ATE455103T1 - Als antikoagulationsmittel geeignete phenylglycinamid- und pyridylglycinamidderivate - Google Patents
Als antikoagulationsmittel geeignete phenylglycinamid- und pyridylglycinamidderivateInfo
- Publication number
- ATE455103T1 ATE455103T1 AT06785361T AT06785361T ATE455103T1 AT E455103 T1 ATE455103 T1 AT E455103T1 AT 06785361 T AT06785361 T AT 06785361T AT 06785361 T AT06785361 T AT 06785361T AT E455103 T1 ATE455103 T1 AT E455103T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- phenylglycinamide
- pyridylglycinamide
- derivatives used
- anticoagulation agents
- Prior art date
Links
- GXBRYTMUEZNYJT-UHFFFAOYSA-N 2-anilinoacetamide Chemical compound NC(=O)CNC1=CC=CC=C1 GXBRYTMUEZNYJT-UHFFFAOYSA-N 0.000 title 1
- 239000003146 anticoagulant agent Substances 0.000 title 1
- KIYRSYYOVDHSPG-UHFFFAOYSA-N 2-amino-2-phenylacetamide Chemical class NC(=O)C(N)C1=CC=CC=C1 KIYRSYYOVDHSPG-UHFFFAOYSA-N 0.000 abstract 1
- 108010054265 Factor VIIa Proteins 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940012414 factor viia Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69407405P | 2005-06-24 | 2005-06-24 | |
| US69407605P | 2005-06-24 | 2005-06-24 | |
| PCT/US2006/024345 WO2007002313A2 (en) | 2005-06-24 | 2006-06-22 | Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE455103T1 true ATE455103T1 (de) | 2010-01-15 |
Family
ID=37467511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06785361T ATE455103T1 (de) | 2005-06-24 | 2006-06-22 | Als antikoagulationsmittel geeignete phenylglycinamid- und pyridylglycinamidderivate |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7456195B2 (de) |
| EP (1) | EP1910298B1 (de) |
| AT (1) | ATE455103T1 (de) |
| DE (1) | DE602006011752D1 (de) |
| ES (1) | ES2337831T3 (de) |
| WO (1) | WO2007002313A2 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1828152B1 (de) * | 2004-12-08 | 2008-08-20 | Bristol-Myers Squibb Company | Heterocyclische verbindungen als inhibitoren von faktor viia |
| EP1856096B1 (de) | 2005-01-10 | 2010-09-01 | Bristol-Myers Squibb Company | Als antikoagulanzien verwendbare phenylglycinamid-derivate |
| AR058380A1 (es) * | 2005-12-23 | 2008-01-30 | Bristol Myers Squibb Co | Inhibidores del factor viia macrociclicos utiles como anticoagulantes |
| JP2009539873A (ja) | 2006-06-08 | 2009-11-19 | ブリストル−マイヤーズ スクイブ カンパニー | 抗凝固剤として有用な第ＶＩＩａ因子インヒビターとしての２−アミノカルボニルフェニルアミノ−２−フェニルアセトアミド類 |
| CN101631784A (zh) * | 2006-12-20 | 2010-01-20 | 百时美施贵宝公司 | 用作抗凝血药的二环内酰胺凝血因子viia抑制剂 |
| PE20081775A1 (es) * | 2006-12-20 | 2008-12-18 | Bristol Myers Squibb Co | Compuestos macrociclicos como inhibidores del factor viia |
| EP2191887A1 (de) | 2008-11-26 | 2010-06-02 | Polymers CRC Limited | Anklickbare Dünnschichtverbundpolyamidmembrane |
| EP2462123B1 (de) | 2009-08-04 | 2013-10-02 | Merck Sharp & Dohme Corp. | 4,5,6-trisubstituierte pyrimidin- derivate als factor ixa inhibitoren |
| JPWO2011043359A1 (ja) | 2009-10-06 | 2013-03-04 | 協和発酵キリン株式会社 | 芳香族複素環化合物を含有する医薬 |
| US8575336B2 (en) | 2011-07-27 | 2013-11-05 | Pfizer Limited | Indazoles |
| JP6182593B2 (ja) | 2012-04-20 | 2017-08-16 | アドヴィーナス セラピューティクス リミテッド | 置換ヘテロ二環化合物、組成物及び医薬並びにそれらの用途 |
| EP2858977A1 (de) | 2012-06-08 | 2015-04-15 | Bristol-Myers Squibb Company | Makrocyclische faktor-viia-hemmer |
| US8987461B2 (en) | 2012-12-06 | 2015-03-24 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
| ES2770123T3 (es) | 2015-02-02 | 2020-06-30 | Forma Therapeutics Inc | Acidos 3-alquil-4-amido-bicíclicos [4,5,0]hidroxámicos como inhibidores de HDAC |
| UY36548A (es) | 2015-02-05 | 2016-06-01 | Bayer Cropscience Ag | Derivados heterocíclicos condensados bicíclicos sustituidos por 2-(het)arilo como pesticidas |
| TWI713530B (zh) | 2015-06-05 | 2020-12-21 | 美商艾佛艾姆希公司 | 作為除草劑之嘧啶氧基苯衍生物 |
| CA2987914C (en) * | 2015-06-30 | 2022-09-13 | Dana-Farber Cancer Institute, Inc. | Inhibitors of egfr and methods of use thereof |
