensetzung
DK1562918T3 (da) Substituerede benzoxazinoner og anvendelser deraf
DE60205718D1 (de) Flexibler wellschlauch und anschlussverfahren
NO20033123L (no) Terapeutisk hinne dannende sammensetning og behandlingsplan derav