DK1421389T3 - Neurofibrilmarkører - Google Patents
NeurofibrilmarkørerInfo
- Publication number
- DK1421389T3 DK1421389T3 DK02720102.9T DK02720102T DK1421389T3 DK 1421389 T3 DK1421389 T3 DK 1421389T3 DK 02720102 T DK02720102 T DK 02720102T DK 1421389 T3 DK1421389 T3 DK 1421389T3
- Authority
- DK
- Denmark
- Prior art keywords
- tau
- tau protein
- derivative
- agent
- binding
- Prior art date
Links
- 210000001682 neurofibril Anatomy 0.000 title 1
- 102000013498 tau Proteins Human genes 0.000 abstract 9
- 108010026424 tau Proteins Proteins 0.000 abstract 9
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 239000003112 inhibitor Substances 0.000 abstract 3
- 239000007790 solid phase Substances 0.000 abstract 3
- 238000002372 labelling Methods 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 239000007791 liquid phase Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000010807 negative regulation of binding Effects 0.000 abstract 1
- 108010064245 urinary gonadotropin fragment Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/583—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with non-fluorescent dye label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Lubricants (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0106953.3A GB0106953D0 (en) | 2001-03-20 | 2001-03-20 | Neufofibrillary labels |
| PCT/GB2002/001318 WO2002075318A2 (en) | 2001-03-20 | 2002-03-20 | Neurofibrillary labels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1421389T3 true DK1421389T3 (da) | 2012-08-13 |
Family
ID=9911161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02720102.9T DK1421389T3 (da) | 2001-03-20 | 2002-03-20 | Neurofibrilmarkører |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7335652B2 (da) |
| EP (1) | EP1421389B1 (da) |
| JP (2) | JP4288073B2 (da) |
| CN (2) | CN1578910A (da) |
| AT (1) | ATE556323T1 (da) |
| AU (1) | AU2002251172B2 (da) |
| CA (1) | CA2440794C (da) |
| DK (1) | DK1421389T3 (da) |
| ES (1) | ES2386773T3 (da) |
| GB (1) | GB0106953D0 (da) |
| PT (1) | PT1421389E (da) |
| WO (1) | WO2002075318A2 (da) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| GB0100119D0 (en) | 2001-01-03 | 2001-02-14 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB0106953D0 (en) * | 2001-03-20 | 2001-05-09 | Univ Aberdeen | Neufofibrillary labels |
| GB0113121D0 (en) | 2001-05-30 | 2001-07-18 | Univ Leeds | Biologically active photosensitisers |
| GB0117326D0 (en) | 2001-07-16 | 2001-09-05 | Univ Aberdeen | Napthoquinone-type inhibitors of protein aggregation |
| US20050032857A1 (en) * | 2003-06-19 | 2005-02-10 | Jeff Kuret | Methods for inhibiting or reversing tau filament fibrillization |
| GB0322756D0 (en) * | 2003-09-29 | 2003-10-29 | Univ Aberdeen | Methods of chemical synthesis |
| SI2322517T1 (sl) | 2004-09-23 | 2019-06-28 | Wista Laboratories Ltd. | Postopki za kemijsko sintezo in čiščenje diaminofenotiazinijevih spojin, vključno metiltioninijevega klorida (MTC) |
| CN101084204B (zh) | 2004-09-23 | 2012-12-05 | 卫思道制药有限公司 | 包括亚甲蓝(mtc)在内的二氨基吩噻嗪鎓化合物的化学合成和纯化方法 |
| WO2007110630A1 (en) | 2006-03-29 | 2007-10-04 | Wista Laboratories Ltd. | Thioninium compounds and their use |
| SI2004155T1 (en) | 2006-03-29 | 2018-05-31 | Wista Laboratories Ltd. | Inhibitors of protein aggregation |
| ES2349322T7 (es) | 2006-03-29 | 2019-10-17 | Wista Lab Ltd | Sales de 3,7-diamino-10H-fenotiazina y su utilización |
