DK1436257T3 - Oxim-analogica af 1-alpha, 25-dihydroxy-vitamin-D3 med ringe kalcemisk virkning - Google Patents

Oxim-analogica af 1-alpha, 25-dihydroxy-vitamin-D3 med ringe kalcemisk virkning

Info

Publication number: DK1436257T3
Authority: DK; Denmark
Prior art keywords: dihydroxy; vitamin; alpha; sub; low calcium
Prior art date: 2001-10-12

Application number

DK02767010T

Other languages

English (en)

Inventor

Heung Bae Jeon

Gary H Posner

Jay A White

Glenville Jones

Bethany Halford

Mehmet Kahraman

Original Assignee

Univ Johns Hopkins

Cytochroma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-12

Filing date

2002-10-11

Publication date

2007-06-25

2002-10-11 Application filed by Univ Johns Hopkins, Cytochroma Inc filed Critical Univ Johns Hopkins

2007-06-25 Application granted granted Critical

2007-06-25 Publication of DK1436257T3 publication Critical patent/DK1436257T3/da

Links

GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 title abstract 3
GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 title 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title 1
239000011612 calcitriol Substances 0.000 title 1
235000020964 calcitriol Nutrition 0.000 title 1
229910052791 calcium Inorganic materials 0.000 title 1
239000011575 calcium Substances 0.000 title 1
150000002923 oximes Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
102100027518 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial Human genes 0.000 abstract 1
101000861278 Homo sapiens 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial Proteins 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Dermatology (AREA)
Emergency Medicine (AREA)
Communicable Diseases (AREA)
Nutrition Science (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK02767010T 2001-10-12 2002-10-11 Oxim-analogica af 1-alpha, 25-dihydroxy-vitamin-D3 med ringe kalcemisk virkning DK1436257T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US32842801P	2001-10-12	2001-10-12
PCT/CA2002/001519 WO2003031400A1 (en)	2001-10-12	2002-10-11	Low-calcemic oxime analogs of 1alpha, 25-dihydroxy vitamin d3

Publications (1)

Publication Number	Publication Date
DK1436257T3 true DK1436257T3 (da)	2007-06-25

Family

ID=23280940

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02767010T DK1436257T3 (da)	2001-10-12	2002-10-11	Oxim-analogica af 1-alpha, 25-dihydroxy-vitamin-D3 med ringe kalcemisk virkning

Country Status (11)

Country	Link
US (1)	US6982258B2 (da)
EP (1)	EP1436257B1 (da)
JP (1)	JP4436674B2 (da)
AT (1)	ATE360000T1 (da)
CA (1)	CA2463505C (da)
CY (1)	CY1106638T1 (da)
DE (1)	DE60219655T2 (da)
DK (1)	DK1436257T3 (da)
ES (1)	ES2283593T3 (da)
PT (1)	PT1436257E (da)
WO (1)	WO2003031400A1 (da)

