DK1427411T3 - -(-)-1-(3,4-dichlorphenyl)-3-azabicyclo[3.1.0]hexan, præparater deraf og anvendelser som dopamingenoptagelsesinhibitor - Google Patents

-(-)-1-(3,4-dichlorphenyl)-3-azabicyclo[3.1.0]hexan, præparater deraf og anvendelser som dopamingenoptagelsesinhibitor

Info

Publication number
DK1427411T3
DK1427411T3 DK02796380T DK02796380T DK1427411T3 DK 1427411 T3 DK1427411 T3 DK 1427411T3 DK 02796380 T DK02796380 T DK 02796380T DK 02796380 T DK02796380 T DK 02796380T DK 1427411 T3 DK1427411 T3 DK 1427411T3
Authority
DK
Denmark
Prior art keywords
azabicyclo
dichlorophenyl
hexane
preparations
uptake inhibitor
Prior art date
Application number
DK02796380T
Other languages
English (en)
Inventor
Arnold Stan Lippa
Joseph Williams Epstein
Original Assignee
Dov Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dov Pharmaceutical Inc filed Critical Dov Pharmaceutical Inc
Application granted granted Critical
Publication of DK1427411T3 publication Critical patent/DK1427411T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
DK02796380T 2001-08-24 2002-08-14 -(-)-1-(3,4-dichlorphenyl)-3-azabicyclo[3.1.0]hexan, præparater deraf og anvendelser som dopamingenoptagelsesinhibitor DK1427411T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/939,071 US6569887B2 (en) 2001-08-24 2001-08-24 (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
PCT/US2002/025870 WO2003017927A2 (en) 2001-08-24 2002-08-14 (-)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake inhibitor

Publications (1)

Publication Number Publication Date
DK1427411T3 true DK1427411T3 (da) 2007-07-02

Family

ID=25472498

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02796380T DK1427411T3 (da) 2001-08-24 2002-08-14 -(-)-1-(3,4-dichlorphenyl)-3-azabicyclo[3.1.0]hexan, præparater deraf og anvendelser som dopamingenoptagelsesinhibitor

Country Status (21)

Country Link
US (6) US6569887B2 (da)
EP (1) EP1427411B1 (da)
JP (1) JP2005504049A (da)
KR (1) KR20040065549A (da)
CN (2) CN1575170A (da)
AT (1) ATE355838T1 (da)
BR (1) BR0212147A (da)
CA (1) CA2458217A1 (da)
DE (1) DE60218703T2 (da)
DK (1) DK1427411T3 (da)
ES (1) ES2284968T3 (da)
HU (1) HUP0401515A2 (da)
IL (1) IL160545A0 (da)
MX (1) MXPA04001643A (da)
NO (1) NO327424B1 (da)
NZ (1) NZ531606A (da)
PL (1) PL368601A1 (da)
PT (1) PT1427411E (da)
RU (1) RU2300522C2 (da)
WO (1) WO2003017927A2 (da)
ZA (1) ZA200401545B (da)

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Also Published As

Publication number Publication date
EP1427411A2 (en) 2004-06-16
PT1427411E (pt) 2007-06-15
US6569887B2 (en) 2003-05-27
RU2004108694A (ru) 2005-03-10
ZA200401545B (en) 2005-03-10
US6716868B2 (en) 2004-04-06
MXPA04001643A (es) 2004-05-31
CN1575170A (zh) 2005-02-02
DE60218703D1 (de) 2007-04-19
US20030045567A1 (en) 2003-03-06
KR20040065549A (ko) 2004-07-22
PL368601A1 (en) 2005-04-04
NO327424B1 (no) 2009-06-29
US20030181508A1 (en) 2003-09-25
IL160545A0 (en) 2004-07-25
EP1427411A4 (en) 2005-04-20
US20070082938A1 (en) 2007-04-12
CA2458217A1 (en) 2003-03-06
ATE355838T1 (de) 2007-03-15
DE60218703T2 (de) 2007-12-06
WO2003017927A3 (en) 2003-04-17
ES2284968T3 (es) 2007-11-16
HUP0401515A2 (hu) 2004-12-28
US7041835B2 (en) 2006-05-09
US20040157870A1 (en) 2004-08-12
US20040157908A1 (en) 2004-08-12
US20040157869A1 (en) 2004-08-12
RU2300522C2 (ru) 2007-06-10
US7098230B2 (en) 2006-08-29
CN101050199A (zh) 2007-10-10
BR0212147A (pt) 2004-08-24
WO2003017927A2 (en) 2003-03-06
NO20040794L (no) 2004-05-17
EP1427411B1 (en) 2007-03-07
JP2005504049A (ja) 2005-02-10
NZ531606A (en) 2005-08-26
US7081471B2 (en) 2006-07-25

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