DK1406888T3 - Substituerede gamma-lactonforbindelser som NMDA-antagonister - Google Patents

Substituerede gamma-lactonforbindelser som NMDA-antagonister

Info

Publication number: DK1406888T3
Authority: DK; Denmark
Prior art keywords: nmda antagonists; lactone compounds; substituted gamma; gamma; substituted
Prior art date: 2001-07-05

Application number

DK02743260T

Other languages

English (en)

Inventor

Corinna Maul

Michael Przewosny

Werner Englberger

Original Assignee

Gruenenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-05

Filing date

2002-07-03

Publication date

2006-09-18

2002-07-03 Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh

2006-09-18 Application granted granted Critical

2006-09-18 Publication of DK1406888T3 publication Critical patent/DK1406888T3/da

Links

HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
125000000457 gamma-lactone group Chemical group 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK02743260T 2001-07-05 2002-07-03 Substituerede gamma-lactonforbindelser som NMDA-antagonister DK1406888T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10132725A DE10132725A1 (de)	2001-07-05	2001-07-05	Substituierte γ-Lactonverbindungen

Publications (1)

Publication Number	Publication Date
DK1406888T3 true DK1406888T3 (da)	2006-09-18

Family

ID=7690792

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02743260T DK1406888T3 (da)	2001-07-05	2002-07-03	Substituerede gamma-lactonforbindelser som NMDA-antagonister

Country Status (11)

Country	Link
US (1)	US6956055B2 (da)
EP (1)	EP1406888B1 (da)
AR (1)	AR036130A1 (da)
AT (1)	ATE327226T1 (da)
CY (1)	CY1105275T1 (da)
DE (2)	DE10132725A1 (da)
DK (1)	DK1406888T3 (da)
ES (1)	ES2266524T3 (da)
PE (1)	PE20030275A1 (da)
PT (1)	PT1406888E (da)
WO (1)	WO2003004483A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002950217A0 (en)	2002-07-16	2002-09-12	Prana Biotechnology Limited	8- Hydroxy Quinoline Derivatives
US8214813B2 (en) *	2007-01-12	2012-07-03	Microsoft Corporation	Code optimization across interfaces
US8703492B2 (en)	2007-04-06	2014-04-22	Qiagen Gaithersburg, Inc.	Open platform hybrid manual-automated sample processing system
US7985375B2 (en)	2007-04-06	2011-07-26	Qiagen Gaithersburg, Inc.	Sample preparation system and method for processing clinical specimens
US8846315B2 (en)	2008-08-12	2014-09-30	Zinfandel Pharmaceuticals, Inc.	Disease risk factors and methods of use
KR20160127181A (ko)	2008-08-12	2016-11-02	진판델 파마슈티컬스 인코포레이티드	질환 위험 인자의 식별 방법
US9953141B2 (en)	2009-11-18	2018-04-24	Becton, Dickinson And Company	Laboratory central control unit method and system
CN107362165A (zh)	2011-01-10	2017-11-21	金帆德尔制药股份有限公司	用于治疗阿尔茨海默病的方法和药物产品
CN113234036B (zh) *	2021-05-12	2023-07-14	斯莱普泰(上海)生物医药科技有限公司	Nmda受体拮抗剂及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL93610A0 (en)	1989-03-08	1990-12-23	Merck Sharp & Dohme	Tetrahydroquinoline derivatives,their preparation and pharmaceutical compositions containing them
DE19536809A1 (de)	1995-10-02	1997-04-03	Basf Ag	Heterocyclisch substituierte Salicylsäurederivate
GB9617305D0 (en)	1996-08-17	1996-09-25	Glaxo Wellcome Spa	Heterocyclic compounds
GB9706294D0 (en)	1997-03-26	1997-05-14	Glaxo Wellcome Spa	Heterocyclic compound

2001
- 2001-07-05 DE DE10132725A patent/DE10132725A1/de not_active Withdrawn
2002
- 2002-07-03 EP EP02743260A patent/EP1406888B1/de not_active Expired - Lifetime
- 2002-07-03 DK DK02743260T patent/DK1406888T3/da active
- 2002-07-03 AT AT02743260T patent/ATE327226T1/de not_active IP Right Cessation
- 2002-07-03 DE DE50206910T patent/DE50206910D1/de not_active Expired - Lifetime
- 2002-07-03 ES ES02743260T patent/ES2266524T3/es not_active Expired - Lifetime
- 2002-07-03 WO PCT/EP2002/007380 patent/WO2003004483A1/de not_active Ceased
- 2002-07-03 PT PT02743260T patent/PT1406888E/pt unknown
- 2002-07-04 PE PE2002000601A patent/PE20030275A1/es not_active Application Discontinuation
- 2002-07-05 AR ARP020102526A patent/AR036130A1/es not_active Application Discontinuation
2004
- 2004-01-05 US US10/751,741 patent/US6956055B2/en not_active Expired - Fee Related
2006
- 2006-08-21 CY CY20061101157T patent/CY1105275T1/el unknown

Also Published As

Publication number	Publication date
ATE327226T1 (de)	2006-06-15
PE20030275A1 (es)	2003-04-26
DE50206910D1 (de)	2006-06-29
AR036130A1 (es)	2004-08-11
ES2266524T3 (es)	2007-03-01
EP1406888A1 (de)	2004-04-14
PT1406888E (pt)	2006-10-31
WO2003004483A1 (de)	2003-01-16
US20040171677A1 (en)	2004-09-02
CY1105275T1 (el)	2010-03-03
US6956055B2 (en)	2005-10-18
EP1406888B1 (de)	2006-05-24
DE10132725A1 (de)	2006-08-03

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