DK1409448T3 - Fremgangsmåde til fremstilling af det indre salt af (R)- eller (S)-aminocarnitin, salte og derivater deraf - Google Patents

Fremgangsmåde til fremstilling af det indre salt af (R)- eller (S)-aminocarnitin, salte og derivater deraf

Info

Publication number: DK1409448T3
Authority: DK; Denmark
Prior art keywords: aminocarnitine; derivatives; salts; preparation; inner salt
Prior art date: 2001-07-26

Application number

DK02767834T

Other languages

English (en)

Inventor

O Piccolo

R Castagnani

Witt Scalfaro De

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-26

Filing date

2002-07-17

Publication date

2007-04-02

2002-07-17 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

2007-04-02 Application granted granted Critical

2007-04-02 Publication of DK1409448T3 publication Critical patent/DK1409448T3/da

Links

150000003839 salts Chemical class 0.000 title abstract 4
DAWBGYHPBBDHMQ-LURJTMIESA-N (3s)-3-amino-4-(trimethylazaniumyl)butanoate Chemical compound C[N+](C)(C)C[C@@H](N)CC([O-])=O DAWBGYHPBBDHMQ-LURJTMIESA-N 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
DAWBGYHPBBDHMQ-ZCFIWIBFSA-N (3r)-3-amino-4-(trimethylazaniumyl)butanoate Chemical compound C[N+](C)(C)C[C@H](N)CC([O-])=O DAWBGYHPBBDHMQ-ZCFIWIBFSA-N 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
WPWLZCVABVFBGW-UHFFFAOYSA-N 3-azido-3-hydroxy-4-(trimethylazaniumyl)butanoate Chemical compound C[N+](C)(C)CC(O)(CC([O-])=O)N=[N+]=[N-] WPWLZCVABVFBGW-UHFFFAOYSA-N 0.000 abstract 1
SKMSOHALMZCXFM-ZETCQYMHSA-N N[C@@](O)(C[N+](C)(C)C)CC([O-])=O Chemical class N[C@@](O)(C[N+](C)(C)C)CC([O-])=O SKMSOHALMZCXFM-ZETCQYMHSA-N 0.000 abstract 1
JTARPNWGYOTOQV-ZETCQYMHSA-N [N+](=O)([O-])O[C@](O)(C[N+](C)(C)C)CC([O-])=O Chemical compound [N+](=O)([O-])O[C@](O)(C[N+](C)(C)C)CC([O-])=O JTARPNWGYOTOQV-ZETCQYMHSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000005984 hydrogenation reaction Methods 0.000 abstract 1
238000011065 in-situ storage Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
- C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
- C07C273/1827—X being H

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Obesity (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK02767834T 2001-07-26 2002-07-17 Fremgangsmåde til fremstilling af det indre salt af (R)- eller (S)-aminocarnitin, salte og derivater deraf DK1409448T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2001RM000456A ITRM20010456A1 (it)	2001-07-26	2001-07-26	Procedimento per la preparazione di (r)- o (s)- amminocarnitina sale interno, dei suoi sali e dei suoi derivati.
PCT/IT2002/000468 WO2003010129A1 (en)	2001-07-26	2002-07-17	Process for the preparation of (r)- or (s)-aminocarnitine inner salt, the salts and derivatives thereof

Publications (1)

Publication Number	Publication Date
DK1409448T3 true DK1409448T3 (da)	2007-04-02

Family

ID=11455694

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02767834T DK1409448T3 (da)	2001-07-26	2002-07-17	Fremgangsmåde til fremstilling af det indre salt af (R)- eller (S)-aminocarnitin, salte og derivater deraf

Country Status (18)

