DK1434588T3 - 2-(amino-3,4-dioxo-1cyclobuten-1-yl)aminoalkylsyrederivater til behandling af smerte - Google Patents

2-(amino-3,4-dioxo-1cyclobuten-1-yl)aminoalkylsyrederivater til behandling af smerte

Info

Publication number: DK1434588T3
Authority: DK; Denmark
Prior art keywords: dioxo; pain; amino; treatment; acid derivatives
Prior art date: 2001-10-10

Application number

DK02789180.3T

Other languages

English (en)

Inventor

Margaret Maria Zaleska

John Allen Moyer

Michael Richard Brandt

Original Assignee

Wyeth Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-10

Filing date

2002-10-09

Publication date

2011-08-15

2002-10-09 Application filed by Wyeth Llc filed Critical Wyeth Llc

2011-08-15 Application granted granted Critical

2011-08-15 Publication of DK1434588T3 publication Critical patent/DK1434588T3/da

Links

239000002253 acid Substances 0.000 title 1
-1 amino-3,4-dioxo-1cyclobutene-1-yl Chemical group 0.000 title 1
125000004103 aminoalkyl group Chemical group 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK02789180.3T 2001-10-10 2002-10-09 2-(amino-3,4-dioxo-1cyclobuten-1-yl)aminoalkylsyrederivater til behandling af smerte DK1434588T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US32824501P	2001-10-10	2001-10-10
PCT/US2002/032252 WO2003031416A2 (en)	2001-10-10	2002-10-09	[[2-(amino-3,4-dioxo-1cyclobuten-1-yl)amino]alkyl]-acid derivatives for the treatment of pain

Publications (1)

Publication Number	Publication Date
DK1434588T3 true DK1434588T3 (da)	2011-08-15

Family

ID=23280159

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02789180.3T DK1434588T3 (da)	2001-10-10	2002-10-09	2-(amino-3,4-dioxo-1cyclobuten-1-yl)aminoalkylsyrederivater til behandling af smerte

Country Status (26)

Country	Link
US (2)	US7098200B2 (da)
EP (1)	EP1434588B1 (da)
JP (1)	JP4350512B2 (da)
KR (1)	KR100922703B1 (da)
CN (1)	CN100448449C (da)
AR (1)	AR036764A1 (da)
AT (1)	ATE515266T1 (da)
AU (1)	AU2009201746A1 (da)
BR (1)	BR0213237A (da)
CA (1)	CA2461348C (da)
CY (1)	CY1111909T1 (da)
DK (1)	DK1434588T3 (da)
EA (1)	EA009993B1 (da)
ES (1)	ES2367356T3 (da)
HU (1)	HUP0401773A3 (da)
IL (2)	IL161275A0 (da)
MX (1)	MXPA04003354A (da)
NO (1)	NO20041378L (da)
NZ (1)	NZ532159A (da)
PL (1)	PL368863A1 (da)
PT (1)	PT1434588E (da)
SI (1)	SI1434588T1 (da)
TW (1)	TWI321472B (da)
UA (1)	UA78529C2 (da)
WO (1)	WO2003031416A2 (da)
ZA (1)	ZA200403406B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE50312678D1 (de)	2002-11-22	2010-06-10	Gruenenthal Gmbh	Verwendung von (1R, 2R)-3-(3-Dimenthylamino-1-ethyl-2-methyl-propyl)-phenol zur Behandlung von Entzündungsschmerz
WO2004092189A1 (en) *	2003-04-09	2004-10-28	Wyeth	Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)alkyl phosphonic acid and their use as n-methyl-d-aspartate (nmda) recetor antagonists
AU2004229567A1 (en) *	2003-04-09	2004-10-28	Wyeth	Pharmaceutical compositions for intranasal administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1 (7)-en-2-yl)alkyl] phosphonic acid and derivatives and methods of use thereof
US20050142192A1 (en) *	2003-10-15	2005-06-30	Wyeth	Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives
TW200514775A (en) *	2003-10-22	2005-05-01	Wyeth Corp	Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid and esters thereof
KR20070100233A (ko) *	2004-10-08	2007-10-10	와이어쓰	[2-(8,9-디옥소-2,6-디아자바이사이클로[5.2.0]논-1(7)-엔-2-일)알킬]포스폰산의 유도체 및 이의 제조 방법
US20090061024A1 (en) *	2007-08-27	2009-03-05	Wyeth	Compositions and methods employing nmda antagonists for achieving an anesthetic-sparing effect
CA2752148A1 (en) *	2009-02-13	2010-08-19	Daniel W. Gil	Pharmaceutical compositions comprising (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol
BRPI1009900A2 (pt)	2009-03-19	2016-03-15	Wyeth Llc	métodos para a preparação de ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfônico e seus precursores
CA2856507C (en)	2011-11-21	2017-03-21	Allergan, Inc.	Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases
WO2015149066A1 (en) *	2014-03-28	2015-10-01	University Of Virginia Patent Foundation	General anesthetics that are not neurotoxic

