DK1406902T3 - Hexahydroazepino[4,5-g]indoler og -indoliner som 5-HT-receptor-ligander - Google Patents

Hexahydroazepino[4,5-g]indoler og -indoliner som 5-HT-receptor-ligander

Info

Publication number
DK1406902T3
DK1406902T3 DK02744532T DK02744532T DK1406902T3 DK 1406902 T3 DK1406902 T3 DK 1406902T3 DK 02744532 T DK02744532 T DK 02744532T DK 02744532 T DK02744532 T DK 02744532T DK 1406902 T3 DK1406902 T3 DK 1406902T3
Authority
DK
Denmark
Prior art keywords
sup
hexahydroazepino
indolines
indoles
receptor ligands
Prior art date
Application number
DK02744532T
Other languages
English (en)
Inventor
Arthur Glenn Romero
Jian-Min Fu
Jeanette Kay Morris
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Application granted granted Critical
Publication of DK1406902T3 publication Critical patent/DK1406902T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK02744532T 2001-07-13 2002-07-10 Hexahydroazepino[4,5-g]indoler og -indoliner som 5-HT-receptor-ligander DK1406902T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30530501P 2001-07-13 2001-07-13

Publications (1)

Publication Number Publication Date
DK1406902T3 true DK1406902T3 (da) 2006-01-30

Family

ID=23180257

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02744532T DK1406902T3 (da) 2001-07-13 2002-07-10 Hexahydroazepino[4,5-g]indoler og -indoliner som 5-HT-receptor-ligander

Country Status (11)

Country Link
US (1) US7022694B2 (da)
EP (1) EP1406902B1 (da)
JP (1) JP2005522408A (da)
AT (1) ATE307133T1 (da)
BR (1) BR0211140A (da)
CA (1) CA2452610A1 (da)
DE (1) DE60206762T2 (da)
DK (1) DK1406902T3 (da)
ES (1) ES2250667T3 (da)
MX (1) MXPA04000358A (da)
WO (1) WO2003006466A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003256793A1 (en) * 2002-08-20 2004-03-11 Eli Lilly And Company Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses
DE60321354D1 (de) * 2002-08-29 2008-07-10 Schering Corp Selektive d1/d5 rezeptorantagonisten zur behandlung von fettleibigkeit und von zns störungen
SI1720836T1 (sl) 2004-02-25 2014-06-30 Eli Lilly And Company 6-substituirani 2,3,4,5-tetrahidro-1h-benzo (d)azepini kot agonisti 5-ht2c receptorja
JP5173190B2 (ja) 2004-08-25 2013-03-27 武田薬品工業株式会社 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法
CN101253153A (zh) 2005-09-01 2008-08-27 伊莱利利公司 作为5－HT<sub>2c</sub>受体激动剂的6－取代的2,3,4,5－四氢－1H－苯并[d]氮杂䓬
CA2619450C (en) 2005-09-01 2013-10-22 Eli Lilly And Company 6-n-linked heterocycle-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
ATE438627T1 (de) 2005-09-01 2009-08-15 Lilly Co Eli 6-substituierte- 2,3,4,5-tetrahydro-1h- benzoädüazepine als 5-ht2c-rezeptoragonisten
AU2006287202B2 (en) 2005-09-01 2013-01-24 Eli Lilly And Company 6-arylalkylamino- 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2c receptor agonists
EP2727585A1 (en) 2006-05-16 2014-05-07 Takeda Pharmaceutical Company Limited In-vivo screening method
EP2789338A3 (en) 2007-11-15 2015-01-14 Takeda Pharmaceutical Company Limited Condensed pyridine derivate and use thereof
EP2510949A4 (en) 2009-12-11 2013-11-13 Astellas Pharma Inc THERAPEUTICS FOR FIBROMYALGIA
CA2947300A1 (en) 2014-05-05 2015-11-12 Zhengbing Cao Antimicrobial surface coatings
US20210052600A1 (en) 2017-12-27 2021-02-25 Takeda Pharmaceutical Company Limited Therapeutic agents for stress urinary incontinence and incotinence of feces
EP3753924A1 (en) * 2019-06-18 2020-12-23 AnaMar AB New tricyclic 5-ht2 antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK26793D0 (da) 1993-03-10 1993-03-10 Novo Nordisk As Benzofuranyl- eller dihydrobenzofuranyl-substituerede tricycliske benzazepiner, der anvendelse og fremstilling
AU687255B2 (en) 1994-09-14 1998-02-19 Neurosearch A/S Indole-2,3-dione-3-oxime derivatives, their preparation and use
UA54403C2 (uk) 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
EP0973778A1 (en) 1997-03-07 2000-01-26 Novo Nordisk A/S 4,5,6,7-TETRAHYDRO-THIENO 3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE
EP1066037B1 (en) 1998-03-31 2004-12-29 Neurosearch A/S Use of indole-2,3-dione-3-oxime derivatives as ampa antagonists
GB9918965D0 (en) * 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxi

Also Published As

Publication number Publication date
WO2003006466A1 (en) 2003-01-23
ATE307133T1 (de) 2005-11-15
US7022694B2 (en) 2006-04-04
ES2250667T3 (es) 2006-04-16
CA2452610A1 (en) 2003-01-23
EP1406902B1 (en) 2005-10-19
EP1406902A1 (en) 2004-04-14
JP2005522408A (ja) 2005-07-28
DE60206762D1 (de) 2006-03-02
DE60206762T2 (de) 2006-07-13
BR0211140A (pt) 2005-10-25
MXPA04000358A (es) 2004-05-04
US20030060458A1 (en) 2003-03-27

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