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US6242434B1 (en)	1997-08-08	2001-06-05	Bone Care International, Inc.	24-hydroxyvitamin D, analogs and uses thereof
US6087350A (en) *	1997-08-29	2000-07-11	University Of Pittsburgh Of The Commonwealth System Of Higher Education	Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
JP2004504295A (ja)	2000-07-18	2004-02-12	ボーン　ケア　インターナショナル　インコーポレイテッド	安定化１α−ヒドロキシビタミンＤ
US20050059641A1 (en) *	2003-06-17	2005-03-17	Aphios Corporation	Compositions and methods for treating and preventing cancer using analogs of vitamin D
US20050192255A1 (en) *	2003-07-30	2005-09-01	Jin Tian	Use of Vitamin Ds or Vitamin D analogs to treat cardiovascular disease
JP2007537263A (ja) *	2004-05-10	2007-12-20	ノバセアインコーポレイティッド	活性ビタミンｄ化合物による動脈再狭窄の予防法
US7094775B2 (en)	2004-06-30	2006-08-22	Bone Care International, Llc	Method of treating breast cancer using a combination of vitamin D analogues and other agents
WO2006032299A1 (en) *	2004-09-24	2006-03-30	Susanna Miettinen	Use of inhibitors of 24-hydroxylase in the treatment of cancer
WO2006074227A2 (en) *	2005-01-04	2006-07-13	Johns Hopkins University	HIGHLY ANTIPROLIFERATIVE, LOW-CALCEMIC, ANALOGS OF THE HORMONE 1α, 25-DIHYDROXYVITAMIN D3 WITH CARBONYL SIDE CHAINS
WO2006113990A2 (en) *	2005-04-25	2006-11-02	Cytochroma Inc.	LOW-CALCEMIC 16,23-DIENE 25-OXIME ANALOGS OF 1α ,25-DIHYDROXY VITAMIN D3
US20070122477A1 (en) *	2005-10-12	2007-05-31	Cytochroma, Inc.	Methods and articles for treating 25-hydroxyvitamin D insufficiency and deficiency
PT3095447T (pt)	2006-02-03	2022-01-24	Opko Renal Llc	Tratamento da insuficiência e deficiência de vitamina d com 25-hidroxivitamina d2 e 25-hidroxivitamina d3
DK2037936T3 (da)	2006-06-21	2014-09-22	Opko Renal Llc	Fremgangsmåde til behandling og forebyggelse af sekundær hyperparathyroidisme
WO2008131267A2 (en) *	2007-04-18	2008-10-30	Johns Hopkins University	Low calcemic, highly antiproliferative, analogs of calcitriol
CA2683628C (en) *	2007-04-25	2018-03-06	Cytochroma Inc.	Method of treating vitamin d insufficiency and deficiency
EP2148685A4 (en) *	2007-04-25	2010-07-28	Cytochroma Inc	METHODS AND COMPOUNDS FOR THERAPY BASED ON VITAMIN D
ES3047207T3 (en)	2007-04-25	2025-12-03	Opko Renal Llc	Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease
KR101691876B1 (ko)	2007-04-25	2017-01-02	사이토크로마 인코포레이티드	비타민 ｄ 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물
US20100048524A1 (en)	2008-03-14	2010-02-25	Angela Brodie	Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
WO2009120565A2 (en)	2008-03-25	2009-10-01	University Of Maryland, Baltimore	Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
ES2593356T3 (es)	2008-04-02	2016-12-07	Opko Ireland Global Holdings, Ltd.	Métodos, composiciones, usos y kits útiles para la deficiencia de la vitamina D y trastornos relacionados
EP2393827B1 (en)	2009-02-05	2015-10-07	Tokai Pharmaceuticals, Inc.	Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
US20100227414A1 (en) *	2009-03-05	2010-09-09	Trex Enterprises Corp.	Affinity capture mass spectroscopy with a porous silicon biosensor
WO2011088209A2 (en)	2010-01-13	2011-07-21	Cytochroma Inc.	1-deoxy analogs of vitamin d-related compounds
US11672809B2 (en)	2010-03-29	2023-06-13	Eirgen Pharma Ltd.	Methods and compositions for reducing parathyroid levels
CA2904170A1 (en)	2013-03-14	2014-09-25	University Of Maryland, Baltimore	Androgen receptor down-regulating agents and uses thereof
KR101847947B1 (ko)	2013-03-15	2018-05-28	옵코 아이피 홀딩스 Ⅱ 인코포레이티드	안정화되고 변형된 비타민 ｄ 방출 제형
KR20160058774A (ko)	2013-08-12	2016-05-25	토카이 파마슈티컬, 아이엔씨.	안드로겐-표적 치료제를 이용하는 종양 질환 치료를 위한 바이오마커
US10220047B2 (en)	2014-08-07	2019-03-05	Opko Ireland Global Holdings, Ltd.	Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
CN104557647B (zh) *	2015-01-13	2016-07-06	南京理工大学	维生素d肟类衍生物、合成方法及其应用
CN104945296B (zh) *	2015-06-09	2016-08-24	南京理工大学	一类芳香醛腙修饰的维生素d2衍生物、合成及其应用
KR20180123100A (ko)	2016-03-28	2018-11-14	옵코 아일랜드 글로벌 홀딩스 리미티드	비타민 d 치료 방법
CN117003679A (zh) *	2022-04-29	2023-11-07	南澳大利亚大学	新型抑制剂化合物
WO2025094144A1 (en)	2023-11-02	2025-05-08	Eirgen Pharma Ltd.	Controlling loss of kidney function

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US4481198A (en) *	1984-02-13	1984-11-06	Wisconsin Alumni Research Foundation	Vitamin D metabolism inhibitor
GB9623569D0 (en) *	1996-11-13	1997-01-08	Immunodiagnostic Systems Ltd	Vitamin D immumoassay systems

