DK1446478T3 - Dimeriseret vækstfaktor samt materialer og fremgangmåder til fremstilling heraf - Google Patents
Dimeriseret vækstfaktor samt materialer og fremgangmåder til fremstilling herafInfo
- Publication number
- DK1446478T3 DK1446478T3 DK02773824T DK02773824T DK1446478T3 DK 1446478 T3 DK1446478 T3 DK 1446478T3 DK 02773824 T DK02773824 T DK 02773824T DK 02773824 T DK02773824 T DK 02773824T DK 1446478 T3 DK1446478 T3 DK 1446478T3
- Authority
- DK
- Denmark
- Prior art keywords
- sub
- polypeptide chains
- amino acid
- making
- materials
- Prior art date
Links
- 239000000463 material Substances 0.000 title abstract 2
- 239000003102 growth factor Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 7
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 abstract 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 abstract 1
- 108091008606 PDGF receptors Proteins 0.000 abstract 1
- 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 abstract 1
- 102100040682 Platelet-derived growth factor D Human genes 0.000 abstract 1
- 101710170209 Platelet-derived growth factor D Proteins 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/49—Platelet-derived growth factor [PDGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Glass Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34611701P | 2001-10-19 | 2001-10-19 | |
| PCT/US2002/033563 WO2003033677A2 (en) | 2001-10-19 | 2002-10-18 | Dimerized growth factor and materials and methods for producing it |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1446478T3 true DK1446478T3 (da) | 2008-06-02 |
Family
ID=23358033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02773824T DK1446478T3 (da) | 2001-10-19 | 2002-10-18 | Dimeriseret vækstfaktor samt materialer og fremgangmåder til fremstilling heraf |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7122351B2 (da) |
| EP (1) | EP1446478B1 (da) |
| JP (1) | JP2005506073A (da) |
| AT (1) | ATE384783T1 (da) |
| AU (1) | AU2002337920A1 (da) |
| CA (1) | CA2463003A1 (da) |
| DE (1) | DE60224822T2 (da) |
| DK (1) | DK1446478T3 (da) |
| ES (1) | ES2302845T3 (da) |
| WO (1) | WO2003033677A2 (da) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6287850B1 (en) * | 1995-06-07 | 2001-09-11 | Affymetrix, Inc. | Bioarray chip reaction apparatus and its manufacture |
| AU784634B2 (en) | 1999-11-30 | 2006-05-18 | Mayo Foundation For Medical Education And Research | B7-H1, a novel immunoregulatory molecule |
| US7030219B2 (en) * | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
| AU2003210996A1 (en) * | 2002-02-11 | 2003-09-04 | Zymogenetics, Inc. | Materials and methods for preparing dimeric growth factors |
| US7432351B1 (en) | 2002-10-04 | 2008-10-07 | Mayo Foundation For Medical Education And Research | B7-H1 variants |
| AR046594A1 (es) * | 2003-10-16 | 2005-12-14 | Applied Research Systems | Usos terapeuticos de variantes de quemoquina |
| ATE517914T1 (de) | 2004-03-08 | 2011-08-15 | Zymogenetics Inc | Dimere fusionsproteine und materialien und verfahren zu deren herstellung |
| ES2671893T3 (es) | 2004-10-06 | 2018-06-11 | Mayo Foundation For Medical Education And Research | B7-H1 y PD-1 en el tratamiento del carcinoma de células renales |
| US7473678B2 (en) * | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| US8114841B2 (en) | 2004-10-14 | 2012-02-14 | Biomimetic Therapeutics, Inc. | Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix |
| EP1801121A1 (en) * | 2005-12-23 | 2007-06-27 | CONARIS research institute AG | Soluble gp130 molecule variants useful as a medicament |
| ES2427993T3 (es) * | 2006-02-09 | 2013-11-05 | Biomimetic Therapeutics, Llc | Composiciones y métodos para el tratamiento de hueso |
| CA2656278C (en) * | 2006-06-30 | 2016-02-09 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating rotator cuff injuries |
| US9161967B2 (en) * | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| US8106008B2 (en) | 2006-11-03 | 2012-01-31 | Biomimetic Therapeutics, Inc. | Compositions and methods for arthrodetic procedures |
| EP2170946A2 (en) | 2007-07-13 | 2010-04-07 | The Johns Hopkins University | B7-dc variants |
| US20100310626A1 (en) * | 2008-01-24 | 2010-12-09 | Remedor Biomed Ltd. | Erythropoietin and fibronectin compositions for bone regeneration |
| EP2259807B1 (en) * | 2008-02-07 | 2013-04-24 | Biomimetic Therapeutics, Inc. | Compositions for distraction osteogenesis |
| CN102203132A (zh) | 2008-08-25 | 2011-09-28 | 安普利穆尼股份有限公司 | Pd-1拮抗剂的组合物和使用方法 |