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5168103A (en)	1991-01-22	1992-12-01	American Home Products Corporation	[[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives
US5124319A (en)	1991-10-11	1992-06-23	American Home Products Corporation	Benzimidazole phosphono-amino acids
DK124393D0 (da) *	1993-11-03	1993-11-03	Lundbeck & Co As H	Compounds
AT400440B (de) *	1993-12-06	1995-12-27	Vianova Kunstharz Ag	Verfahren zur herstellung von wasserverdünnbaren lackbindemitteln und deren verwendung
TW427904B (en) *	1995-12-07	2001-04-01	American Home Prod	Neuroprotective agents
UA52698C2 (uk) *	1996-10-04	2003-01-15	Х. Луннбек А/С	Похідні (3-алкоксіізоксазол-4-іл)заміщеної 2-амінокарбонової кислоти та їх сірковмісні аналоги, фармацевтична композиція на їх основі
BR9811807A (pt)	1997-08-01	2000-08-15	American Home Prod	Processo para a preparação de ácido [2-(8,9)-dioxo-2,6-diazabiciclo-[5.2.0]-non-1(7)-en-2-il)-etil] fosfÈnico
US5990307A (en)	1997-08-01	1999-11-23	American Home Products Corporation	Process for the preparation of [2-((8.9)-Dioxo-2,6-Diazabicyclo [5.2.0]-Non-1(7)-en-2yl) Ethyl]Phosphonic acid
US6362371B1 (en)	1998-06-08	2002-03-26	Advanced Medicine, Inc.	β2- adrenergic receptor agonists
US6225343B1 (en)	1999-06-16	2001-05-01	Nastech Pharmaceutical Company, Inc.	Compositions and methods comprising morphine gluconate
US20030158254A1 (en)	2002-01-24	2003-08-21	Xenoport, Inc.	Engineering absorption of therapeutic compounds via colonic transporters
US20040082543A1 (en)	2002-10-29	2004-04-29	Pharmacia Corporation	Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain

2002
- 2002-09-10 UA UA20040503402A patent/UA78529C2/uk unknown
- 2002-10-08 AR ARP020103791A patent/AR036764A1/es unknown
- 2002-10-09 JP JP2003534400A patent/JP4350512B2/ja not_active Expired - Fee Related
- 2002-10-09 NZ NZ532159A patent/NZ532159A/en not_active IP Right Cessation
- 2002-10-09 MX MXPA04003354A patent/MXPA04003354A/es active IP Right Grant
- 2002-10-09 CA CA2461348A patent/CA2461348C/en not_active Expired - Fee Related
- 2002-10-09 ES ES02789180T patent/ES2367356T3/es not_active Expired - Lifetime
- 2002-10-09 BR BR0213237-0A patent/BR0213237A/pt not_active Application Discontinuation
- 2002-10-09 AT AT02789180T patent/ATE515266T1/de active
- 2002-10-09 IL IL16127502A patent/IL161275A0/xx unknown
- 2002-10-09 EA EA200400523A patent/EA009993B1/ru not_active IP Right Cessation
- 2002-10-09 TW TW091123270A patent/TWI321472B/zh not_active IP Right Cessation
- 2002-10-09 EP EP02789180A patent/EP1434588B1/en not_active Expired - Lifetime
- 2002-10-09 US US10/267,159 patent/US7098200B2/en not_active Expired - Fee Related
- 2002-10-09 DK DK02789180.3T patent/DK1434588T3/da active
- 2002-10-09 PT PT02789180T patent/PT1434588E/pt unknown
- 2002-10-09 KR KR1020047005298A patent/KR100922703B1/ko not_active Expired - Fee Related
- 2002-10-09 PL PL02368863A patent/PL368863A1/xx not_active IP Right Cessation
- 2002-10-09 HU HU0401773A patent/HUP0401773A3/hu unknown
- 2002-10-09 WO PCT/US2002/032252 patent/WO2003031416A2/en not_active Ceased
- 2002-10-09 SI SI200230959T patent/SI1434588T1/sl unknown
- 2002-10-09 CN CNB028202430A patent/CN100448449C/zh not_active Expired - Fee Related
2004
- 2004-04-02 NO NO20041378A patent/NO20041378L/no unknown
- 2004-04-04 IL IL161275A patent/IL161275A/en not_active IP Right Cessation
- 2004-05-05 ZA ZA200403406A patent/ZA200403406B/en unknown
2006
- 2006-05-12 US US11/433,737 patent/US7759346B2/en not_active Expired - Fee Related
2009
- 2009-05-01 AU AU2009201746A patent/AU2009201746A1/en not_active Ceased
2011
- 2011-08-02 CY CY20111100744T patent/CY1111909T1/el unknown