| LT3319959T (lt) | 2015-07-06 | 2021-12-27 | Alkermes, Inc. | Histono deacetilazės hetero-halogeno inhibitoriai |
| WO2017007755A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| CN105481733A (zh) * | 2015-12-30 | 2016-04-13 | 苏州诚和医药化学有限公司 | 一种一步法合成2-甲氧基-5-氨磺酰基苯甲酸甲酯的方法 |
| US10793567B2 (en) | 2017-01-11 | 2020-10-06 | Rodin Therapeutics, Inc. | Bicyclic inhibitors of histone deacetylase |
| EA039417B1 (ru) | 2017-08-07 | 2022-01-25 | Родин Терапеутикс, Инк. | Бициклические ингибиторы гистондеацетилазы |
| CN111606827B (zh) * | 2020-06-23 | 2022-10-25 | 内蒙古京东药业有限公司 | 一种制备依度沙班手性胺中间体的方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2667864B2 (fr) * | 1990-03-07 | 1994-08-05 | Rhone Poulenc Sante | Derives de n-phenyl glycinamides, leur preparation et les medicaments les contenant. |
| IL123986A (en) * | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
| PT921116E (pt) * | 1997-12-04 | 2003-11-28 | Hoffmann La Roche | Derivados de n-(4-carbamimido-fenil)-glicinamida |
| AU2300699A (en) * | 1998-02-17 | 1999-08-30 | Ono Pharmaceutical Co. Ltd. | Amidino derivatives and drugs containing the same as the active ingredient |
| HRP20010427A2 (en) * | 1998-12-14 | 2002-06-30 | Hoffmann La Roche | Phenylglycine derivatives |
| US6472393B1 (en) * | 1999-01-13 | 2002-10-29 | Genentech, Inc. | Serine protease inhibitors |
| EP1059302A1 (de) * | 1999-06-08 | 2000-12-13 | Aventis Pharma Deutschland GmbH | Faktor VIIa Inhibitore |
| US6548694B2 (en) * | 2000-05-23 | 2003-04-15 | Hoffman-La Roche Inc. | N-(4-carbamimidoyl-phenyl)-glycine derivatives |
| HUP0400651A2 (hu) * | 2000-11-07 | 2004-06-28 | Bristol-Myers Squibb Company | Szerin proteáz inhibitorokként alkalmazható savszármazékok és ezeket tartalmazó gyógyszerkészítmények |
| DE10102322A1 (de) | 2001-01-19 | 2002-07-25 | Merck Patent Gmbh | Phenylderivate |
| ES2332090T3 (es) * | 2001-04-06 | 2010-01-26 | Biocryst Pharmaceuticals, Inc. | Compuestos biarilicos como inhibidores de serina proteasa. |
| DE10139060A1 (de) * | 2001-08-08 | 2003-02-20 | Merck Patent Gmbh | Phenylderivate |
| US6642386B2 (en) * | 2002-02-06 | 2003-11-04 | Hoffmann-La Roche Inc. | N-(4-carbamimidoyl-phenyl)-glycine derivatives |
| US6821974B2 (en) * | 2002-03-05 | 2004-11-23 | Barbeau Pharma, Inc | Stable pharmaceutical compositions |
| DE10214832A1 (de) | 2002-04-04 | 2003-10-16 | Merck Patent Gmbh | Phenylderivate 4 |
| US7122559B2 (en) * | 2003-02-11 | 2006-10-17 | Bristol-Myers Squibb Company | Phenylglycine derivatives useful as serine protease inhibitors |
| EP1594845A4 (de) * | 2003-02-11 | 2008-05-21 | Bristol Myers Squibb Co | Als serinproteaseinhibitoren geeignete benzolacetamidverbindungen |
| EP1828152B1 (de) * | 2004-12-08 | 2008-08-20 | Bristol-Myers Squibb Company | Heterocyclische verbindungen als inhibitoren von faktor viia |
| EP1856096B1 (de) * | 2005-01-10 | 2010-09-01 | Bristol-Myers Squibb Company | Als antikoagulanzien verwendbare phenylglycinamid-derivate |
| ATE489386T1 (de) * | 2005-10-05 | 2010-12-15 | Hoffmann La Roche | Naphthyridin-derivate |
| US7618985B2 (en) * | 2005-12-08 | 2009-11-17 | N.V. Organon | Isoquinoline derivatives |
-
2006
- 2006-06-22 DE DE602006011752T patent/DE602006011752D1/de active Active
- 2006-06-22 ES ES06785361T patent/ES2337831T3/es active Active
- 2006-06-22 EP EP06785361A patent/EP1910298B1/de not_active Not-in-force
- 2006-06-22 AT AT06785361T patent/ATE455103T1/de not_active IP Right Cessation
- 2006-06-22 US US11/472,845 patent/US7456195B2/en active Active
- 2006-06-22 WO PCT/US2006/024345 patent/WO2007002313A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US7456195B2 (en) | 2008-11-25 |
| EP1910298B1 (de) | 2010-01-13 |
| WO2007002313A3 (en) | 2007-05-18 |
| DE602006011752D1 (de) | 2010-03-04 |
| EP1910298A2 (de) | 2008-04-16 |
| WO2007002313A2 (en) | 2007-01-04 |
| ES2337831T3 (es) | 2010-04-29 |
| US20070003539A1 (en) | 2007-01-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |