DK1421380T3 - Indretning og fremgangsmåde til registrering af bioelektriske signaler fra elektrofysiologisk aktive områder i sfæroider - Google Patents

Indretning og fremgangsmåde til registrering af bioelektriske signaler fra elektrofysiologisk aktive områder i sfæroider

Info

Publication number
DK1421380T3
DK1421380T3 DK02772172T DK02772172T DK1421380T3 DK 1421380 T3 DK1421380 T3 DK 1421380T3 DK 02772172 T DK02772172 T DK 02772172T DK 02772172 T DK02772172 T DK 02772172T DK 1421380 T3 DK1421380 T3 DK 1421380T3
Authority
DK
Denmark
Prior art keywords
spheroids
measuring
bioelectric signals
active areas
measuring chamber
Prior art date
Application number
DK02772172T
Other languages
English (en)
Inventor
Hagen Thielecke
Andrea Robitzki
Original Assignee
Fraunhofer Ges Forschung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Ges Forschung filed Critical Fraunhofer Ges Forschung
Application granted granted Critical
Publication of DK1421380T3 publication Critical patent/DK1421380T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
    • G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
    • G01N15/131—Details
    • G01N15/132—Circuits
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
    • G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
    • G01N2015/135—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
    • G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
    • G01N2015/135—Electrodes
    • G01N2015/136—Scanning electrodes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Signal Processing (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
DK02772172T 2001-08-30 2002-08-20 Indretning og fremgangsmåde til registrering af bioelektriske signaler fra elektrofysiologisk aktive områder i sfæroider DK1421380T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10142393A DE10142393C1 (de) 2001-08-30 2001-08-30 Vorrichtung und Verfahren zur Erfassung bioelektrischer Signale aus elektrophysiologisch aktiven Bereichen in Sphäroiden
PCT/EP2002/009267 WO2003020125A2 (de) 2001-08-30 2002-08-20 Vorrichtung und verfahren zur erfassung bioelektrischer signale aus elektrophysiologisch aktiven bereichen in sphäroiden

Publications (1)

Publication Number Publication Date
DK1421380T3 true DK1421380T3 (da) 2009-04-20

Family

ID=7697040

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02772172T DK1421380T3 (da) 2001-08-30 2002-08-20 Indretning og fremgangsmåde til registrering af bioelektriske signaler fra elektrofysiologisk aktive områder i sfæroider

Country Status (6)

Country Link
US (1) US7709246B2 (da)
EP (1) EP1421380B1 (da)
AT (1) ATE421087T1 (da)
DE (2) DE10142393C1 (da)
DK (1) DK1421380T3 (da)
WO (1) WO2003020125A2 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19946458C2 (de) * 1999-09-28 2002-10-24 Fraunhofer Ges Forschung Vorrichtung und Verfahren zur Charakterisierung von Sphäroiden
WO2004086940A2 (en) * 2003-03-25 2004-10-14 Fresenius Medical Care Holdings, Inc. Device and method for performing electrical impedance tomography
FR2859788B1 (fr) * 2003-09-11 2006-05-05 Univ Bourgogne Cellule de mesure d'activites biologiques et/ou de grandeurs physiologiques de micro-organismes
DE102004017474A1 (de) * 2004-04-08 2005-10-27 Evotec Technologies Gmbh Messeinrichtung zur Impedanzspektroskopie und zugehöriges Messverfahren
KR101119381B1 (ko) * 2009-06-18 2012-03-07 한국과학기술원 세포 특성 측정 장치 및 시스템과 이를 이용한 세포 특성 측정 방법
EP2354217B1 (en) 2010-02-03 2015-09-02 Universität Leipzig Integrated cultivation and measurement device for label-free detection and classification of cellular alterations, in particular for generation and characterisation of cell-spheroids, components and uses thereof
JP5922361B2 (ja) * 2010-09-09 2016-05-24 アイメックＩｍｅｃ 活性マイクロシーブおよび生物学的応用のための方法
US20130096029A1 (en) * 2011-09-06 2013-04-18 The Trustees Of Columbia University In The City Of New York Multiplexed in vivo screening of biological samples
US9488641B2 (en) * 2012-07-18 2016-11-08 Case Western Reserve University Multicellular system and method for multiparametric analysis
CN105195241B (zh) * 2015-10-15 2019-02-15 思澜科技（成都）有限公司 用于生物组织检测的自动吸附式辅助器皿
CN110799830B (zh) * 2017-04-27 2023-04-14 多元生物学公司 正交多生物感测和成像系统
US10816453B2 (en) * 2017-11-03 2020-10-27 Sharp Life Science (Eu) Limited Co-planar micro-impedance cytometry device

