DK1425272T3 - Optiske isomerer af en iloperidon-metabolit - Google Patents

Optiske isomerer af en iloperidon-metabolit

Info

Publication number: DK1425272T3
Authority: DK; Denmark
Prior art keywords: optical isomers; iloperidone metabolite; fouoro; isoxazol; piperidin
Prior art date: 2001-08-31

Application number

DK02767454.8T

Other languages

English (en)

Inventor

Dominique Grimler

Hequn Yin

Hans O Kalkman

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-31

Filing date

2002-08-30

Publication date

2011-11-21

2002-08-30 Application filed by Novartis Ag filed Critical Novartis Ag

2011-11-21 Application granted granted Critical

2011-11-21 Publication of DK1425272T3 publication Critical patent/DK1425272T3/da

Links

XMXHEBAFVSFQEX-UHFFFAOYSA-N iloperidone Chemical class COC1=CC(C(C)=O)=CC=C1OCCCN1CCC(C=2C3=CC=C(F)C=C3ON=2)CC1 XMXHEBAFVSFQEX-UHFFFAOYSA-N 0.000 title 1
230000003287 optical effect Effects 0.000 title 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
125000004284 isoxazol-3-yl group Chemical group [H]C1=C([H])C(*)=NO1 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Cosmetics (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK02767454.8T 2001-08-31 2002-08-30 Optiske isomerer af en iloperidon-metabolit DK1425272T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US31639001P	2001-08-31	2001-08-31
PCT/EP2002/009700 WO2003020707A1 (en)	2001-08-31	2002-08-30	Optical isomers of an iloperidone metabolite

Publications (1)

Publication Number	Publication Date
DK1425272T3 true DK1425272T3 (da)	2011-11-21

Family

ID=23228843

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK02767454.8T DK1425272T3 (da)	2001-08-31	2002-08-30	Optiske isomerer af en iloperidon-metabolit
DK10009915.9T DK2305656T3 (da)	2001-08-31	2002-08-30	Optiske isomerer of en iloperidonmetabolit

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK10009915.9T DK2305656T3 (da)	2001-08-31	2002-08-30	Optiske isomerer of en iloperidonmetabolit

Country Status (9)

Country	Link
US (4)	US20050020632A1 (da)
EP (2)	EP1425272B1 (da)
JP (6)	JP2005504783A (da)
AT (1)	ATE518845T1 (da)
CY (2)	CY1112039T1 (da)
DK (2)	DK1425272T3 (da)
ES (2)	ES2370634T3 (da)
PT (2)	PT1425272E (da)
WO (1)	WO2003020707A1 (da)