| JP5132090B2 (ja) * | 2006-06-16 | 2013-01-30 | 東和薬品株式会社 | 塩酸エピナスチンドライシロップ剤 |
| MY148145A (en) | 2006-07-11 | 2013-03-15 | Wista Lab Ltd | Methods of synthesis and/or purification of diaminophenothiazinium compounds |
| CA2701075C (en) | 2007-10-03 | 2019-02-12 | Wista Laboratories Ltd. | Therapeutic use of diaminophenothiazines. |
| CN102014967A (zh) * | 2008-03-21 | 2011-04-13 | 阿德利夫股份有限公司 | 芘携带肽穿过血脑屏障的用途 |
| WO2009117042A1 (en) * | 2008-03-21 | 2009-09-24 | Adlyfe, Inc. | Use of pyrene to carry non-peptide agents across the blood brain barrier |
| CA2737028C (en) * | 2008-09-23 | 2017-06-27 | Wista Laboratories Ltd. | Ligands for aggregated tau molecules |
| PL3689346T3 (pl) | 2008-12-10 | 2024-06-24 | Wista Laboratories Ltd. | 3,6-Dipodstawione sole ksantyliowe do leczenia tauopatii |
| US8703952B2 (en) | 2008-12-12 | 2014-04-22 | Wista Laboratories Ltd. | Synthesis of 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline and analogues and intermediates |
| CU23844B1 (es) | 2009-04-17 | 2012-10-15 | Ct De Neurociencias De Cuba | Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer |
| SI2430007T1 (sl) | 2009-05-12 | 2014-05-30 | Wista Laboratories Ltd. | Postopki kemijske sinteze diaminofenotiazinijevih spojin, ki vključujejo uporabo persulfatnih oksidantov |
| JP5868955B2 (ja) | 2010-04-30 | 2016-02-24 | プロセッタ アンチバイラル インコーポレイテッド | 抗ウイルス化合物 |
| TW201217387A (en) | 2010-09-15 | 2012-05-01 | Hoffmann La Roche | Azabenzothiazole compounds, compositions and methods of use |
| KR20130129975A (ko) * | 2010-11-16 | 2013-11-29 | 지이 헬쓰케어 리미티드 | 타우 병리의 영상화 프로브로서의 헤테로시클릭 화합물 |
| JP6093707B2 (ja) | 2010-11-30 | 2017-03-08 | ウィスタ ラボラトリーズ リミテッド | 化合物製剤 |
| US20120244174A1 (en) | 2011-01-31 | 2012-09-27 | Intellect Neurosciences Inc. | Treatment of tauopathies |
| JP5898701B2 (ja) | 2011-02-11 | 2016-04-13 | ウィスタ ラボラトリーズ リミテッド | フェノチアジンジアミニウム塩およびそれらの使用 |
| EP2699241B1 (en) | 2011-04-20 | 2016-07-27 | Prosetta Antiviral Inc. | Antiviral compounds |
| US9464064B2 (en) | 2011-09-07 | 2016-10-11 | University Of Kansas | HCV helicase inhibitors and methods of use thereof |
| CN102942537B (zh) * | 2012-11-09 | 2014-07-02 | 浙江大学 | 一种用作pH荧光探针的苯并噻唑-苯胺类化合物及其制备方法 |
| WO2014151630A2 (en) | 2013-03-15 | 2014-09-25 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
| US9588129B2 (en) | 2013-03-15 | 2017-03-07 | Amira Medical Technologies Inc. | Methods for analyzing blood to detect diseases associated with abnormal protein aggregation |
| US9296754B2 (en) | 2013-03-15 | 2016-03-29 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| WO2014151729A1 (en) | 2013-03-15 | 2014-09-25 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| US10765755B1 (en) | 2013-11-20 | 2020-09-08 | University Of South Florida | Preparation and characterization of methylene blue nanoparticles for Alzheimer's disease and other tauopathies |
| BR112016014004B1 (pt) | 2013-12-19 | 2022-11-01 | Novartis Ag | Compostos para tratamento de doenças parasíticas, seus usos, e composições farmacêuticas |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| CN107163022B (zh) * | 2016-03-07 | 2021-07-16 | 上海如絮生物科技有限公司 | 一种异喹啉类化合物、其中间体、制备方法和应用 |
| JP7073330B2 (ja) | 2016-07-25 | 2022-05-23 | ウィスタ ラボラトリーズ リミテッド | ジアミノフェノチアジンの投与及び投与量 |
| MX2019005007A (es) * | 2016-11-01 | 2019-07-18 | Arvinas Inc | Protac dirigidos a la proteína tau y métodos asociados de uso. |
| IL312367A (en) | 2017-01-31 | 2024-06-01 | Arvinas Operations Inc | Cereblon ligands and bifunctional compounds comprising the same |