Also Published As

Publication number	Publication date
KR20050034604A (ko)	2005-04-14
HK1064609A1 (en)	2005-02-04
ATE515266T1 (de)	2011-07-15
JP2005508950A (ja)	2005-04-07
SI1434588T1 (sl)	2011-10-28
CN1568189A (zh)	2005-01-19
AU2009201746A1 (en)	2009-05-28
ES2367356T3 (es)	2011-11-02
ZA200403406B (en)	2007-04-25
IL161275A (en)	2009-09-01
CA2461348C (en)	2011-02-15
JP4350512B2 (ja)	2009-10-21
WO2003031416A2 (en)	2003-04-17
WO2003031416A3 (en)	2003-08-14
KR100922703B1 (ko)	2009-10-22
EA200400523A1 (ru)	2004-08-26
US7759346B2 (en)	2010-07-20
US7098200B2 (en)	2006-08-29
IL161275A0 (en)	2004-09-27
CN100448449C (zh)	2009-01-07
BR0213237A (pt)	2004-09-28
PT1434588E (pt)	2011-09-05
NO20041378L (no)	2004-05-28
HUP0401773A3 (en)	2005-06-28
EA009993B1 (ru)	2008-06-30
MXPA04003354A (es)	2004-09-28
CY1111909T1 (el)	2015-11-04
EP1434588A2 (en)	2004-07-07
PL368863A1 (en)	2005-04-04
AR036764A1 (es)	2004-09-29
HUP0401773A2 (hu)	2005-01-28
US20030114444A1 (en)	2003-06-19
US20060205696A1 (en)	2006-09-14
UA78529C2 (en)	2007-04-10
NZ532159A (en)	2006-02-24
TWI321472B (en)	2010-03-11
EP1434588B1 (en)	2011-07-06
CA2461348A1 (en)	2003-04-17

Publication	Publication Date	Title
DK1803718T3 (da)	2008-10-27	4-Tetrazolyl-4-phenylpiperidin-derivater til behandling af smerter
DK1343773T3 (da)	2007-02-05	Thiazolderivater til behandling af PPAR-beslægtede forstyrrelser
DK1459749T3 (da)	2006-01-09	(S,S)-reboxetin til behandling af inkontinens
DE60219292D1 (de)	2007-05-16	Pyrazolderivate zur behandlung von hiv
DK1147083T3 (da)	2004-08-16	Arylpiperazinyl-cyclohexylindolderivater til behandling af depression
DK1144395T3 (da)	2005-08-15	2-amino-benzoxazinon-derivater til behandling af fedme
NO20035156L (no)	2004-01-20	Fremgangsmåter for brønnbehandling
DK1432707T3 (da)	2012-06-11	Azabicyklisk-substituerede kondenserede heteroarylforbindelser til behandling af sygdomme
DK1425001T3 (da)	2009-04-14	Phenethanolaminderivater til behandling af respiratoriske sygdomme
DK2412368T3 (da)	2013-11-04	Sammensætning til behandling af ar
DK1446012T3 (da)	2013-10-14	Bakteriolytisk kombinationsterapi til behandling af tumorer
DK1282616T3 (da)	2004-09-20	Hydroxyphenylpiperidin-4-ylidenmethylbenzamidderivater til behandling af smerter
NO20022087D0 (no)	2002-05-02	Fremgangsmåte for behandling av diabetes
DK1448205T3 (da)	2011-12-12	Kombinationer til behandling af immunoinflammatoriske sygdomme
DK1411926T3 (da)	2005-08-29	Integrininhibitorer til behandling af öjensygdomme
NO20045554L (no)	2004-12-20	Fremgangsmate for behandling av diabetes
DK2189162T3 (da)	2014-02-03	Fremgangsmåder til behandling af cellulære proliferative forstyrrelser
NO20024776D0 (no)	2002-10-03	Hydroksyfenyl-piperazinyl-metyl-benzamidderivater til behandling av smerte
NO20041378L (no)	2004-05-28	[[2-(Amino-3,4-diokso-1-cyklobuten-1-yl)amino]alkyl]-syrederivater for behandling av smerte
NO20024777D0 (no)	2002-10-03	Kinolinyl-piperidin-4-yliden-metyl-benzamidderivater til behandling av smerte
DK1309322T3 (da)	2006-10-23	Anvendelse af 3-benzoylphenyleddikesyrederivater til behandling af retinale lidelser
DK1268482T3 (da)	2003-12-22	Pyranoindoler til behandling af glaukom
DK1200447T3 (da)	2004-02-02	Oxazinocarbazoler til behandling af CNS-sygdomme
DK1341766T3 (da)	2006-02-20	Imidazolonderivater til behandling af virussygdomme
IS6020A (is)	2001-07-23	S-nítrósóþíól til meðferðar við blóðrásartruflunum