DK1436263T3 - Fremgangsmåde til fremstilling af beta-ketoesterforbindelse - Google Patents
Fremgangsmåde til fremstilling af beta-ketoesterforbindelseInfo
- Publication number
- DK1436263T3 DK1436263T3 DK02781941T DK02781941T DK1436263T3 DK 1436263 T3 DK1436263 T3 DK 1436263T3 DK 02781941 T DK02781941 T DK 02781941T DK 02781941 T DK02781941 T DK 02781941T DK 1436263 T3 DK1436263 T3 DK 1436263T3
- Authority
- DK
- Denmark
- Prior art keywords
- beta
- preparation
- ketoester compound
- compound
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 4
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- GSDSWSVVBLHKDQ-JTQLQIEISA-N Levofloxacin Chemical compound C([C@@H](N1C2=C(C(C(C(O)=O)=C1)=O)C=C1F)C)OC2=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-JTQLQIEISA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229960003405 ciprofloxacin Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229960003170 gemifloxacin Drugs 0.000 abstract 1
- ZRCVYEYHRGVLOC-HYARGMPZSA-N gemifloxacin Chemical compound C1C(CN)C(=N/OC)/CN1C(C(=C1)F)=NC2=C1C(=O)C(C(O)=O)=CN2C1CC1 ZRCVYEYHRGVLOC-HYARGMPZSA-N 0.000 abstract 1
- 229960003376 levofloxacin Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 229960000497 trovafloxacin Drugs 0.000 abstract 1
- WVPSKSLAZQPAKQ-CDMJZVDBSA-N trovafloxacin Chemical compound C([C@H]1[C@@H]([C@H]1C1)N)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F WVPSKSLAZQPAKQ-CDMJZVDBSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20010063349 | 2001-10-15 | ||
| PCT/KR2002/001918 WO2003033469A1 (en) | 2001-10-15 | 2002-10-14 | A process for preparing beta-ketoester compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1436263T3 true DK1436263T3 (da) | 2007-11-05 |
Family
ID=19715116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02781941T DK1436263T3 (da) | 2001-10-15 | 2002-10-14 | Fremgangsmåde til fremstilling af beta-ketoesterforbindelse |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6987199B2 (da) |
| EP (1) | EP1436263B1 (da) |
| JP (1) | JP4147190B2 (da) |
| KR (1) | KR100589966B1 (da) |
| CN (1) | CN1308309C (da) |
| AT (1) | ATE373641T1 (da) |
| DE (1) | DE60222574T2 (da) |
| DK (1) | DK1436263T3 (da) |
| ES (1) | ES2294179T3 (da) |
| PT (1) | PT1436263E (da) |
| WO (1) | WO2003033469A1 (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007064077A1 (en) * | 2005-09-16 | 2007-06-07 | Lg Life Sciences Ltd. | A process for preparing beta-ketoester compounds |
| KR100968576B1 (ko) * | 2008-06-10 | 2010-07-08 | 이화여자대학교 산학협력단 | 2-아실-3-아미노-2-알케노에이트의 제조방법 |
| CN101774967B (zh) * | 2010-01-27 | 2011-07-27 | 常州寅盛药业有限公司 | 一种制备2,6-二氯-5-氟烟酰乙酸乙酯的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3508816A1 (de) | 1985-01-10 | 1986-07-10 | Bayer Ag, 5090 Leverkusen | 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren |
| EP0333020A3 (en) * | 1988-03-18 | 1991-03-20 | Abbott Laboratories | Process for the preparation of substituted pyridines |
| EP0449445A3 (en) * | 1990-03-27 | 1993-08-25 | Pfizer Inc. | Preparation of beta-ketoesters useful in preparing quinolone antibiotics |
| US5204478A (en) * | 1992-08-20 | 1993-04-20 | Warner-Lambert Company | Process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride |
| KR100372563B1 (ko) | 1996-12-16 | 2003-11-20 | 주식회사 엘지생명과학 | 퀴놀론계항생제중간체인베타-케토에스테르유도체의제조방법 |
| KR19980047902U (ko) * | 1996-12-28 | 1998-09-25 | 박병재 | 차량의 자동변속기 유온 예측 장치 |
-
2002
- 2002-10-14 ES ES02781941T patent/ES2294179T3/es not_active Expired - Lifetime
- 2002-10-14 JP JP2003536209A patent/JP4147190B2/ja not_active Expired - Fee Related
- 2002-10-14 DK DK02781941T patent/DK1436263T3/da active
- 2002-10-14 PT PT02781941T patent/PT1436263E/pt unknown
- 2002-10-14 US US10/492,092 patent/US6987199B2/en not_active Expired - Lifetime
- 2002-10-14 WO PCT/KR2002/001918 patent/WO2003033469A1/en not_active Ceased
- 2002-10-14 CN CNB028204387A patent/CN1308309C/zh not_active Expired - Lifetime
- 2002-10-14 AT AT02781941T patent/ATE373641T1/de active
- 2002-10-14 KR KR1020020062393A patent/KR100589966B1/ko not_active Expired - Lifetime
- 2002-10-14 DE DE60222574T patent/DE60222574T2/de not_active Expired - Lifetime
- 2002-10-14 EP EP02781941A patent/EP1436263B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60222574D1 (de) | 2007-10-31 |
| WO2003033469A1 (en) | 2003-04-24 |
| KR100589966B1 (ko) | 2006-06-15 |
| ES2294179T3 (es) | 2008-04-01 |
| JP2005510486A (ja) | 2005-04-21 |
| KR20030031433A (ko) | 2003-04-21 |
| US20040249163A1 (en) | 2004-12-09 |
| DE60222574T2 (de) | 2008-01-31 |
| ATE373641T1 (de) | 2007-10-15 |
| PT1436263E (pt) | 2007-12-17 |
| EP1436263A1 (en) | 2004-07-14 |
| US6987199B2 (en) | 2006-01-17 |
| EP1436263A4 (en) | 2005-11-02 |
| CN1308309C (zh) | 2007-04-04 |
| CN1571771A (zh) | 2005-01-26 |
| EP1436263B1 (en) | 2007-09-19 |
| JP4147190B2 (ja) | 2008-09-10 |
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