| SE540570C2 (en) * | 2017-07-14 | 2018-10-02 | A method for analyzing the 3d structure of biomolecules | |
| WO2019148055A1 (en) | 2018-01-26 | 2019-08-01 | Yale University | Imide-based modulators of proteolysis and methods of use |
| WO2020201828A1 (en) | 2019-04-05 | 2020-10-08 | Tauc3 Biologics Limited | Anti-tauc3 antibodies and uses thereof |
| GB201909493D0 (en) | 2019-07-01 | 2019-08-14 | Wista Lab Ltd | Therapeutic interactions |
| EP3999182A1 (en) | 2019-07-17 | 2022-05-25 | Arvinas Operations, Inc. | Tau-protein targeting compounds and associated methods of use |
| AU2020405129A1 (en) | 2019-12-19 | 2022-06-23 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| GB202010620D0 (en) | 2020-07-10 | 2020-08-26 | Wista Lab Ltd | System |
| GB202010652D0 (en) | 2020-07-10 | 2020-08-26 | Wista Lab Ltd | Anti-tau antibodies |
| US20250147051A1 (en) | 2022-01-12 | 2025-05-08 | Gtinvent Limited | Method for detecting a tau protein in a saliva sample |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2815926A1 (de) * | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US4389393A (en) * | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| CA1302250C (en) * | 1986-04-04 | 1992-06-02 | Khalid Iqbal | Diagnostic for alzheimer's disease |
| AU620327B2 (en) * | 1987-04-08 | 1992-02-20 | Salutar, Inc. | Amyloidosis and alzheimer's disease diagnostic assay and reagents therefor |
| US5008099A (en) * | 1987-04-08 | 1991-04-16 | Salutar, Inc. | Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor |
| GB8724412D0 (en) | 1987-10-19 | 1987-11-25 | Medical Res Council | Protein |
| FI101344B1 (fi) * | 1988-03-31 | 1998-06-15 | Tanabe Seiyaku Co | Menetelmä valmistaa valmiste, josta kontrolloidusti vapautuu farmaseuttisesti aktiivista ainetta |
| KR100231226B1 (ko) | 1991-07-10 | 1999-11-15 | 스프레이그 로버트 월터 | 발수 처리용 및 발유 처리용 플루오로케미칼 조성물 |
| EP0600951A4 (en) * | 1991-08-01 | 1996-10-30 | Paul H Voorheis | Diagnostic method for alzheimer's disease. |
| DK0618968T3 (da) | 1991-12-06 | 2000-04-10 | Max Planck Gesellschaft | Midler til diagnostisering og behandling af Alzheimer's sygdom |
| WO1993019143A1 (en) * | 1992-03-17 | 1993-09-30 | Lord Corporation | Colorant-containing electrorheological materials |
| US5536761A (en) | 1992-12-07 | 1996-07-16 | Sakura Color Products Corporation | Water base dye ink composition |
| GB9317193D0 (en) | 1993-08-18 | 1993-10-06 | Zeneca Ltd | Method |
| AU708682B2 (en) * | 1994-08-08 | 1999-08-12 | Albert Einstein College Of Medicine Of Yeshiva University | Methods for treating and/or preventing Alzheimer's disease using phenothiazines and/or thioxanthenes |
| DE4430091A1 (de) * | 1994-08-25 | 1996-02-29 | Bayer Ag | Verwendung von N-substituierten Phenothiazinen |
| GB9506197D0 (en) * | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| US5697985A (en) * | 1995-06-07 | 1997-12-16 | Bayer Corporation | Process for the preparation storage-stable dye dispersions |
| WO1999062548A1 (en) | 1998-06-01 | 1999-12-09 | Advanced Research And Technology Institute | Methods and compositions for diagnosing tauopathies |
| JP2000344685A (ja) | 1999-03-26 | 2000-12-12 | Bf Kenkyusho:Kk | アズールａ類似化合物によるアミロイドが蓄積する疾患の画像診断プローブおよびそれを含む画像診断用組成物 |
| JP2000344684A (ja) | 1999-03-26 | 2000-12-12 | Bf Kenkyusho:Kk | ピロニンｂ類似化合物によるアミロイドが蓄積する疾患の画像診断プローブおよびそれを含む画像診断用組成物 |
