DK145799C - Tripeptider eller salte deraf til anvendelse som diagnostisk kromogent substrat med hoej specificitet overfor thrombin og thrombinlignende enzymer - Google Patents

Tripeptider eller salte deraf til anvendelse som diagnostisk kromogent substrat med hoej specificitet overfor thrombin og thrombinlignende enzymer

Info

Publication number
DK145799C
DK145799C DK312676A DK312676A DK145799C DK 145799 C DK145799 C DK 145799C DK 312676 A DK312676 A DK 312676A DK 312676 A DK312676 A DK 312676A DK 145799 C DK145799 C DK 145799C
Authority
DK
Denmark
Prior art keywords
thrombin
chromogent
tripeptides
diagnostic
salts
Prior art date
Application number
DK312676A
Other languages
Danish (da)
English (en)
Other versions
DK312676A (da
DK145799B (da
Inventor
Af Ekenstam Bo Thuresson
Leif Erik Aurell
Karl Goeran Claeson
Birgitta Gunilla Karlsson
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Publication of DK312676A publication Critical patent/DK312676A/da
Publication of DK145799B publication Critical patent/DK145799B/da
Application granted granted Critical
Publication of DK145799C publication Critical patent/DK145799C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/064—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/30—Naphthyl amides, e.g. beta-NA, 2-NA, 4-methoxy-beta-naphthylamine, i.e. 4MNA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK312676A 1975-07-11 1976-07-09 Tripeptider eller salte deraf til anvendelse som diagnostisk kromogent substrat med hoej specificitet overfor thrombin og thrombinlignende enzymer DK145799C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE7507975-6A SE407405B (sv) 1975-07-11 1975-07-11 Nya kromogena trombinsubstrat
SE7507975 1975-07-11

Publications (3)

Publication Number Publication Date
DK312676A DK312676A (da) 1977-01-12
DK145799B DK145799B (da) 1983-03-07
DK145799C true DK145799C (da) 1983-08-29

Family

ID=20325116

Family Applications (1)

Application Number Title Priority Date Filing Date
DK312676A DK145799C (da) 1975-07-11 1976-07-09 Tripeptider eller salte deraf til anvendelse som diagnostisk kromogent substrat med hoej specificitet overfor thrombin og thrombinlignende enzymer

Country Status (22)

Country Link
JP (1) JPS5224590A (fr)
AT (1) AT348686B (fr)
AU (1) AU497547B2 (fr)
BE (1) BE843970A (fr)
CA (1) CA1068261A (fr)
CH (1) CH622287A5 (fr)
CS (1) CS196314B2 (fr)
DD (1) DD128691A5 (fr)
DE (1) DE2629195C3 (fr)
DK (1) DK145799C (fr)
ES (1) ES449739A1 (fr)
FI (1) FI56525C (fr)
FR (1) FR2317280A1 (fr)
GB (1) GB1510926A (fr)
IL (1) IL49829A (fr)
IT (1) IT1062605B (fr)
NL (1) NL188355C (fr)
NO (1) NO142576C (fr)
PL (1) PL103003B1 (fr)
SE (1) SE407405B (fr)
SU (1) SU719492A3 (fr)
ZA (1) ZA763586B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5255593A (en) * 1975-10-30 1977-05-07 Ajinomoto Kk Measuring method of enzyme activity
DE2757992A1 (de) * 1977-12-24 1979-06-28 Boehringer Mannheim Gmbh Verfahren zur prothrombin-bestimmung
DE2812943C3 (de) * 1978-03-23 1981-05-14 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma
US4289498A (en) * 1979-01-08 1981-09-15 Ortho Diagnostics, Inc. One-stage prothrombin assay and compositions useful therein
EP0018002B1 (fr) * 1979-04-24 1983-02-09 Marcel Jozefonvicz Procédé pour la détermination de protéases et d'anti-protéases
FR2471410A2 (fr) * 1979-12-17 1981-06-19 Jozefonvicz Marcel Perfectionnements apportes a un procede de dosage des proteases et des anti-proteases et notamment des proteases et antiproteases des systemes de la coagulation et du complement
DE3005540A1 (de) * 1980-02-14 1981-08-20 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und reagens zur bestimmung der biologischen aktivitaet von heparin im plasma
DK155051C (da) * 1980-05-06 1989-07-03 Pentapharm Ag Tripeptidderivater samt fremgangsmaade til kvantitativ analyse for proteolytiske enzymer under anvendelse deraf
JPS5856695A (ja) * 1981-09-28 1983-04-04 Nitto Boseki Co Ltd 新規なトロンビン測定用基質
DE3211254A1 (de) * 1982-03-26 1983-09-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens
DK201084A (da) * 1983-04-28 1984-10-29 Kimberly Clark Co Fremgangsmaade til bestemmelse af cathepsin b i naervaerelse af andre proteolytiske enzymer, og forbindelser til anvendelse ved fremgangsmaaden
CN101180405A (zh) 2005-05-20 2008-05-14 株式会社三菱化学药得论 酶分析方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
SE380258B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser

Also Published As

Publication number Publication date
CH622287A5 (en) 1981-03-31
DE2629195A1 (de) 1977-01-13
SE407405B (sv) 1979-03-26
FI762010A7 (fr) 1977-01-12
DE2629195B2 (de) 1980-01-10
AU497547B2 (en) 1978-12-14
JPS5615239B2 (fr) 1981-04-09
SU719492A3 (ru) 1980-02-29
DD128691A5 (de) 1977-12-07
IL49829A (en) 1978-12-17
NL188355B (nl) 1992-01-02
JPS5224590A (en) 1977-02-24
FR2317280B1 (fr) 1980-05-16
IL49829A0 (en) 1976-08-31
SE7507975L (sv) 1977-01-12
FI56525C (fi) 1980-02-11
GB1510926A (en) 1978-05-17
AT348686B (de) 1979-02-26
AU1530576A (en) 1978-01-05
FR2317280A1 (fr) 1977-02-04
CS196314B2 (en) 1980-03-31
ES449739A1 (es) 1978-01-16
IT1062605B (it) 1984-10-20
DK312676A (da) 1977-01-12
NL7607104A (nl) 1977-01-13
CA1068261A (fr) 1979-12-18
DE2629195C3 (de) 1983-11-17
FI56525B (fi) 1979-10-31
DK145799B (da) 1983-03-07
NL188355C (nl) 1992-06-01
NO762407L (fr) 1977-01-12
NO142576B (no) 1980-06-02
ATA463976A (de) 1978-07-15
PL103003B1 (pl) 1979-05-31
ZA763586B (en) 1977-05-25
NO142576C (no) 1980-09-10
BE843970A (fr) 1976-11-03

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