Country	Link
US (1)	US6953865B2 (da)
EP (1)	EP1409448B1 (da)
JP (1)	JP4212473B2 (da)
KR (1)	KR100879125B1 (da)
CN (1)	CN1231460C (da)
AT (1)	ATE346837T1 (da)
AU (1)	AU2002330738B2 (da)
CA (1)	CA2453019A1 (da)
CY (1)	CY1107567T1 (da)
DE (1)	DE60216466T2 (da)
DK (1)	DK1409448T3 (da)
ES (1)	ES2280570T3 (da)
HU (1)	HUP0401617A3 (da)
IT (1)	ITRM20010456A1 (da)
MX (1)	MXPA04000676A (da)
PL (1)	PL367614A1 (da)
PT (1)	PT1409448E (da)
WO (1)	WO2003010129A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1299266B1 (it) *	1998-05-15	2000-02-29	Sigma Tau Ind Farmaceuti	Inibitori reversibili della carnitina palmitoil trasferasi
US7776915B2 (en) *	2005-03-24	2010-08-17	Tracie Martyn International, Llc	Topical formulations and methods of use
WO2008109991A1 (en) *	2007-03-09	2008-09-18	University Health Network	Inhibitors of carnitine palmitoyltransferase and treating cancer
CA2694724C (en)	2007-08-01	2017-09-12	University Health Network	Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer
CN111621541B (zh) *	2019-02-27	2025-10-31	广安摩珈生物科技有限公司	使用电渗析技术拆分光学异构体的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4767781A (en) *	1981-11-26	1988-08-30	Takeda Chemical Industries, Ltd.	Derivatives of beta-amino-gamma-trimethylammonio-butyrate and their production and use
IT1261489B (it)	1993-07-29	1996-05-23	Sigma Tau Ind Farmaceuti	Procedimento per la produzione di r amminocarnitina e s amminocarnitina.
IT1299266B1 (it) *	1998-05-15	2000-02-29	Sigma Tau Ind Farmaceuti	Inibitori reversibili della carnitina palmitoil trasferasi
IT1306184B1 (it)	1999-08-05	2001-05-30	Sigma Tau Ind Farmaceuti	Nitrilossi derivati della (r) e (s)-carnitina.

2001
- 2001-07-26 IT IT2001RM000456A patent/ITRM20010456A1/it unknown
2002
- 2002-07-17 DK DK02767834T patent/DK1409448T3/da active
- 2002-07-17 KR KR1020037017244A patent/KR100879125B1/ko not_active Expired - Fee Related
- 2002-07-17 HU HU0401617A patent/HUP0401617A3/hu unknown
- 2002-07-17 EP EP02767834A patent/EP1409448B1/en not_active Expired - Lifetime
- 2002-07-17 CA CA002453019A patent/CA2453019A1/en not_active Abandoned
- 2002-07-17 PT PT02767834T patent/PT1409448E/pt unknown
- 2002-07-17 US US10/482,729 patent/US6953865B2/en not_active Expired - Fee Related
- 2002-07-17 DE DE60216466T patent/DE60216466T2/de not_active Expired - Lifetime
- 2002-07-17 AU AU2002330738A patent/AU2002330738B2/en not_active Ceased
- 2002-07-17 ES ES02767834T patent/ES2280570T3/es not_active Expired - Lifetime
- 2002-07-17 AT AT02767834T patent/ATE346837T1/de not_active IP Right Cessation
- 2002-07-17 CN CNB028140222A patent/CN1231460C/zh not_active Expired - Fee Related
- 2002-07-17 JP JP2003515489A patent/JP4212473B2/ja not_active Expired - Fee Related
- 2002-07-17 PL PL02367614A patent/PL367614A1/xx unknown
- 2002-07-17 WO PCT/IT2002/000468 patent/WO2003010129A1/en not_active Ceased
- 2002-07-17 MX MXPA04000676A patent/MXPA04000676A/es active IP Right Grant
2007
- 2007-02-26 CY CY20071100269T patent/CY1107567T1/el unknown

Also Published As

Publication number	Publication date
CN1231460C (zh)	2005-12-14
US20040171875A1 (en)	2004-09-02
AU2002330738B2 (en)	2008-05-08
CA2453019A1 (en)	2003-02-06
EP1409448B1 (en)	2006-11-29
ES2280570T3 (es)	2007-09-16
PL367614A1 (en)	2005-03-07
CN1527811A (zh)	2004-09-08
PT1409448E (pt)	2007-02-28
KR20040032116A (ko)	2004-04-14
US6953865B2 (en)	2005-10-11
CY1107567T1 (el)	2013-03-13
HUP0401617A2 (hu)	2004-12-28
JP2004536867A (ja)	2004-12-09
HK1068327A1 (en)	2005-04-29
JP4212473B2 (ja)	2009-01-21
HUP0401617A3 (en)	2008-05-28
KR100879125B1 (ko)	2009-01-19
DE60216466T2 (de)	2007-09-20
DE60216466D1 (de)	2007-01-11
MXPA04000676A (es)	2004-04-05
EP1409448A1 (en)	2004-04-21
ITRM20010456A1 (it)	2003-01-27
WO2003010129A1 (en)	2003-02-06
ITRM20010456A0 (it)	2001-07-26
ATE346837T1 (de)	2006-12-15

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