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2232769B (en) * 1989-06-13 1994-06-22 Timothy Charles Fisher Counting and volume measurement of particles and biological cells,and determination of their deformability
US6122599A (en) * 1998-02-13 2000-09-19 Mehta; Shailesh Apparatus and method for analyzing particles
DE19946458C2 (de) * 1999-09-28 2002-10-24 Fraunhofer Ges Forschung Vorrichtung und Verfahren zur Charakterisierung von Sphäroiden
ATE317545T1 (de) * 1999-10-01 2006-02-15 Sophion Bioscience As Anordnung und verfahren zum feststellen und/oder überwachen elektrophysiologischer eigenschaften von ionenkanälen
DE19953424B4 (de) * 1999-11-06 2006-04-13 Universität Leipzig Verfahren und Anordnung zur Charakterisierung und Vereinzelung von multizellulären Sphäroiden

Also Published As

Publication number Publication date
US20040209351A1 (en) 2004-10-21
WO2003020125A3 (de) 2003-11-27
US7709246B2 (en) 2010-05-04
EP1421380B1 (de) 2009-01-14
EP1421380A2 (de) 2004-05-26
WO2003020125A2 (de) 2003-03-13
ATE421087T1 (de) 2009-01-15
DE10142393C1 (de) 2003-01-23
DE50213221D1 (de) 2009-03-05

Similar Documents

Publication Publication Date Title
AU2003267998A8 (en) Impedance based devices and methods for use in assays
ATE349008T1 (de) Vorrichtung zum messen an in einer flüssigen umgebung befindlichen zellen
MXPA02005614A (es) Dispositivos y metodo para muestreo de fluido biologico y medicion de analito.
DE3582532D1 (de) Vorrichtungen zur verwendung in chemischen analyseverfahren.
JPS56106149A (en) Method and device for electrochemical test and*or analysis of sample solution
EP1702207B8 (en) Cartridge device for blood analysis
GB2435769A (en) Multiwell sample plate with integrated impedance electrodes and connection scheme
DE60136292D1 (de) Multiarraysystem zur integration von bioarrays
IL179295A (en) Method and device for determining a parameter of living tissue
ATE421087T1 (de) Vorrichtung und verfahren zur erfassung bioelektrischer signale aus elektrophysiologisch aktiven bereichen in sphäroiden
ATE283476T1 (de) Elektrochemisches messgerät
ATE96546T1 (de) Kompakte elektrochemische zelle zum gasnachweis.
EP1744668A4 (en) DEVICE AND DEVICE FOR DETECTING MOISTURE
JP2010535340A5 (da)
MX2010001160A (es) Sensores de prueba y metodo de uso de contactos de medidor de montaje lateral.
ATE6310T1 (de) Geraet zur zaehlung von in elektrisch leitenden probenfluessigkeiten schwebenden teilchen.
FR2951547B1 (fr) Dispositif capteur de biomasse reference electriquement.
JP2005535906A5 (da)
RU93005234A (ru) Измерительный пробник
JPS6455126A (en) Sensor for concentration of nutritious solution in culture medium
SU1474535A1 (ru) Электрохимическа чейка дл потенциометрического измерени концентрации ионов
RU2003117267A (ru) Устройство для электрохимических измерений
RU2024129414A (ru) Модульное сенсорное устройство и система для воздействия аэрозолем in vitro
HRPK20030936B3 (en) Multiple sensor for simultaneous measurement (activation) of electrolytes concentration in serum, plasma and blood samples
RU47365U1 (ru) Устройство для мониторинга физико-химических параметров образцов горных пород