DK1648882T3 - 3-fluor-piperidiner som NMDA/NR2B-antagonister - Google Patents

3-fluor-piperidiner som NMDA/NR2B-antagonister

Info

Publication number: DK1648882T3
Authority: DK; Denmark
Prior art keywords: nmda; piperidines; fluoro; nr2b antagonists; nr2b
Prior art date: 2003-06-04

Application number

DK04753896T

Other languages

English (en)

Inventor

Nigel J Liverton

Christopher F Claiborne

David A Claremon

John A Mccauley

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-04

Filing date

2004-05-28

Publication date

2008-11-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33511734&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1648882(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-05-28 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2008-11-24 Application granted granted Critical

2008-11-24 Publication of DK1648882T3 publication Critical patent/DK1648882T3/da

Links

YUKQZLBLVRAJSW-UHFFFAOYSA-N 3-fluoropiperidine Chemical class FC1CCCNC1 YUKQZLBLVRAJSW-UHFFFAOYSA-N 0.000 title 1
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title 1
102000034527 Retinoid X Receptors Human genes 0.000 title 1
108010038912 Retinoid X Receptors Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/36—Opioid-abuse
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Immunology (AREA)
Addiction (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Molecular Biology (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Communicable Diseases (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychology (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
AIDS & HIV (AREA)

DK04753896T 2003-06-04 2004-05-28 3-fluor-piperidiner som NMDA/NR2B-antagonister DK1648882T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US47593803P	2003-06-04	2003-06-04
PCT/US2004/017175 WO2004108705A1 (en)	2003-06-04	2004-05-28	3-fluoro-piperidines as nmda/nr2b antagonists

Publications (1)

Publication Number	Publication Date
DK1648882T3 true DK1648882T3 (da)	2008-11-24

Family

ID=33511734

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04753896T DK1648882T3 (da)	2003-06-04	2004-05-28	3-fluor-piperidiner som NMDA/NR2B-antagonister

Country Status (30)

Country	Link
EP (1)	EP1648882B1 (da)
JP (1)	JP3927228B2 (da)
KR (1)	KR20060017839A (da)
CN (1)	CN1798744A (da)
AR (1)	AR044579A1 (da)
AT (1)	ATE403651T1 (da)
AU (1)	AU2004245522B2 (da)
BR (1)	BRPI0410837A (da)
CA (1)	CA2527093C (da)
CL (1)	CL2004001365A1 (da)
CO (1)	CO5700762A2 (da)
DE (1)	DE602004015610D1 (da)
DK (1)	DK1648882T3 (da)
EC (1)	ECSP056192A (da)
ES (1)	ES2309540T3 (da)
HR (1)	HRP20080490T3 (da)
IS (1)	IS8117A (da)
MA (1)	MA27781A1 (da)
MX (1)	MXPA05013151A (da)
MY (1)	MY138547A (da)
NO (1)	NO20060020L (da)
PE (1)	PE20050245A1 (da)
PL (1)	PL1648882T3 (da)
PT (1)	PT1648882E (da)
RU (1)	RU2339630C2 (da)
SI (1)	SI1648882T1 (da)
TW (1)	TW200510378A (da)
UA (1)	UA81319C2 (da)
WO (1)	WO2004108705A1 (da)
ZA (1)	ZA200509000B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007128056A1 (en) *	2006-05-03	2007-11-15	Cnsbio Pty Ltd	Methods and composition for treatment of inflammatory pain
RU2489431C2 (ru) *	2007-04-23	2013-08-10	Янссен Фармацевтика Н.В.	Тиа(диа)золы как быстро диссоциирующие антагонисты рецептора допамина 2
WO2009000038A1 (en) *	2007-06-28	2008-12-31	Cnsbio Pty Ltd	Combination methods and compositions for treatment of neuropathic pain
KR20120123089A (ko)	2010-02-16	2012-11-07	화이자 인코포레이티드	5-ＨＴ₄ 수용체의 부분 효능제인 (Ｒ)-4-((4-((4-(테트라히드로푸란-3-일옥시)벤조［ｄ］이속사졸-3-일옥시)메틸)피페리딘-1-일)메틸)테트라히드로-2Ｈ-피란-4-올
AU2013251079B2 (en)	2012-04-20	2017-03-23	Ucb Pharma S.A.	Methods for treating Parkinson's disease
CN103936663B (zh) *	2013-01-23	2016-12-28	艾琪康医药科技（上海）有限公司	一种1-r1-3,3-二氟(或3-氟)-4-r2-4-氨甲基哌啶及其衍生物的制备方法
US9221796B2 (en)	2014-01-09	2015-12-29	Bristol-Myers Squibb Company	Selective NR2B antagonists
US9187506B2 (en)	2014-01-09	2015-11-17	Bristol-Myers Squibb Company	(R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one and its prodrugs for the treatment of psychiatric disorders
US10030026B2 (en)	2014-06-04	2018-07-24	Rugen Holdings (Cayman) Limited	Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists
MX2017002775A (es)	2014-09-15	2017-08-10	Rugen Holdings (Cayman) Ltd	Derivados de pirrolopirimidina como antagonistas del receptor de n-metil-d-aspartato (nmda), subunidad nr2b.
US20180271869A1 (en) *	2014-09-22	2018-09-27	Jie Liu	Treatment of anxiety disorders and autism spectrum disorders
CA2970958A1 (en)	2014-12-23	2016-06-30	Cerecor, Inc.	Compounds, compositions and methods
US10221182B2 (en)	2015-02-04	2019-03-05	Rugen Holdings (Cayman) Limited	3,3-difluoro-piperidine derivatives as NR2B NMDA receptor antagonists
CA2987606C (en) *	2015-06-01	2024-02-20	Rugen Holdings (Cayman) Limited	3,3-difluoropiperidine carbamate heterocyclic compounds as nr2b nmda receptor antagonists
MX2018004256A (es)	2015-10-14	2018-05-16	Squibb Bristol Myers Co	Antagonistas de receptor de n-metil-d-aspartato subtipo 2b (nr2b) selectivos.
CA3001894A1 (en)	2015-10-14	2017-04-20	Bristol-Myers Squibb Company	Selective nr2b antagonists
ES2886840T3 (es)	2016-08-31	2021-12-21	Eisai R&D Man Co Ltd	Compuesto de pirazolo[1,5-a]pirimidina
WO2018098128A1 (en)	2016-11-22	2018-05-31	Rugen Holdings (Cayman) Limited	Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA03007621A (es) *	2001-02-23	2003-12-04	Merck & Co Inc	Antagonistas nr2b de n-metil-d-aspartato no arilheterociclicos n-sustituidos.