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US20100063093A1 (en)	2007-03-28	2010-03-11	Curt Wolfgang	Methods for the administration of iloperidone
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US20070262395A1 (en)	2006-05-11	2007-11-15	Gibbons Jasper S	Memory cell access devices and methods of making the same
US20090306137A1 (en) *	2006-05-22	2009-12-10	Wolfgang Curt D	Treatment for depressive disorders
US20150259747A1 (en)	2007-03-29	2015-09-17	Vanda Pharmaceuticals Inc.	Method of predicting a predisposition to qt prolongation
US9074254B2 (en)	2007-03-29	2015-07-07	Vanda Pharmaceuticals, Inc.	Method of predicting a predisposition to QT prolongation
US8198305B2 (en)	2007-04-13	2012-06-12	Concert Pharmaceuticals Inc.	1,2-benzisoxazol-3-yl compounds
ES2569480T3 (es)	2007-05-18	2016-05-11	Vanda Pharmaceuticals Inc.	Marcadores genéticos de eficacia de iloperidona en el tratamiento de síntomas psicóticos
EP2198048A2 (en)	2007-09-10	2010-06-23	Vanda Pharmaceuticals Inc.	Prediction of qt prolongation based on snp genotype
EP2508177A1 (en)	2007-12-12	2012-10-10	Glaxo Group Limited	Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline
BRPI0820993A2 (pt)	2007-12-13	2017-05-09	Vanda Pharmaceuticals Inc	método e composição para tratar uma condição mediada por alfa adrenoceptor
SI2222300T1 (sl)	2007-12-13	2014-11-28	Vanda Pharmaceuticals Inc.	Postopek in sestavek za zdravljenje stanja, posredovanega z receptorjem serotonina
US20110061014A1 (en)	2008-02-01	2011-03-10	Energyhub	Interfacing to resource consumption management devices
WO2009123714A2 (en)	2008-04-02	2009-10-08	Arena Pharmaceuticals, Inc.	Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
WO2010062321A1 (en)	2008-10-28	2010-06-03	Arena Pharmaceuticals, Inc.	Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
US7824986B2 (en)	2008-11-05	2010-11-02	Micron Technology, Inc.	Methods of forming a plurality of transistor gates, and methods of forming a plurality of transistor gates having at least two different work functions
US8999638B2 (en)	2009-04-06	2015-04-07	Vanda Pharmaceuticals, Inc.	Method of treatment based on polymorphisms of the KCNQ1 gene
WO2010117941A1 (en)	2009-04-06	2010-10-14	Vanda Pharmaceuticals, Inc.	Method of predicting a predisposition to qt prolongation based on abcc2 gene sequence or product thereof
WO2010117937A1 (en)	2009-04-06	2010-10-14	Vanda Pharmaceuticals, Inc.	Method of predicting a predisposition to qt prolongation
WO2010117943A1 (en)	2009-04-06	2010-10-14	Vanda Pharmaceuticals, Inc.	Method of predicting a predisposition to qt prolongation based on bai3 gene sequence or product thereof
MX2012007365A (es)	2009-12-23	2012-08-15	Lupin Ltd	Composiciones farmaceuticas de liberacion lenta de iloperidona.
WO2012032532A1 (en) *	2010-09-07	2012-03-15	Symed Labs Limited	"processes for the preparation of 4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone and intermediates thereof"
WO2012063269A2 (en)	2010-11-12	2012-05-18	Cadila Healthcare Limited	Process for preparing iloperidone
CN108938632A (zh) *	2012-03-14	2018-12-07	万达制药公司	用于治疗精神疾病的伊潘立酮代谢物及其应用
WO2016134049A1 (en)	2015-02-17	2016-08-25	Vanda Pharmaceuticals Inc.	Iloperidone for the treatment of schizophrenia
WO2016201373A1 (en)	2015-06-12	2016-12-15	Axovant Sciences Ltd.	Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of rem sleep behavior disorder
WO2017011767A2 (en)	2015-07-15	2017-01-19	Axovant Sciences Ltd.	Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease
JP7416831B2 (ja) *	2019-02-21	2024-01-17	アセンタウィッツファーマシューティカルズリミテッド	高エナンチオ選択性第２級アルコールを作製する方法
US11607408B2 (en)	2019-10-15	2023-03-21	Vanda Pharmaceuticals Inc.	Method of treatment of schizophrenia
WO2023201182A1 (en)	2022-04-13	2023-10-19	Vanda Pharmaceuticals Inc.	Treatment of parkinson's disease and parkinson's disease psychosis
WO2024137439A1 (en)	2022-12-19	2024-06-27	Vanda Pharmaceuticals Inc.	Dosage regime of iloperidone for treating bipolar i disorder and schizophrenia
AU2024278999A1 (en)	2023-06-02	2025-11-13	Vanda Pharmaceuticals Inc.	Method of treatment with iloperidone

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US4804663A (en) *	1985-03-27	1989-02-14	Janssen Pharmaceutica N.V.	3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
US5158952A (en) *	1988-11-07	1992-10-27	Janssen Pharmaceutica N.V.	3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
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JPH05286868A (ja)	1992-04-03	1993-11-02	Kiyoshi Okawa	制がん剤複合体およびそのスクリーニング法
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AU2003268026A1 (en)	2002-07-30	2004-02-16	Peter Migaly	Combination therapy for depression, prevention of suicide, and varous medical and psychiatric conditions