| EP1048302A3 (en) * | 1999-04-30 | 2002-07-17 | Pfizer Products Inc. | Radiotracers for in vivo study of acetylcholinesterase and Alzheimer's disease |
| AU2001244549A1 (en) | 2000-03-22 | 2001-10-03 | Bf Research Institute, Inc. | Azure a analogues useful as probes in the diagnostic imaging for diseases due toaccumulation of amyloid and compositions for diagnostic imaging containing the analogues |
| RU2324686C2 (ru) | 2000-08-24 | 2008-05-20 | Юнивесити Оф Питсбэг | ПРОИЗВОДНЫЕ ТИОФЛАВИНА, СВЯЗЫВАЮЩИЕ АМИЛОИД, СПОСОБ ОБНАРУЖЕНИЯ in vivo ОТЛОЖЕНИЙ АМИЛОИДА И СПОСОБ РАСПОЗНАВАНИЯ БОЛЕЗНИ АЛЬЦГЕЙМЕРА |
| GB0100119D0 (en) | 2001-01-03 | 2001-02-14 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB0106953D0 (en) * | 2001-03-20 | 2001-05-09 | Univ Aberdeen | Neufofibrillary labels |
| GB0117326D0 (en) | 2001-07-16 | 2001-09-05 | Univ Aberdeen | Napthoquinone-type inhibitors of protein aggregation |
| US6953974B2 (en) * | 2003-08-26 | 2005-10-11 | Texas Instruments Incorporated | EEPROM device and method for providing lower programming voltage |
| GB0322756D0 (en) | 2003-09-29 | 2003-10-29 | Univ Aberdeen | Methods of chemical synthesis |
| SI2322517T1 (sl) | 2004-09-23 | 2019-06-28 | Wista Laboratories Ltd. | Postopki za kemijsko sintezo in čiščenje diaminofenotiazinijevih spojin, vključno metiltioninijevega klorida (MTC) |
-
2001
- 2001-03-20 GB GBGB0106953.3A patent/GB0106953D0/en not_active Ceased
-
2002
- 2002-03-20 EP EP02720102A patent/EP1421389B1/en not_active Expired - Lifetime
- 2002-03-20 ES ES02720102T patent/ES2386773T3/es not_active Expired - Lifetime
- 2002-03-20 PT PT02720102T patent/PT1421389E/pt unknown
- 2002-03-20 DK DK02720102.9T patent/DK1421389T3/da active
- 2002-03-20 WO PCT/GB2002/001318 patent/WO2002075318A2/en not_active Ceased
- 2002-03-20 JP JP2002573679A patent/JP4288073B2/ja not_active Expired - Lifetime
- 2002-03-20 AU AU2002251172A patent/AU2002251172B2/en not_active Expired
- 2002-03-20 CN CN02810291.6A patent/CN1578910A/zh active Pending
- 2002-03-20 CN CN200810185342.XA patent/CN101696977B/zh not_active Expired - Lifetime
- 2002-03-20 AT AT02720102T patent/ATE556323T1/de active
- 2002-03-20 CA CA2440794A patent/CA2440794C/en not_active Expired - Lifetime
-
2003
- 2003-09-22 US US10/665,008 patent/US7335652B2/en not_active Expired - Lifetime
-
2008
- 2008-02-25 US US12/071,693 patent/US7713962B2/en not_active Expired - Lifetime
- 2008-09-24 JP JP2008243567A patent/JP2009035566A/ja active Pending
-
2010
- 2010-05-10 US US12/662,887 patent/US8097615B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1421389B1 (en) | 2012-05-02 |
| CA2440794C (en) | 2012-05-01 |
| AU2002251172B2 (en) | 2007-12-06 |
| US20040213736A1 (en) | 2004-10-28 |
| ES2386773T3 (es) | 2012-08-30 |
| HK1062044A1 (en) | 2004-10-15 |
| ATE556323T1 (de) | 2012-05-15 |
| US20100285605A1 (en) | 2010-11-11 |
| US7713962B2 (en) | 2010-05-11 |
| CA2440794A1 (en) | 2002-09-26 |
| EP1421389A2 (en) | 2004-05-26 |
| JP2009035566A (ja) | 2009-02-19 |
| US20080219929A1 (en) | 2008-09-11 |
| CN101696977A (zh) | 2010-04-21 |
| US8097615B2 (en) | 2012-01-17 |
| JP2004537034A (ja) | 2004-12-09 |
| CN1578910A (zh) | 2005-02-09 |
| JP4288073B2 (ja) | 2009-07-01 |
| US7335652B2 (en) | 2008-02-26 |
| WO2002075318A3 (en) | 2004-03-11 |
| CN101696977B (zh) | 2014-02-19 |
| PT1421389E (pt) | 2012-07-10 |
| WO2002075318A2 (en) | 2002-09-26 |
| GB0106953D0 (en) | 2001-05-09 |
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