DK1453852T3 - Selektive arylguanidinpeptider som urokinaseinhibitorer - Google Patents

Selektive arylguanidinpeptider som urokinaseinhibitorer

Info

Publication number
DK1453852T3
DK1453852T3 DK02787942T DK02787942T DK1453852T3 DK 1453852 T3 DK1453852 T3 DK 1453852T3 DK 02787942 T DK02787942 T DK 02787942T DK 02787942 T DK02787942 T DK 02787942T DK 1453852 T3 DK1453852 T3 DK 1453852T3
Authority
DK
Denmark
Prior art keywords
arylguanidine
peptides
selective
urokinase inhibitors
urokinase
Prior art date
Application number
DK02787942T
Other languages
English (en)
Inventor
Stefan Sperl
Original Assignee
Wilex Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2002140452 external-priority patent/DE10240452A1/de
Application filed by Wilex Ag filed Critical Wilex Ag
Application granted granted Critical
Publication of DK1453852T3 publication Critical patent/DK1453852T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C07K5/06069—Ser-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DK02787942T 2001-12-12 2002-12-12 Selektive arylguanidinpeptider som urokinaseinhibitorer DK1453852T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10161062 2001-12-12
DE2002140452 DE10240452A1 (de) 2002-09-02 2002-09-02 Urokinase Inhibitoren
PCT/EP2002/014157 WO2003053999A2 (de) 2001-12-12 2002-12-12 Selektive arylguanidinpeptide als urokinaseinhibitoren

Publications (1)

Publication Number Publication Date
DK1453852T3 true DK1453852T3 (da) 2007-05-21

Family

ID=26010763

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02787942T DK1453852T3 (da) 2001-12-12 2002-12-12 Selektive arylguanidinpeptider som urokinaseinhibitorer

Country Status (11)

Country Link
US (1) US20040266766A1 (da)
EP (1) EP1453852B1 (da)
JP (1) JP4418680B2 (da)
AU (1) AU2002352245B2 (da)
CA (1) CA2470078C (da)
DE (1) DE50209313D1 (da)
DK (1) DK1453852T3 (da)
ES (1) ES2275937T3 (da)
PT (1) PT1453852E (da)
SI (1) SI1453852T1 (da)
WO (1) WO2003053999A2 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7838560B2 (en) * 2002-03-11 2010-11-23 The Medicines Company (Leipzig) Gmbh Urokinase inhibitors, production and use thereof
DE10301300B4 (de) * 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
DE10342108A1 (de) * 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
DE102004045720A1 (de) * 2004-09-21 2006-03-23 Wilex Ag Stabile Dosierungsform von Phenylalanin-Derivaten
MX2007016439A (es) 2005-06-24 2008-03-04 Wilex Ag Uso de inhibidores de urocinasa para el tratamiento y/o prevencion de enfermedades neuropatologicas.
DE102006050672A1 (de) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins
AU2012329098B2 (en) 2011-10-26 2017-08-03 Allergan, Inc. Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators
IT202200007754A1 (it) * 2022-04-19 2023-10-19 Iridea S R L Nuovi composti con attivita’ farmacologica

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US6576613B1 (en) * 1998-07-24 2003-06-10 Corvas International, Inc. Title inhibitors of urokinase
DE19940389A1 (de) * 1999-08-25 2001-03-01 Wilex Biotechnology Gmbh Selektive Inhibitoren des Urokinase-Plasminogen Aktivators
DE10013715A1 (de) * 2000-03-20 2001-09-27 Wilex Biotechnology Gmbh Hochselektive Inhibitoren des Urokinase-Plasminogenaktivators
DE10029014A1 (de) * 2000-06-15 2001-12-20 Univ Schiller Jena Urokinase-Hemmstoffe
DE10029015A1 (de) * 2000-06-15 2001-12-20 Curacyte Ag Hemmstoffe für den Gerinnungsfaktor Xa
NZ547626A (en) * 2000-08-11 2007-10-26 Wilex Ag Non-covalent inhibitors of urokinase and blood vessel formation

Also Published As

Publication number Publication date
EP1453852B1 (de) 2007-01-17
AU2002352245A1 (en) 2003-07-09
CA2470078A1 (en) 2003-07-03
JP2005518388A (ja) 2005-06-23
EP1453852A2 (de) 2004-09-08
SI1453852T1 (sl) 2007-06-30
AU2002352245B2 (en) 2008-10-16
JP4418680B2 (ja) 2010-02-17
DE50209313D1 (de) 2007-03-08
WO2003053999A2 (de) 2003-07-03
US20040266766A1 (en) 2004-12-30
PT1453852E (pt) 2007-02-28
ES2275937T3 (es) 2007-06-16
CA2470078C (en) 2011-07-12
WO2003053999A3 (de) 2003-11-06

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