2002
- 2002-08-30 DK DK02767454.8T patent/DK1425272T3/da active
- 2002-08-30 PT PT02767454T patent/PT1425272E/pt unknown
- 2002-08-30 EP EP02767454A patent/EP1425272B1/en not_active Expired - Lifetime
- 2002-08-30 AT AT02767454T patent/ATE518845T1/de active
- 2002-08-30 ES ES02767454T patent/ES2370634T3/es not_active Expired - Lifetime
- 2002-08-30 WO PCT/EP2002/009700 patent/WO2003020707A1/en not_active Ceased
- 2002-08-30 DK DK10009915.9T patent/DK2305656T3/da active
- 2002-08-30 PT PT100099159T patent/PT2305656E/pt unknown
- 2002-08-30 ES ES10009915T patent/ES2398434T3/es not_active Expired - Lifetime
- 2002-08-30 US US10/488,128 patent/US20050020632A1/en not_active Abandoned
- 2002-08-30 EP EP10009915A patent/EP2305656B1/en not_active Expired - Lifetime
- 2002-08-30 JP JP2003524978A patent/JP2005504783A/ja not_active Withdrawn
2009
- 2009-03-13 US US12/403,755 patent/US7977356B2/en not_active Expired - Lifetime
- 2009-12-11 JP JP2009281094A patent/JP2010100633A/ja not_active Withdrawn
2011
- 2011-04-28 US US13/096,015 patent/US8314129B2/en not_active Expired - Lifetime
- 2011-11-02 CY CY20111101053T patent/CY1112039T1/el unknown
2012
- 2012-10-26 US US13/661,609 patent/US20130296366A1/en not_active Abandoned
2013
- 2013-01-23 CY CY20131100058T patent/CY1113550T1/el unknown
- 2013-01-31 JP JP2013017050A patent/JP2013116905A/ja not_active Withdrawn
- 2013-07-08 JP JP2013142873A patent/JP2013227335A/ja active Pending
2015
- 2015-08-06 JP JP2015156359A patent/JP2015214577A/ja active Pending
- 2015-08-06 JP JP2015156358A patent/JP2015227368A/ja active Pending

Also Published As

Publication number	Publication date
EP2305656B1 (en)	2012-10-24
PT1425272E (pt)	2011-10-19
PT2305656E (pt)	2013-01-10
EP1425272A1 (en)	2004-06-09
ES2398434T8 (es)	2017-10-09
EP1425272B1 (en)	2011-08-03
CY1112039T1 (el)	2015-11-04
DK2305656T3 (da)	2013-02-11
JP2015227368A (ja)	2015-12-17
ATE518845T1 (de)	2011-08-15
JP2010100633A (ja)	2010-05-06
JP2013116905A (ja)	2013-06-13
WO2003020707A1 (en)	2003-03-13
US20130296366A1 (en)	2013-11-07
US20110201646A1 (en)	2011-08-18
US20050020632A1 (en)	2005-01-27
US20090176739A1 (en)	2009-07-09
CY1113550T1 (el)	2016-06-22
ES2370634T3 (es)	2011-12-21
EP2305656A1 (en)	2011-04-06
JP2015214577A (ja)	2015-12-03
JP2005504783A (ja)	2005-02-17
HK1156309A1 (en)	2012-09-07
JP2013227335A (ja)	2013-11-07
ES2398434T3 (es)	2013-03-19
US8314129B2 (en)	2012-11-20
US7977356B2 (en)	2011-07-12
HK1066536A1 (en)	2005-03-24

Publication	Publication Date	Title
DK1425272T3 (da)	2011-11-21	Optiske isomerer af en iloperidon-metabolit
DE502004009532D1 (de)	2009-07-09	Fungizide ternäre wirkstoffkombinationen
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PE20080952A1 (es)	2008-09-10	Amidas azociclicas fungicidas
ATE324371T1 (de)	2006-05-15	N-substituierte heterocyclische nichtaryl- nmda/nr2b-antagonisten
NO341632B1 (no)	2017-12-11	Ny polymorf form av 5-klor-N({(5S)-2-okso-3[4-(3-okso-4-morfolinyl)-fenyl]-1,3-oksazolidin-5-yl}-metyl)-2-tiofenkarboksamid
PE20110299A1 (es)	2011-05-15	Nuevos derivados de acilaminobenzamida
HRP20080446T3 (en)	2008-10-31	Monohydrochloride salt of 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine
NO20075022L (no)	2007-10-04	(7-(2-(4-(3-trifluormetylfenyl)-1,2,3,6-tetrahydropyrid-1-yl)etyl) isokinolinbesylatsalt, fremstilling og terapeutiske anvendelser derav
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PE20091431A1 (es)	2009-10-19	Compuestos derivados de azetidinas, su preparacion y su aplicacion en terapeutica
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