2002
- 2002-10-11 DK DK02767010T patent/DK1436257T3/da active
- 2002-10-11 AT AT02767010T patent/ATE360000T1/de active
- 2002-10-11 JP JP2003534384A patent/JP4436674B2/ja not_active Expired - Fee Related
- 2002-10-11 DE DE60219655T patent/DE60219655T2/de not_active Expired - Lifetime
- 2002-10-11 PT PT02767010T patent/PT1436257E/pt unknown
- 2002-10-11 WO PCT/CA2002/001519 patent/WO2003031400A1/en not_active Ceased
- 2002-10-11 CA CA2463505A patent/CA2463505C/en not_active Expired - Lifetime
- 2002-10-11 EP EP02767010A patent/EP1436257B1/en not_active Expired - Lifetime
- 2002-10-11 ES ES02767010T patent/ES2283593T3/es not_active Expired - Lifetime
- 2002-10-15 US US10/270,158 patent/US6982258B2/en not_active Expired - Lifetime
2007
- 2007-06-04 CY CY20071100741T patent/CY1106638T1/el unknown

Also Published As

Publication number	Publication date
US6982258B2 (en)	2006-01-03
CY1106638T1 (el)	2012-01-25
JP2005536444A (ja)	2005-12-02
CA2463505A1 (en)	2003-04-17
DE60219655D1 (de)	2007-05-31
JP4436674B2 (ja)	2010-03-24
ES2283593T3 (es)	2007-11-01
US20030171342A1 (en)	2003-09-11
WO2003031400A1 (en)	2003-04-17
CA2463505C (en)	2011-07-12
PT1436257E (pt)	2007-05-31
EP1436257A1 (en)	2004-07-14
ATE360000T1 (de)	2007-05-15
DE60219655T2 (de)	2007-12-27
EP1436257B1 (en)	2007-04-18

Publication	Publication Date	Title
ATE360000T1 (de)	2007-05-15	Oxim-analoga von 1-alpha,25-dihydroxy-vitamin-d3 mit geringer calcemischer wirkung
SE0301373D0 (sv)	2003-05-09	Novel compounds
DK1379239T3 (da)	2008-01-07	N(2-aryl-ethyl)-benzyl-aminer som antagonister af 5 HT6 receptoren
SE0303180D0 (sv)	2003-11-26	Novel compounds
SE0302232D0 (sv)	2003-08-18	Novel Compounds
BRPI0410630A (pt)	2006-06-13	antagonista de nk1
SE0301010D0 (sv)	2003-04-07	Novel compounds
SE0101675D0 (sv)	2001-05-11	Novel composition
MXPA03011484A (es)	2004-03-18	Heteroarilos multiciclicos sustituidos con quinuclidinas para el tratamiento de enfermedades.
DK0783486T3 (da)	2000-01-31	Hidtil ukendte prostaglandinsynthaseinhibitorer
BR0010555A (pt)	2003-09-23	Inibidores de neuraminidases
BR0212733A (pt)	2004-11-16	Composto, composição farmacêutica, uso de um composto, e, método para o tratamento de um distúrbio afetivo
SE0301009D0 (sv)	2003-04-07	Novel compounds
BR9804437A (pt)	2001-05-02	Compostos para a osteoporose
EA200301232A1 (ru)	2004-04-29	Новые соединения арилсульфонамида и их применение для лечения ожирения, диабета типа ii и нарушений центральной нервной системы
DK0705254T3 (da)	1999-01-25	Phenylheterocykliske forbindelser som cyclooxygenase-2-inhibitorer
ATE433447T1 (de)	2009-06-15	Pyrimiidinverbindungen
ATE232873T1 (de)	2003-03-15	Phosphonsaürederivate als ptp-1b-inhibitoren
SE0302760D0 (sv)	2003-10-20	New compounds
DE60324544D1 (de)	2008-12-18	Muskarin antagonisten
ATE543796T1 (de)	2012-02-15	24-sulfoximine vitamin d3 derivate
EA200600605A1 (ru)	2006-10-27	Перегруппированные пентанолы, способ их получения и их применение в качестве противовоспалительных средств
BR0100234A (pt)	2001-08-28	Compostos de piperidina-4-sulfonamida, processo para a sua preparação e composições farmacêuticas contendo os mesmos
DE60329326D1 (de)	2009-10-29	Tace inhibitoren
DK1441724T3 (da)	2007-12-03	Fremgangsmåde til forögelse af endogene testosteronniveauer