2004
- 2004-05-28 KR KR1020057023218A patent/KR20060017839A/ko not_active Ceased
- 2004-05-28 ES ES04753896T patent/ES2309540T3/es not_active Expired - Lifetime
- 2004-05-28 PT PT04753896T patent/PT1648882E/pt unknown
- 2004-05-28 BR BRPI0410837-0A patent/BRPI0410837A/pt not_active IP Right Cessation
- 2004-05-28 CN CNA2004800153228A patent/CN1798744A/zh active Pending
- 2004-05-28 MX MXPA05013151A patent/MXPA05013151A/es active IP Right Grant
- 2004-05-28 CA CA002527093A patent/CA2527093C/en not_active Expired - Lifetime
- 2004-05-28 DK DK04753896T patent/DK1648882T3/da active
- 2004-05-28 AU AU2004245522A patent/AU2004245522B2/en not_active Expired
- 2004-05-28 EP EP04753896A patent/EP1648882B1/en not_active Expired - Lifetime
- 2004-05-28 DE DE602004015610T patent/DE602004015610D1/de not_active Expired - Lifetime
- 2004-05-28 WO PCT/US2004/017175 patent/WO2004108705A1/en not_active Ceased
- 2004-05-28 RU RU2005137704/04A patent/RU2339630C2/ru not_active IP Right Cessation
- 2004-05-28 UA UAA200511411A patent/UA81319C2/uk unknown
- 2004-05-28 HR HR20080490T patent/HRP20080490T3/xx unknown
- 2004-05-28 PL PL04753896T patent/PL1648882T3/pl unknown
- 2004-05-28 AT AT04753896T patent/ATE403651T1/de not_active IP Right Cessation
- 2004-05-28 JP JP2006515051A patent/JP3927228B2/ja not_active Expired - Lifetime
- 2004-05-28 SI SI200430845T patent/SI1648882T1/sl unknown
- 2004-05-31 MY MYPI20042091A patent/MY138547A/en unknown
- 2004-05-31 AR ARP040101878A patent/AR044579A1/es unknown
- 2004-06-01 PE PE2004000552A patent/PE20050245A1/es not_active Application Discontinuation
- 2004-06-03 CL CL200401365A patent/CL2004001365A1/es unknown
- 2004-06-03 TW TW093115972A patent/TW200510378A/zh unknown
2005
- 2005-11-07 IS IS8117A patent/IS8117A/is unknown
- 2005-11-07 ZA ZA200509000A patent/ZA200509000B/en unknown
- 2005-11-28 MA MA28626A patent/MA27781A1/fr unknown
- 2005-11-29 EC EC2005006192A patent/ECSP056192A/es unknown
- 2005-11-30 CO CO05121658A patent/CO5700762A2/es not_active Application Discontinuation
2006
- 2006-01-03 NO NO20060020A patent/NO20060020L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
MA27781A1 (fr)	2006-02-01
MXPA05013151A (es)	2006-03-17
RU2005137704A (ru)	2006-05-27
UA81319C2 (en)	2007-12-25
SI1648882T1 (sl)	2009-02-28
CA2527093A1 (en)	2004-12-16
EP1648882A1 (en)	2006-04-26
PL1648882T3 (pl)	2008-12-31
TW200510378A (en)	2005-03-16
WO2004108705A1 (en)	2004-12-16
PE20050245A1 (es)	2005-04-13
JP2006526650A (ja)	2006-11-24
CL2004001365A1 (es)	2005-05-06
CO5700762A2 (es)	2006-11-30
KR20060017839A (ko)	2006-02-27
DE602004015610D1 (de)	2008-09-18
IS8117A (is)	2005-11-07
AU2004245522B2 (en)	2009-10-29
BRPI0410837A (pt)	2006-06-27
CN1798744A (zh)	2006-07-05
RU2339630C2 (ru)	2008-11-27
CA2527093C (en)	2009-10-20
JP3927228B2 (ja)	2007-06-06
ECSP056192A (es)	2006-04-19
EP1648882B1 (en)	2008-08-06
NO20060020L (no)	2006-03-03
HRP20080490T3 (en)	2008-11-30
ATE403651T1 (de)	2008-08-15
AU2004245522A1 (en)	2004-12-16
ZA200509000B (en)	2006-12-27
MY138547A (en)	2009-06-30
AR044579A1 (es)	2005-09-21
ES2309540T3 (es)	2008-12-16
PT1648882E (pt)	2008-10-20

Publication	Publication Date	Title
NO20044654L (no)	2004-10-28	Piperidinoylpiperidiner som 5-HTIF-agonister
NO20052739D0 (no)	2005-06-07	CCR5-antagonister som medikamenter
DK3494995T3 (da)	2020-03-23	Superfin formoterolformulering
ATE481402T1 (de)	2010-10-15	Pyrazolopyridin-derivate
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