| KR20110067035A (ko) | 2008-09-09 | 2011-06-20 | 바이오미메틱 세라퓨틱스, 인크. | 건 및 인대 손상의 치료를 위한 혈소판-유래 성장 인자 조성물 및 방법 |
| WO2010102266A1 (en) * | 2009-03-05 | 2010-09-10 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects |
| CN102811622A (zh) | 2010-02-22 | 2012-12-05 | 生物模拟治疗公司 | 用于治疗腱病的血小板衍生生长因子组合物和方法 |
| US9133486B2 (en) * | 2012-03-12 | 2015-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrogenase fusion protein for improved hydrogen production |
| CN104185474B (zh) | 2012-03-30 | 2017-08-25 | 拜尔健康护理有限责任公司 | 蛋白酶调节的抗体 |
| US9302005B2 (en) | 2013-03-14 | 2016-04-05 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| ES2714708T3 (es) | 2013-10-01 | 2019-05-29 | Mayo Found Medical Education & Res | Procedimientos para el tratamiento de cáncer en pacientes con niveles elevados de Bim |
| US10302653B2 (en) | 2014-05-22 | 2019-05-28 | Mayo Foundation For Medical Education And Research | Distinguishing antagonistic and agonistic anti B7-H1 antibodies |
| EP3171896A4 (en) | 2014-07-23 | 2018-03-21 | Mayo Foundation for Medical Education and Research | Targeting dna-pkcs and b7-h1 to treat cancer |
| US10875923B2 (en) | 2015-10-30 | 2020-12-29 | Mayo Foundation For Medical Education And Research | Antibodies to B7-H1 |
| WO2020092736A1 (en) | 2018-10-31 | 2020-05-07 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| US12264189B2 (en) | 2018-10-31 | 2025-04-01 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5013653A (en) * | 1987-03-20 | 1991-05-07 | Creative Biomolecules, Inc. | Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage |
| US5336603A (en) * | 1987-10-02 | 1994-08-09 | Genentech, Inc. | CD4 adheson variants |
| DE68926888T2 (de) * | 1988-01-22 | 1997-01-09 | Zymogenetics Inc | Verfahren zur Herstellung von sekretierten Rezeptoranalogen |
| US6018026A (en) * | 1988-01-22 | 2000-01-25 | Zymogenetics, Inc. | Biologically active dimerized and multimerized polypeptide fusions |
| EP1201757A3 (en) | 1988-12-22 | 2002-09-11 | Genentech, Inc. | Method for preparing water soluble polypeptides |
| US5116964A (en) * | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| CA2182498A1 (en) * | 1994-02-01 | 1995-08-10 | William J. Larochelle | Fusion proteins that include antibody and nonantibody portions |
| US5731168A (en) * | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US20020137890A1 (en) * | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| GB9720054D0 (en) * | 1997-09-19 | 1997-11-19 | Celltech Therapeutics Ltd | Biological products |
| AU770899B2 (en) * | 1998-11-10 | 2004-03-04 | Licentia Ltd | Platelet-derived growth factor D, DNA coding therefor, and uses thereof |
| US6468543B1 (en) * | 1999-05-03 | 2002-10-22 | Zymogenetics, Inc. | Methods for promoting growth of bone using ZVEGF4 |
| EP1672070A3 (en) | 1999-12-01 | 2006-10-04 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| EP1254242A4 (en) | 2000-01-31 | 2005-02-23 | Human Genome Sciences Inc | 17 HUMAN SECRETED PROTEINS |
| CA2410551A1 (en) | 2000-06-30 | 2002-01-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw (Vib) | Heterodimeric fusion proteins |
| AU2002245652A1 (en) | 2001-03-09 | 2002-09-24 | Zymogenetics, Inc. | Soluble heterodimeric cytokine receptor |
-
2002
- 2002-10-18 ES ES02773824T patent/ES2302845T3/es not_active Expired - Lifetime
- 2002-10-18 AU AU2002337920A patent/AU2002337920A1/en not_active Abandoned
- 2002-10-18 EP EP02773824A patent/EP1446478B1/en not_active Expired - Lifetime
- 2002-10-18 DE DE60224822T patent/DE60224822T2/de not_active Expired - Fee Related
- 2002-10-18 AT AT02773824T patent/ATE384783T1/de not_active IP Right Cessation
- 2002-10-18 JP JP2003536407A patent/JP2005506073A/ja active Pending
- 2002-10-18 US US10/274,638 patent/US7122351B2/en not_active Expired - Fee Related
- 2002-10-18 DK DK02773824T patent/DK1446478T3/da active
- 2002-10-18 WO PCT/US2002/033563 patent/WO2003033677A2/en not_active Ceased
- 2002-10-18 CA CA002463003A patent/CA2463003A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE384783T1 (de) | 2008-02-15 |
| EP1446478A4 (en) | 2005-03-16 |
| CA2463003A1 (en) | 2003-04-24 |
| EP1446478A2 (en) | 2004-08-18 |
| US20030109000A1 (en) | 2003-06-12 |
| DE60224822T2 (de) | 2009-01-22 |
| DE60224822D1 (de) | 2008-03-13 |
| US7122351B2 (en) | 2006-10-17 |
| JP2005506073A (ja) | 2005-03-03 |
| ES2302845T3 (es) | 2008-08-01 |
| WO2003033677A2 (en) | 2003-04-24 |
| WO2003033677A3 (en) | 2003-07-10 |
| AU2002337920A1 (en) | 2003-04-28 |
| EP1446478B1 (en) | 2008-01-23 |
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